Nerve regulation treatment method, system, equipment and medium

Abstract

The invention discloses a nerve regulation and control treatment method, system and device and a medium, and the method comprises the steps: designing a nerve regulation and control investigation and inquiry template, evaluating the nerve state of a patient, and generating an evaluation report; carrying out sound treatment technology applicability screening on the patient; selecting a plurality of sections of universal biological natural sound noise, providing the universal biological natural sound noise to the patient passing the applicability screening of the sound treatment technology for audition, and selecting the universal biological natural sound noise with a relatively high adaptability threshold as an initial nerve regulation treatment audio; carrying out hearing test, generating debugging parameters, debugging the initial treatment audio, and generating recommended nerve regulation treatment audio; and performing nerve regulation treatment on the patient based on the recommended nerve regulation treatment audio, and checking the treatment effect. According to the invention, a series of hearing tests are carried out on the patient, the debugged recommended nerve regulation treatment audio is generated for patients with different symptom types, and the nerve regulation treatment effect is effectively improved.

Description

TECHNICAL FIELD

[0001] The present application relates to the technical field of neuromodulation therapy, and in particular to a neuromodulation therapy method, system, device and medium. BACKGROUND

[0002] With the development of social economy, the competition in various industries intensifies, leading to excessive psychological pressure of people, imbalance of nervous state, causing related negative emotions such as spiritual anxiety and unrest, depressed mood, irritability, and further leading to insomnia, illness, tinnitus and other physiological health problems, which not only cause great harm to body and mind, but also seriously affect the quality of life. Such health problems have gradually become one of the problems concerned by the society.

[0003] In view of such health problems, more and more people begin to seek non-traditional medical methods to treat physical and mental problems, such as using sound to perform neuromodulation therapy on patients. It is found in clinical practice that when such patients have related symptoms, various aspects of the human body will be affected to varying degrees, including the auditory system, the visual system, the balance system, and specific organs such as the brain, the skeleton, and the muscles, all of which will appear abnormal conditions. It is found through a large number of clinical treatments that by simulating the generation of neuromodulation therapy audio for patients and playing it for a long time, the psychological and physiological discomfort of patients can be effectively relieved. At present, the treatment audio used in such neuromodulation therapy method is usually a general biological natural sound noise, which has different treatment effects on different patients. The treatment effect of some special patients is not good, and for such or more serious patients, a longer listening time of the treatment audio is often needed, which may cause hearing damage and affect the treatment effect after a long time. SUMMARY

[0004] The present application aims to overcome the shortcomings of the prior art, and provides a neuromodulation therapy method, system, device and medium, which performs a series of hearing tests on patients, generates recommended neuromodulation therapy audio after debugging for patients with different symptom types, and effectively improves the neuromodulation therapy effect.

[0005] The present application provides a neuromodulation therapy method, which comprises:

[0006] designing a neuromodulation research and diagnosis template, evaluating the nervous state of the patient based on the research and diagnosis template, and generating an evaluation report;

[0007] screening the applicability of sound therapy technology for the patient based on the evaluation report;

[0008] selecting several segments of general biological natural sound noises, providing the several segments of general biological natural sound noises to a patient who passes the suitability screening of the sound therapy technology for a trial listening, and selecting general biological natural sound noises with a higher adaptability threshold as initial neural regulation therapy audio;

[0009] performing a hearing test on the patient, generating a debugging parameter according to the result of the hearing test, debugging the initial therapy audio based on the debugging parameter, and generating recommended neural regulation therapy audio;

[0010] performing neural regulation therapy on the patient based on the recommended neural regulation therapy audio, and testing the effect of the therapy.

[0011] Further, the design of the neural regulation research consultation template is based on the evaluation of the patient's neural state, and the generation of the evaluation report includes:

[0012] setting up multiple evaluation scale templates, providing the evaluation scale templates to the patient for filling out, collecting the filled evaluation scales, and generating corresponding evaluation reports. The evaluation scale templates include a tinnitus self-rating scale, an emotional self-rating scale, and other symptom self-rating scales.

[0013] Further, the suitability screening of the sound therapy technology for the patient based on the evaluation report includes:

[0014] generating a screening parameter based on the evaluation report, using repetitive transcranial magnetic stimulation technology to test the suitability of the sound therapy technology for the patient, and comparing the test result with the screening parameter to determine whether the patient passes the suitability screening of the sound therapy and the type of sound therapy suitable for the patient.

[0015] Further, the selection of several segments of general biological natural sound noises, the provision of the several segments of general biological natural sound noises to a patient who passes the suitability screening of the sound therapy technology for a trial listening, and the selection of general biological natural sound noises with a higher adaptability threshold as initial neural regulation therapy audio includes:

[0016] selecting several segments of general biological natural sound noises of different types;

[0017] providing the general biological natural sound noises to the patient for a trial listening;

[0018] adjusting the frequency, pitch, amplitude, timbre, and volume of the general biological natural sound noises back and forth according to the trial listening experience of the patient;

[0019] collecting the adaptability of the patient to general biological natural sound noises of different frequencies, pitches, amplitudes, timbres, and volumes, and selecting several segments of general biological natural sound noises with a higher adaptability threshold as initial neural regulation therapy audio.

[0020] Further, the hearing test is performed on the patient, the debugging parameters are generated according to the hearing test results, and the recommended neuroregulation treatment audio is generated by debugging the initial treatment audio based on the debugging parameters.

[0021] The pure tone threshold response test is performed on the patient, and the pure tone threshold range of the patient is extracted;

[0022] The noise threshold response test is performed on the patient, and the noise threshold range of the patient is extracted;

[0023] The pure tone threshold range and the noise threshold range are overlapped to obtain the hearing sensitivity threshold range of the patient;

[0024] The audio track score of the initial neuroregulation treatment audio in the hearing sensitivity threshold range is extracted, and is extended to both sides of the audio track to modulate the first semi-finished neuroregulation treatment audio.

[0025] Further, the hearing test is performed on the patient, the debugging parameters are generated according to the hearing test results, and the recommended neuroregulation treatment audio is generated by debugging the initial treatment audio based on the debugging parameters.

[0026] The energy balance analysis is performed on the first semi-finished neuroregulation treatment audio to determine the energy balance threshold of the first semi-finished neuroregulation treatment audio;

[0027] The auditory brainstem response test is performed on the patient to obtain the auditory pathway unobstructed coefficient of the patient;

[0028] The auditory pathway unobstructed coefficient is compared with the standard value of the auditory pathway unobstructed coefficient to obtain the energy gain multiple corresponding to the patient;

[0029] The energy balance threshold of the first semi-finished neuroregulation treatment audio is gain compensated based on the energy gain multiple to obtain the second semi-finished neuroregulation treatment audio.

[0030] Further, the hearing test is performed on the patient, the debugging parameters are generated according to the hearing test results, and the recommended neuroregulation treatment audio is generated by debugging the initial treatment audio based on the debugging parameters.

[0031] The visual inspection is performed on the inside of the left ear canal and the inside of the right ear canal of the patient respectively to obtain the visual inspection results;

[0032] The distortion product otoacoustic emission test is performed on the inside of the left ear canal and the inside of the right ear canal of the patient respectively to obtain the distortion product otoacoustic emission test results;

[0033] The visual inspection results and the distortion product otoacoustic emission test results are compared to obtain the left ear distortion parameters and the right ear distortion parameters of the patient;

[0034] The left ear component of the second semi-neuroregulation treatment audio is debugged based on the left ear distortion parameter, and a debugged left ear component is obtained, the right ear component of the second semi-neuroregulation treatment audio is debugged based on the right ear distortion parameter, and a debugged right ear component is obtained, the debugged left ear component and the debugged right ear component are synthesized, and recommended neuroregulation treatment audio is generated.

[0035] The application further provides a neuroregulation treatment system for implementing the neuroregulation treatment method.

[0036] A neural state evaluation module is configured to design a neuroregulation investigation questionnaire template, evaluate the neural state of a patient based on the investigation questionnaire template, and generate an evaluation report.

[0037] A suitability screening module is configured to perform a sound treatment technology suitability screening on the patient based on the evaluation report.

[0038] An initial audio generation module is configured to select a plurality of general biological natural sound noises, provide the plurality of general biological natural sound noises to a patient who passes the sound treatment technology suitability screening for trial listening, and select a general biological natural sound noise with a high adaptability threshold as an initial neuroregulation treatment audio.

[0039] An audio debugging module is configured to perform a hearing test on the patient, generate a debugging parameter according to the hearing test result, debug the initial treatment audio based on the debugging parameter, and generate recommended neuroregulation treatment audio.

[0040] A treatment effect verification module is configured to perform neuroregulation treatment on the patient based on the recommended neuroregulation treatment audio, and verify the treatment effect.

[0041] The application further provides an electronic device including a memory, a processor, and a computer program stored in the memory and executable on the processor, and the processor executes the computer program to implement the neuroregulation treatment method.

[0042] The application further provides a computer readable storage medium having a computer program stored thereon, and the computer program is executable on a processor to implement the neuroregulation treatment method.

[0043] The application provides a neuromodulation treatment method, system, device and medium, which evaluates the nerve state of a patient based on a neuromodulation investigation and diagnosis template, and performs sound treatment technology applicability screening, effectively determines whether the sound treatment technology is applicable according to the actual nerve state of the patient, and reduces the treatment risk and side effects in the follow-up treatment; hearing test is performed on the patient, including pure tone threshold response test and noise threshold response test, the hearing sensitivity threshold range of the patient is distinguished, the audio track of the neuromodulation treatment audio is adjusted to the optimal range, and the treatment experience of the patient is fully considered; auditory brainstem response test, according to the patient's auditory pathway unobstructed coefficient, the energy gain of the neuromodulation treatment audio is performed, and the problem that the treatment effect is poor due to the low energy of the general biological natural sound noise of the patient with special conditions or more serious symptoms is optimized; distortion product otoacoustic emission test, considering the physiological conditions of the patient's ear canal and the problem of left and right ear imbalance, the left and right ear components of the neuromodulation treatment audio are adjusted respectively, the recommended neuromodulation treatment audio is generated, the recommended neuromodulation treatment audio after adjustment is generated for patients with different symptom types, the problems of large difference in treatment effect of the existing treatment audio for different patients, poor treatment effect of part of the patients and possible hearing damage are effectively solved, and the effect and safety of neuromodulation treatment are improved. BRIEF DESCRIPTION OF DRAWINGS

[0044] In order to more clearly illustrate the technical solutions in the embodiments of the application or the prior art, the following will briefly introduce the drawings needed to be used in the embodiments or the prior art description. Obviously, the drawings in the following description are only some embodiments of the application, and for those skilled in the art, other drawings can also be obtained without creative labor on the basis of these drawings.

[0045] Figure 1 is a neuromodulation treatment method flowchart in the embodiment one of the application;

[0046] Figure 2 is a flowchart for generating an initial neuromodulation treatment audio in the embodiment one of the application;

[0047] Figure 3 is a flowchart for generating a first half neuromodulation treatment audio in the embodiment one of the application;

[0048] Figure 4 is a flowchart for generating a second half neuromodulation treatment audio in the embodiment one of the application;

[0049] Figure 5 is a flowchart for generating a recommended neuromodulation treatment audio in the embodiment one of the application;

[0050] Figure 6 is a neuromodulation treatment system architecture diagram in the embodiment two of the application. Detailed Implementation

[0051] The technical solutions of the embodiments of the present invention will be clearly and completely described below with reference to the accompanying drawings. Obviously, the described embodiments are only some embodiments of the present invention, and not all embodiments. Based on the embodiments of the present invention, all other embodiments obtained by those skilled in the art without creative effort are within the scope of protection of the present invention.

[0052] In this invention, it should be understood that terms such as “comprising” or “having” are intended to indicate the presence of features, figures, steps, behaviors, components, portions or combinations thereof disclosed in this specification, and are not intended to exclude the possibility that one or more other features, figures, steps, behaviors, components, portions or combinations thereof are present or added.

[0053] It should also be noted that, unless otherwise specified, the embodiments and features described in the present invention can be combined with each other. The present invention will now be described in detail with reference to the accompanying drawings and embodiments.

[0054] With socio-economic development, competition in all sectors has intensified, leading to increased psychological stress and resulting in nervous system disorders. This, in turn, triggers a series of mental and physical health problems, such as anxiety, insomnia, and tinnitus. These issues not only severely impact people's quality of life but also cause significant harm to their physical and mental well-being. In response to these health problems, more and more people are seeking non-traditional medical treatments, among which the use of sound for neuromodulation therapy is gaining increasing attention.

[0055] Current neuromodulation treatments primarily employ generic bio-sound noise. While this method can alleviate symptoms to some extent, the treatment effectiveness varies significantly due to individual patient differences. Particularly for patients with more severe symptoms, longer audio therapy sessions are often required, which may lead to hearing damage and affect treatment outcomes. Therefore, providing a personalized neuromodulation treatment method to improve treatment effectiveness and reduce the risk of hearing loss has become an urgent problem to be solved.

[0056] Example 1

[0057] Embodiment 1 of the present invention provides a neuromodulation treatment method, the method comprising: designing a neuromodulation survey template, assessing the patient's neurological state based on the survey template, and generating an assessment report; screening the patient for the suitability of sound therapy technology based on the assessment report; selecting several segments of general bio-natural noise, providing the several segments of general bio-natural noise to patients who have passed the sound therapy technology suitability screening for listening, and selecting general bio-natural noise with a high adaptability threshold as the initial neuromodulation treatment audio; conducting hearing tests on the patient, generating adjustment parameters based on the hearing test results, and adjusting the initial treatment audio based on the adjustment parameters to generate recommended neuromodulation treatment audio; performing neuromodulation treatment on the patient based on the recommended neuromodulation treatment audio, and verifying the treatment effect.

[0058] In one optional implementation of this embodiment, such as Figure 1 As shown, Figure 1 The flowchart of the neuromodulation therapy method according to Embodiment 1 of the present invention is shown, including the following steps:

[0059] S101. Design a neuromodulation survey and consultation template, assess the patient's neurological state based on the survey and consultation template, and generate an assessment report;

[0060] In one optional implementation of this embodiment, multiple assessment scale templates are set up, the assessment scale templates are provided to patients for completion, the completed assessment scales are collected, and corresponding assessment reports are generated.

[0061] Specifically, the assessment scale templates include tinnitus self-rating scales, emotion self-rating scales, and other symptom self-rating scales. The tinnitus self-rating scales include the Tinnitus Handicap Inventory (THI), Tinnitus Handicap Questionnaire (THQ), Tinnitus Reaction Questionnaire (TRQ), Tinnitus Questionnaire (TQ), Tinnitus Evaluation Questionnaire (TEQ), Tinnitus Functional Index (TFI), Tinnitus Severity Questionnaire (TSQ), and Tinnitus Severity Index (TSI), etc. These tinnitus self-rating scales are mainly used to assess the patient's physiological tinnitus symptoms. The emotion self-rating scales include the Vertigo Symptom Scale (VSS) and the Self-Rating Anxiety Scale (SAS). The following are some of the self-rating symptom scales used to assess a patient's emotional symptoms: the Self-Rating Depression Scale (SDS), the Hospital Anxiety and Depression Scale (HAD), and the 9-item Patient Health Questionnaire-9 (PHQ-9). Other self-rating symptom scales include the Visual Analogue Scale (VAS) and the Pittsburgh Sleep Quality Index (PSQI), which are used to assess a patient's symptoms in other areas.

[0062] This system uses multiple assessment scale templates, including a tinnitus self-assessment scale, a mood self-assessment scale, and other symptom self-assessment scales. Patients can complete these scales in detail, providing comprehensive information about their neurological state. After collecting the completed assessment scales, a corresponding assessment report is generated, providing basic data for subsequent treatment.

[0063] S102. Based on the assessment report, conduct a sound therapy technology suitability screening for the patient;

[0064] In one optional implementation of this embodiment, screening parameters are generated based on the assessment report, and repetitive transcranial magnetic stimulation is used to perform a sound therapy suitability test on the patient. The test results are then compared with the screening parameters to determine whether the patient passes the sound therapy suitability screening and the applicable type of sound therapy.

[0065] Specifically, repetitive transcranial magnetic stimulation (rTMS) is a technique that involves repeated transcranial magnetic stimulation (TMS), commonly used to stimulate the human brain. Its magnetic signals can penetrate the skull without attenuation to stimulate brain nerves. RTMS achieves the purpose of exciting or inhibiting local cerebral cortex function by changing the stimulation frequency. In this embodiment, by collecting the potentials after stimulating the patient's local cerebral cortex function and combining this with the patient's own sensations, it is determined whether the patient is suitable for sound therapy and whether they have passed the sound therapy suitability screening. When the test results match the screening coefficient obtained from the previous evaluation report to a high degree in the control group, the patient is deemed to have passed the sound therapy suitability screening. Furthermore, by matching the potentials, the type of sound therapy suitable for the patient is determined.

[0066] Here, screening parameters are generated, and repetitive transcranial magnetic stimulation (rTMS) is used to test the patient's suitability for sound therapy. The test results are then compared with the screening parameters to determine whether the patient passes the sound therapy suitability screening and, consequently, the appropriate type of sound therapy. This step ensures that the patient is suitable for sound therapy and identifies the appropriate sound type, guaranteeing the safety of subsequent treatment.

[0067] S103. Select several segments of general biological natural sound noise, and provide the several segments of general biological natural sound noise to patients who have passed the sound therapy technology suitability screening for listening. Select the general biological natural sound noise with a higher adaptability threshold as the initial neuromodulation therapy audio.

[0068] In one optional implementation of this embodiment, such as Figure 2 As shown, Figure 2 The flowchart illustrating the generation of initial neuromodulation therapy audio in Embodiment 1 of the present invention is shown, including the following steps:

[0069] S201. Select several segments of different types of general biological natural sound noise;

[0070] In one optional implementation of this embodiment, the types of general biological natural sound noise selected include pure tone, uniform noise, Gaussian noise, masking noise, impulse noise, and warbling.

[0071] S202. Provide the patient with the general bio-natural sound noise for listening;

[0072] In one optional implementation of this embodiment, the generated general biological natural sound noise is played to the patient for listening test through an audio playback device, which may include an external amplifier and a headphone device with left and right channel functions.

[0073] S203. Adjust the frequency, pitch, amplitude, timbre, and volume of the general biological natural sound noise back and forth according to the patient's listening experience;

[0074] In one optional implementation of this embodiment, the frequency, pitch, amplitude, timbre, and volume of the general bio-natural sound noise are adjusted back and forth, and the patient is asked whether the adjusted general bio-natural sound noise is similar to the patient's own tinnitus. All general bio-natural sound noises that the patient subjectively believes are similar to their own tinnitus are selected.

[0075] The therapeutic effect is better when the patient is treated with neuromodulation audio that has the same frequency, pitch, amplitude, timbre and volume as the patient's own tinnitus.

[0076] S204. Collect patients' adaptation to general biological natural sound noise of different frequencies, pitches, amplitudes, timbres, and volumes, and select several general biological natural sound noise segments with higher adaptation thresholds as initial neuromodulation therapy audio.

[0077] In an optional implementation of this embodiment, the patient's satisfaction with and acceptability of the general biological natural sound noise collected in step S203 is combined into an adaptability threshold, and a number of general biological natural sound noise segments with higher adaptability thresholds are selected as the initial neuromodulation therapy audio.

[0078] By collecting patients' subjective feelings, the personalization and effectiveness of the initial neuromodulation therapy audio are ensured.

[0079] S104. Perform a hearing test on the patient, generate adjustment parameters based on the hearing test results, and adjust the initial treatment audio based on the adjustment parameters to generate recommended neuromodulation treatment audio.

[0080] In one optional implementation of this embodiment, a first semi-synthetic neuromodulation therapy audio, a second semi-synthetic neuromodulation therapy audio, and a final recommended neuromodulation therapy audio are generated sequentially by performing pure tone hearing threshold response test, noise hearing threshold response test, auditory brainstem response test, and distortion product otoacoustic emission test on the patient.

[0081] In one optional implementation of this embodiment, such asFigure 3 As shown, Figure 3 The flowchart illustrating the generation of the first semi-neural modulation therapy audio in Embodiment 1 of the present invention is shown, including the following steps:

[0082] S301. Perform a pure-tone hearing threshold response test on the patient and extract the patient's pure-tone hearing threshold range;

[0083] In one optional implementation of this embodiment, a pure tone audiometry (PTA) test is performed on the patient to extract the patient's pure tone audiometry range.

[0084] Specifically, the pure tone hearing threshold response test is used to test the softest sound that a patient can just hear for pure tones of different frequencies. It is a means of judging the patient's hearing sensitivity. Here, the patient's pure tone hearing threshold range is extracted to determine the lower limit of the patient's sensitivity to therapeutic audio.

[0085] S302. Perform a noise hearing threshold response test on the patient and extract the patient's noise hearing threshold range;

[0086] In one optional implementation of this embodiment, a noise threshold response test (NTA) is performed on the patient to extract the patient's noise hearing threshold range.

[0087] Specifically, the noise hearing threshold response test is used to test the range of noise that a patient can perceive at different frequencies. Here, the patient's noise hearing threshold range is extracted to determine the upper limit of the patient's sensitivity to therapeutic audio.

[0088] S303. Overlap the pure tone hearing threshold range with the noise hearing threshold range to obtain the patient's hearing sensitivity threshold range;

[0089] In an optional implementation of this embodiment, the pure tone hearing threshold range and the noise hearing threshold range obtained in steps S301 and S302 are overlapped, and the overlap range is extracted, which is the patient's hearing sensitivity threshold range. The sound within this hearing sensitivity threshold range is the sound with appropriate sensitivity for the patient and can be used for sound therapy.

[0090] S304. Extract the track score of the initial neuromodulation therapy audio within the hearing sensitivity threshold range, and extend it to both sides of the track to modulate it into a first semi-neuromodulation therapy audio.

[0091] In one optional implementation of this embodiment, the audio track score of the initial neuromodulation therapy audio within the hearing sensitivity threshold range is extracted, and the audio track score is used as the center to extend to both sides of the audio track. The extension is stopped after a certain extension degree. The standard for extension is no distortion. After the extension is completed, modulation is performed to generate the first semi-finished neuromodulation therapy audio.

[0092] This method involves conducting pure-tone hearing threshold response tests and noise hearing threshold response tests on patients to obtain their sensitivity threshold range. Then, it generates the first half-syndrome neuromodulation therapy audio corresponding to this sensitivity threshold range, effectively ensuring the patient's experience during treatment.

[0093] In one optional implementation of this embodiment, such as Figure 4 As shown, Figure 4 The flowchart illustrating the generation of second semi-neuromodulation therapy audio in Embodiment 1 of the present invention is shown, including the following steps:

[0094] S401. Perform energy balance analysis on the first semi-neural modulation therapy audio and determine the energy balance threshold of the first semi-neural modulation therapy audio.

[0095] In one optional implementation of this embodiment, energy balance analysis is performed on the first semi-neuromodulation therapy audio to determine the energy distribution of the first semi-neuromodulation therapy audio and to determine the energy balance threshold of the first semi-neuromodulation therapy audio.

[0096] Specifically, it is assumed here that the energy of the first semi-neuromodulation therapy audio is uniformly distributed on the logarithmic frequency axis. Specifically, four frequency points are arbitrarily selected on the spectrum, including f1, f2, f3, and f4, where logf2 - logf1 = logf4 - logf3, i.e. This means that the energy within the continuous frequency band from f1 to f2 is the same as and equal to the energy within the continuous frequency band from f3 to f4.

[0097] Furthermore, setting the sampling frequency to f0, sampling is performed on the first semi-synthetic neuromodulation therapy audio, with a sampling quantity of m. The total energy of the first semi-synthetic neuromodulation therapy audio is then:

[0098]

[0099] The energy balance threshold is:

[0100]

[0101] In the formula, E is the total energy of the first semi-neuromodulation therapy audio, E0 is the energy equalization threshold, m is the number of samples, and f0 is the sampling frequency.

[0102] S402. Perform auditory brainstem response testing on the patient to obtain the patient's auditory pathway patency coefficient;

[0103] In one optional implementation of this embodiment, the patient undergoes a Brainstem Auditory Evoked Response (BAER) test to obtain the patient's auditory pathway patency coefficient.

[0104] Specifically, the auditory brainstem response test can be used to assess the patient's brainstem auditory function and development, thereby determining the patient's brainstem auditory sensitivity and comparing it with the normal level to determine the patient's auditory pathway patency and generate a specific indicator, the auditory pathway patency coefficient μ.

[0105] S403. Compare the auditory pathway patency coefficient with the auditory pathway patency standard value to obtain the energy gain multiple corresponding to the patient;

[0106] In an optional implementation of this embodiment, the auditory pathway patency coefficient μ is compared with the auditory pathway patency standard value μ0 to obtain the energy gain multiple corresponding to the patient.

[0107] Specifically, the formula for calculating the energy gain factor is as follows:

[0108]

[0109] In the formula, A is the energy gain factor, μ is the auditory pathway patency coefficient, and μ0 is the standard value for auditory pathway patency.

[0110] S404. Based on the energy gain multiple, perform gain compensation on the energy balance threshold of the first semi-neuromodulation therapy audio to obtain the second semi-neuromodulation therapy audio.

[0111] In an optional implementation of this embodiment, the energy balance threshold of the first semi-neuromodulation therapy audio is compensated based on the energy gain multiple obtained in step S403 to obtain the second semi-neuromodulation therapy audio.

[0112] Considering the special circumstances of some patients, the therapeutic effect of conventional intensity audio is poor. By conducting auditory brainstem response tests on patients, the degree of their hearing impairment is determined, specifically reflected in the auditory pathway patency coefficient. The auditory pathway patency coefficient is used to generate an energy gain factor, which effectively solves the problem of large differences in the therapeutic effect of audio on different patients and poor treatment effect for some patients in the existing technology.

[0113] In one optional implementation of this embodiment, such as Figure 5 As shown, Figure 5The flowchart of the recommended neuromodulation therapy audio in Embodiment 1 of the present invention is shown, including the following steps:

[0114] S501. Perform visual examinations on the inside of the patient's left and right ear canals respectively, and obtain the visual examination results.

[0115] In one optional implementation of this embodiment, a camera is used to visually inspect the inside of the patient's left and right ear canals, respectively, to obtain inspection images, and the visual inspection results are obtained from the inspection images.

[0116] Specifically, this mainly involves determining whether there are certain physical characteristics inside the patient's left and right ear canals, and judging the differences between the left and right ear canals.

[0117] S502. Perform distortion product otoacoustic emission (OAE) tests on the inside of the patient's left and right ear canals respectively, and obtain the OAE test results.

[0118] In one optional implementation of this embodiment, a distortion product otoacoustic emission (DPOAE) test is performed on the patient to obtain the DPOAE test results.

[0119] Specifically, two initial pure tone stimuli with a certain frequency ratio were emitted into the patient's left ear canal, and the potential changes in the patient's left cochlea were collected. Similarly, two identical initial pure tone stimuli were emitted into the patient's right ear canal, and the potential changes in the patient's right cochlea were collected.

[0120] S503. Compare the visual examination results and the otoacoustic test results of the distortion products to obtain the distortion parameters of the patient's left ear and right ear.

[0121] In an optional implementation of this embodiment, the differences between the left and right ear canals obtained in step S501 are combined with the changes in cochlear potential in the left and right ears obtained in step S502, and the patient's left ear distortion parameters and right ear distortion parameters are obtained by comparison.

[0122] It should be noted that here, the distortion parameter of the left ear can be calibrated to 1, and the relative calibration value of the distortion parameter of the right ear can be calculated. Alternatively, the distortion parameter of the right ear can be calibrated to 1, and the relative calibration value of the distortion parameter of the left ear can be calculated. Or, a calibration standard value can be set to calculate the distortion parameters of the left ear and the right ear separately.

[0123] S504. Based on the left ear distortion parameters, the left ear component of the second half-adjustment neuromodulation therapy audio is adjusted to obtain the adjusted left ear component. Based on the right ear distortion parameters, the right ear component of the second half-adjustment neuromodulation therapy audio is adjusted to obtain the adjusted right ear component. The adjusted left ear component and the adjusted right ear component are synthesized to generate the recommended neuromodulation therapy audio.

[0124] In an optional implementation of this embodiment, the left ear component of the second hemi-neural modulation therapy audio is adjusted based on the left ear distortion parameters to obtain the adjusted left ear component;

[0125] The right ear component of the second hemi-neural modulation therapy audio is adjusted based on the right ear distortion parameters to obtain the adjusted right ear component.

[0126] Specifically, when the left ear distortion parameter is calibrated to 1, the left ear component of the second hemisphere neuromodulation therapy audio is adjusted based on the left ear distortion parameter. After obtaining the adjusted left ear component, the adjusted left ear component is copied and the auditory direction is reversed. Then, it is adjusted based on the relative calibration value of the right ear distortion parameter to obtain the adjusted right ear component. Similarly, when the right ear distortion parameter is calibrated to 1, the right ear component of the second hemisphere neuromodulation therapy audio is adjusted based on the right ear distortion parameter. After obtaining the adjusted right ear component, the adjusted right ear component is copied and the auditory direction is reversed. Then, it is adjusted based on the relative calibration value of the left ear distortion parameter to obtain the adjusted left ear component.

[0127] Furthermore, if calibration standard values ​​have been set, the left and right ear components of the second hemisphere neuromodulation therapy audio are adjusted based on the left ear distortion parameters and the right ear distortion parameters, respectively, to obtain the adjusted left and right ear components.

[0128] In an optional implementation of this embodiment, the adjusted left ear component and the adjusted right ear component are synthesized to generate recommended neuromodulation therapy audio.

[0129] This approach considers the patient's internal ear canal physiological condition and the imbalance between the left and right ears. The left and right ear components of the neuromodulation therapy audio are adjusted separately to generate recommended neuromodulation therapy audio. This is further optimized to address the patient's left and right ear imbalance and improve the treatment effect.

[0130] S105. Perform neuromodulation therapy on the patient based on the recommended neuromodulation therapy audio, and verify the treatment effect.

[0131] In one optional implementation of this embodiment, neuromodulation therapy is performed on the patient based on the recommended neuromodulation therapy audio, and the treatment effect is verified after a certain course of treatment.

[0132] Specifically, after a certain course of treatment, the patient's treatment effect and experience are collected through follow-up visits and other means.

[0133] In summary, Embodiment 1 of this invention provides a neuromodulation treatment method. Based on a neuromodulation survey and consultation template, it assesses the patient's neurological state and screens for the applicability of sound therapy technology. This effectively determines whether sound therapy is suitable based on the patient's actual neurological state, reducing subsequent treatment risks and side effects. Hearing tests are performed on the patient, including pure-tone audiometry and noise-based audiometry, to differentiate the patient's hearing sensitivity threshold range and adjust the audio track of the neuromodulation treatment to the optimal range, fully considering the patient's treatment experience. Auditory brainstem response testing is conducted, and energy gain is applied to the neuromodulation treatment audio based on the patient's auditory pathway patency coefficient, optimizing the treatment effect for some special cases or patients with more severe symptoms who experience poor treatment results due to low energy levels in general biological natural noise. Distortion product otoacoustic emission testing considers the patient's internal ear canal physiological condition and left-right ear imbalance, adjusting the left and right ear components of the neuromodulation treatment audio separately to generate recommended neuromodulation treatment audio. Adjusted recommended neuromodulation treatment audio is generated for patients with different symptom types, effectively solving the problems of large differences in the effectiveness of treatment audio for different patients, poor treatment effect for some patients, and potential hearing damage in existing technologies, thus improving the efficacy and safety of neuromodulation treatment.

[0134] Example 2

[0135] Embodiment 2 of the present invention provides a neuromodulation therapy system, which is used to implement the neuromodulation therapy method described in Embodiment 1. The system includes a neurostate assessment module, an applicability screening module, an initial audio generation module, an audio debugging module, and a treatment effect verification module.

[0136] In one optional implementation of this embodiment, such as Figure 6 As shown, Figure 6 The diagram shows the architecture of the neuromodulation therapy system according to Embodiment 2 of the present invention, which includes the following modules:

[0137] The neurological state assessment module 10 is used to design a neuromodulation survey and consultation template, assess the patient's neurological state based on the survey and consultation template, and generate an assessment report.

[0138] This system uses multiple assessment scale templates, including a tinnitus self-assessment scale, a mood self-assessment scale, and other symptom self-assessment scales. Patients can complete these scales in detail, providing comprehensive information about their neurological state. After collecting the completed assessment scales, a corresponding assessment report is generated, providing basic data for subsequent treatment.

[0139] The applicability screening module 20 is used to screen the patient for the applicability of sound therapy technology based on the assessment report;

[0140] Here, screening parameters are generated, and repetitive transcranial magnetic stimulation (rTMS) is used to test the patient's suitability for sound therapy. The test results are then compared with the screening parameters to determine whether the patient passes the sound therapy suitability screening and, consequently, the appropriate type of sound therapy. This step ensures that the patient is suitable for sound therapy and identifies the appropriate sound type, guaranteeing the safety of subsequent treatment.

[0141] The initial audio generation module 30 is used to select several segments of general biological natural sound noise, provide the several segments of general biological natural sound noise to patients who have passed the sound therapy technology suitability screening for listening, and select general biological natural sound noise with a higher adaptability threshold as the initial neuromodulation therapy audio.

[0142] In one optional implementation of this embodiment, several segments of different types of general biological natural sound noise are selected;

[0143] The general bio-natural sound noise is provided to the patient for listening;

[0144] The frequency, pitch, amplitude, timbre, and volume of the general biological natural sound noise are adjusted back and forth based on the patient's listening experience;

[0145] The patients' adaptability to general biological natural sound noise of different frequencies, pitches, amplitudes, timbres, and volumes was collected, and several general biological natural sound noise segments with high adaptability thresholds were selected as the initial neuromodulation therapy audio.

[0146] By collecting patients' subjective feelings, the personalization and effectiveness of the initial neuromodulation therapy audio are ensured.

[0147] The audio debugging module 40 is used to perform hearing tests on patients, generate debugging parameters based on the hearing test results, and debug the initial treatment audio based on the debugging parameters to generate recommended neuromodulation treatment audio.

[0148] In one optional implementation of this embodiment, a first semi-synthetic neuromodulation therapy audio, a second semi-synthetic neuromodulation therapy audio, and a final recommended neuromodulation therapy audio are generated sequentially by performing pure tone hearing threshold response test, noise hearing threshold response test, auditory brainstem response test, and distortion product otoacoustic emission test on the patient.

[0149] In one optional implementation of this embodiment, a pure-tone hearing threshold response test is performed on the patient to extract the patient's pure-tone hearing threshold range;

[0150] The patient's noise hearing threshold response test was performed to extract the patient's noise hearing threshold range;

[0151] The pure tone hearing threshold range is overlapped with the noise hearing threshold range to obtain the patient's hearing sensitivity threshold range;

[0152] The audio track score of the initial neuromodulation therapy audio within the hearing sensitivity threshold range is extracted and extended to both sides of the audio track to modulate it into a first semi-synthetic neuromodulation therapy audio.

[0153] This method involves conducting pure-tone hearing threshold response tests and noise hearing threshold response tests on patients to obtain their sensitivity threshold range. Then, it generates the first half-syndrome neuromodulation therapy audio corresponding to this sensitivity threshold range, effectively ensuring the patient's experience during treatment.

[0154] In an optional implementation of this embodiment, energy balance analysis is performed on the first semi-neuromodulation therapy audio to determine the energy balance threshold of the first semi-neuromodulation therapy audio.

[0155] The patient underwent auditory brainstem response testing to obtain the patient's auditory pathway patency coefficient;

[0156] The auditory pathway patency coefficient is compared with the standard value of auditory pathway patency to obtain the corresponding energy gain multiple for the patient;

[0157] Based on the energy gain factor, the energy balance threshold of the first semi-neuromodulation therapy audio is compensated to obtain the second semi-neuromodulation therapy audio.

[0158] Considering the special circumstances of some patients, the therapeutic effect of conventional intensity audio is poor. By conducting auditory brainstem response tests on patients, the degree of their hearing impairment is determined, specifically reflected in the auditory pathway patency coefficient. The auditory pathway patency coefficient is used to generate an energy gain factor, which effectively solves the problem of large differences in the therapeutic effect of audio on different patients and poor treatment effect for some patients in the existing technology.

[0159] In one optional implementation of this embodiment, visual examination is performed on the inside of the patient's left and right ear canals respectively to obtain visual examination results;

[0160] Distortion product otoacoustic emission (OAE) tests were performed inside the left and right ear canals of the patient, and the OAE test results were obtained.

[0161] The visual examination results and the otoacoustic test results of the distortion products were compared to obtain the distortion parameters of the patient's left ear and right ear.

[0162] Based on the left ear distortion parameters, the left ear component of the second half-adjustment neuromodulation therapy audio is adjusted to obtain the adjusted left ear component. Based on the right ear distortion parameters, the right ear component of the second half-adjustment neuromodulation therapy audio is adjusted to obtain the adjusted right ear component. The adjusted left ear component and the adjusted right ear component are then synthesized to generate the recommended neuromodulation therapy audio.

[0163] This approach considers the patient's internal ear canal physiological condition and the imbalance between the left and right ears. The left and right ear components of the neuromodulation therapy audio are adjusted separately to generate recommended neuromodulation therapy audio. This is further optimized to address the patient's left and right ear imbalance and improve the treatment effect.

[0164] The treatment effect verification module 50 is used to perform neuromodulation therapy on the patient based on the recommended neuromodulation therapy audio and to verify the treatment effect.

[0165] In summary, Embodiment 2 of the present invention provides a neuromodulation therapy system for implementing the neuromodulation therapy method described in Embodiment 1. Based on a neuromodulation survey and consultation template, it assesses the patient's neurological state and performs a suitability screening for sound therapy techniques. This effectively determines whether sound therapy is suitable based on the patient's actual neurological state, reducing subsequent treatment risks and side effects. Hearing tests are performed on the patient, including pure-tone audiometry and noise-based hearing threshold tests, to differentiate the patient's hearing sensitivity threshold range and adjust the audio track of the neuromodulation therapy to the optimal range, fully considering the patient's treatment experience. Auditory brainstem response testing is also conducted, based on the patient's auditory pathway patency coefficient... The neuromodulation therapy audio undergoes energy gain adjustment, optimizing the treatment effect for patients with special conditions or more severe symptoms who experience poor treatment results due to the low energy of general biological natural sound noise. Distortion product otoacoustic emission testing considers the physiological condition inside the patient's ear canal and the imbalance between the left and right ears, adjusting the left and right ear components of the neuromodulation therapy audio separately to generate recommended neuromodulation therapy audio. This effectively solves the problems of large differences in the effectiveness of treatment audio for different patients, poor treatment results for some patients, and potential hearing damage in existing technologies, thus improving the efficacy and safety of neuromodulation therapy.

[0166] Example 3

[0167] Embodiment 3 of the present invention provides an electronic device, including a memory, a processor, and a computer program stored in the memory and executable on the processor. The processor executes the computer program to implement the neuromodulation therapy method described in Embodiment 1.

[0168] In summary, Embodiment 3 of the present invention provides an electronic device for implementing the neuromodulation treatment method described in Embodiment 1. Based on a neuromodulation survey and consultation template, it assesses the patient's neurological state and performs a sound therapy technology suitability screening. This effectively determines whether sound therapy is suitable based on the patient's actual neurological state, reducing subsequent treatment risks and side effects. Hearing tests are performed on the patient, including pure-tone audiometry and noise-based hearing response tests, to differentiate the patient's hearing sensitivity threshold range and adjust the audio track of the neuromodulation treatment to the optimal range, fully considering the patient's treatment experience. Auditory brainstem response testing is also conducted, assessing the patient's auditory pathway patency coefficient. By adjusting the energy gain of the therapeutic audio, the treatment effect is optimized for patients with special conditions or more severe symptoms who experience poor treatment results due to the low energy of general biological natural noise. Distortion product otoacoustic emission testing considers the physiological condition of the patient's ear canal and the imbalance between the left and right ears, adjusting the left and right ear components of the neuromodulation therapeutic audio separately to generate recommended neuromodulation therapeutic audio. This effectively solves the problems of large differences in the effectiveness of therapeutic audio among different patients, poor treatment results for some patients, and potential hearing damage in existing technologies, thus improving the efficacy and safety of neuromodulation therapy.

[0169] Example 4

[0170] Embodiment 4 of the present invention provides a computer-readable storage medium storing a computer program, which, when executed by a processor, implements the neuromodulation therapy method described in Embodiment 1.

[0171] In summary, Embodiment 4 of the present invention provides a computer-readable storage medium for executing the neuromodulation treatment method described in Embodiment 1. It assesses the patient's neurological state based on a neuromodulation survey and consultation template, and performs a suitability screening for sound therapy technology. This effectively determines whether sound therapy is suitable based on the patient's actual neurological state, reducing subsequent treatment risks and side effects. Hearing tests are performed on the patient, including pure-tone audiometry and noise-based hearing threshold tests, to differentiate the patient's hearing sensitivity threshold range and adjust the audio track of the neuromodulation treatment to the optimal range, fully considering the patient's treatment experience. Auditory brainstem response testing is also conducted based on the patient's auditory pathway patency. The energy gain of several pairs of neuromodulation therapy audios is optimized to address the issue of poor treatment efficacy caused by low energy of general biological natural noise in some special cases or patients with more severe symptoms. Distortion product otoacoustic emission testing considers the physiological condition inside the patient's ear canal and the imbalance between the left and right ears, adjusting the left and right ear components of the neuromodulation therapy audio separately to generate recommended neuromodulation therapy audio. This effectively solves the problems of large differences in the effectiveness of treatment audio for different patients, poor treatment efficacy for some patients, and potential hearing damage in existing technologies, thus improving the efficacy and safety of neuromodulation therapy.

[0172] Those skilled in the art will understand that all or part of the steps in the various methods of the above embodiments can be implemented by a program instructing related hardware. The program can be stored in a computer-readable storage medium, which may include: read-only memory (ROM), random access memory (RAM), disk or optical disk, etc.

[0173] Furthermore, the embodiments of the present invention have been described in detail above. Specific examples have been used to illustrate the principles and implementation methods of the present invention. The description of the above embodiments is only for the purpose of helping to understand the method and core ideas of the present invention. At the same time, for those skilled in the art, there will be changes in the specific implementation methods and application scope based on the ideas of the present invention. Therefore, the content of this specification should not be construed as a limitation of the present invention.

Claims

1. A neuromodulation treatment method, characterized by, The method comprises: designing a neuroregulation investigation and diagnosis template, evaluating the neurological state of a patient based on the investigation and diagnosis template, and generating an evaluation report; based on the evaluation report, screening the applicability of sound therapy technology for the patient; selecting several segments of general biological natural sound noise, providing the several segments of general biological natural sound noise to the patient who passes the sound therapy technology applicability screening for trial listening, and selecting general biological natural sound noise with a higher adaptability threshold as initial neuroregulation treatment audio; conducting a hearing test on the patient, generating adjustment parameters according to the hearing test results, adjusting the initial treatment audio based on the adjustment parameters, and generating recommended neuroregulation treatment audio; based on the recommended neuroregulation treatment audio, conducting neuroregulation treatment on the patient, and testing the treatment effect.

2. The neuromodulation treatment method of claim 1, wherein, The design of the neuroregulation investigation and diagnosis template, and the evaluation of the neurological state of the patient based on the investigation and diagnosis template, and the generation of the evaluation report comprise: setting up multiple evaluation scale templates, providing the evaluation scale templates to the patient for filling, collecting the filled evaluation scales, and generating corresponding evaluation reports, wherein the evaluation scale templates include a tinnitus self-evaluation scale, an emotional self-evaluation scale, and other symptom self-evaluation scales.

3. The neuromodulation treatment method of claim 1, wherein, The screening of the applicability of sound therapy technology for the patient based on the evaluation report comprises: generating screening parameters based on the evaluation report, using repetitive transcranial magnetic stimulation technology to test the applicability of sound therapy technology for the patient, comparing the test results with the screening parameters, determining whether the patient passes the sound therapy applicability screening, and determining the type of sound therapy applicable to the patient.

4. The neuromodulation treatment method of claim 1, wherein, The selection of several segments of general biological natural sound noise, the provision of the several segments of general biological natural sound noise to the patient who passes the sound therapy technology applicability screening for trial listening, and the selection of general biological natural sound noise with a higher adaptability threshold as initial neuroregulation treatment audio comprise: selecting several segments of general biological natural sound noise of different types; providing the general biological natural sound noise to the patient for trial listening; adjusting the frequency, pitch, amplitude, timbre, and volume of the general biological natural sound noise back and forth according to the patient's trial listening experience; collecting the patient's adaptability to general biological natural sound noise of different frequencies, pitches, amplitudes, timbres, and volumes, and selecting several segments of general biological natural sound noise with a higher adaptability threshold as initial neuroregulation treatment audio.

5. The neuromodulation treatment method of claim 1, wherein, The hearing test on the patient, the generation of adjustment parameters according to the hearing test results, the adjustment of the initial treatment audio based on the adjustment parameters, and the generation of recommended neuroregulation treatment audio comprise: conducting a pure tone threshold response test on the patient to extract the pure tone threshold range of the patient; conducting a noise threshold response test on the patient to extract the noise threshold range of the patient; overlapping the pure tone threshold range and the noise threshold range to obtain the hearing sensitivity threshold range of the patient; extracting the audio track score of the initial neuroregulation treatment audio within the hearing sensitivity threshold range, and extending to both sides of the audio track to modulate the first semi-neuroregulation treatment audio.

6. The neuromodulation treatment method of claim 5, wherein, The hearing test is performed on the patient, the debugging parameters are generated according to the hearing test results, and the initial treatment audio is debugged based on the debugging parameters to generate the recommended neuromodulation treatment audio, and the method further comprises: performing energy equalization analysis on the first semi-finished neuromodulation treatment audio to determine an energy equalization threshold of the first semi-finished neuromodulation treatment audio; performing an auditory brainstem response test on the patient to obtain an auditory pathway patency coefficient of the patient; comparing the auditory pathway patency coefficient with an auditory pathway patency standard value to obtain an energy gain multiple corresponding to the patient; performing gain compensation on the energy equalization threshold of the first semi-finished neuromodulation treatment audio based on the energy gain multiple to obtain a second semi-finished neuromodulation treatment audio.

7. The neuromodulation treatment method of claim 6, wherein, The hearing test is performed on the patient, the debugging parameters are generated according to the hearing test results, and the initial treatment audio is debugged based on the debugging parameters to generate the recommended neuromodulation treatment audio, and the method further comprises: respectively performing visual inspection on the inside of the left ear canal and the inside of the right ear canal of the patient to obtain visual inspection results; respectively performing distortion product otoacoustic emission tests on the inside of the left ear canal and the inside of the right ear canal of the patient to obtain distortion product otoacoustic emission test results; comparing the visual inspection results and the distortion product otoacoustic emission test results to obtain left ear distortion parameters and right ear distortion parameters of the patient; debugging a left ear component of the second semi-finished neuromodulation treatment audio based on the left ear distortion parameters to obtain a debugged left ear component, debugging a right ear component of the second semi-finished neuromodulation treatment audio based on the right ear distortion parameters to obtain a debugged right ear component, and synthesizing the debugged left ear component and the debugged right ear component to generate the recommended neuromodulation treatment audio.

8. A neuromodulation therapy system, comprising: The neuromodulation treatment system is used to implement the neuromodulation treatment method of any one of claims 1-7, and the system comprises: a neural state evaluation module, which is used to design a neuromodulation investigation consultation template, evaluate the neural state of a patient based on the investigation consultation template, and generate an evaluation report; a suitability screening module, which is used to perform suitability screening of a sound treatment technology on the patient based on the evaluation report; an initial audio generation module, which is used to select a plurality of general biological natural sound noises, provide the plurality of general biological natural sound noises to the patient who passes the suitability screening of the sound treatment technology for trial listening, and select a general biological natural sound noise with a higher adaptability threshold as an initial neuromodulation treatment audio; an audio debugging module, which is used to perform a hearing test on the patient, generate debugging parameters according to the hearing test results, and debug the initial treatment audio based on the debugging parameters to generate a recommended neuromodulation treatment audio; a treatment effect verification module, which is used to perform neuromodulation treatment on the patient based on the recommended neuromodulation treatment audio, and verify the treatment effect.

9. An electronic device, comprising: A computer program product comprising a computer readable storage medium having stored thereon computer program means which, when executed by a processor, cause the processor to carry out the neuromodulation treatment method according to any one of claims 1-7.

10. A computer-readable storage medium, characterized in that, A computer program product comprising a computer readable storage medium having stored thereon computer program means which, when executed by a processor, cause the processor to carry out the neuromodulation treatment method according to any one of claims 1-7.

Images