Screening device for cell separation

Through the combination of wicking assembly and temperature control system, the physical damage and activity reduction of cell separation devices in the prior art are solved, and efficient and accurate cell separation and simultaneous collection of multiple cells are achieved.

CN223189188UActive Publication Date: 2025-08-05SUZHOU ZHIYOUTANGHUA PHARMACEUTICAL TECHNOLOGY CO LTD
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Patent Information

Application Number
CN202422004321.0
Authority / Receiving Office
CN · China
Patent Type
Utility models(China)
Current Assignee / Owner
Filing Date
2024-08-19
Publication Date
2025-08-05
Estimated Expiration
2034-08-19

AI Technical Summary

Technical Problem

The existing cell separation devices are prone to physical damage to cells during stirring and filtration, and fail to maintain a constant temperature environment, affecting cell activity, and cannot filter and collect cells of different sizes at the same time.

Method used

Using wicking assembly and temperature control system, cells are adsorbed through wicking beam and capillary action, combined with peristaltic pump and flow sensor, the dilution flow is accurately controlled, the temperature sensor and heating rod are used to maintain constant temperature, the inclined bottom plate is designed to reduce liquid residue, and cell separation and filtration are achieved through multiple cleanings.

Benefits of technology

A gentle cell separation process is achieved, reducing mechanical friction, maintaining cell activity, and being able to collect cells of different sizes at the same time, improving separation efficiency and accuracy.

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Abstract

The utility model discloses a screening device for cell separation. The screening device comprises a shell and a wicking assembly arranged above the shell, an automatic dilution system, a supporting table and a valve are arranged on the surface of the shell, a viscosity monitoring system, a temperature control system and a stirrer are arranged in the shell, and a wicking assembly connected with the supporting table through a telescopic assembly comprises a screening plate and a wicking bundle; the wicking beam adsorbs, separates and screens the cells by virtue of a wicking effect, a capillary action and an adhesion characteristic of the cells to the wicking beam, a stirrer is used for generating eddy current to stir liquid, and the whole cell adsorption screening and separation filtering process does not have too much mechanical friction, so that the problem of physical damage caused by cell separation is solved; the temperature control system can maintain a constant-temperature environment through a temperature sensor and a heating rod, the problem that the cell activity is reduced is solved, after adsorption screening, the shell can be subjected to separation and filtration operation after being cleaned, and the device is more flexible.
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