Biomimetic catalyst based on MOF material, preparation method of biomimetic catalyst and application of biomimetic catalyst in peptide synthesis
By introducing thiol, imidazole, and carboxyl functional ligands onto MOF materials, a triplet catalytic reaction catalyzed by cysteine protease is simulated, solving the problems of high cost and environmental pollution associated with chemical peptide synthesis methods. This enables the application of stable and efficient biomimetic catalysts suitable for peptide synthesis using various amino acid substrates.
CN121086256APending Publication Date: 2025-12-09JIANGNAN UNIV
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Patent Information
- Application Number
- CN202511200399.2
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- Filing Date
- 2025-08-26
- Publication Date
- 2025-12-09
AI Technical Summary
Technical Problem
Existing chemical synthesis methods for peptides suffer from high costs, low atom economy, and environmental pollution. Natural proteases are unstable in industrial applications and difficult to reuse.
Method used
A biomimetic catalyst based on MOF materials is designed by covalently introducing thiol, imidazole and carboxyl functional ligands to mimic the catalytic triplet structure of cysteine proteases, which can be used to catalyze peptide synthesis under mild conditions.
Benefits of technology
It achieves highly efficient and selective peptide synthesis, with good catalyst stability, easy recycling and reuse, and is suitable for a variety of amino acid substrates, in line with the concept of green chemistry.
✦ Generated by Eureka AI based on patent content.
Abstract
The invention discloses a biomimetic catalyst based on an MOF material, a preparation method of the biomimetic catalyst and application of the biomimetic catalyst in peptide synthesis. According to the method, firstly, a novel functional ligand is designed and synthesized, and the ligand integrates nucleophilic sulfydryl, proton transfer imidazolyl and skeleton connection carboxyl and can simulate a'catalytic triad 'of an enzyme active center. Then, the ligand, metal salt and terephthalic acid are co-assembled through a solvothermal method, and the bionic MOF material is prepared. The material has regular nanopore channels and high stability, and can accurately simulate the catalytic mechanism of cysteine protease. The catalyst is used for catalyzing peptide synthesis reaction, amino-acid ester condensation can be efficiently catalyzed to form peptide bonds under the mild and green conditions without chemical coupling agents, the conversion rate is high, the catalyst is easy to recycle, the inherent defects of a traditional chemical synthesis method and an enzyme method are overcome, and a new strategy is provided for green peptide synthesis.
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