Double-stranded RNA containing nucleotide analogs
CN121729422APending Publication Date: 2026-03-24SHANGHAI RONA THERAPEUTICS CO LTD
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Patent Information
- Application Number
- CN202480050856.1
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- Priority Date
- 2023-08-10
- Filing Date
- 2024-08-09
- Publication Date
- 2026-03-24
AI Technical Summary
Technical Problem
The existing siRNA drugs have low stability and effectiveness in vivo, and new nucleotide modification methods are needed to improve their performance.
Method used
A novel nucleotide analog is provided to improve the stability of siRNA and reduce off-target toxicity by introducing specific nucleotide compounds into the sense and antisense strands of double-stranded RNA.
Benefits of technology
By using these new nucleotide analogs, the stability and effectiveness of siRNA in vivo is significantly improved, reducing off-target toxicity and enhancing the degradation ability of targeted mRNA.
✦ Generated by Eureka AI based on patent content.
Abstract
The present invention provides a double-stranded RNA having a nucleotide analogue. The double stranded RNAs of the present invention exhibit reduced off-target toxicity.
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