A pesticide composition and use thereof

Abstract

The present application relates to a kind of pesticide composition and its application.The present application contains the insecticidal fungicidal composition of compound I can improve the prevention effect, reduce the amount of drug, while solving the resistance generation, drug efficacy decline and other problems that may be caused by long-term use of insecticide, acaricide single agent, to meet the needs of agricultural pest control.

Description

[0001] This application is a divisional application of application number 202210259183.3, filed on March 14, 2022, entitled "A pesticide composition and its application". Technical Field

[0002] This invention relates to the field of compound compositions of insecticides and other agents, and specifically to a pesticide composition containing compound I and its application. Background Technology

[0003] Combining the active ingredients of different pesticides to create new pesticides is currently an effective and rapid method for developing and researching new pesticides and controlling resistant pathogens in agriculture. When different pesticides are mixed, they typically exhibit three types of effects: additive, synergistic, and antagonistic. However, the specific type of effect is unpredictable. Well-formulated, highly synergistic combinations can significantly improve actual control efficacy, reduce pesticide usage, broaden the insecticidal and fungicidal spectrum, and increase insecticidal and fungicidal efficiency, thereby greatly slowing down the development of pesticide resistance in pests and diseases. This is an important means of integrated pest management.

[0004] Patent document CN 111909143 A discloses compound I, which has broad-spectrum insecticidal activity, especially effective against pests of the orders Lepidoptera, Hemiptera, Coleoptera, Thysanoptera, Diptera, and mites. However, it does not disclose how to combine it with other drugs to achieve synergistic effects.

[0005] The structural formula of compound I is shown below. .

[0006] I Summary of the Invention

[0007] The purpose of this invention is to overcome the problems existing in the prior art and provide a composition containing compound I and its uses, which can meet the needs of current agricultural production, expand the control spectrum of pesticides, and achieve simultaneous control of pests and diseases while reducing the amount of compound I used.

[0008] This objective has been found to be achieved, in part or entirely, by a combination of active compounds as defined below.

[0009] A first aspect of the present invention provides a composition comprising compound I, compound II, and / or compound III, wherein compound I is as follows:

[0010] I Compound II is selected from at least one of the following: (1) II-M.1 nicotinic acetylcholine receptor agonists, for example: II-M.1A neonicotinoids: chlorthiazoline, piperazine, cyclopyridamole; or II-M.1A.1: 1-[(6-chloro-3-pyridinyl)methyl]-2,3,5,6,7,8-hexahydro-9-nitro-(5S,8R)-5,8-epoxy-1H-imidazo[1,2-a]azapyridine; or II-M.1A.2: (2E-)-1-[(6-chloropyridin-3-yl)methyl]-N'-nitro-2-pentylaminoguanidine; or II-M.1A.3: 1-[(6-chloropyridin-3-yl)methyl]-7-methyl-8-nitro-5-propoxy-1,2,3,5,6,7-hexahydroimidazo[1,2-a]pyridine; or II-M.1B dichlorothiapyrimidine; (2) II-M.2 sodium channel modulators, for example: II-M.2A Pyrethroids: Pyrethrin, D-trans-cypermethrin, Flufenoxuron, Propyrethrin, D-allethrin, D-trans-allethrin, Flucypermethrin, Bio-allethrin, 2-Cyclopentenyl Bio-allethrin, Bio-benzalofop-p-ethyl, Cypermethrin, Lambda-cyhalothrin, Lambda-cyhalothrin, Ethyl-Cypermethrin, High-efficiency trans-cypermethrin, Hexyl-Cypermethrin, Cypermethrin, Enzymetrozine, Cypermethrin, High-efficiency Cypermethrin, Cypermethrin, Flufenoxuron, Flufenoxuron, Flufenoxuron, Bromofenoxuron, D-heptaflumethrin, Imazalil, Cypermethrin, Methoxyfenozide, [2,3,5,6-Tetrafluoro-4-(methoxymethyl)phenyl]methyl-3-(2-cyano-1-propen-1-yl)-2,2-dimethylcyclopropanecarboxylate (CAS: 609346-29-4), permethrin, fenpropathrin, pyrethrin, propargite, pyrethrin, pyrethroid, pyrethroid, tetrafluoromethrin, cypermethrin, fenpropathrin, fenpropathrin, d-propargite, fenpropathrin, d-propargite, tetrabromomethrin, and tetrafluoromethrin; or II-M.2B DDT and methoxydiphenyltrichloro ... II-M.2C Cyfluthrin, indoxacarb, veratrine; (3) II-M.3 diamide ryanodine receptor modulators, for example: Phthalate compounds: II-M.3.1: (R)-3-chloro-N1-(2-methyl-4-(heptafluoroisopropyl)phenyl)-N2-(1-(methylsulfonyl)propyl-2-yl)phthalamide; or II-M.3.2: (S)-3-chloro-N1-(2-methyl-4-(heptafluoroisopropyl)phenyl)-N2-(1-(methylsulfonyl)propyl-2-yl)phthalamide; or II-M.3.3: 2-[3,5-dibromo-2-({[3-bromo-1-(3-chloropyridin-2-yl)-1H-pyrazol-5-yl])yl}amino)benzoyl]-1,2-dimethylhydrazine carboxylate; or Ⅱ-M.3.4a) N-[4,6-dichloro-2-[(diethyl-λ-4-thionyl)carbamoyl]phenyl]-2-(3-chloro-2-pyridyl)-5-trifluoromethylpyrazole-3-carboxamide; Ⅱ-M.3.4b) N-[4-chloro-2-[(diethyl-λ-4-thionyl)carbamoyl]-6-methylphenyl]-2-(3-chloro-2-pyridinyl)-5-trifluoromethylpyrazole-3-carboxamide; Ⅱ-M.3.4c) N-[4-chloro-2-[(di-2-propyl-λ-4-thionyl)carbamoyl]-6-methylphenyl]-2-(3-chloro-2-pyridinyl)-5-trifluoromethylpyrazole-3-carboxamide; Ⅱ-M.3.4d) N-[4,6-dichloro-2-[(di-2-propyl-λ-4-thionyl)carbamoyl]phenyl]-2-(3-chloro-2-pyridinyl)-5-trifluoromethylpyrazole-3-carboxamide; Ⅱ-M.3.4e) N-[4,6-dichloro-2-[(diethyl-λ-4-thionyl)carbamoyl]-phenyl]-2-(3-chloro-2-pyridinyl)-5-difluoromethylpyrazole-3-carboxamide; Ⅱ-M.3.4f) N-[4,6-dibromo-2-[(di-2-propyl-λ-4-thionyl)carbamoyl]-phenyl]-2-(3-chloro-2-pyridinyl)-5-trifluoromethylpyrazole-3-carboxamide; Ⅱ-M.3.4g) N-[4-chloro-2-[(di-2-propyl-λ-4-thionyl)carbamoyl]-6-cyanophenyl]-2-(3-chloro-2-pyridinyl)-5-trifluoromethylpyrazole-3-carboxamide; Ⅱ-M.3.4h) N-[4,6-dibromo-2-[(diethyl-λ-4-thionyl)carbamoyl]-phenyl]-2-(3-chloro-2-pyridinyl)-5-trifluoromethylpyrazole-3-carboxamide; Ⅱ-M.3.4i) N-[2-(5-amino-1,3,4-thiadiazol-2-yl)-4-chloro-6-methylphenyl]-3-bromo-1-(3-chloro-2-pyridyl)-1H-pyrazole-5-carboxamide; Ⅱ-M.3.4j) 3-Chloro-1-(3-Chloro-2-pyridyl)-N-[2,4-dichloro-6-[[(1-cyano-1-methylethyl)amino]carboxyl]phenyl]-1H-pyrazole-5-carboxamide; Ⅱ-M.3.4k) 3-bromo-N-[2,4-dichloro-6-(methylcarbamoyl)phenyl]-1-(3,5-dichloro-2-pyridyl)-1H-pyrazole-5-carboxamide; Ⅱ-M.3.41) N-[4-chloro-2-[[(1,1-dimethylethyl)amino]carboxyl]]-6-methylphenyl]-1-(3-chloro-2-pyridinyl)-3-(fluoromethoxy)-1H-pyrazole-5-carboxamide; II-M.3.5: N-(2-cyanopropyl-2-yl)-N-(2,4-dimethylphenyl)-3-iodobenzene-1,2-dicarboxamide; or II-M.3.6: 3-Chloro-N-(2-cyanopropyl-2-yl)-N-(2,4-dimethylphenyl)-phenyl-1,2-dicarboxamide; II-M.3.7a) 1-(3-chloro-2-pyridyl)-N-[4-cyano-2-methyl-6-[(methylamino)carboxyl]phenyl]-3-[[5-(trifluoromethyl)-2H-tetrazole-2-yl]methyl]-1H-pyrazole-5-carboxamide; or Ⅱ-M.3.7b) 1-(3-chloro-2-pyridyl)-N-[4-cyano-2-methyl-6-[(methylamino))yl]phenyl]-3-[[5-(trifluoromethyl)-1H-tetrazole-1-yl]methyl]-1H-pyrazole-5-carboxamide; (4) II-M.4 GABA-gated chloride channel antagonists, for example: II-M.4A Organochlorine Compounds: Toxaphene, Dildrin, Heptachlor, Miridin, Aldrin, Endothelium Sulfide, Chlordane, Trichlorfon; or II-M.4B Phenylepiazoles: acetamiprid, buprofen, fipronil, pyrazinfluenza, pyridinium flufenoxuron, acetamiprid, butenylflufenoxuron; (5) Ⅱ-M.5 Selective feeding blockers for homoptera, such as: bispyribac-methyl, pyrazinone, flonicamid, pyrifluquinazon (CAS: 337458-27-2). (6) II-M.6 acetylcholinesterase inhibitors, for example: II-M.6A carbamates: aldicarb, fenvalerate, carbofuran, carbaryl, chlorfenapyr, thiamethoxam, methomyl, methoxyfenozide, pymetrozine, propoxur, thiamethoxam, oxadiazon, dicofol, oxydimethoxam, chlorfenapyr, methyl sulfone, carbaryl, carbofuran, ethoxymethyl, methyl methoxyfenozide, amitraz, furazolidone, isoprocarb, methomyl, fenvalerate, dichlorvos, pymetrozine, pymetrozine, benzoylcarb, benzoylcarb, dicofol, pymetrozine, pymetrozine, dimethylcarbide, and chlorpyrifos; or II-M.6B Organophosphates: Thiazolephosphide, Methyl isofenphos, Nifedipine, Chlorpyrifos, High-methylenephos, Ethyl phosmet, Phoxim, Phoxim, Benzoate, Mefenoxam, Ammonium sulfide, Pyrimethanil, Chlorpyrifos, Methyl chlorpyrifos, Hemoxyfen, Neonicotinamide (CAS:140163-89-9), Methyl demeton-methyl, Diazinon, Dibromophos, Dichlorvos, Phosphate, Dimethoate, Methyl phorate, Phosphate, Ethiophanate-methyl, Fenthion, Isoxazolium, Malathion, Phosphate, Methamidophos, Phosphate, Phosphate, Mefenoxam Phosphorus, Omethoate, Sulfonate, 1605, Methyl 1605, Methyl Parathion, Indomethacin, Phosphate, Phosphamidon, Phosphamidon, Phosphamidon, Phosphamidon, Chlorpyrifos, Profenofos, Acetaminophen, Profenofos, Quinalphos, Terbufos, Acetaminophen, Methylpyrazophos, Ethamazolium, Pyrazophos, Quinalphos, Phosphamidon, Thiophanate, Thiophanate, Pyrimethanil, Thiophanate, Phosphamidon, Chlorpyrifos, Phosphamidon, Fenoxam, Fenoxam, Terbufos, Parcelyl, Citronella, Citronella, Citronella, Citronella, Citronella, Citronella, Citronella, Citronella, Citronella, Citronella, Citronella, Triazophos, Profenofos, O-(Methoxyaminothiophosphoryl)isopropyl salicylate, Trichlorfon, Azoxystrobin, Chlorpyrifos, Chlorpyrifos, Methyl chlorpyrifos, Thiazolone phosphate, Aphidicide; (7) II-M.7 chloride channel agonists, such as: milbemycin, ivermectin, mibamicin, oleanil, raphemycin and milbemycin; (8) II-M.8 Juvenile hormone mimics, such as: monazine, monazine, acetamiprid, monazine, dioxane, fenpyroxen, acetamiprid, acetamiprid, phenoxycarb, pyriproxyfen. (9) II-M.9 mite growth inhibitors, such as: tetradifon, thiamethoxam, terfenoxam, flufenoxam; (10) II-M.10 Mitochondrial ATP synthase inhibitors, such as: chlorfenapyr, chlorfenapyr tin, azithromyr tin, tricyclotin, chlorfenapyr, trichlorfon, triazole tin, phenylbutazone, dicyclohexylcarbodiimide, propargite, 4,6-dinitro-o-cresol (DNOC). (11) II-M.11 Oxidative phosphorylation decoupling agents that interfere with the proton gradient, such as flufenoxuron, dinitrocresol, and fipronil; (12) II-M.12 Nicotinic acetylcholine receptor channel blockers, such as: chlorpyrifos, bacalan, thiocycline, chlorpyrifos mononitrate, chlorpyrifos acetonitrile, chlorpyrifos dichlorvos; (13) Type II-M.13 O chitin biosynthesis inhibitors, such as benzoylurea, including diflubenzuron, diflubenzuron, flufenoxuron, flufenoxuron, flufenoxuron, flufenoxuron, flufenoxuron, flufenoxuron, flufenoxuron, diflubenzuron, polyflubenzuron, fenflurfen, flufenoxuron, flufenoxuron, flufenoxuron, lufenuron, flufenoxuron, and fenflurfen; (14) Type I chitin biosynthesis inhibitors, such as thiamethoxam; (15) II-M.15 Ecdyskin disruptors, such as: cyromazine, etoxazole, KK-42; (16) II-M.16 Ecdysone receptor agonists, such as: methoxybenzoylhydrazine, bisbenzoylhydrazine, terbutaline, furazolidone, cyclophosphamide, azadirachtin; (17) II-M.17 Octopus amine receptor agonists, such as amitraz (amitraz). (18) II-M.18 mitochondrial complex electron transport inhibitors, for example: II-M.18.A Mitochondrial complexes I electron transport inhibitors: quinclorac, pyrimethanil, pyridaben, pyrimethanil, pyrimethanil, rotenone; II-M.18.B Mitochondrial complexes III electron transport inhibitors: mitochondrial hydrazone, mitochondrial quinone, pyrimethanil, antimycin; (19) II-M.19 Voltage-dependent sodium channel blockers, such as: oxadiazon, cyfluthrin, 2-[2-(4-cyanophenyl)-1-[3-(trifluoromethyl)phenyl]ethylene]-N-[4-(difluoromethoxy)phenyl]aminourea, N-(3-chloro-2-methylphenyl)-2-[(4-chlorophenyl)[4-[methyl(methylsulfonyl)amino]phenyl]methylene]aminourea; (20) II-M.20 Acetyl-CoA carboxylase inhibitors, such as terfenicol and traamic acid derivatives, spirodiclofen, spirotetrafen, spirotetrafen, methoxypiperidine ethyl ester; (21) II-M.21 Inhibitors of electron transport in mitochondrial complex IV, for example: II-M.21.A Phosphorus-containing compounds: aluminum phosphide, phosphine, calcium phosphide, phosphine, and zinc phosphide; II-M.21.B Cyanide; (22) II-M.22 Confounded nonspecific (multi-site) inhibitors, such as: II-M.22.A Halogenated alkanes: bromomethane; II-M.22.B Chloropicrin, sulfuryl fluoride, borax, tartaric acid; II-M.22.C releases methyl isothiocyanate: dazomet, methamidophos; (23) II-M.23 Biogenic amine receptor competitive compounds, such as: dimethylurea, benzaldehyde hydrazone, benzaldehyde hemicarbazone; II-M.24 Cis-Aconitic Acid Inhibitor: Fluoroacetic Acid; II-M.25 Insect midgut membrane microbial disruptors: Bacillus subtilis, Bacillus thuringiensis, or Bacillus coccidioides and their produced insecticidal proteins, such as Bacillus thuringiensis Israelensis subsp., Bacillus thuringiensis Aizawai subsp., Bacillus thuringiensis Kurstaki subsp., Bacillus thuringiensis Tenebrionis subsp., or Bt crop proteins: Cry1Ab, Cry1Ac, Cry1Fa, Cry2Ab, mCry3A, Cry3Ab, Cry3Bb, and Cry34 / 35Ab1; II-M.26 Parasitic fungi: Verticillium chlamydosporium, Paecilomyces lilacinus, Pseudomonas chlamydosporium, Paecilomyces lilacinus, Beauveria bassiana, Metarhizium anisopliae; II-M.27 Insecticidal or nematicidal active compounds with unknown or indeterminate modes of action: pyrimethanil, *Bletilla striata* extract, calcium cyanamide, calcium cyanamide, allyl isothiocyanate, *Microsorum sulforaphane* HNI-1, dimethyl disulfide, dimethyl disulfide, oxadiazine, trifluoropyridineamine, 1,3-dichloropropene, α-trithiophene, fluoxetine sulfone, trifluoroimidazolium, furfural, ricinole, dithiocyanomethane, sulfadiazine, benzylpyridinium, bromopropylate, quinacrine, cryolite, matrine, veratrine, squalene, olive squalene, spirodiclofen, pyrimethanil, fluoxetine sulfone, 4-(methoxyoxime)-a-[(3,3,3-trifluoropropyl)sulfonyl]cyclohexylacetonitrile (CAS: 1097630-26-6), oxadiazon, thiodimethyl fluoride, flufenoxuron, pyridaben, acetamiprid (triflumethrin), flufenoxuron (CAS: 337458-27-2), 3-phenyl-5-(thiophen-2-yl)-1,2,4-diazole (CAS: 330459-31-9), thiazolyl pyridineamines: (6-methoxy-N-((thiazolyl-5-yl)methyl)-N-methyl-3-nitropyridine-2-amine, 6-methoxy-N-((thiazolyl-5-yl)methyl)-N-ethyl-3-nitropyridine-2-amine, 6-methoxy-N-((5-bromothiazolyl-4-yl)methyl)-N-ethyl-3-nitropyridine-2-amine); Compound III is selected from at least one of the following compounds: (1) III-FI respiratory inhibitors, for example; Inhibitors of the III-F.I1 complex III at the Qo site: azoxystrobin, pyraclostrobin, eugenol, fenvalerate, pyraclostrobin, pyraclostrobin, pyraclostrobin, acetamiprid, fluopyram, fluopyram, imidacloprid, pyraclostrobin, pyraclostrobin, pyraclostrobin, pyraclostrobin, pyraclostrobin, chlorpyrifos, fenoxystrobin, oxadiazon, formamide, pyraclostrobin, pyraclostrobin; Inhibitors of the III-F.I2 complex III (cytochrome c reductase) at the Qi site: cyazofamid, indolesulfonamide; III-F.I3 Complex II (succinate dehydrogenase) inhibitors: [List of inhibitors follows, including but not limited to] [List of inhibitors follows, including ... III-F.I4 Other respiratory depressants: diflubenzuron; nitrophenyl derivatives: chlorfenapyr, fenpropathrin, fluazinam; pyraclostrobin; organometallic compounds: tin pyraclostrobin, triphenyltin chloride and tin pyraclostrobin; azoxystrobin; and silthiamethoxam, cymoxanil, pyraclostrobin; (2) III-F.II sterol biosynthesis inhibitors, for example: III-F.II1 C14 demethylase inhibitors, for example: Triazoles: Tebuconazole, Bismutharidin, Fenoxacillin, Cycloconazole, Oxadiazon, Tebuconazole, Zimbaben, Oxadiazon, Cycloconazole, Quinazole, Flusilazole, Tebuconazole, Hexaconazole, Amiconazole, Cyclobuconazole, Cyclobuconazole, Cycloconazole, Oxadiazon, Paclobutrazol, Tebuconazole, Propiconazole, Prothioconazole, Silozolid, Tebuconazole, Fludioxonazole, Triadimefon, Azoxystrobin, Tebuconazole, Uniconazole, Miconazole, Triazole, Imidazole, Imidazole, Etiazole; Imidazoles: imazalil, isoprothiolane, propiconazole, fluopyram; Pyrimidine, pyridine, and piperazine derivatives: isopyram, fluphenylpyrimidin, pyridaben, and azithromycin; Thiazoles: Thiazole copper, Thiazine copper, Thiazole zinc; III-F.II2 δ14-reductase inhibitors, such as: morpholine, morpholine acetate, butylmorpholine, tridemorpholine, piperam, spirocyclohexane, clindamycin, benzyl benzoate, fenvalerate, and spiroxam. III-F.II3 3-keto reductase inhibitors, such as cyclophosphamide and acetamiprid; (3) III-F.III nucleic acid synthesis inhibitors, for example: III-F.III1 Phenylamide or acyl amino acid fungicides, such as: benzalkonium chloride, metalaxyl-methyl, metalaxyl-methyl, oxadixyl, and oxadixyl; III-F.III2 Others, such as: tebuconazole, octothiazoline, isothiazine, oxaflutole, sulfadiazine; (4) Inhibitors of cell division and cytoskeleton in cells III-F and IV, such as: III-F.IV1 is selected from the following classes of tubulin inhibitors, for example: Benzimidazole and thiophanate-methyl: thiamethoxam, benomyl, carbendazim, thiamethoxam, thiamethoxam, and methyl thiophanate; III-F.IV2 Other cell division inhibitors, such as: ethoxysulfuron, thiamethoxam, pendimethalin, fluopyram, benomyl, benzoyl sulfide, cyazofamid; (5) III-FV amino acid and protein synthesis inhibitors, such as: III-F.V1 is selected from the following phenylaminopyrimidine class of methionine synthesis inhibitors: cyclopropionidine, methoxyfenozide, pyraclostrobin, and dimethoprim; III-F.V2 protein synthesis inhibitors, such as: methimazole, tetracycline, kasugamycin, kasugamycin, allicin, ethoxycycline, hydrated kasugamycin, midomycin, streptomycin, oxytetracycline, polyoxin and jinggangmycin; (6) Inhibitors of III-F.VI signaling, such as: F.VI1 MAP / histidine protein kinase inhibitors, such as: fluopyram, fludioxonil, isopropylamine, cyproconazole, tebuconazole, cyproconazole, and fluoxastrobin; III-F.VI2 G protein inhibitors, such as quinacrine; (7) Inhibitors of lipid and membrane synthesis of types III-F.VII, for example: F.VII1 Phospholipid biosynthesis inhibitors, such as: chlorpyrifos, isoprothiolane, difenoconazole, and isoprothiolane; F.VII2 Lipid peroxidation, such as: chloronitrosamine, chloromethoxybenzene, pentachloronitrobenzene, tetrachloronitrobenzene, methyl thiophanate, and dimethomorph; F.VII3 Phospholipid biosynthesis and cell wall deposition, such as: dimethomorph, flumethomorph, dimethomorph, buprofen, benzimidazole, and isopyram; Compounds and fatty acids that affect cell membrane permeability (III-F.VII4), such as: cyclophosphamide; III-F.VII5 fatty acid amide hydrolase inhibitors, such as fluthiazopyrone; (8) Inhibitors of III-F.VIII with multiple sites of action, such as: III-F.VIII1 Inorganic active substances, such as: chlorobromoisocyanuric acid, Bordeaux mixture, copper rosinate, copper acetate, copper hydroxide, copper oxychloride, basic copper sulfate and sulfur; III-F.VIII2 thio- and dithiocarbamates, such as: ferrous sulfate, mancozeb, mancozeb, thiamethoxam, mancozeb, methyl mancozeb, thiram, mancozeb, and zinc thiram; III-F.VIII3 is selected from organochlorine compounds of the following phthalimide, thioamide and chloronitrile class: chlorothalonil, chlorothalonil, captan, chlorfenapyr, thiophanate-methyl, dichlorophenol, hexachlorobenzene, pentachlorophenol and its salts, tetrachlorophthalide, parathion, ethephon, sclerotinia tincture, iprodione, procymidone, and sclerotinia tincture. III-F.VIII4 guanidines and others, such as: guanidine, dextrin, dextrin free base, biguanide salts, biguanide octylamine, biguanide octyl acetate, biguanide octylamine triacetate, bioctylguanide salts, dithiazolinone; (9) Inhibitors of III-F. IX cell wall synthesis, for example: III-F.IX1 glucan synthesis inhibitors, such as jinggangmycin and polyoxin; III-F.IX2 melanin synthesis inhibitors, such as: quinolones, tricyclazole, chlorpyrifos, diclofenac, and cyazofamid; (10) III-FX plant defense inducers, for example: III-F.X1, for example: thiamethoxam, thiabendazole, isothiazamide, thiamethoxam, calcium cyclohexane; III-F.X2 phosphonates, such as: alginate, aluminum phosphite, phosphorous acid and its salts, potassium or sodium bicarbonate; (11) III-F.XI unknown mode of action, for example: Cyclofluoromethane, Dazomet, Imazalil, Dazomet, Wild Bean Curd, Wild Bean Curd Methyl Sulfate, Diphenylamine, Fluorobifen, Sulfocarb, (2Z)-2-[[2-fluoro-5-(trifluoromethyl)phenyl]thio]-2-[3-(2-methoxyphenyl)-2-thiazolyl]acetonitrile (CAS: 958647-10-4), sulfadiazine, chlorfenapyr, isopropylamine, 2,2,2-trifluoroethyl N-[(1S)-2-methyl-1[[(4-methylbenzoyl)amino]methyl]propyl]carbamate (CAS: 911499-62-2), quinoline copper, propoxyquinoline, (6-tert-butyl-8-fluoro-2,3-dimethylquinoline-4-yl) acetate (CAS: 376645-78-2), chlorothalonil, azoxystrobin, bromonitol, trichloroisocyanuric acid, morpholine guanidine hydrochloride, lentinan, amino oligosaccharide, pyrimethanil, methamidophos, nonylated copper, octochlor acetate, dextran, oligosaccharide, chitosan, phenethylmycin, ningnanmycin, rhein methyl ether, flufenoxuron, carvacrol.

[0011] According to an embodiment of the present invention, compound I was prepared by the method of Example 1 in patent document CN 111909143 A, the entire contents of which are incorporated herein by reference.

[0012] According to some embodiments of the present invention, the compound represented by Formula I is applied in combination with at least one compound II and / or III.

[0013] According to some embodiments of the present invention, the weight ratio of the compound represented by Formula I to compound II or compound III is 50:1 to 1:50, such as 50:1, 45:1, 40:1, 35:1, 30:1, 25:1, 20:1, 15:1, 10:1, 5:1, 4:1, 3:1, 2:1, 1:1, 1:2, 1:3, 1:4, 1:5, 1:10, 1:15, 1:20, 1:25, 1:30, 1:35, 1:40, 1:45, 1:50 or any value between the above values.

[0014] Preferably, the weight ratio of the compound represented by Formula I to compound II or compound III is 30:1 to 1:10.

[0015] According to some embodiments of the present invention, the composition can be prepared into any applicable dosage form, such as: suspension, suspension emulsion, microemulsion, water-dispersible granules, granules, fumigation, microcapsule suspension, microcapsule suspension-suspension, powder, wettable powder, soluble powder, aqueous solution, ultra-low volume liquid, dry suspension, emulsifiable concentrate, water emulsion, or seed coating agent.

[0016] Preferably, the dosage form is a suspension concentrate, water-dispersible granule, pellet, emulsifiable concentrate, powder, or seed coating agent.

[0017] Preferably, the seed coating agent is a suspension seed coating agent, an emulsion seed coating agent, a seed treatment dispersible powder, or a seed treatment dispersible granule.

[0018] The present invention also provides a method for preparing the composition as described above, comprising: mixing the compound represented by Formula I with compound II and / or compound III.

[0019] The present invention also provides a method for controlling pests and pathogens, the method comprising contacting the pests and pathogens or their food supply chain, habitat, breeding ground and other locations with an effective amount of the aforementioned composition of pesticide.

[0020] The present invention also provides a method for protecting plant propagation material, the method comprising contacting the plant propagation material with an effective amount of the aforementioned composition of pesticide.

[0021] The present invention also provides a seed product comprising seeds and the aforementioned composition in a content of 0.1g to 100kg / 100kg of seeds.

[0022] The present invention also provides the use of the aforementioned composition in combating pests and pathogens.

[0023] The present invention also provides a pesticide composition comprising a solid or liquid carrier and the aforementioned composition.

[0024] The present invention also provides the use of the aforementioned composition in the prevention and control of plant diseases and pests.

[0025] The present invention has the following advantages: The present invention provides an insecticidal and fungicidal composition containing compound I, which can improve the control efficacy, reduce the dosage, and solve the problems of resistance and decreased efficacy that may result from long-term use of single insecticides and acaricides, thereby meeting the needs of agricultural pest and disease control.

[0026] The synergistic effect of the composition provided by this invention is specifically manifested in the following ways: 1. The composition of the present invention exhibits a significant synergistic effect, improving the control effect of compound I on pests.

[0027] 2. This composition reduces the dosage of pesticides used in application, thereby reducing usage costs, lowering pesticide residues on crops, enhancing environmental friendliness, and reducing environmental pollution.

[0028] 3. The active ingredients in this composition have different mechanisms of action and there is no problem of cross-resistance. This can delay the development of pesticide resistance in pests and improve the control effect on resistant populations.

[0029] 4. This composition can prevent and control a variety of diseases and pests. Detailed Implementation

[0030] The technical solution of the present invention will be further described in detail below with reference to specific embodiments. It should be understood that the following embodiments are merely illustrative and explanatory of the present invention, and should not be construed as limiting the scope of protection of the present invention. All technologies implemented based on the above content of the present invention are covered within the scope of protection intended by the present invention.

[0031] Unless otherwise stated, the raw materials and reagents used in the following examples are commercially available products or can be prepared by known methods.

[0032] Compound I used in Example 1 below was prepared by the method described in Example 1 of patent document CN 111909143 A.

[0033] The formula for calculating the control effect of the treatment agent on pests in the following examples is shown below:

[0035]

[0036] The formula for calculating the control effect of the treatment agent on plants in the following examples is shown below: Disease severity grading criteria: Grade 0: The entire plant is disease-free; Grade 1: Disease occurs on the 4th leaf and all leaf sheaths and leaves below it (with the top leaf as the 1st leaf). Level 3: Disease occurs on the third leaf and all leaf sheaths and leaves below it; Level 5: Disease occurs on the second leaf and all leaf sheaths and leaves below it; Level 7: Disease occurs on the sword-shaped leaf blade and all leaf sheaths and leaves below it; Level 9: The entire plant is infected and dies prematurely.

[0037]

[0038]

[0039] In the formula: CK0 - Disease index before drug administration (blank control area) CK1 - Disease index after drug administration in blank control area PTO - Disease index before application of pesticide in the treatment area PT1 - Disease index after drug treatment in the treatment area Unless otherwise specified, all percentages in the formulations described in the following examples refer to mass percentages.

[0040] Example 1 1) The experimental crop was chili pepper. The target pest for control is the two-spotted spider mite (Tetranychus spp.)Cinnabar spider mite ) Field efficacy trials were conducted in accordance with the "Guidelines for Field Efficacy Trials of Pesticides". The control pesticide must be a registered product proven to have good efficacy in practice, and the test dose should be the recommended dose. A water treatment was included as a blank control. Each dose was replicated four times in a randomized block design, with each plot no smaller than 15 m². 2 Application should be carried out according to the agreement requirements and label instructions. Before application, the population of two-spotted spider mites should be investigated using random sampling to record the number of surviving and nymphal mites. The results should be investigated 14 days after application, and the number of surviving and nymphal spider mites should be checked and recorded. The mite population reduction rate and the control effect of the treated pesticide should be calculated. The results are shown in Table 1. [In Table 1, the compound formulations of Compound I and Compound II were all prepared and tested at a 1:1 weight ratio. The compound formulations of Compound I and Compound II or III mentioned in other tables were also prepared and tested at a 1:1 weight ratio. Taking 50% diethyl urea (Compound II) suspension as an example, 50% refers to the mass percentage of the active ingredient diethyl urea in the pesticide. In 50% Compound I·diethyl urea suspension (1:1), 50% refers to the total mass percentage of active ingredients Compound I and diethyl urea, where 1:1 refers to the weight ratio of the two active ingredients. Furthermore, the above single-agent and combined formulations were prepared in the same manner.]

[0041] The single-agent and compound agents in the table below are also prepared in this manner, and will not be described further in this invention. Table 1 Results of field control efficacy against two-spotted spider mite

[0042] 2) The experimental crop was maize. The target pest for control is corn armyworm ( Separate myths Walker) Field efficacy trials were conducted in accordance with the "Guidelines for Field Efficacy Trials of Pesticides". The test dose of the control agent was the recommended dose. A water treatment was used as a blank control. Each dose was replicated four times in a randomized block design, with each plot no less than 20 m². 2 The pesticide was sprayed evenly on both sides of the plants, ensuring full contact between the pesticide and the corn armyworms. Before application, the initial insect population was assessed. After application, a 5-point sampling method was used, with 5 samples taken from each plot, and 10 infested plants sampled at each point. On the 14th day after application, the number of live insects in each plot was assessed to calculate the insect population reduction rate and control effect. The results are shown in Table 2.

[0043] Table 2 Results of field control efficacy against corn armyworm

[0044] 3) The experimental crop was tomato. The target pest for control is the tomato whitefly ( Bemisia tabaci ) Field efficacy trials were conducted in accordance with the "Guidelines for Field Efficacy Trials of Pesticides". The control pesticide should be a registered pesticide proven effective in practice, and the test dose should be the recommended dose. A water treatment was included as a blank control. Each dose was replicated four times in a randomized block design, with each plot no smaller than 15 m². 2 Apply pesticides according to the agreement or label instructions. Investigate the adult insect population before application and collect results 7 days after application using a random sampling method. Mark at least 10 plants in each plot, record the number of surviving adults, and calculate the insect population reduction rate and the control effect of the pesticide. Results are shown in Table 3.

[0045] Table 3 Results of field control efficacy against tomato whiteflies

[0046] 4) The experimental crop was cotton. The target pest for control is cotton aphids ( Aphis gossypii Glover) Field efficacy trials were conducted in accordance with the "Guidelines for Field Efficacy Trials of Pesticides". The test crop should be a sensitive cotton variety, and all test plots should be grown under identical conditions. The control pesticide should be a registered product proven to have good efficacy in practice, and each plot should be at least 20 m². 2 At least four replicates were required. Application was carried out according to the contract or label instructions, ensuring accurate dosage and even distribution. The aphid population in each plot should be no less than 500 before treatment. The number of live aphids was assessed 7 days after treatment to calculate the population reduction rate and control efficacy. Results are shown in Table 4.

[0047] Table 4 Results of field control efficacy against cotton aphids

[0048] 5) The experimental crop was rice. The target pest for control is the rice leaf roller ( Cnaphalocrocis medinalis ) Field efficacy trials were conducted in accordance with the "Guidelines for Field Efficacy Trials of Pesticides". The test dose of the control agent was the recommended dose. A water treatment was used as a blank control. Each dose was replicated four times in a randomized block design, with each plot no less than 15 m². 2 The application of pesticides was carried out in accordance with the agreement requirements and label instructions. Samples were taken from 5 points in each plot, totaling 25 rice clumps. The leaf curling rate was recorded, and compared with the control area on the 14th day after application to calculate the relative control efficacy. The rate of insects present inside the curled leaves was also investigated. The results are shown in Table 5.

[0049] Table 5 Results of field control efficacy trials against rice leaf roller.

[0050] 6) The experimental crop was cabbage. The target pest for control is the diamondback moth ( Plutella xylostella (Linnaeus) Field efficacy trials were conducted in accordance with the "Guidelines for Field Efficacy Trials of Pesticides". The test dose of the control agent was the recommended dose. A water treatment was used as a blank control. Each dose was replicated four times in a randomized block design, with each plot no less than 20 m². 2 The pesticide was sprayed evenly on both sides of the plants, ensuring full contact between the pesticide and the diamondback moths. Before application, the initial insect population was assessed. After application, a 5-point sampling method was used, with 5 samples taken from each plot, and 10 plants with insects detected at each sample point. On the 14th day after application, the number of live insects in each plot was assessed to calculate the insect population reduction rate and control effect. The results are shown in Table 6.

[0051] Table 6 Results of field control efficacy trials against diamondback moth in cabbage.

[0052] 7) The experimental crop was cucumber. The target of prevention and control is bacterial keratosis ( Pseudomonas syringae ) Field efficacy trials were conducted in accordance with the "Guidelines for Field Efficacy Trials of Pesticides." All test plots were grown under identical conditions and conformed to local scientific agricultural practices. The control pesticide should be a registered product proven to have good efficacy in practice, and the test dose should be the recommended dose. A water treatment was used as a blank control. Each dose was replicated four times in a randomized block design, with each plot no smaller than 15 m². 2 Application of pesticides was carried out according to the agreement requirements and label instructions, ensuring accurate dosage and even distribution. Five diagonal sampling points were taken from each plot, with three plants at each point. All leaves were examined, and the disease severity was graded based on the percentage of diseased area per leaf. The baseline disease incidence was assessed before application, and the control effect was assessed 14 days after application. Results are shown in Table 7.

[0053] Table 7 Results of field control efficacy trials against bacterial angular leaf spot of cucumber.

[0054] 8) The experimental crop was maize. The target for control is stem base rot (fungus strain: Fusarium graminearum). Fusarium gramineae ) Field efficacy trials were conducted in accordance with the "Guidelines for Field Efficacy Trials of Pesticides". The test dose of the control agent was the recommended dose. A water treatment was used as a blank control. Each dose was replicated four times in a randomized block design, with each plot no less than 20 m². 2 Ensure accurate dosage and even distribution of the pesticide during application. Before application, investigate the baseline disease incidence. Classify the damage based on the symptoms and severity of damage to the corn leaf sheaths and leaves. Using a plant-by-plant sampling method, sample five diagonally across each plot, investigating five adjacent clumps at each point, for a total of 25 clumps. Record the total number of plants, the number of diseased plants, and the disease severity. Investigate the control effect 14 days after application. Results are shown in Table 8.

[0055] Table 8 Results of field control efficacy trials for maize stalk base rot.

[0056] 9) The experimental crop was rice. Control target: Rhizoctonia solani (strain: Rhizoctonia solani) Rhizoctonia solani ) Field efficacy trials were conducted in accordance with the "Guidelines for Field Efficacy Trials of Pesticides". The test dose of the control agent was the recommended dose. A water treatment was used as a blank control. Each dose was replicated four times in a randomized block design, with each plot no less than 20 m². 2 Ensure accurate dosage and even distribution of pesticide during application. Before application, investigate the baseline disease incidence. Classify the damage based on symptoms and severity on rice leaf sheaths and leaves. Using a plant-by-plant sampling method, sample five diagonally across each plot, investigating five adjacent clumps at each point, for a total of 25 clumps. Record the total number of plants, the number of diseased plants, and the disease severity. Investigate the control effect 14 days after application. Results are shown in Table 9.

[0057] Table 9 Results of field control efficacy trials against rice sheath blight

[0058] 10) The experimental crop was Chinese cabbage. Soft rot disease (a disease that is difficult to control) Erwinia carotovora) Field efficacy trials were conducted in accordance with the "Guidelines for Field Efficacy Trials of Pesticides." All test plots were grown under identical conditions and conformed to local scientific agricultural practices. The control pesticide should be a registered product proven to have good efficacy in practice, and the test dose should be the recommended dose. A water treatment was used as a blank control. Each dose was replicated four times in a randomized block design, with each plot no smaller than 15 m². 2 The application of pesticides was carried out according to the agreement requirements and label instructions, ensuring accurate dosage and even distribution. Before application, all vegetable plants in each plot were surveyed, and the total number of plants surveyed and the number of diseased plants were recorded. The control effect was assessed 14 days after application. The results are shown in Table 10.

[0059] Table 10 Results of field control efficacy trials against soft rot in Chinese cabbage.

[0060] 11) The experimental crop was tomato. Target disease for prevention and control: bacterial wilt ( Pseudomonas solanacearum ) Field efficacy trials were conducted in accordance with the "Guidelines for Field Efficacy Trials of Pesticides." All test plots were grown under identical conditions and conformed to local scientific agricultural practices. The control pesticide should be a registered product proven to have good efficacy in practice, and the test dose should be the recommended dose. A water treatment was used as a blank control. Each dose was replicated four times in a randomized block design, with each plot no smaller than 15 m². 2 Application of pesticides was carried out according to the agreement requirements and label instructions, ensuring accurate dosage and even distribution. All plants in each plot were surveyed, and the total number of plants and the number of diseased plants were recorded. The baseline disease incidence was assessed before application, and the control effect was assessed 14 days after application. Results are shown in Table 11.

[0061] Table 11 Results of field efficacy trials against bacterial wilt of tomato

[0062] 12) The experimental crop was citrus. Target of prevention and treatment: peptic ulcer disease Xanthomonas campestris ) Field efficacy trials were conducted in accordance with the "Guidelines for Field Efficacy Trials of Pesticides." All experimental plots maintained consistent cultivation conditions and conformed to local scientific agricultural practices. The control pesticide was a registered product proven to have good efficacy in practice, and the experimental dosage was the recommended dosage. A water treatment served as a blank control. Each dosage treatment was replicated four times in a randomized block design, with each plot containing 2-3 mature fruit trees. Application was carried out according to the agreement and label instructions, ensuring accurate dosage and uniform distribution. Accurate dosage and uniform distribution were maintained during application. Before application, the disease incidence was assessed, with two trees sampled per plot. Sampling was taken from each tree at five points (east, south, west, north, and center), and at each point, 10 fruits and all leaves on two shoots were examined. The control effect was assessed 20 days after application. Results are shown in Table 12.

[0063] Table 12 Results of field control efficacy trials against citrus canker.

[0064] As shown in the above examples, when compound I is combined with other agents (compound II and / or compound III), it can reduce the dosage of both agents and improve the control efficacy against pests and diseases.

[0065] During the observation period from application to the end of the investigation, no visible phytotoxic symptoms were observed in the crops produced by any of the formulations in the examples, and the crops grew well after application. This indicates that the active ingredients in the composition of the present invention have different mechanisms of action, and there is no problem of cross-resistance. This can delay the occurrence of pesticide resistance in pests and improve the control effect on resistant species.

[0066] It should be understood that the above embodiments are some embodiments of the present invention, provided only for a better understanding of the embodiments of the present invention, and are not all embodiments of the present invention. In practical applications, by adjusting the content of each component and the combination of components in the present invention, different and numerous embodiments can be obtained, all of which are within the scope of the present invention.

Claims

1. A composition, characterized in that, The composition comprises compound I and compound II, wherein compound I is shown below. I Compound II is selected from one of flufenoxuron, spirotetramat, and spirodiclofen.

2. The composition according to claim 1, characterized in that, The weight ratio of the compound shown in Formula I to compound II is 50:1 to 1:

50.

3. The composition according to claim 1, characterized in that, The composition can be prepared into any applicable dosage form of: suspension, suspension emulsion, microemulsion, water-dispersible granules, granules, fumigation, microcapsule suspension, microcapsule suspension-suspension, powder, wettable powder, soluble powder, aqueous solution, ultra-low volume liquid, dry suspension, emulsifiable concentrate, water emulsion, or seed coating agent.

4. The composition according to claim 3, characterized in that, The dosage forms are suspensions, water-dispersible granules, granules, emulsifiable concentrates, powders, and seed coating agents.

5. A method for controlling pests and pathogens, characterized in that, The method includes contacting pests and pathogens or their food supply chains, habitats, breeding grounds and other locations with an effective amount of the composition of any one of claims 1-4.

6. A method for protecting plant propagation material, characterized in that, The method includes contacting plant propagation material with an effective amount of the composition according to any one of claims 1-4.

7. A seed product, characterized in that, The seed product includes seeds and the composition according to any one of claims 1-4, in a content of 0.1g to 100kg / 100kg of seeds.

8. Use of the composition according to any one of claims 1-4 in combating pests and pathogens.

9. A pesticide composition, characterized in that, It comprises a solid or liquid carrier and the composition according to any one of claims 1-4.

10. Use of the composition of claim 9 in the prevention and control of plant diseases and pests.

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