Application of lactoferrin and composition thereof in promoting intestinal development

By regulating the expression of intestinal glycocalyx genes through lactoferrin and casein phosphopeptides, the problem of insufficient development of the intestinal glycocalyx layer in existing products is solved, thereby improving the intestinal barrier and enhancing intestinal health.

CN120939209AActive Publication Date: 2025-11-14AUSNUTRIA DAIRY CHINA
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Patent Information

Application Number
CN202511461664.2
Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
Filing Date
2025-10-14
Publication Date
2025-11-14
Estimated Expiration
2045-10-14

AI Technical Summary

Technical Problem

Existing gut health products lack effective measures to promote the development of the intestinal glycocalyx layer, leading to instability in intestinal barrier function and microbial community balance, making it difficult to effectively prevent infections and inflammatory bowel disease.

Method used

By using lactoferrin and casein phosphopeptide, the transcriptional levels of related genes are regulated, promoting the synthesis of the protein backbone, hyaluronic acid, and heparan sulfate in the intestinal glycocalyx, thereby enhancing intestinal barrier function.

Benefits of technology

It significantly promotes the development of the intestinal glycocalyx layer, improves the intestinal barrier, regulates the intestinal flora, improves intestinal health, prevents or treats infections and inflammation caused by glycocalyx damage, and enhances the level of intestinal health maintenance.

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Abstract

The invention provides application of lactoferrin and a composition thereof in promoting intestinal development. The lactoferrin provided by the invention can up-regulate the transcriptional level of a coding gene gpc1 of phospholipid globulin glycan, the transcriptional level of a coding gene has1 of hyaluronic acid synthetase 1, the transcriptional level of a coding gene has2 of hyaluronic acid synthetase 2, the transcriptional level of a coding gene has3 of hyaluronic acid synthetase 3, the transcriptional level of a coding gene ext1 of exosome glycosyltransferase 1 and the transcriptional level of a coding gene ext2 of exosome glycosyltransferase 2; therefore, the development of a protein skeleton of the glycocalyx layer, the synthesis of hyaluronic acid and the synthesis of heparan sulfate are promoted, the development of the glycocalyx layer is further promoted, and the effects of improving the intestinal barrier, regulating the intestinal flora and improving the intestinal health are achieved.
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