Bacillus subtilis composition for improving animal intestinal health and preparation method thereof
By employing gradient domestication and homologous recombination technology using a combination of engineered Bacillus subtilis bacterial powder and other components, a highly tolerant intestinal strain was constructed. Furthermore, through cinnamaldehyde microcapsules and a multidimensional anti-stress network, multiple synergistic effects of highly efficient antibacterial activity, safe immunity, and root-cause anti-stress were achieved, overcoming the shortcomings of existing additives in intestinal health and stress adaptation.
Patent Information
- Application Number
- CN202610318194.2
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- Filing Date
- 2026-03-16
- Publication Date
- 2026-06-02
- Estimated Expiration
- 2046-03-16
AI Technical Summary
Existing feed additives have insufficient synergy in terms of efficient antibacterial activity, safe immune regulation, root-cause stress resistance, and ecological safety, especially in intensive farming and high-density feeding, where it is difficult to achieve a balanced balance of multiple effects.
A combination of Bacillus subtilis engineered bacterial powder, cinnamaldehyde microcapsules, proanthocyanidins B2, selenium-enriched yeast culture, glycoterpenoids, and trehalose was used to construct a highly tolerant engineered bacterial strain through gradient domestication and homologous recombination technology. Combined with β-cyclodextrin microcapsule technology, cinnamaldehyde was delivered to the intestine in a targeted manner, and the intestinal Nrf2-Keap1 pathway was activated and a multidimensional anti-stress network was constructed, forming a synergistic system of microbiota regulation, immune reinforcement, and stress buffering.
It achieves multiple synergistic effects of highly efficient antibacterial activity, safe immunity, and root cause anti-stress, solving the deficiencies of existing additives in terms of biosafety and functional synergy, and improving animal gut health and stress adaptability.