Indole hair dye based on air oxidation and application thereof

Abstract

The invention relates to an indole hair dye based on air oxidation. The hair dye provided by the invention is characterized in that a chemical strong oxidant is not added, and oxygen in air can be catalyzed by using an air oxidation catalyst and a metal ion catalyst to naturally finish the oxidative polymerization process of indole substances (natural bionic melanin precursor substances). The used reducing agent is a combination of cysteine and a derivative thereof and sodium sulfite and a derivative thereof, the oxidative polymerization speed of indole substances can be controlled, and finally generated melanin macromolecules are embedded in hair cortex, so that white hair is obviously blackened. The natural oxidation process does not need hydrogen peroxide, destructive strong base or organic base, so that the use of harmful chemical reagents is reduced, the formula is simplified, the hair dyeing process is milder, potential hazards to hair and scalp are reduced, and the natural oxidation hair dye is safe, environmentally friendly and sustainable.

Description

TECHNICAL FIELD

[0001] The present application belongs to the field of special cosmetics, and particularly relates to an indole-based hair dye based on air oxidation and application thereof. BACKGROUND

[0002] The Cosmetic Safety Technical Specifications point out that hair dye is a substance added in cosmetics to change the color of hair, and is a kind of cosmetic for dyeing hair. According to whether the dyeing component is natural, the hair dye can be divided into chemical hair dye and plant hair dye. The chemical hair dye is the mainstream product on the market at present, generally containing dye intermediates and coupling agents. After the dye intermediates and coupling agents penetrate into the cortex layer of hair, oxidation reaction, coupling and condensation reaction occur to form larger dye molecules, which are enclosed in the hair fibers. The dye intermediates mentioned here are generally aniline substances and derivatives, and the oxidizing agent used in the oxidation reaction is generally a strong oxidizing agent such as hydrogen peroxide. In order to create an alkaline environment, ammonia, ethanolamine and other strong alkaline substances are often added, which have the dual functions of bleaching and dyeing. The advantages of chemical hair dye are short dyeing time and strong coloring power, and the defects are that it contains aniline substances with sensitization and carcinogenicity, strong oxidizing agents and strong alkalis, which are irritating substances, and there are unavoidable hazards and damages to the human body and hair itself. In comparison, the dyeing components of plant hair dye are pigments and active ingredients extracted from plants, which are natural, less toxic, and have natural hair dyeing effect. However, the dyeing mechanism of the existing plant hair dye is mainly direct adsorption or complexation with metal salts to develop color, which has the defects of unstable dyeing and short-lasting effect.

[0003] It can be seen that although chemical and plant hair dyes have their own obvious advantages, they also have unavoidable use disadvantages. Therefore, it is urgent to develop a hair dye product with strong coloring power, long-lasting dyeing effect, no irritation, and natural and non-toxic. Under this demand, the biomimetic approach becomes the only choice. The biomimetic approach avoids the defects of separation of chemical and plant dyeing components from the human body itself, follows the objective law of human pigment generation, and is more in line with the natural and health development trend of the public. SUMMARY

[0004] To meet the above needs, the present application relates to an air oxidation-based indole hair dye. The hair dye of the present application uses biomimetic indole raw materials as melanin precursors, which is different from chemical and plant hair dyes in terms of both dyeing mechanism and formula composition. In terms of dyeing mechanism, the dyeing of the hair dye of the present application relies on the oxidative polymerization of the melanin precursors contained therein with air; the dyeing of the chemical hair dye relies on the oxidation, coupling, condensation and other reactions of small molecule dye intermediates and coupling agents contained therein under the catalysis of strong chemical oxidants; the dyeing of the plant hair dye relies on the direct adsorption or adsorption after complexation with metal salts of pigment macromolecules. In terms of formula composition, the hair dye of the present application does not add chemical dyeing components and strong oxidants, thereby avoiding the risks of carcinogenicity, allergy, irritation and the like in the hair dyeing process from the source.

[0005] To achieve the above-mentioned application purposes, the present application adopts the following technical solutions.

[0006] On the one hand, the present application provides an air oxidation-based indole hair dye. On the other hand, the present application also provides a preparation method of the hair dye. On the further hand, the present application provides a use method of the hair dye. On the still further hand, the present application provides the use of the hair dye in covering gray hair and / or dyeing gray hair black.

[0007] Specifically, the present application provides an air oxidation-based indole hair dye, wherein the hair dye contains the following components by weight:

[0008] 0.5-5 parts of main dyeing components, 0.1-2 parts of catalysts, 0.1-4 parts of reducing agents, 0.2-8 parts of pH regulators, 2-10 parts of pure natural penetration aids, 1-20 parts of thickening agents, and 1-3 parts of surfactants.

[0009] In the hair dye of the present application, the main dyeing components are indole natural biomimetic melanin precursor substances. Preferably, the indole natural biomimetic melanin precursor substances can be selected from one or more of 5,6-dihydroxyindole, 5,6-dihydroxyindoline, 5,6-dihydroxyindoline hydrobromide, polydihydroxyindole, and acetylated indole.

[0010] In the hair dye of the present application, the weight fraction of the indole natural biomimetic melanin precursor substance is 1-3, preferably 1, 1.2, 1.5, 1.6, 2, 2.5 and 3.

[0011] In the hair dye of the present application, the weight fraction of the catalyst used is 1.2-1.9, preferably 1.2, 1.7, 1.8 and 1.9.

[0012] Furthermore, the catalyst used in this invention is a combination of an air oxidation catalyst and a metal ion catalyst. More specifically, the air oxidation catalyst is N-hydroxyphthalimide (NHPI). In the hair dye of this invention, the metal ion catalyst used can be selected from one or more of ferric chloride, ferrous sulfate, magnesium chloride, magnesium carbonate, copper chloride, and copper sulfate. More preferably, the weight ratio of the air oxidation catalyst to the metal ion catalyst used in the hair dye of this invention is 0.2-0.4:1-1.6, for example, 0.2:1, 0.2:1.2, 0.2:1.5, 0.2:1.6, 0.3:1.6, or 0.4:1.5.

[0013] In the hair dye of the present invention, the reducing agent used has a weight ratio of 1-3, more preferably 1.1-2.6, and even more preferably 1.1, 1.3, 1.9, 2.2, 2.3, 2.4, or 2.6.

[0014] Furthermore, the reducing agent used in this invention is a combination of cysteine ​​and its derivatives and sodium sulfite and its derivatives, wherein the cysteine ​​and its derivatives are one or more selected from L-cysteine, L-cysteine, glutathione, and cysteine ​​hydrochloride; and the sodium sulfite and its derivatives are one or more selected from sodium sulfite, sodium bisulfite, sodium metabisulfite, and sodium thiosulfate. More preferably, the weight ratio of cysteine ​​and its derivatives to sodium sulfite and its derivatives used in the hair dye of this invention is 0.8-2:0.2-0.6, for example, 0.8:0.3, 1:0.3, 1.5:0.4, 1.8:0.4, 2:0.2, 2:0.3, or 2:0.4.

[0015] In the hair dye of the present invention, the pH adjuster used has a weight ratio of 0.9-6, more preferably 0.9, 1, 1.2, 2, 2.2, 2.8, 3, 3.3, 3.4, 5, 5.3, or 6.

[0016] Furthermore, the pH adjuster used in this invention is a conventional alkali and amino acid, used to provide an alkaline environment with a pH value of 7.5-9 for the formulated hair dye, and does not contain destructive strong alkalis or destructive organic alkalis. Even further, the pH adjuster is selected from one or more of sodium carbonate, sodium bicarbonate, disodium hydrogen phosphate, sodium dihydrogen phosphate, sodium citrate, L-arginine, and L-lysine. In some specific embodiments of this invention, the pH value of the hair dye (hair dye cream) is 7.5-9.

[0017] In the hair dye of the present invention, the weight of the pure natural penetration enhancer used is 5-7, preferably 5, 6, or 7.

[0018] Furthermore, the all-natural penetration enhancer used in this invention is selected from one or more of the following: aloe vera leaf extract, tea extract, cactus extract, oat extract, quaternary ammonium salt-79 hydrolyzed keratin, licorice extract, clove flower extract, tremella polysaccharide, maltitol, and sorbitol.

[0019] In the hair dye of the present invention, the thickener used has a weight ratio of 6-12, more preferably 6, 9, 10, 11, or 12.

[0020] Furthermore, the thickener used in this invention is one or more selected from mung bean powder, barley grass juice powder, Bletilla striata extract, Marshmallow root extract, sodium carboxymethyl cellulose, sodium alginate, carrageenan, locust bean gum, and konjac gum.

[0021] In the hair dye of the present invention, the surfactant used has a weight ratio of 1-2.5, more preferably 1, 1.5, 2, or 2.5.

[0022] Furthermore, the surfactant used in this invention is selected from one or more of sodium dodecyl sulfate, sodium dodecylbenzene sulfonate, hexadecyltrimethylammonium chloride, sodium lauroyl glutamate, and sodium laureth sulfate.

[0023] In some specific embodiments of the present invention, the present invention provides an indole-based hair dye based on air oxidation, wherein the hair dye comprises the following components in parts by weight:

[0024] 1-3 parts of indole-based natural biomimetic melanin precursor, 1.2-1.9 parts of catalyst, 1.1-2.6 parts of reducing agent, 0.9-6 parts of pH adjuster, 5-7 parts of pure natural penetration enhancer, 6-12 parts of thickener, and 1-2.5 parts of surfactant;

[0025] The indole-based natural biomimetic melanin precursor is selected from one or more of 5,6-dihydroxyindole, 5,6-dihydroxyindoleline, 5,6-dihydroxyindoleline hydrobromide, polydihydroxyindole, and acetylated indole.

[0026] The catalyst is a combination of an air oxidation catalyst and a metal ion catalyst; the reducing agent is a combination of cysteine ​​and its derivatives and sodium sulfite and its derivatives.

[0027] Preferably, the air oxidation catalyst is N-hydroxyphthalimide (NHPI);

[0028] Preferably, the metal ion catalyst is selected from one or more of ferric chloride, ferrous sulfate, magnesium chloride, magnesium carbonate, copper chloride, and copper sulfate;

[0029] Preferably, the cysteine ​​and its derivatives are one or more selected from L-cysteine, L-cysteine, glutathione, and cysteine ​​hydrochloride;

[0030] Preferably, the sodium sulfite and its derivatives are selected from one or more of sodium sulfite, sodium bisulfite, sodium metabisulfite, and sodium thiosulfate.

[0031] In a specific embodiment of the present invention, the present invention provides an indole-based hair dye based on air oxidation, wherein the hair dye comprises the following components in parts by weight:

[0032] 1) 1 part 5,6-dihydroxyindole, 0.2 parts NHPI, 1.5 parts magnesium chloride, 0.6 parts sodium thiosulfate, 2 parts L-cysteine, 1 part sodium carbonate, 3 parts aloe vera leaf extract, 3 parts sorbitol, 4 parts mung bean powder, 7 parts Bletilla striata extract, 2 parts sodium lauroyl glutamate; or

[0033] 2) 1.5 parts 5,6-dihydroxyindoline, 0.2 parts NHPI, 1 part ferric chloride, 0.2 parts sodium bisulfite, 2 parts glutathione, 5 parts sodium bicarbonate, 2 parts cactus extract, 4 parts tea extract, 10 parts marshmallow root extract, and 1 part sodium lauryl sulfate; or

[0034] 3) 2 parts 5,6-dihydroxyindoline hydrobromide, 0.3 parts NHPI, 1.6 parts magnesium carbonate, 0.3 parts sodium sulfite, 1 part L-cysteine, 1 part L-arginine, 1 part sodium citrate, 3 parts oat extract, 4 parts quaternary ammonium salt-79 hydrolyzed keratin, 2 parts sodium alginate, 3 parts sodium carboxymethyl cellulose, 4 parts barley grass juice powder, 2.5 parts sodium lauryl ether sulfate; or

[0035] 4) 3 parts polydihydroxyindole, 0.4 parts NHPI, 0.5 parts copper sulfate, 1 part copper chloride, 0.4 parts sodium metabisulfite, 1.5 parts cysteine ​​hydrochloride, 0.4 parts L-lysine, 3 parts disodium hydrogen phosphate, 2 parts tremella polysaccharide, 3 parts clove flower extract, 2 parts carrageenan, 10 parts barley grass juice powder, 1.5 parts sodium dodecylbenzenesulfonate; or

[0036] 5) 2.5 parts acetylated indole, 0.3 parts NHPI, 0.7 parts ferric chloride, 0.8 parts ferrous sulfate, 0.3 parts sodium sulfite, 2 parts cysteine ​​hydrochloride, 0.3 parts L-lysine, 5 parts sodium dihydrogen phosphate, 2 parts maltitol, 3 parts licorice extract, 2 parts konjac gum, 4 parts locust bean gum, 2.5 parts hexadecyltrimethylammonium chloride; or

[0037] 6) 1.5 parts 5,6-dihydroxyindoline, 0.2 parts NHPI, 1 part ferrous sulfate, 0.4 parts sodium sulfite, 2 parts glutathione, 0.8 parts L-arginine, 2 parts sodium citrate, 3 parts aloe vera leaf extract, 4 parts tea extract, 2 parts sodium carboxymethyl cellulose, 8 parts Bletilla striata extract, and 2 parts sodium lauryl sulfate; or

[0038] 7) 1.6 parts 5,6-dihydroxyindoline hydrobromide, 0.2 parts NHPI, 1.6 parts magnesium chloride, 0.3 parts sodium sulfite, 0.8 parts L-cysteine, 1 part L-arginine, 2 parts sodium bicarbonate, 3 parts clove extract, 4 parts quaternary ammonium salt-79 hydrolyzed keratin, 1 part sodium carboxymethyl cellulose, 10 parts barley grass juice powder, 2.5 parts sodium lauryl sulfate; or

[0039] 8) 1.6 parts 5,6-dihydroxyindoline hydrobromide, 0.2 parts NHPI, 1.6 parts magnesium chloride, 0.3 parts sodium sulfite, 0.8 parts L-cysteine, 6 parts sodium bicarbonate, 3 parts clove extract, 4 parts quaternary ammonium salt-79 hydrolyzed keratin, 1 part sodium carboxymethyl cellulose, 10 parts barley grass juice powder, 2.5 parts sodium lauryl sulfate; or

[0040] 9) 1.6 parts 5,6-dihydroxyindoline hydrobromide, 0.2 parts NHPI, 1.6 parts magnesium chloride, 0.3 parts sodium sulfite, 0.8 parts L-cysteine, 0.3 parts L-lysine, 0.6 parts disodium hydrogen phosphate, 3 parts clove flower extract, 4 parts quaternary ammonium salt-79 hydrolyzed keratin, 1 part sodium carboxymethyl cellulose, 10 parts barley grass juice powder, 2.5 parts sodium lauryl sulfate; or

[0041] 10) 1.6 parts of 5,6-dihydroxyindoline hydrobromide, 0.2 parts of NHPI, 1.6 parts of magnesium chloride, 0.3 parts of sodium sulfite, 0.8 parts of L-cysteine, 0.2 parts of sodium carbonate, 2 parts of sodium citrate, 3 parts of clove extract, 4 parts of quaternary ammonium salt-79 hydrolyzed keratin, 1 part of sodium carboxymethyl cellulose, 10 parts of barley grass juice powder, and 2.5 parts of sodium lauryl sulfate; or

[0042] 11) 1.6 parts of 5,6-dihydroxyindoline hydrobromide, 0.2 parts of NHPI, 1.6 parts of magnesium chloride, 0.3 parts of sodium sulfite, 0.8 parts of L-cysteine, 0.2 parts of L-lysine, 1 part of sodium dihydrogen phosphate, 3 parts of clove extract, 4 parts of quaternary ammonium salt-79 hydrolyzed keratin, 1 part of sodium carboxymethyl cellulose, 10 parts of barley grass juice powder, and 2.5 parts of sodium lauryl sulfate; or

[0043] 12) 1.2 parts of 5,6-dihydroxyindole, 0.4 parts of NHPI, 1.5 parts of magnesium carbonate, 0.4 parts of sodium bisulfite, 1.8 parts of glutathione, 0.5 parts of L-lysine, 2.8 parts of disodium hydrogen phosphate, 2 parts of maltitol, 4 parts of quaternary ammonium salt-79 hydrolyzed keratin, 2 parts of locust bean gum, 10 parts of marshmallow root extract, and 2.5 parts of sodium lauroyl glutamate.

[0044] In some embodiments of the present invention, the hair dye of the present invention may be in powder form. Specifically, the hair dye is packaged in a single powder packet.

[0045] Furthermore, this invention also provides a method for preparing the hair dye of this invention, the method comprising the following steps: weighing each component according to the formula and mixing them thoroughly. In addition, this invention also provides a method for using the hair dye of this invention, the method comprising the following steps:

[0046] S1: Pour the hair dye of the present invention into a hair dyeing bowl, add water and stir thoroughly until the paste becomes viscous, with uniform color and texture and no lumps. The weight of the water added is 2 to 3 times the total weight of the hair dye of the present invention, preferably 2 times, 2.5 times, or 3 times.

[0047] S2: Use a hair dyeing comb to evenly apply the paste obtained in step S1 to the hair, cover with plastic wrap and wait for 15-45 minutes;

[0048] S3: Remove the plastic wrap and wait for 20-60 minutes. During this time, you can gently massage your hair to accelerate the blackening of the paste.

[0049] S4: After the paste has completely turned black, rinse your hair thoroughly and blow-dry it.

[0050] Finally, the present invention also provides the use of the hair dye of the present invention in covering gray hair and / or dyeing gray hair black.

[0051] Compared with the prior art, the advantages of the present invention are:

[0052] (1) The hair dye of the present invention follows the principle of melanin production in human hair, uses biomimetic indole raw materials as melanin precursors, and does not add aniline dyeing raw materials, thus avoiding the risks of carcinogenicity, allergy, and irritation in the hair dyeing process from the source.

[0053] (2) The hair dye of the present invention utilizes the combination of air oxidation catalyst and metal ion catalyst to catalyze the natural oxidation and polymerization process of indole substances by oxygen in the air, which can turn white hair black naturally. No strong chemical oxidants are added throughout the process. It is mild, non-irritating, and has strong sustainability. Moreover, the color is more natural and less harsh than that of chemical hair dyes.

[0054] (3) The hair dye of the present invention uses a combination of cysteine ​​and its derivatives and sodium sulfite and its derivatives as a reducing agent to control the oxidation and polymerization rate of indole substances. Among them, cysteine ​​is a common amino acid in the body, and its reduction mechanism is closer to the natural laws of the human body, which is more forward-looking in concept.

[0055] (4) The hair dye of the present invention does not contain hydrogen peroxide, strong alkali or organic alkali, and the dyeing process will not cause damage to the hair.

[0056] (5) Other ingredients in the hair dye of the present invention, such as pure natural penetration enhancers and thickeners (especially penetration enhancers), are preferably made of pure natural plant-derived substances, which have strong hydrophilicity and better solubility, and are more in line with a healthy and environmentally friendly lifestyle.

[0057] (6) The hair dye of the present invention can be formulated into a powder, which not only makes the product more stable, but also has great advantages in production, packaging, transportation and storage. Attached Figure Description

[0058] The embodiments of the present invention will now be described in detail with reference to the accompanying drawings, wherein:

[0059] Figure 1 The image shows a (model) hair sample before dyeing, used in the experiment.

[0060] Figure 2 The images show the effects of dyeing hair samples with the hair dyes / hair dyes of Examples 1-5 and Control Groups 1-4.

[0061] Figure 3 The images show the effect of dyeing hair samples with the hair dye / hair dye cream of Examples 6-12.

[0062] Figure 4 The images show the effect of dyeing hair samples with the hair dye / hair dye cream of Examples 13-17.

[0063] Figure 5 The images show the results of dyeing hair samples with the hair dyes / hair dyes of Examples 18-25.

[0064] Figure 6 Results of the durability tests of hair dyes / hair dye creams in Examples 1-5 and Control Groups 1-4.

[0065] Figure 7 Results of the durability tests of hair dyes / hair dye creams in Examples 6-12.

[0066] Figure 8 Results of the durability tests of hair dyes / hair dye creams in Examples 13-17.

[0067] Figure 9 Results of the durability tests of hair dyes / hair dye creams in Examples 18-25.

[0068] Figure 10 The results of optical microscopy analysis of hair samples after dyeing with the hair dye / hair dye cream of control group 1, control group 3, control group 4 and Example 1 are shown.

[0069] Figure 11 The results of optical microscopy analysis of hair samples after different alkali treatments are shown. Detailed Implementation

[0070] The present invention will be further described in detail below with reference to specific embodiments. The embodiments given are only for illustrating the present invention and are not intended to limit the scope of the present invention.

[0071] 1. Unless otherwise specified, all raw materials used in the following examples are commercially available products. The purchase details of some of these raw materials are as follows:

[0072] 5,6-Dihydroxyindole (CAS No.: 3131-52-0) was purchased from Shanghai Shumeng Pharmaceutical Technology Co., Ltd.

[0073] 5,6-Dihydroxyindoline (CAS No.: 29539-03-5) was purchased from Shanghai Aladdin Biochemical Technology Co., Ltd.

[0074] 5,6-Dihydroxyindoline hydrobromide (CAS No.: 138937-28-7, alias: 5,6-dihydroxydihydroindoline hydrobromide) was purchased from Shanghai Haohong Biomedical Technology Co., Ltd.

[0075] Polydihydroxyindole (CAS No.: 8049-97-6) was purchased from Hubei Jianchu Biomedical Co., Ltd.

[0076] Acetylindole (CAS No.: 15069-79-1, alias: 5,6-diacetoxyindole) was purchased from Shanghai Aladdin Biochemical Technology Co., Ltd.

[0077] N-hydroxyphthalimide (NHPI) was purchased from Wuhan Kemic Biomedical Technology Co., Ltd.

[0078] Ferric chloride (anhydrous ferric chloride) and ferrous sulfate were purchased from Sinopharm Chemical Reagent Co., Ltd.

[0079] Magnesium chloride (anhydrous magnesium chloride) was purchased from Weifang Haizhiyuan Chemical Co., Ltd.

[0080] Magnesium carbonate was purchased from Jiangsu Kelunduo Food Ingredients Co., Ltd.

[0081] Copper chloride (anhydrous copper chloride) and copper sulfate were purchased from Tianjin Kemeo Chemical Reagent Co., Ltd.

[0082] L-cysteine ​​and L-cysteine ​​were purchased from Hebei Huayang Biotechnology Co., Ltd.

[0083] Glutathione was purchased from Hebei Jiuxing Chemical Products Co., Ltd.

[0084] Cysteine ​​hydrochloride was purchased from Shanghai Maclean Biochemical Technology Co., Ltd.

[0085] Sodium sulfite, sodium bisulfite, sodium metabisulfite, and sodium thiosulfate were purchased from Hongyan Reagent Factory in Hedong District, Tianjin.

[0086] Sodium carbonate (anhydrous sodium carbonate) was purchased from Ocean Star Chemical Technology Co., Ltd.

[0087] Sodium bicarbonate was purchased from Sinopharm Chemical Reagent Co., Ltd.

[0088] Disodium hydrogen phosphate and sodium dihydrogen phosphate were purchased from Jiangsu Kelunduo Food Ingredients Co., Ltd.

[0089] Sodium citrate was purchased from Hunan Ercon Pharmaceutical Co., Ltd.

[0090] L-arginine and L-lysine were purchased from Hebei Huaheng Biotechnology Co., Ltd.

[0091] Aloe vera leaf extract, tea extract, cactus extract, and oat extract were purchased from Shaanxi Huike Plant Development Co., Ltd.

[0092] Quaternium-79 hydrolyzed keratin was purchased from Shanxi Baichuan Biotechnology Co., Ltd.

[0093] The licorice extract was purchased from Shaanxi Tianxingjian Biochemical Technology Co., Ltd.

[0094] Clove flower extract was purchased from Shanxi Baichuan Biotechnology Co., Ltd.

[0095] Tremella polysaccharide was purchased from Shaanxi Longzhou Biotechnology Co., Ltd.

[0096] Maltitol was purchased from Shandong Futian Pharmaceutical Co., Ltd.

[0097] Sorbitol was purchased from Jinan Dongxuan Bioengineering Co., Ltd.

[0098] The barley grass juice powder was purchased from Changsha Bojian Biotechnology Co., Ltd.

[0099] Bletilla striata extract and Althaea rubra root extract were purchased from Shaanxi Huike Plant Development Co., Ltd.

[0100] Sodium carboxymethyl cellulose (FH9) was purchased from Chongqing Lihong Fine Chemical Co., Ltd.

[0101] Sodium alginate was purchased from Qingdao Haizhilin Biotechnology Development Co., Ltd.

[0102] Carrageenan was purchased from Linyi Aidesen Biotechnology Co., Ltd.

[0103] Locust bean gum was purchased from Jiangsu Kelunduo Food Ingredients Co., Ltd.

[0104] Konjac gum was purchased from Shaanxi Longzhou Biotechnology Co., Ltd.

[0105] Sodium dodecyl sulfate (also known as sodium lauryl sulfate) and sodium dodecylbenzene sulfonate were purchased from Tianjin Kemeo Chemical Reagent Co., Ltd.

[0106] Hexadecyltrimethylammonium chloride was purchased from Shanghai Aladdin Biochemical Technology Co., Ltd.

[0107] Sodium lauroyl glutamate was purchased from Jiangsu Runfeng Synthetic Technology Co., Ltd.

[0108] Sodium lauryl ether sulfate was purchased from Wuhan Kemic Biomedical Technology Co., Ltd.

[0109] 2. The mung bean powder used in the following examples is homemade. The raw material is edible mung beans. The mung beans are crushed by a sealed pulverizer (model AF-04S) for 30 seconds to 1 minute to obtain a material with a particle size of approximately 400 to 850 micrometers. Then, the mung bean powder is crushed by a vibrating cell-level ultrafine pulverizer (model XDW-6J) for about 10 minutes to obtain a material with a particle size of approximately 100 to 180 micrometers, which is the "mung bean powder" of this invention.

[0110] 3. The optical microscope used in the following examples is from Olympus, model CX43, with an observation magnification of 40x10, where 40 represents the objective lens magnification and 10 represents the eyepiece magnification.

[0111] 4. In the following examples, unless otherwise specified, all hair samples used were real human hair, white, short strands collected from a hair salon, with moderate softness and hardness. The amount of hair used in each hair dyeing experiment was approximately 2g. Due to inconsistencies in subsequent investigation factors and experimental conditions, the hair bundles used in the demonstration of the hair dye / hair dye effect on the hair in each example and in the durability experiments (friction resistance, wash resistance) described later were all taken from a portion of the dyed hair (approximately 0.5g, which was arranged into small bundles by the user, and the weight may vary slightly).

[0112] Examples 1-5

[0113] Based on a total mass of 10g of the mixed paste, calculate the amount of each component according to the mass percentage of each component in Table 1, weigh them, mix them evenly, and obtain the hair dye; then pour the hair dye into the hair dyeing bowl, add water and stir thoroughly until the paste becomes viscous, with uniform color and texture and no lumps, and obtain the hair dye paste for hair dyeing.

[0114]

[0115] In addition, the applicant selected four representative commercially available hair dyes (control groups 1-4) and compared their dyeing effects with the hair dye of the present invention. Product information for control groups 1-4 is as follows:

[0116] Control group 1: Schwarzkopf Natural Hair Dye Cream, Shine Pearl Black, whose main dyeing ingredients are toluene-2,5-diamine sulfate and resorcinol; the alkali is ethanolamine and potassium hydroxide; and the oxidizing agent is hydrogen peroxide.

[0117] Control group 2: L'Oréal Excellence Cream Natural Black, whose main dyeing components are p-phenylenediamine and resorcinol; the alkali agents are ammonium hydroxide and ethanolamine; and the oxidizing agent is hydrogen peroxide;

[0118] Control group 3: Green Love Beautifying Plant Hair Dye Italian Version Brown-Black, its main dyeing components are: toluene-2,5-diamine sulfate and senna; the alkali is ethanolamine; the oxidizing agent is hydrogen peroxide;

[0119] Control group 4: Florenda hair melanin supplement, whose main dyeing component is dihydroxyindole; the alkali is ethanolamine; oxidizing agent: none;

[0120] Examples 6-12: Screening of catalysts

[0121] The hair dye paste for hair dyeing is prepared according to the method described in Examples 1-5 and according to the component types and phase application amounts shown in Table 2.

[0122]

[0123]

[0124]

[0125] Test Example 1: Measurement of hair dyeing effect

[0126] The hair dye prepared in Examples 1-25 was used to dye the hair as follows:

[0127] S2: Use a hair dyeing comb to evenly apply the mixed paste to the hair, cover with plastic wrap and wait for a certain time (first stage time);

[0128] S3: Remove the plastic wrap and wait for a certain period of time (second stage time). During this time, you can rub your hair appropriately to accelerate the blackening of the paste.

[0129] S4: After the paste has completely turned black, rinse your hair thoroughly and blow-dry it.

[0130] Note: When using commercially available control group products for hair dyeing, the dyeing process should be performed according to the instructions for each product.

[0131] The hair dyeing effects of the hair dyes prepared in each example and the hair dyes in the control group are shown in Table 5 below. Figures 2-5 As shown.

[0132] Table 5:

[0133]

[0134]

[0135]

[0136] Figure 1 The effect of the hair sample used in this experiment before dyeing is shown.

[0137] From Table 5 and Figure 2 As can be seen from the table, except for the control group 4 (indole hair dye) which had a slightly worse hair color after dyeing, the hair dyes prepared in each example in Table 1 and the products of the control groups 1-3 can all turn white hair black or dark brown-black. This shows that the hair dye of the present invention, which is based on the principle of natural oxidation of air, has a dyeing effect comparable to chemical hair dyes and is superior to indole-based hair dye products of the same type.

[0138] From Table 5 and Figure 3 As can be seen from Table 2, except for the hair dye prepared in Example 6 which can significantly turn white hair black, the hair color after dyeing with the hair dye prepared in the other examples (7-12) is acceptable, but slightly worse than that in Example 6. This indicates that the synergistic effect of air oxidation catalyst and metal catalyst is of great significance for improving the dyeing effect.

[0139] From Table 5 and Figure 4 As can be seen from the table, after using the hair dye prepared in each of the examples in Table 3, the white hair turned black significantly, indicating that the hair dye of the present invention, which does not contain destructive strong alkali or destructive organic alkali, has excellent dyeing effect.

[0140] From Table 5 and Figure 5 As can be seen from Table 4, except for the hair dye prepared in Example 18 which can significantly turn white hair black, the hair color after dyeing with the hair dye prepared in the other examples (19-25) is also acceptable, but slightly worse than that of Example 18. This indicates that the combined use of cysteine ​​and its derivatives with sodium sulfite and its derivatives has a better dyeing effect than using them alone.

[0141] Test Example 2: Measurement of durability

[0142] The durability of the hair color after dyeing in each example in Tables 1, 2, 3, and 4 was verified. Verification parameters included abrasion resistance and washability. Abrasion resistance was determined by rubbing the hair 30 times with a light-colored, dry towel (100% cotton) and observing whether the hair color faded, i.e., whether there was a visible change in hair color. Washability was determined by washing the hair with regular shampoo every two days and observing whether significant fading occurred within two months, i.e., whether there was a visible change in hair color. The experimental results are shown in Tables 6 and 4. Figures 6-9 .

[0143] Table 6: Statistics on the Permanence of Hair Dyeing

[0144]

[0145]

[0146]

[0147] The above experimental results show that the hair dye of the present invention exhibits good abrasion resistance and washability after dyeing. Under these conditions, the abrasion resistance and washability of hair dyed with the hair dye of the present invention are consistent with those of hair dyed with chemical hair dyes, and superior to the hair dye group with slightly worse results.

[0148] Test Example 3: Observation of damage to hair cuticle

[0149] Hair samples from control group 1 (chemical hair dye), control group 3 (chemical-plant composite hair dye), control group 4 (indole hair dye), and the hair dye from Example 1 were observed under an optical microscope at a magnification of 40x10. The distribution of hair cuticles is shown in the figure. Figure 10 As shown.

[0150] Depend on Figure 10 It can be seen that the hair surface structure of chemical, chemical plant compound hair dyes and commercially available indole hair dyes is relatively loose after dyeing, and the hair cuticles are more obviously opened or damaged. The hair dye prepared in Example 1 has a relatively dense hair structure after dyeing, and the hair cuticles are basically closed. This shows that the hair dye of the present invention is mild and friendly, and conforms to the concept of green and sustainable development.

[0151] Test Example 4: Measurement of damage to hair by different alkali treatments

[0152] Commercially available hair dyes containing destructive strong alkalis or organic bases, especially chemical hair dyes, typically contain 1% to 5% (by weight). While these dyes offer good coloring results, they often cause significant damage to the hair. To compare the degree of hair damage caused by the destructive strong alkalis or organic bases in commercially available hair dyes with the alkali used in the hair dye of this invention, different types of alkaline aqueous solutions were prepared according to the amount of alkali used. The hair to be dyed was then soaked in these solutions, and the distribution of hair cuticles after treatment was observed under a microscope. The mass fraction of the destructive strong alkali or organic base aqueous solution was reduced from 1% to 0.1% during preparation because attempts to prepare a 1% solution resulted in pH values ​​significantly approaching or exceeding 14, making objective comparative analysis impossible.

[0153] Table 7 Composition and dosage of different alkaline solutions used for hair treatment

[0154]

[0155]

[0156] The specific methods for treating hair with different alkaline solutions are shown in Table 7 below:

[0157] Weigh the materials according to the types and amounts of each component in Table 7, add water to prepare the corresponding alkaline solution, and soak an appropriate amount of broken hair in the alkaline solution for 10 minutes. After soaking, rinse with clean water until neutral, blow dry, and then observe the distribution of hair cuticles under a 40x10x optical microscope. The hair samples used for the soaking treatment were all real white broken hair collected from barbershops.

[0158] Depend on Figure 11 The observation results of hair cuticles in each group showed that the hair treated with alkaline solutions 1-3 in the control group all showed obvious opening or falling off of the hair cuticles to varying degrees, while the hair treated with the alkaline solution used in this invention had a relatively dense structure and no obvious signs of damage.

Claims

1. An indole-based hair dye based on air oxidation, wherein, The hair dye comprises the following components in parts by weight: Main dyeing component 0.5-5 parts, catalyst 0.1-2 parts, reducing agent 0.1-4 parts, pH adjuster 0.2-8 parts, pure natural penetration enhancer 2-10 parts, thickener 1-20 parts, surfactant 1-3 parts; The main staining component is an indole-based natural biomimetic melanin precursor. The catalyst is a combination of an air oxidation catalyst and a metal ion catalyst, wherein the air oxidation catalyst is N-hydroxyphthalimide (NHPI), and the metal ion catalyst can be selected from one or more of ferric chloride, ferrous sulfate, magnesium chloride, magnesium carbonate, copper chloride, and copper sulfate. The reducing agent is a combination of cysteine ​​and its derivatives and sodium sulfite and its derivatives.

2. The hair dye according to claim 1, wherein, The indole-based natural biomimetic melanin precursor can be selected from one or more of 5,6-dihydroxyindole, 5,6-dihydroxyindoleline, 5,6-dihydroxyindoleline hydrobromide, polydihydroxyindole, and acetylated indole. Preferably, the indole-based natural biomimetic melanin precursor substance has a weight ratio of 1-3, and more preferably 1, 1.2, 1.5, 1.6, 2, 2.5 and 3.

3. The hair dye according to claim 1 or 2, wherein, The catalyst has a weight ratio of 1.2-1.9, preferably 1.2, 1.7, 1.8, or 1.

9. Preferably, the weight ratio between the air oxidation catalyst and the metal ion catalyst is 0.2-0.4:1-1.6, more preferably 0.2:1, 0.2:1.2, 0.2:1.5, 0.2:1.6, 0.3:1.6 or 0.4:1.

5.

4. The hair dye according to any one of claims 1-3, wherein, The reducing agent has a weight ratio of 1-3, preferably 1.1-2.6, and more preferably 1.1, 1.3, 1.9, 2.2, 2.3, 2.4, or 2.

6. More preferably, the cysteine ​​and its derivatives are one or more selected from L-cysteine, L-cysteine, glutathione, and cysteine ​​hydrochloride; More preferably, the sodium sulfite and its derivatives are selected from one or more of sodium sulfite, sodium bisulfite, sodium metabisulfite, and sodium thiosulfate; More preferably, the weight ratio of cysteine ​​and its derivatives to sodium sulfite and its derivatives is 0.8-2:0.2-0.6, and more preferably 0.8:0.3, 1:0.3, 1.5:0.4, 1.8:0.4, 2:0.2, 2:0.3, or 2:0.

4.

5. The hair dye according to any one of claims 1-4, wherein, The pH adjuster is selected from one or more of sodium carbonate, sodium bicarbonate, disodium hydrogen phosphate, sodium dihydrogen phosphate, sodium citrate, L-arginine, and L-lysine. Preferably, the pH adjuster has a weight ratio of 0.9-6, and more preferably 0.9, 1, 1.2, 2, 2.2, 2.8, 3, 3.3, 3.4, 5, 5.3, or 6.

6. The hair dye according to any one of claims 1-5, wherein, The all-natural penetration enhancer is selected from one or more of the following: aloe vera leaf extract, tea extract, cactus extract, oat extract, quaternary ammonium salt-79 hydrolyzed keratin, licorice extract, clove flower extract, tremella polysaccharide, maltitol, and sorbitol. Preferably, the weight of the all-natural penetration enhancer used is 5-7, more preferably 5, 6, or 7.

7. The hair dye according to any one of claims 1-6, wherein, The thickener is selected from one or more of the following: mung bean powder, barley grass juice powder, Bletilla striata extract, Althaea sylvestris root extract, sodium carboxymethyl cellulose, sodium alginate, carrageenan, locust bean gum, and konjac gum. Preferably, the thickener is present in 6-12 parts by weight, and more preferably in 6, 9, 10, 11, or 12 parts by weight.

8. The hair dye according to any one of claims 1-7, wherein, The surfactant is selected from one or more of sodium dodecyl sulfate, sodium dodecylbenzene sulfonate, hexadecyltrimethylammonium chloride, sodium lauroyl glutamate, and sodium laureth sulfate. Preferably, the surfactant is present in a weight ratio of 1-2.5, and more preferably 1, 1.5, 2, or 2.

5.

9. A method of using the hair dye according to any one of claims 1-8, wherein, The method includes the following steps: S1: Pour the hair dye of any one of claims 1-8 into a hair dyeing bowl, add water and stir thoroughly until the paste becomes viscous, with uniform color and texture and no lumps, wherein the weight of the water added is 2 to 3 times the total weight of the hair dye of the present invention, preferably 2 times, 2.5 times, or 3 times. S2: Use a hair dyeing comb to evenly apply the paste obtained in step S1 to the hair, cover with plastic wrap and wait for 15-45 minutes; S3: Remove the plastic wrap and wait for 20-60 minutes. During this time, you can gently massage your hair to accelerate the blackening of the paste. S4: After the paste has completely turned black, rinse your hair thoroughly and blow-dry it.

10. Use of the hair dye according to any one of claims 1-8 in covering gray hair and / or dyeing gray hair black.

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