Method for hydroxyalkenylation of iron-catalyzed oxyalkylene

By combining an iron catalyst with an amino acid ligand, the hydroxylation reaction of olefins was realized, which solved the problems of cumbersome steps and low yield in the existing technology and provided a cheap and efficient method for olefin hydroxylation.

CN122127200APending Publication Date: 2026-06-02NANJING NORMAL UNIVERSITY
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Patent Information

Application Number
CN202610201833.7
Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
Filing Date
2026-02-12
Publication Date
2026-06-02

AI Technical Summary

Technical Problem

Existing olefin bifunctionalization reactions suffer from problems such as numerous reaction steps, low reaction yields, and the need for noble metal catalysts, which limit their application in the synthesis of complex molecules.

Method used

Using an iron catalyst and amino acids or their derivatives as ligands, hydroxylation of olefins is achieved in a one-step reaction under mild conditions. Inexpensive oxidants and solvents are used to form a highly active catalytic species that directly undergoes free radical addition with nitrostyrene compounds.

Benefits of technology

This method achieves highly selective and high-yield hydroxylylation of olefins, has a wide range of applicable substrates, is compatible with drug molecules, reduces reaction costs, and provides an economical and environmentally friendly synthetic method.

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Abstract

The invention discloses a method for catalyzing hydroxyalkenylation of oxidized alkene by iron, which comprises the following steps: catalyzing hydroxyalkenylation reaction of alkene in a solvent by taking nitrostyrene compounds and alkene compounds as substrates, peroxide as an oxidant, iron as a catalyst and amino acid and derivatives thereof as ligands to generate alkenylated alcohol compounds. The method can be used for synthesizing the alkenylated alcohol compound in one step, and the steps are simple and convenient; the used catalyst and oxidant are wide in source and low in cost; reaction conditions are mild, and selectivity is high; 1-2 equivalents of olefin substrates are used, so that the compatibility of functional groups of the substrates is good, and the application range of the substrates is wide; the drug molecules and the drug molecule derivatives can be compatible, so that the hydroxyalkenylation reaction of alkene is realized. Under optimized reaction conditions, the yield of the separated target product can reach 86%.
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