Pharmaceutical composition for preventing or treating ramo sleeve traffic containing detectolicon collagen and induced pluripotent stem cell-derived

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By attaching induced pluripotent stem cell-derived tendon cells to a determinate peptide collagen patch, a complex is formed for the treatment of rotator cuff tears, solving the problems of high re-tear rate and insufficient tissue regeneration in existing technologies, and achieving the effects of restoring mechanical strength and tissue regeneration.

CN121588069APending Publication Date: 2026-03-03THE CATHOLIC UNIV OF KOREA IND ACADEMIC COOP FOUND

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Patent Information

Application Number: CN202511504621.8
Authority / Receiving Office: CN · China
Patent Type: Applications(China)
Current Assignee / Owner
Priority Date: 2025-08-20
Filing Date: 2025-10-21
Publication Date: 2026-03-03

Application Information

Patent Timeline

20 Aug 2025

Priority

21 Oct 2025

Application

CN202511504621.8

03 Mar 2026

Publication

CN121588069A

IPC: A61K9/70; A61K47/42; A61K38/39; A61K35/545; A61K35/32; A61P19/04

CPC: A61K9/7023; A61K47/42; A61K38/39; A61K35/545; A61K35/32; A61P19/04; A61K2300/00

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Application Domain

Peptide/protein ingredients Skeletal disorder

Technology Topics

Pluripotential stem cell Therapeutic effect

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AI Technical Summary

Technical Problem

In existing technologies, the treatment of rotator cuff tears suffers from problems such as high re-tear rates and insufficient tissue regeneration capacity, and lacks effective combined applications of collagen and induced pluripotent stem cell-derived tendon cells.

Method used

A determinate peptide collagen patch is used to attach tendon cells derived from induced pluripotent stem cells, forming a complex for the treatment of rotator cuff tears. Physicochemical processing is used to improve biocompatibility and cell adhesion.

Benefits of technology

This complex survives long-term within rotator cuff tears, restoring mechanical strength and tissue regeneration, and significantly improving tissue toughness and functional recovery at the tear site.

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Abstract

The present invention relates to a pharmaceutical composition for preventing or treating rotator cuff laceration comprising, as active ingredients, deteptided collagen and induced pluripotent stem cell-derived tendinocytes, and has confirmed that the induced pluripotent stem cell-derived tendinocytes have excellent adhesion and viability, can be used to produce a cell-support complex, and can be used to treat rotator cuff laceration. Especially, the compound with the detelopeptide collagen can enable cells to survive and maintain for a long time in the rotator cuff lacerated tissue. Furthermore, the apotelocollagen-induced pluripotent stem cell-derived tendinocyte complex exhibits a more excellent therapeutic effect than other complexes in terms of mechanical strength recovery and tissue regeneration promotion, and thus can be effectively used as a preparation for preventing or treating rotator cuff tear.

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