Rehmannia pigment compound as well as preparation method and application thereof in medicines

By isolating and purifying a novel rehmannia pigment compound from Rehmannia glutinosa, the problem of unclear rehmannia pigment structure was solved, and a highly effective and low-toxicity anti-inflammatory compound was obtained, which is suitable for the pharmaceutical and cosmetic fields.

CN121991089APending Publication Date: 2026-05-08INST OF MEDICINAL PLANT DEV CHINESE ACADEMY OF MEDICAL SCI
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Patent Information

Application Number
CN202512052828.2
Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
Filing Date
2025-12-31
Publication Date
2026-05-08

AI Technical Summary

Technical Problem

The chemical structure of rehmannia pigment in the prior art is unclear, and there is a lack of clearly defined anti-inflammatory active compounds, which limits the in-depth understanding of the medicinal material basis of rehmannia and the development of new drugs.

Method used

A new class of rehmannia pigment compounds with novel general formulas were isolated and identified from Rehmannia glutinosa. The compounds with well-defined structures were purified by normal-phase, reverse-phase, and size exclusion chromatography, as well as semi-preparative high-performance liquid chromatography.

Benefits of technology

A rehmannia pigment compound with highly efficient and low-toxicity anti-inflammatory activity was obtained. In vitro experiments showed that it significantly inhibited nitric oxide release in a lipopolysaccharide-induced macrophage inflammation model, exhibited low cytotoxicity, and has the potential to serve as a lead compound for anti-inflammatory drugs. It can also be used as a natural pigment and cosmetic colorant.

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Abstract

The invention provides a rehmannia pigment compound as shown in a formula (I), a stereoisomer thereof or pharmaceutically acceptable salt thereof, and particularly relates to the technical field of natural pharmaceutical chemistry and pharmaceutical compounds. The invention aims to solve the problems that the radix rehmanniae pigment is not clear in material basis and lacks a compound with a clear structure and excellent anti-inflammatory activity. The rehmannia pigment compound disclosed by the invention comprises a structure as shown in a formula (I). The invention also discloses a preparation method of the compound and application of the compound in medicines. The compound has a novel chemical structure and remarkable anti-inflammatory activity, release of nitric oxide can be effectively inhibited in a lipopolysaccharide induced macrophage model, the cytotoxicity is far lower than that of a positive control drug quercetin, and the compound shows huge potential as an anti-inflammatory drug lead compound.
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