April and baff inhibitory immunomodulatory proteins and methods of use thereof

By designing truncated TACI peptides and substituting amino acids, the binding with APRIL and BAFF is enhanced, while the binding with BCMA or TACI is blocked. This solves the problem of effectively regulating B cell immune responses in existing technologies and achieves therapeutic effects on a variety of immune diseases.

CN122277700APending Publication Date: 2026-06-26ALPINE IMMUNE SCIENCES INC
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
ALPINE IMMUNE SCIENCES INC
Filing Date
2021-05-07
Publication Date
2026-06-26

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Abstract

This invention relates to APRIL and BAFF inhibitory immunomodulatory proteins and methods of using them, specifically providing immunomodulatory proteins exhibiting neutralizing activity against BAFF and APRIL (or BAFF / APRIL heterotrimers). The immunomodulatory proteins provided herein include variant domains of transmembrane activators and CAML interactors (TACI). The provided immunomodulatory proteins include TACI-Fc fusion proteins. Nucleic acid molecules encoding said immunomodulatory proteins are also provided. The immunomodulatory proteins provide therapeutic efficacy against a variety of immune diseases, disorders, or conditions. Compositions and methods for preparing and using such proteins are also provided.
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