Medicine prescription for treating radiodermatitis and application thereof

By developing an acetate topical gel containing peptide compounds, the skin's κ-opioid receptors are directly activated, solving the problem of local treatment for radiation dermatitis and atopic dermatitis itching in existing technologies, and achieving efficient and safe relief of skin itching.

CN121197359APending Publication Date: 2025-12-26SUZHOU TIANMAYIYAO GRP TIANJI BIOLOGY PHARMACY CO LTD
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Patent Information

Application Number
CN202511279129.5
Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
Filing Date
2025-09-09
Publication Date
2025-12-26

AI Technical Summary

Technical Problem

Current technology lacks effective and safe topical preparations for treating radiation dermatitis and atopic dermatitis itching. Traditional oral or injectable drugs are difficult to target effectively on the local skin and may cause systemic adverse reactions.

Method used

Develop a topical gel comprising acetate of peptide compounds, solvent, antibacterial agent, gel matrix and metal ion complexing agent, which directly inhibits pruritus signal transduction by activating κ-opioid receptors in the stratum corneum of the skin. It is prepared using a low-irritant aqueous matrix, has moderate transdermal permeability and reduces insoluble impurities.

Benefits of technology

It achieves effective local itch relief, reduces the risk of systemic adverse reactions, improves patient compliance, and is suitable for the treatment of radiation dermatitis and atopic dermatitis.

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Abstract

The invention relates to a medicine prescription for treating radiodermatitis and application thereof. The medicine comprises the following components in percentage by weight: 0.01%-2% of acetate of a peptide compound, 2%-5% of a first solvent, 0.05%-1.75% of a bacteriostatic agent, 0.5%-3% of a gel matrix, 0.05%-3% of a metal ion complexing agent, a pH regulator for regulating the pH value to 3-7, and a second solvent supplemented to 100%. The prescription of the medicine for treating radiodermatitis is especially suitable for symptomatic treatment of chronic pruritus such as atopic dermatitis, and the local action mechanism of the medicine gives consideration to both curative effect and safety. The medicine can be directly administered to an affected part, so that the uncertainty of in-vivo circulation is reduced; the use by patients is convenient and the compliance is improved.
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