Multi-stage vacuum heat-insulation high-temperature experimental equipment

Abstract

The invention relates to the technical field of biological medicine industry, and provides a multi-stage vacuum heat-insulation high-temperature experimental facility which comprises a body, the body comprises an external box body and an inner container fixed in the box body, a flow guide cover is fixedly installed in the inner container, a detachable material plate is installed in the flow guide cover in a clamped mode, and the material plate is connected with the box body. Steps which are diagonally arranged are formed at the upper end and the lower end of the inner container, an air channel is formed between the inner container and the flow guide cover, an air cavity is formed between the inner side of each step and the flow guide cover, and a movable push plate is arranged in each air cavity; it can be understood that the flow guide cover is arranged in the inner container, the air channel and the air cavity are formed between the flow guide cover and the inner container, airflow circulation is driven by means of movement of the push plate in the air cavity, and materials are evenly heated on the material plate; meanwhile, the material plate is clamped in the flow guide cover through the elastic piece and can be easily installed and taken out through operation of a hand lever, direct contact with the hand is avoided, and using convenience and safety are improved.

Description

Technical Field

[0001] This invention relates to the field of biomedicine industry, and more specifically, to a multi-stage vacuum insulation high-temperature experimental device. Background Technology

[0002] In the production and research and development of biopharmaceuticals, vacuum high-temperature testing is a crucial step, primarily used to assess the stability, purity, and sterility of materials and products. The main categories of components and items requiring this type of testing include:

[0003] Active pharmaceutical ingredient (API): This refers to the active ingredient in a drug that exerts its therapeutic effect. The vacuum high-temperature testing performed on it is typically part of a forced degradation study.

[0004] Excipients: These are the other components in a pharmaceutical preparation besides the API. They have no medicinal effect on their own, but play a key role (such as fillers, binders, lubricants, disintegrants, etc.).

[0005] Vacuum ovens are high-temperature experimental devices used in biopharmaceutical production and R&D laboratories. They combine a high-vacuum heating chamber (significantly reducing solvent boiling points) with a precisely controlled heating system, specifically designed for the safe and efficient processing of heat-sensitive or easily oxidized materials. Their core value lies in achieving rapid and gentle drying at relatively low temperatures, effectively preventing the denaturation and inactivation of bioactive components (such as antibiotic raw materials, enzyme preparations, and protein powders) due to high temperatures, or preventing oxidative degradation of materials. Simultaneously, they efficiently and thoroughly remove residual high-boiling-point organic solvents (such as DMSO and DMF), ensuring sample purity and stability. In applications, they are widely used for drying active pharmaceutical ingredients, preparing standards / references to constant weight, dehydrating pharmaceutical excipients, and accelerating product stability studies. Their sealed chamber also avoids the risk of environmental contamination of experimental samples, making them an important tool for meeting GMP requirements and ensuring the accuracy and reproducibility of biopharmaceutical experimental data.

[0006] Because the oven needs to be evacuated, the gas flow in the vacuum environment is very poor. When the heating module heats up, the heat is difficult to spread evenly, which results in uneven heating of the items and poor standardization of the experiment. Secondly, after the items are heated, the entire inside of the oven and the items are in a high-temperature state, making it impossible to remove them for testing in time.

[0007] To address the aforementioned issues, this application proposes a multi-stage vacuum insulation high-temperature experimental device. Summary of the Invention

[0008] The purpose of this invention is to provide a multi-stage vacuum insulation high-temperature experimental device, which solves the problems in the prior art by promoting gas flow inside the chamber and setting up a linked extraction tool.

[0009] The objective of this invention can be achieved through the following technical solution: a multi-stage vacuum insulation high-temperature experimental device, comprising a main body, the main body comprising an outer box and an inner liner fixed in the box, a flow guide hood fixedly installed inside the inner liner, a detachable material plate being fitted into the flow guide hood, diagonally arranged steps forming at the upper and lower ends of the inner liner, an air passage forming between the inner liner and the flow guide hood, and an air cavity forming between the inner side of the steps and the flow guide hood, the air cavity being provided with a movable push plate; the airflow is facilitated by the unidirectional movement of the two push plates, which in turn promote the flow of air between the air passage, the air cavity, and the inside of the flow guide hood.

[0010] Preferably, the outer side of the air guide is formed with symmetrical partitions to separate the air passages vertically, and the side of the air guide is provided with air holes to guide the airflow separated by the partitions into the air guide.

[0011] Preferably, the material plate has several vertically distributed blocks, and the air holes on the side of the flow guide are arranged between two adjacent material plates.

[0012] Preferably, the push plate slides between the step and the guide shroud, and an electric cylinder is fixedly installed on the outside of the step. The output end of the electric cylinder passes through the step and is fixedly installed with the push plate.

[0013] Preferably, a support strip and a positioning strip are fixed inside the flow guide, and square tubes are fixed on both sides of the lower end of the material plate and slide between the support strip and the positioning strip. A spring sheet that abuts against the baffle is installed inside the square tube, and a handle is provided between the square tube and the spring sheet.

[0014] Preferably, the inner side of the flow guide is provided with a slot between the support strip and the positioning strip, the square tube is formed with a baffle, the spring includes a bottom and an elastic part, the elastic part is formed with a locking part, and the front end of the elastic part passes through the through hole and locks the locking part with the slot.

[0015] Preferably, the handle includes a release plate, a guide portion is formed at the end of the elastic part away from the bottom, and a movable groove communicating with the guide portion is provided on the engaging part.

[0016] Preferably, the handle further includes a positioning rod fixed to the release plate, a handle fixed to the positioning rod, the positioning rod being inserted into one end of the square tube, and a reinforcing plate being fixed between the positioning rod and the handle and in close contact with the outside of the square tube.

[0017] Preferably, the inner liner consists of an inner stainless steel layer, a first heat insulation layer, a second heat insulation layer, and an outer stainless steel layer, arranged from the inside out.

[0018] Preferably, the housing is equipped with a vacuum tube that communicates with the port, and the inner liner is equipped with symmetrical heating plates through the mounting port.

[0019] The beneficial effects of this invention are:

[0020] The present invention provides a flow guide hood inside the inner liner, and then provides an air passage, an air chamber, and a pusher plate that moves in the air chamber between the two. The movement of the pusher plate can drive the airflow to move in the inner liner and the flow guide hood, thereby ensuring uniform heating of the material on the material plate.

[0021] This invention connects the material plate to the flow guide shroud via a spring clip, making it easy to install; at the same time, the material plate can be disengaged and removed by the action of the lever; in actual use, the material plate can be easily removed from the flow guide shroud without the need for hand contact, improving convenience. Attached Figure Description

[0022] To more clearly illustrate the technical solutions in the embodiments of the present invention or the prior art, the drawings used in the description of the embodiments or the prior art will be briefly introduced below. Obviously, for those skilled in the art, other drawings can be obtained based on these drawings without creative effort.

[0023] Figure 1 This is a schematic diagram of the structure of the present invention;

[0024] Figure 2 for Figure 1 A structural diagram viewed from below;

[0025] Figure 3 This is a schematic diagram of the structure for removing the material plate using a lever.

[0026] Figure 4 This is a schematic diagram of the external structure of the present invention;

[0027] Figure 5 This is a structural diagram illustrating the first possible airflow direction.

[0028] Figure 6 This is a structural diagram illustrating the second type of airflow direction.

[0029] Figure 7 A schematic diagram showing the disassembled structure of the inner liner and the air deflector;

[0030] Figure 8 This is a structural diagram of the handle, square tube, and spring clip.

[0031] Figure 9 This is an enlarged structural diagram of the spring sheet;

[0032] Figure 10 for Figure 7 Enlarged structural diagram of section A;

[0033] The attached diagram lists the components represented by each number as follows:

[0034] In the picture:

[0035] 1. Main body; 11. Box body; 111. Box door; 12. Inner liner; 121. Pipe opening; 122. Step; 123. Mounting port; 1201. Inner stainless steel layer; 1202. First heat insulation layer; 1203. Second heat insulation layer; 1204. Outer stainless steel layer; 13. Flow guide; 131. Spacer bar; 132. Air hole; 133. Support bar; 134. Positioning bar; 135. Slot; 14. Vacuum tube; 15. Pressure gauge; 16. Control panel; 17. Temperature controller; 18. Material plate; 181. Square tube; 1811. Baffle plate; 1812. Through hole; 19. Heating plate;

[0036] 2. Push plate; 21. Electric cylinder; 3. Spring; 31. Bottom; 32. Elastic part; 33. Guide part; 34. Engaging part; 35. Movable groove; 4. Hand lever; 41. Release plate; 42. Positioning rod; 43. Handle; 44. Reinforcing plate;

[0037] 100. Airway; 200. Air chamber. Detailed Implementation

[0038] To make the objectives, technical solutions, and advantages of this invention clearer, the invention will be further described in detail below with reference to specific embodiments. It should be understood that the specific embodiments described herein are merely illustrative and not intended to limit the invention. All other embodiments obtained by those skilled in the art based on the embodiments of this invention without inventive effort are within the scope of protection of this invention.

[0039] like Figure 1 - Figure 10 As shown: This embodiment provides a multi-stage vacuum insulation high-temperature experimental device, including a main body 1. The main body 1 includes an outer box 11 and an inner liner 12 fixed in the box 11. A door 111 is hinged to one side of the box 11 and locked to the other end of the door 111. A pressure gauge 15, a control panel 16, and a temperature controller 17 are also installed on the box 11.

[0040] Specifically, a flow guide shroud 13 is fixedly installed inside the inner liner 12. The front and rear ends of the flow guide shroud 13 are sealed and fixed to the inner wall of the inner liner 12, so that the airflow can only flow on both sides and up and down of the flow guide shroud 13, forming a directional airflow channel 100. A detachable material plate 18 is snapped into the flow guide shroud 13. The upper and lower ends of the inner liner 12 form diagonally arranged steps 122. An airway 100 is formed between the inner liner 12 and the flow guide shroud 13. An air cavity 200 is formed between the inner side of the steps 122 and the flow guide shroud 13 and communicates with the airway 100. A movable push plate 2 is provided in the air cavity 200. The airflow is caused to flow between the airway 100, the air cavity 200 and the interior of the flow guide shroud 13 by the unidirectional movement of the two push plates 2.

[0041] Specifically, the outer side of the flow guide 13 is formed with symmetrical partitions 131 to divide the air passage 100 vertically. The side of the flow guide 13 is provided with air holes 132 to guide the airflow blocked by the partitions 131 into the flow guide 13. In this embodiment, by setting the partitions 131, the length of the air passage 100 is shortened, and after the push plate 2 moves, the airflow can be driven to flow more fully in the flow guide 13.

[0042] Furthermore, the material plate 18 is provided with several vertically distributed blocks, and the air holes 132 opened on the side of the flow guide shroud 13 are arranged between two adjacent material plates 18. Even if there are multiple material plates 18, the airflow can be fully and evenly flow inside the flow guide shroud 13 through the correspondingly provided air holes 132.

[0043] Furthermore, the push plate 2 slides between the step 122 and the guide shroud 13 to ensure that when the push plate 2 slides, it can simultaneously drive the air flow on both sides. An electric cylinder 21 is fixedly installed on the outside of the step 122. The output end of the electric cylinder 21 passes through the step 122 and is fixedly installed with the push plate 2. In this embodiment, the step 122 can form a large-capacity air cavity 200 between the inner liner 12 and the guide shroud 13, and at the same time, it can form a space for the electric cylinder 21 between the step 122 and the outside of the inner liner 12, making the overall structure more compact and the layout more reasonable in the box 11.

[0044] Furthermore, to facilitate the installation, removal, and positioning of the material plate 18 within the flow guide shroud 13, a support strip 133 and a positioning strip 134 are fixed inside the flow guide shroud 13. Square tubes 181 are fixed on both sides of the lower end of the material plate 18 and slide between the support strip 133 and the positioning strip 134. A spring piece 3 that abuts against the baffle 1811 is installed inside the square tube 181. A handle 4 is provided between the square tube 181 and the spring piece 3. In this embodiment, the length of the support strip 133 is greater than that of the positioning strip 134. When installing the material plate 18, the square tube 181 can first be placed on the support strip 133 and then inserted for quick docking.

[0045] Specifically, the inner side of the flow guide 13 is provided with a slot 135 located between the support strip 133 and the positioning strip 134, the square tube 181 is formed with a baffle 1811 inside, the spring 3 includes a bottom 31 and an elastic part 32, the elastic part 32 is formed with a locking part 34, the front end of the elastic part 32 passes through the through hole 1812 and locks the locking part 34 with the slot 135;

[0046] More specifically, the square tube 181 has a recessed groove to accommodate the bottom 31. The locking part 34, under normal conditions, passes through the through hole 1812 and protrudes from the outside of the square tube 181. When the material plate 18 is connected to the flow guide 13, the locking part 34 will automatically engage with the slot 135, thereby facilitating the quick installation of the material plate 18 on the flow guide 13.

[0047] Furthermore, in order to facilitate the disengagement of the locking part 34 and the slot 135 by means of the lever 4, the lever 4 includes a release plate 41, a guide part 33 is formed at the end of the elastic part 32 away from the bottom 31, and a movable groove 35 communicating with the guide part 33 is provided on the locking part 34.

[0048] In use, the release plate 41 is inserted into the square tube 181 and passes through the movable groove 35 under the guidance of the guide part 33. During the process of passing through the movable groove 35, the elastic part 32 is pressed down, causing the locking part 34 to disengage from the locking groove 135. The release plate 41 passes through the movable groove 35. At this time, under the elastic force of the elastic part 32, the release plate 41 is squeezed and adhered to the square tube 181. While disengaging from the locking, the material plate 18 is stably connected to the handle 4, making it easy to remove at the same time.

[0049] Specifically, the lever 4 also includes a positioning rod 42 fixed to the release plate 41. A handle 43 is fixed on the positioning rod 42. The positioning rod 42 is inserted into one end of the square tube 181. A reinforcing plate 44 is fixed between the positioning rod 42 and the handle 43 and is in close contact with the outside of the square tube 181. In this embodiment, after the positioning rod 42 is inserted into the square tube 181, it ensures that the release plate 41 and the movable groove 35 are precisely matched. At the same time, the lever 4 is tightly inserted into the material plate 18. Then, under the action of the reinforcing plate 44 and the square tube 181, the lever 4 is stably connected to the square tube 181, thereby facilitating the quick and stable removal of the material plate 18 from the guide cover 13.

[0050] Furthermore, in order to ensure the heat preservation and insulation effect of the inner liner 12, the entire liner 12 is a sealed structure, with only the pipe opening 121 connected to the vacuum tube 14. The inner liner 12 consists of an inner stainless steel layer 1201, a first heat insulation layer 1202, a second heat insulation layer 1203, and an outer stainless steel layer 1204 from the inside out.

[0051] Specifically, the first insulation layer 1202 is made of ceramic fiber board, which has a long-term operating temperature of 1260℃~1400℃. It can directly face high-temperature heat sources without pulverizing, melting or failing, ensuring the safety and stability of the system.

[0052] The second insulation layer 1203 uses aerogel felt. The thermal conductivity of aerogel at room temperature is typically between 0.015 and 0.025 W / (m·K), far lower than that of ceramic fiber (~0.09 W / (m·K)) and rock wool (~0.04 W / (m·K)). This means that at the same thickness, its insulation effect is several times that of traditional materials; or, to achieve the same insulation effect, its thickness can be minimized. After being buffered by the first layer of ceramic fiber, the temperature transferred to the second layer has entered the optimal working range of the aerogel. At this temperature, it can exert its best insulation performance, greatly inhibiting heat transfer to the outer shell.

[0053] Understandably, ceramic fibers excel in high-temperature resistance but are less efficient at insulating than aerogels; aerogels, on the other hand, boast extremely high insulating efficiency but suffer from insufficient high-temperature resistance. The solution involves allowing ceramic fibers to leverage their high-temperature resistance to protect the aerogel, while enabling the aerogel to perform at its best within its less demanding temperature range. However, aerogels are expensive. The high cost of aerogels and their performance degradation at high temperatures, combined with the relatively lower cost of ceramic fibers, allows for better overall cost control while ensuring optimal performance.

[0054] Specifically, a vacuum tube 14 connected to the port 121 is installed on the box body 11, and symmetrical heating plates 19 are installed on the side of the inner liner 12 through the installation port 123. The two heating plates 19 are connected to the thermostat 17 at the same time, and the heating temperature of the heating plates 19 is adjusted under the control of the thermostat 17.

[0055] More specifically, the pressure gauge 15 is connected to the vacuum tube 14 to obtain the vacuum level inside the inner liner 12. When in use, the vacuum tube 14 is connected to a vacuum pump, and the vacuum value is set according to the requirements of the experimental materials.

[0056] It is understood that the present invention sets a flow guide in the inner liner and forms an air passage and air chamber between the two. The movement of the push plate in the air chamber drives the airflow to circulate, so as to achieve uniform heating of the material on the material plate. At the same time, the material plate is snapped into the flow guide by a spring clip, and can be easily loaded and unloaded by a lever, avoiding direct hand contact and improving the convenience and safety of use.

[0057] A specific application of the present invention: such as Figure 1 - Figure 2 To prepare the experimental equipment for use, place the materials to be tested on the material plate 18, close the chamber door 111, and use the vacuum pump connected to the vacuum tube 14 to continuously evacuate the inside of the inner chamber 12. The vacuum level can be obtained through the pressure gauge 15. Then, heat is applied through the heating plate 19, and the heating temperature is controlled by the temperature controller 17. The temperature is displayed on the display panel of the control panel 16. At this time, the two electric cylinders 21 are started under the control of the control panel 16. The two electric cylinders 21 work in the same direction on the inner chamber 12.

[0058] As attached Figure 5 As shown, at this time, the two electric cylinders 21 drive the two push plates 2 to move to the left simultaneously in the two air chambers 200, causing the gas to enter the inner liner 12 from the left and flow from the right to the space between the inner liner 12 and the guide shroud 13; and as shown in the attached figure Figure 6 As shown, at this time, the push plate 2 moves to the right in the air chamber 200, driving the gas to enter the inner liner 12 from the right and flow from the left to between the inner liner 12 and the guide shroud 13; through the reciprocating extension and retraction of the two electric cylinders 21, the gas is driven to flow continuously in the inner liner 12.

[0059] After the heating experiment is completed, open the chamber door 111, grasp the handle 43 and insert the release plate 41 and positioning rod 42 into the square tube 181. The positioning rod 42 engages with the square tube 181, and the release plate 41 contacts the guide part 33. Continue to push the handle 4, causing the elastic part 32 to shift under the action of elasticity, and causing the locking part 34 to disengage from the slot 135. At this time, the release plate 41 is pressed between the square tube 181 and the spring piece 3. The material plate 18 is then directly removed from the guide cover 13 along the support bar 133 and the positioning bar 134, which is the attached material plate. Figure 3 The state shown.

[0060] In the description of this invention, unless otherwise stated, "a plurality of" means two or more; it should be understood that the terms "opening", "upper", "lower", "thickness", "top", "middle", "length", "inner", "around", etc., which indicate orientation or positional relationship, are only for the convenience of describing this invention and simplifying the description, and do not indicate or imply that the components or elements referred to must have a specific orientation, or be constructed and operated in a specific orientation, and therefore should not be construed as limiting this invention.

[0061] Finally, it should be noted that the above description is only a preferred embodiment of the present invention and is not intended to limit the present invention. Although the present invention has been described in detail with reference to the foregoing embodiments, those skilled in the art can still modify the technical solutions described in the foregoing embodiments or make equivalent substitutions for some of the technical features. Any modifications, equivalent substitutions, improvements, etc., made within the spirit and principles of the present invention should be included within the protection scope of the present invention.

Claims

1. A multi-stage vacuum insulated high-temperature experimental device, comprising a main body (1), wherein the main body (1) comprises an outer casing (11) and an inner liner (12) fixed within the casing (11), characterized in that: The inner liner (12) is fixedly installed with a flow guide (13), and a detachable material plate (18) is snapped into the flow guide (13). The upper and lower ends of the inner liner (12) are formed with diagonally arranged steps (122). An air passage (100) is formed between the inner liner (12) and the flow guide (13). An air cavity (200) is formed between the inner side of the step (122) and the flow guide (13). A movable push plate (2) is provided in the air cavity (200). The airflow is facilitated by the unidirectional movement of the two push plates (2) between the air passage (100), the air chamber (200), and the guide shroud (13).

2. The multi-stage vacuum insulation high-temperature experimental device according to claim 1, characterized in that: The outer side of the air guide (13) is formed with symmetrical partitions (131) to separate the air passage (100) vertically. The side of the air guide (13) is provided with air holes (132) to guide the airflow separated by the partitions (131) into the air guide (13).

3. The multi-stage vacuum insulation high-temperature experimental device according to claim 2, characterized in that: The material plate (18) is provided with several vertically distributed blocks, and the air holes (132) on the side of the flow guide (13) are arranged between two adjacent material plates (18).

4. The multi-stage vacuum insulation high-temperature experimental device according to claim 1, characterized in that: The push plate (2) slides between the step (122) and the guide shroud (13). An electric cylinder (21) is fixedly installed on the outside of the step (122). The output end of the electric cylinder (21) passes through the step (122) and is fixedly installed with the push plate (2).

5. The multi-stage vacuum insulation high-temperature experimental device according to claim 1, characterized in that: The inner side of the flow guide (13) is fixed with a support strip (133) and a positioning strip (134). The lower ends of the material plate (18) are fixed with square tubes (181) which slide between the support strips (133) and the positioning strips (134). A spring piece (3) that abuts against the baffle (1811) is installed inside the square tube (181). A handle (4) is provided between the square tube (181) and the spring piece (3).

6. The multi-stage vacuum insulation high-temperature experimental device according to claim 5, characterized in that: The inner side of the flow guide (13) is provided with a slot (135) between the support strip (133) and the positioning strip (134). The square tube (181) has a baffle (1811) formed inside. The spring (3) includes a bottom (31) and an elastic part (32). The elastic part (32) has a locking part (34) formed on it. The front end of the elastic part (32) passes through the through hole (1812) and locks the locking part (34) into the slot (135).

7. The multi-stage vacuum insulation high-temperature experimental device according to claim 6, characterized in that: The lever (4) includes a release plate (41), and the elastic part (32) has a guide part (33) formed at one end away from the bottom (31). The engaging part (34) has an active groove (35) that communicates with the guide part (33).

8. The multi-stage vacuum insulation high-temperature experimental device according to claim 7, characterized in that: The handle (4) also includes a positioning rod (42) fixed to the release plate (41), a handle (43) fixed on the positioning rod (42), the positioning rod (42) is inserted into one end of the square tube (181), and a reinforcing plate (44) is fixed between the positioning rod (42) and the handle (43) and is in contact with the outside of the square tube (181).

9. The multi-stage vacuum insulation high-temperature experimental device according to claim 1, characterized in that: The inner liner (12) consists of an inner stainless steel layer (1201), a first heat insulation layer (1202), a second heat insulation layer (1203), and an outer stainless steel layer (1204) from the inside to the outside.

10. The multi-stage vacuum insulation high-temperature experimental device according to claim 1, characterized in that: The housing (11) is equipped with a vacuum tube (14) that communicates with the port (121), and the inner liner (12) is equipped with symmetrical heating plates (19) through the mounting port (123).

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