Topical skin preparations

Abstract

To provide an active ingredient of an external preparation for skin which is derived from a natural product, has excellent biological safety and stability, protects barrier function of skin from external factors (ultraviolet ray, air pollutant, chemical substance, pathogenic bacterium, pollen etc.), and by which chappy, dermatitis, and damage or the like is improved, skin is held in a fresh and healthy state, or skin is kept in a smooth state.SOLUTION: An external preparation for skin has an extract from white asparagus as an active ingredient.SELECTED DRAWING: None

Description

Technical Field

[0001] The present invention relates to a topical skin preparation containing a plant-derived component as an active ingredient and protecting the skin from various external factors (ultraviolet rays, air pollutants, chemical substances, pathogenic bacteria, pollen, etc.).

Background Art

[0002] In recent years, various studies have been conducted on the effects of external factors (ultraviolet rays, air pollutants, chemical substances, pathogenic bacteria, pollen, etc.) on the skin, and active ingredients that can sufficiently protect the skin from these external factors are required.

Disclosure of the Invention

Problems to be Solved by the Invention

[0003] As a result of intensive studies in view of the above conventional problems, the inventors have newly found that among asparagus, which is a plant of the genus Asparagus in the family Asparagaceae, particularly the extract of white asparagus exhibits an effect of protecting the skin from various external factors.

[0004] Conventionally, although topical skin preparations containing an extract of green asparagus as an active ingredient are known from, for example, Patent Documents 1 to 4, topical skin preparations containing an extract of white asparagus as an active ingredient are not known.

[0005]

Patent Document 1

Patent Document 2

Patent Document 3

Patent Document 4

Means for Solving the Problems

[0006] The present invention is a topical skin preparation containing an extract of white asparagus as an active ingredient. This invention relates to a barrier function improving agent containing an extract of white asparagus as an active ingredient. The present invention relates to a humectant containing an extract of white asparagus as an active ingredient. [Effects of the Invention]

[0007] According to the present invention, by using an extract of white asparagus as the active ingredient in a topical skin preparation, this active ingredient provides a topical skin preparation that protects the skin's barrier function through the protective effect of occludin and claudin, which form tight junctions (skin barrier structures due to cell adhesion). [Modes for carrying out the invention]

[0008] Preferred embodiments of the present invention will be described in detail below. First, the white asparagus used as the extraction material is a plant of the genus Asparagus (Asparagus officinalis) belonging to the family Asparagaceae, and refers to the white variety grown without sunlight. This white asparagus is distinguished from green asparagus, which is grown in sunlight and contains chlorophyll. In this invention, it is preferable to use the stems of white asparagus.

[0009] The white asparagus used as the extraction material may be fresh, or it may be pre-dried or semi-dried. In terms of form, it can be used as is after harvesting, or as dried and ground asparagus.

[0010] The extraction is prepared by washing the material as needed to remove impurities, then either leaving it as is or drying it, and then finely chopping or grinding it as needed, before contacting it with the extraction solvent for extraction. Extraction can be carried out by contacting the material with the extraction solvent according to conventional methods such as immersion, but supercritical fluid extraction can also be used in addition to immersion.

[0011] Examples of extraction solvents include water; lower alcohols such as methanol, ethanol, and propanol; polyhydric alcohols such as ethylene glycol, propylene glycol, 1,3-butylene glycol, and glycerin; esters such as ethyl acetate, butyl acetate, and methyl propionate; ketones such as acetone and methyl ethyl ketone; ethers such as ethyl ether and isopropyl ether; and hydrocarbon solvents such as n-hexane, toluene, and chloroform. These can be used individually or in combination of two or more.

[0012] Among these extraction solvents, hydrophilic solvents such as water, lower alcohols, or polyhydric alcohols are preferred in the present invention, from the viewpoint of skin irritation and effectiveness, as well as their broad applicability to cosmetics. Preferred examples of using these hydrophilic solvents include, for example, the use of water, lower alcohols (especially ethanol), or polyhydric alcohols (especially 1,3-butylene glycol) alone, or a mixed solvent of water and lower alcohols (especially ethanol), or a mixed solvent of water and polyhydric alcohols (especially 1,3-butylene glycol, glycerin), but among these, water alone or a mixed solvent of water and 1,3-butylene glycol are particularly preferred.

[0013] When using a mixed solvent, the mixing ratio is preferably in the range of 1:10 to 20:1 by volume (hereinafter the same) for a mixed solvent of water and 1,3-butylene glycol, 1:10 to 25:1 for a mixed solvent of water and ethanol, and 1:10 to 20:1 for a mixed solvent of water and glycerin.

[0014] While there are no particular limitations on the pH of the extract during preparation, it is generally preferable to have a pH in the range of 3 to 9. In this sense, if necessary, the extraction solvent may be adjusted to the desired pH by adding an alkaline adjusting agent such as sodium hydroxide, sodium carbonate, or potassium hydroxide, or an acidic adjusting agent such as citric acid, hydrochloric acid, phosphoric acid, or sulfuric acid.

[0015] Extraction conditions such as extraction temperature and extraction time vary depending on the type of solvent and pH used. For example, when using water, 1,3-butylene glycol, or a mixture of water and 1,3-butylene glycol as the solvent, the extraction temperature is preferably in the range of 0°C to 130°C. The extraction time is preferably in the range of 1 to 168 hours (1 hour to 1 week).

[0016] Furthermore, it is preferable that the extract according to the present invention be subjected to adsorption treatment using activated carbon or a nonionic porous resin, etc., for the purpose of improving stability and enhancing skin physiological activity.

[0017] For the activated carbon used in the adsorption treatment, plant materials such as pine wood, bamboo, coconut shells, and walnut shells may be used as raw materials, as well as coal and petroleum materials. In addition, activated carbon obtained by treating the above raw materials with physical methods such as high-temperature carbonization using gases such as steam, carbon dioxide, or air, or by heating them with chemicals such as zinc chloride to make them porous, or by performing activation treatment by chemical methods may also be used.

[0018] When treating the above extract with activated carbon, commonly used methods include adding powdered or granular activated carbon to the extract, stirring, and then removing the activated carbon; treating the extract by passing it through an activated carbon column; or passing the extract through filter paper or cartridge filter containing activated carbon. However, from the viewpoint of adsorption efficiency, it is preferable to add activated carbon to the extract and stir it.

[0019] Furthermore, nonionic porous resins can also be used as adsorbents. Examples of nonionic porous resins include styrene / divinylbenzene copolymers and methacrylic acid ester polymers, with a specific surface area generally ranging from 100 to 2000 m². 2 / g, preferably 300-1000m 2 / g, a porous resin having a pore volume generally in the range of 0.1 to 3.0 mL / g, preferably 0.5 to 1.5 mL / g, is used. Examples of such nonionic porous resins include styrene / divinylbenzene-based Diaion HP10, 20, 21, Sepabeads SP800, SP850, SP700, SP207 (above, Mitsubishi Chemical Corporation), Amberlite XAD4, 16, Duolite S874, 877 (Rohm & Haas), methacrylic acid ester-based Diaion HP1MG, 2MG (Mitsubishi Chemical Corporation), Amberlite XAD7 (Rohm & Haas), and the like.

[0020] As the conditions for the adsorption treatment with the nonionic porous resin, either a batch method or a continuous method may be used. For example, in the case of the batch method, it is 0.1 to 200 parts by weight, preferably 1 to 100 parts by weight, based on 1 part by weight of the solid content of the extract.

[0021] The extract prepared as described above is generally adjusted to a pH of 3 to 8 and may be used as it is as a cosmetic formulation, or may be used at a desired concentration by concentration under reduced pressure or the like. Further, the extract may be made into a dried product by a conventional method such as the spray drying method.

[0022] Examples of the external preparation for skin (external pharmaceutical products, external quasi-drug products, and cosmetics) containing the extract of the present invention include emulsions, creams, lotions, essences, gels, packs, sheet masks, lipsticks, foundations, liquid foundations, makeup press powders, blushers, white powders, facial cleansers, body shampoos, slimming agents, hair shampoos, soaps, etc. Also, hair growth agents and hair nourishing agents, and furthermore bath agents, etc. are included, but are not limited thereto.

[0023] The amount of the active ingredient according to the present invention in topical skin preparations (cosmetics and quasi-drugs) is generally in the range of 0.0002 to 1.0% by weight (solids by weight, the same applies hereinafter) as solids in the case of basic cosmetics, preferably in the range of 0.002 to 0.2% by weight, in the case of makeup cosmetics, generally in the range of 0.0002 to 1.0% by weight, preferably in the range of 0.002 to 0.2% by weight, and in the case of cleansing cosmetics, generally in the range of 0.002 to 10.0% by weight. Furthermore, in the case of hair cosmetics, the solids of the extract are generally in the range of 0.00001 to 5.0% by weight, preferably in the range of 0.0001 to 3.0% by weight.

[0024] Here, oily components include, for example, plant-derived oils and fats such as olive oil, jojoba oil, castor oil, soybean oil, rice oil, rice germ oil, coconut oil, palm oil, cocoa oil, meadowfoam oil, shea butter, tea tree oil, avocado oil, macadamia nut oil, bergamot oil, lavender oil, rose oil, chamomile oil, etc.; vitamin A oil; animal-derived oils and fats such as mink oil, turtle oil, etc.; waxes such as beeswax, carnauba wax, rice wax, lanolin, etc.; liquid paraffin, petrolatum, paraffin wax. Examples include hydrocarbons such as custard and squalane; fatty acids such as myristic acid, palmitic acid, stearic acid, oleic acid, isostearic acid, and cis-11-eicosenoic acid; higher alcohols such as lauryl alcohol, cetanol, pantothenyl alcohol, and stearyl alcohol; synthetic esters and synthetic triglycerides such as isopropyl myristate, isopropyl palmitate, butyl oleate, 2-ethylhexylglyceride, and higher fatty acid octyldodecyl (octyldodecyl stearate, etc.).

[0025] Examples of surfactants include nonionic surfactants such as polyoxyethylene alkyl ethers, polyoxyethylene fatty acid esters, polyoxyethylene sorbitan fatty acid esters, glycerin fatty acid esters, polyglycerin fatty acid esters, polyoxyethylene glycerin fatty acid esters, polyoxyethylene hydrogenated castor oil, and polyoxyethylene sorbitol fatty acid esters; fatty acid salts, alkyl sulfates, alkylbenzene sulfonates, polyoxyethylene alkyl ether sulfates, polyoxyethylene fatty amine sulfates, polyoxyethylene alkylphenyl ether sulfates, polyoxyethylene alkyl ether phosphates, α-sulfonated fatty acid alkyl ester salts, and polyoxyethylene Anionic surfactants such as ethylene alkylphenyl ether phosphates; cationic surfactants such as quaternary ammonium salts, primary to tertiary fatty amine salts, trialkylbenzylammonium salts, alkylpyridinium salts, 2-alkyl-1-alkyl-1-hydroxyethylimidazolinium salts, N,N-dialkylmorphonium salts, polyethylene polyamine fatty acid amide salts; and amphoteric surfactants such as N,N-dimethyl-N-alkyl-N-carboxymethylammonium betaine, N,N,N-trialkyl-N-alkyleneammonium carboxybetaine, and N-acylamidopropyl-N′,N′-dimethyl-N′-β-hydroxypropylammonium sulfobetaine can be used.

[0026] As emulsifiers and / or emulsifying aids, stevia derivatives such as enzyme-treated stevia, saponins or their derivatives, casein or its salts (sodium, etc.), sugar-protein complexes, sucrose or its esters, lactose, water-soluble polysaccharides derived from soybeans, complexes of soybean-derived proteins and polysaccharides, lanolin or its derivatives, cholesterol, stevia derivatives (such as enzyme-treated stevia), silicates (aluminum, magnesium, etc.), carbonates (calcium, sodium, etc.), saponins and their derivatives, lecithin and its derivatives (such as hydrogenated lecithin), lactic acid bacteria-fermented rice, lactic acid bacteria-fermented germinated rice, lactic acid bacteria-fermented grains (wheat, beans, grains, etc.), etc. may also be included.

[0027] Examples of humectants include glycerin, propylene glycol, dipropylene glycol, 1,3-butylene glycol, polyethylene glycol, sorbitol, xylitol, sodium pyrrolidone carboxylate, and sugars such as trehalose and raffinose, mucopolysaccharides (e.g., hyaluronic acid and its derivatives, hyaluronic acid ferment filtrate, chondroitin and its derivatives, heparin and its derivatives, etc.), elastin and its derivatives, collagen and its derivatives, collagen peptides, NMF-related substances, lactic acid, urea, higher fatty acid octyldodecyl, seaweed extracts, estradiol, various amino acids and their derivatives.

[0028] Examples of thickening agents include components derived from brown algae, green algae, or red algae such as alginic acid, agar, carrageenan, and fucoidan; polysaccharides such as pectin and aloe polysaccharide; gums such as tragacanth gum, locust bean gum, xanthan gum, and guar gum; cellulose derivatives such as carboxymethylcellulose, hydroxyethylcellulose, and hydroxypropylcellulose; synthetic polymers such as carboxyvinyl polymer, alkyl-modified carboxyvinyl polymer, polyvinyl alcohol, polyvinylpyrrolidone, and acrylic acid / methacrylic acid copolymer; hyaluronic acid and its derivatives; polyglutamic acid and its derivatives, polyacrylic acid, etc.

[0029] Anti-inflammatory agents include allantoin, dipotassium glycyrrhizinate, monoammonium glycyrrhizinate, β-glycyrrhetinic acid, stearyl glycyrrhetinate, ε-aminocaproic acid, d-camphor, dl-camphor, zinc oxide, panthenol, pyridoxine hydrochloride, and riboflavin or its derivatives.

[0030] Examples of preservatives and disinfectants include urea; benzoic acid or its salts, parahydroxybenzoic acid esters such as methyl parahydroxybenzoate, ethyl parahydroxybenzoate, propyl parahydroxybenzoate, and butyl parahydroxybenzoate; phenoxyethanol, dichlorophene, hexachlorophene, chlorhexidine hydrochloride, benzalkonium chloride, salicylic acid, sodium salicylate, zinc pyrithione, benzalkonium chloride, ethanol, undecylenic acid, phenols, and aluminum bromide. These include chloroisoquinolinium, resorcinol, jamal (imidazodinylurea), isopropylmethylphenol, triclosan, trichlorocarbanide, trichlorohydroxydiphenol ether, hinokitiol, 1,2-pentanediol, propanediol, concentrated benzalkonium chloride solution 50, essential oils such as peppermint oil and eucalyptus oil, tree bark distillates, radish ferment filtrate, plant-derived ethanol such as sugarcane and corn, or 1,3-butylene glycol.

[0031] Examples of cell activators include pantothenyl alcohol, menthol, dl-menthol, and γ-oryzanol.

[0032] Examples of anti-acne agents include sulfur, salicylic acid or its salts, photosensitizer 201, and pyridoxine dicaprylate.

[0033] Examples of powder components include sericite, titanium dioxide, talc, kaolin, bentonite, zinc oxide, magnesium carbonate, magnesium oxide, zirconium oxide, barium sulfate, anhydrous silicic acid, mica, nylon powder, polyethylene powder, silk powder, cellulose-based powders, grain powders (rice, wheat, corn, millet, etc.), and legume powders (soybeans, adzuki beans, etc.).

[0034] Examples of UV absorbers include ethyl para-aminobenzoate, ethylhexyl para-dimethylaminobenzoate, amyl salicylate and its derivatives, 2-ethylhexyl para-methoxycinnamate, octyl cinnamate, oxybenzone, 2,4-dihydroxybenzophenone, 2-hydroxy-4-methoxybenzophenone-5-sulfonate, 4-tert-butyl-4-methoxybenzoylmethane, 2-(2-hydroxy-5-methylphenyl)benzotriazole, urocanic acid, ethyl urocanate, and aloe extract.

[0035] Examples of antioxidants include carotenoids such as butylhydroxyanisole, butylhydroxytoluene, propyl gallate, and astaxanthin, vitamin E and its derivatives (e.g., tocopherol acetate, tocopherol nicotinate), and vitamin A or its derivatives (e.g., retinol palmitate).

[0036] Furthermore, examples of whitening agents include one or more selected from ellagic acid and its derivatives, resorcinol derivatives, potassium 4-methoxysalicylate, magnolignan (5,5'-dipropyl-biphenyl-2,2'-diol), hydroxybenzoic acid and its derivatives, vitamin E and its derivatives, α-hydroxy acids, nicotinic acid derivatives, and AMP (adenosine monophosphate, adenosine monophosphate).

[0037] Examples of resorcinol derivatives include 4-n-butylresorcinol and 4-isoamylresorcinol; examples of 2,5-dihydroxybenzoic acid derivatives include 2,5-diacetoxybenzoic acid, 2-acetoxy-5-hydroxybenzoic acid, and 2-hydroxy-5-propionyloxybenzoic acid; and examples of α-hydroxy acids include lactic acid, malic acid, succinic acid, citric acid, and α-hydroxyoctanoic acid. One or more substances selected from kojic acid and its derivatives, ascorbic acid and its derivatives, hydroquinone or its derivatives, ellagic acid and its derivatives, nicotinic acid and its derivatives, resorcinol derivatives, tranexamic acid and its derivatives, potassium 4-methoxysalicylate, magnolignan (5,5'-dipropyl-biphenyl-2,2'-diol), hydroxybenzoic acid and its derivatives, vitamin E and its derivatives, α-hydroxy acids, AMP (adenosine monophosphate, adenosine monophosphate), t-cycloamino acid derivatives, mulberry bark extract, chamomile extract, hydrolyzed rice bran extract, saxifrage extract, and white poppy extract or their hydrolyzed products.

[0038] Examples of kojic acid derivatives include kojic acid esters such as kojic acid monobutyrate, kojic acid monocaprate, kojic acid monopalmitate, and kojic acid dibutyrate, kojic acid ethers, and kojic acid sugar derivatives such as kojic acid glucoside. Examples of ascorbic acid derivatives include ascorbic acid ester salts such as L-ascorbic acid-2-phosphate sodium, L-ascorbic acid-2-phosphate magnesium, L-ascorbic acid-2-sulfate sodium, and L-ascorbic acid-2-sulfate magnesium. Ascorbic acid sugar derivatives such as ascorbic acid-2-glucoside, L-ascorbic acid-5-glucoside, ascorbyl tocopheryl maleate, ascorbyl tocopheryl potassium phosphate, myristyl 3-glyceryl ascorbate, caprylyl 2-glyceryl ascorbate, 6-position acylated products of these ascorbic acid sugar derivatives (acyl groups include hexanoyl, octanoyl, and decanoyl groups), L-ascorbic acid tetra fatty acid esters such as L-ascorbic acid tetraisopalmitate and L-ascorbic acid tetralaurate, 3 As for hydroquinone derivatives, examples include -O-ethyl ascorbic acid, L-ascorbic acid-2-phosphate-6-O-palmitate sodium, glyceryl ascorbic acid or its acylated derivatives, ascorbic acid glycerin derivatives such as bisglyceryl ascorbic acid, L-ascorbic acid aminopropyl phosphate, hyaluronic acid derivatives of L-ascorbic acid, 3-OD lactose-L-ascorbic acid, isostearyl ascorbyl phosphate, etc. Hydroquinone derivatives include arbutin (hydroquinone-β-D-glucopyranoside), α-arbutin (hydroquinone-α-D-glucopyranoside), Examples of tranexamic acid derivatives include lucopyranoside, tranexamic acid esters (e.g., lauryl tranexamic acid ester, hexadecyl tranexamic acid ester, cetyl tranexamic acid ester or their salts), amide forms of tranexamic acid (e.g., methyl tranexamic acid amide), resorcinol derivatives include 4-n-butylresorcinol, 4-isoamylresorcinol, and 2,5-dihydroxybenzoic acid derivatives include 2,5-diacetoxybenzoic acid, 2-acetoxy-5-hydroxybenzoic acid,Examples of nicotinic acid derivatives include 2-hydroxy-5-propionyloxybenzoic acid, nicotinamide (niacinamide) and benzyl nicotinate, and alpha-hydroxy acids include lactic acid, malic acid, succinic acid, citric acid, and alpha-hydroxyoctanoic acid.

[0039] Furthermore, the following animal, plant, or microorganism-derived ingredients can also be used in combination: for example, collagen or its hydrolysates, yeast extracts or hydrolysates, lactic acid bacteria cultures, grasses, cruciferous plants, camellias, roses, peonyes, citrus plants, amaranthaceae plants, eelgrasses, legumes, daisies, legumes, mallows, gentians, mints, lotus, cucurbits, Araliaceae plants, nightshades, bignoniaceae plants, Actinidiaceae plants, mulberries, irises, bellflowers, olives, Actinidiaceae plants, mulberries, rhamnoides, orchids, and sumac. Examples include extracts or hydrolyzed or fermented products thereof from one or more plants selected from the families of plants, Garcinia, Valenciaceae, Rutaceae, Myrtaceae, Liliaceae, Crassulaceae, Cupressaceae, Convolvulaceae, and Asparagaceae; extracts or hydrolyzed or fermented products thereof from one or more seaweeds selected from the families of Laminariaceae, Mylinaceae, and Ulvaceae; jellyfish (autolyzed products of moon jellyfish, Echizen jellyfish, etc.); hydrolyzed or fermented products of hyaluronic acid; and extracts or hydrolyzed or fermented products thereof from royal jelly.

[0040] As plant-derived components from the grass family, rice leaf hydrolysate, rice extract hydrolysate, rice bran extract hydrolysate, germinated brown rice hydrolysate, rice ferment filtrate, sake lees extract derived from sake, bamboo shoot peel extract of Madake or Moso bamboo, and adlay seed ferment. As plant-derived components from the Brassicaceae family, extracts or hydrolysates or fermentations thereof of the seeds of Hakugai, Ougai, or Kokugai are particularly preferred. As plant-derived components from the Camellia family, green tea (Yabukita, Samidori, Asahi, Gokou, Ujimidori, Kyomidori, Ujihikari, Samidori, Benifuki, etc.) and black tea (Darjeeling, Assam, Ceylon, Earl Grey, Honey Black Tea, etc.) are particularly preferred. As plant-derived components from the Rosaceae family, extracts of Damask rose flowers, peach flowers, leaves, or immature fruits, apricot fruit or seed extracts, strawberry flower extracts, and cherry blossom or leaf extracts are preferred. Furthermore, as ingredients derived from Paeoniaceae plants, extracts of peony root or flower, and peony flower or root are preferred. As ingredients derived from Amaranthaceae plants, glasswort extract is particularly preferred. As ingredients derived from Zosteraceae plants, eelgrass or dwarf eelgrass extract is particularly preferred. As ingredients derived from Fabaceae plants, extracts of white soybeans or black soybeans or their hydrolysates or fermented soy milk liquid, adzuki bean extract, red clover extract, and kudzu root extract are particularly preferred. As ingredients derived from Asteraceae plants, burdock root extract, sunflower sprout extract, starflower extract, arnica extract, or chamomile flower extract are particularly preferred. As ingredients derived from Malvaceae plants, fermented products of hibiscus, rose of Sharon, or hibiscus are preferred. As ingredients derived from Gentianaceae plants, gentian extract is preferred. As ingredients derived from Lamiaceae plants, green perilla extract and purple beautyberry fruit extract are preferred. As for ingredients derived from Nelumbonaceae plants, lotus flower or lotus seed extract or lotus seed ferment is particularly preferred. As for ingredients derived from Cucurbitaceae plants, loofah extract is particularly preferred. As for ingredients derived from Araliaceae plants, ginseng extract or ferment is preferred. As for ingredients derived from Solanaceae plants, eggplant (long eggplant, water eggplant, American eggplant, Kamo eggplant, etc.) extract is an example. As for ingredients derived from Bignoniaceae plants, Pau d'arco bark extract is preferred. As for ingredients derived from Actinidiaceae plants, immature kiwi extract is preferred.Preferred ingredients from the Moraceae family include mulberry bark extract, mulberry fruit extract, and fig fruit or bark extract. Preferred ingredients from the Rhamnaceae family include jujube fruit extract. Preferred ingredients from the Iridaceae family include saffron. Preferred ingredients from the Campanulaceae family include root extract or hydrolysate of Codonopsis lanceolata. Preferred ingredients from the Anacardiaceae family include mango fruit extract. Preferred ingredients from the Garciniaaceae family include mangosteen fruit extract. Preferred ingredients from the Valenciaceae family include cherimoya fruit extract. Preferred ingredients from the Rutaceae family include Satsuma mandarin, bergamot fruit extract, grapefruit or pomelo fruit (including immature fruit), extracts containing flavonoids and their glycosides found in plants such as grapefruit or hassaku, or sansho seed extract. As ingredients derived from lily-family plants, extracts of Hemerocallis middendorffii, Hemerocallis fulva, Casablanca lily, Madonna lily, or Lilium japonicum are preferred. As ingredients derived from crasliaceae plants, extracts or fermented products of Rhodiola rosea are particularly preferred. As ingredients derived from olive-family plants, extracts of jasmine flowers are particularly preferred. As ingredients derived from cypress-family plants, extracts of Juniperus chinensis fruit are particularly preferred. As ingredients derived from myrtaceae plants, extracts of guava leaf are particularly preferred. As ingredients derived from orchids, extracts of Bletilla striata root are particularly preferred. As ingredients derived from morning glory-family plants, extracts or fermented products thereof of sweet potato, or extracts or fermented products thereof of sweet potato shochu lees are preferred. As ingredients derived from lamibariaceae seaweed, extracts of kelp are particularly preferred, as ingredients derived from miltiorrhiza, extracts of Sargassum fuciformis are preferred, and as ingredients derived from Ulvaceae seaweed, extracts of Ulva lactuca are particularly preferred. As for components derived from seaweed of the family *Sargassum*, *Sargassum* extract is particularly preferred.

[0041] Next, the present invention will be described in more detail with reference to manufacturing examples, formulation examples, and test examples, but the present invention is not limited thereto. In the following, all parts refer to parts by weight, and all percentages refer to weight percent.

[0042] Manufacturing Example 1. Preparation of White Asparagus Extract (1) 100g of dried stems of white asparagus (Sesamum indicum), a plant belonging to the genus Sesamum in the family Asparagaceae, were added to 750g of purified water and extracted at 70°C for 2 hours. Then, 750g of a mixed solvent of purified water and 1,3-butylene glycol was added and extracted for 72 hours. Insoluble matter was removed by filtration to obtain 1560g of brown white asparagus stem extract (solid content concentration 0.95%).

[0043] Manufacturing Example 2. Preparation of White Asparagus Extract (2) 100g of dried stems of white asparagus (Asparagus officinalis), a plant belonging to the genus Asparagus in the family Asparagaceae, were added to 750g of purified water. After extraction at 70°C for 2 hours, insoluble matter was removed by filtration to obtain 1578g of brown white asparagus stem extract (solid content concentration 0.98%).

[0044] Manufacturing Example 3. Preparation of White Asparagus Extract (3) 100g of dried stems of white asparagus (Asparagus officinalis), a plant belonging to the genus Asparagus in the family Asparagaceae, were mixed with 750g of purified water and heated at 121°C. Further extraction was performed using purified water and 750g of 1,3-butylene glycol for 72 hours, followed by treatment with activated carbon. After treatment, insoluble matter was removed by filtration to obtain 1578g of brown white asparagus stem extract (solid content concentration 1.02%).

[0045] Manufacturing Example 4. Preparation of White Asparagus Extract (4) 100g of dried stems of white asparagus (Asparagus officinalis), a plant belonging to the genus Asparagus in the family Asparagaceae, were mixed with 750g of purified water and heated at 121°C. Further extraction was performed using purified water and 750g of 1,3-butylene glycol for 72 hours, followed by treatment with an ion exchange resin. After treatment, insoluble matter was removed by filtration to obtain 1578g of brown white asparagus stem extract (solid content concentration 1.01%).

[0046] Comparative manufacturing example 1. Preparation of green asparagus extract (1) 100g of dried stems of green asparagus (Asparagus officinalis), a plant belonging to the genus Asparagus in the family Asparagaceae, were mixed with 750g of purified water and heated at 121°C. Further extraction was performed using purified water and 750g of 1,3-butylene glycol for 72 hours, followed by treatment with activated carbon. After treatment, insoluble matter was removed by filtration to obtain 1492g of brown green asparagus stem extract (solid content concentration 1.10%).

[0047] Test Example 1: Protective Effect of Occuludin Normal human epidermal cells were subjected to 0.8 × 10⁶ growth in HuMediaKG2 [Kurabo Corporation] containing a growth additive. 5The culture medium was prepared at 100 μL per mL, seeded into a 96-well plate, and cultured at 37°C under 5% CO2 and saturated steam. After 4 days of culture, the supernatant was used to replace the culture medium in the 96-well plate with 100 μL of HuMediaKB2 [Kurabo Industries Ltd.] which does not contain growth additives. Culture was then performed using culture media containing extracts from Production Examples 1 and 3 (with extracts from Production Examples 1 and 3 added to the total culture medium to achieve final concentrations of 1.0% and 2.0% respectively) and culture media containing sodium dodecyl sulfate (with sodium dodecyl sulfate added to the total culture medium to achieve a final concentration of 20 μg / mL). Furthermore, as a control group, instead of the extracts from Production Examples 1 and 3, the sample solutions included a culture medium containing the extract from Comparative Production Example 1 (with the extract from Comparative Production Example 1 added so that the final concentrations as solution were 1.0% and 2.0% of the total culture medium volume), a culture medium containing sodium dodecyl sulfate (with sodium dodecyl sulfate added so that the final concentration as solution was 20 μg / mL of the total culture medium volume), and a culture medium containing only a 30% 1,3-butylene glycol aqueous solution (total culture medium volume Two control groups were established: a control group to which a 30% 1,3-butylene glycol solution (adjusted to a final concentration of 2.0%) was added, and a test group (sodium dodecyl sulfate treated control group) to which a culture medium containing only a 30% 1,3-butylene glycol aqueous solution (adjusted to a final concentration of 2% of the total culture medium) and a culture medium containing sodium dodecyl sulfate (sodium dodecyl sulfate was added to the total culture medium to a final concentration of 20 μg as a solution) was added. After 1 day of incubation, the culture supernatant was removed, and 200 μL of PBS(-) was added to remove it. Next, 50 μL of 15% neutral buffered formalin solution (Wako Pure Chemical Industries, Ltd.) was added to each group, and the culture was incubated at cold temperature for 30 minutes, after which the supernatant was removed. Subsequently, the culture was washed with 100 μL of PBS(-), and 50 μL of 0.2% Triton-X-containing PBS(-) was added to each group, and the culture was incubated at room temperature for 1 hour. The supernatant was removed, and 50 μL of Blocking One P (Nacalai Tesque) was added to each sample, followed by incubation at room temperature for 2 hours.The supernatant was removed and washed with 100 μL of PBS(-) containing 0.2% Triton-X. 50 μL of anti-Occuludin antibody (Life Span BioScience, Inc.) solution was added, and the mixture was incubated at cold temperature for 24 hours. The supernatant was removed, and the washing with 100 μL of PBS(-) containing 0.2% Triton-X was repeated three times. 50 μL of a mixture of Alexa Fluor 488 anti-mouse secondary antibody (Life Technologies) and Alexa Fluor 546 anti-rabbit secondary antibody (Life Technologies) was added, and the mixture was incubated at room temperature in the dark for 2 hours. The supernatant was removed, and the washing with 100 μL of PBS(-) containing 0.2% Triton-X was repeated five times. 100 μL of PBS(-) was added each time, and the fluorescence intensity on Ex485 / Em520 was measured using a fluorescence plate reader (Dainippon Pharmaceutical Co., Ltd.). Then, the amount of occuludin was calculated based on the fluorescence intensity of the test group and the control group, and the relative values ​​of each test group were shown with the amount of occuludin in the control group set to 100.

[0048] The results of Test Example 1 are shown in Table 1. [Table 1] JPEG0007872973000001.jpg83126

[0049] As shown in Table 1, although it was confirmed that sodium dodecyl sulfate, a surfactant, reduced occludin, a protein involved in the skin's barrier function, the extract according to the present invention was confirmed to have the effect of suppressing the damage to occludin caused by sodium dodecyl sulfate. On the other hand, this effect was not confirmed in comparative sample 1. From this, it is suggested that the extract according to the present invention protects the skin's barrier function from external stimuli and can provide preventive and ameliorative effects against rough skin, inflammation, atopic dermatitis, contact dermatitis, psoriasis, or seborrheic dermatitis.

[0050] Test Example 2. Evaluation Test of Claudin's Protective Efficacy Normal human epidermal cells were subjected to 0.8 × 10⁶ growth in HuMediaKG2 [Kurabo Corporation] containing a growth additive. 5The culture medium was prepared at 100 μL per mL, seeded into a 96-well plate, and cultured at 37°C under 5% CO2 and saturated steam. After 4 days of culture, the supernatant was used to replace the culture medium in the 96-well plate with 100 μL of HuMediaKB2 [Kurabo Industries Ltd.] which does not contain growth additives. Culture was then performed using the culture medium containing the extract from Production Example 2 (with extracts from Production Examples 1 and 3 added to the total culture medium to achieve final concentrations of 1.0% and 2.0% respectively) and the culture medium containing sodium dodecyl sulfate (with sodium dodecyl sulfate added to the total culture medium to achieve a final concentration of 20 μg / mL). Furthermore, as a comparative measure, instead of the extracts from Production Examples 1 and 3, the following samples were prepared: a culture medium containing the extract from Comparative Production Example 1 (with the extract from Comparative Production Example 1 added so that the final concentrations as solution were 1.0% and 2.0% of the total culture medium volume), a test section (comparative test section) containing sodium dodecyl sulfate (with sodium dodecyl sulfate added so that the final concentration as solution was 20 μg / mL of the total culture medium volume), a control section containing only a 30% 1,3-butylene glycol aqueous solution (with the final concentration of the 30% 1,3-butylene glycol solution adjusted to 2% of the total culture medium volume), and a culture medium containing only a 30% 1,3-butylene glycol aqueous solution (with the final concentration of the 30% 1,3-butylene glycol solution adjusted to 2% of the total culture medium volume). A test group (sodium dodecyl sulfate treated control group) was set up with a culture medium containing sodium dodecyl sulfate (sodium dodecyl sulfate added to the total volume of culture medium to a final concentration of 20 μg as solution). After 1 day of incubation, the culture supernatant was removed, and 200 μL of PBS(-) was added to each group to remove the supernatant. Next, 50 μL of 15% neutral buffered formalin solution (Wako Pure Chemical Industries, Ltd.) was added to each group, and the mixture was incubated at cold temperature for 30 minutes, after which the supernatant was removed. Then, the mixture was washed with 100 μL of PBS(-), and 50 μL of 0.2% Triton-X-containing PBS(-) was added to each group, and the mixture was incubated at room temperature for 1 hour. The supernatant was removed, and 50 μL of Blocking One P (Nacalai Tesque Corporation) was added to each group, and the mixture was incubated at room temperature for 2 hours.The supernatant was removed and washed with 100 μL of PBS(-) containing 0.2% Triton-X. 50 μL of anti-Claudin antibody (Bioworld Technology) solution was added, and the mixture was incubated at cold temperature for 24 hours. The supernatant was removed, and the washing with 100 μL of PBS(-) containing 0.2% Triton-X was repeated three times. 50 μL of a mixture of Alexa Fluor 488 anti-mouse secondary antibody (Life Technologies) and Alexa Fluor 546 anti-rabbit secondary antibody (Life Technologies) was added, and the mixture was incubated at room temperature in the dark for 2 hours. The supernatant was removed, and the washing with 100 μL of PBS(-) containing 0.2% Triton-X was repeated five times. 100 μL of PBS(-) was added each time, and the fluorescence intensity at Ex544 / Em590 was measured using a fluorescence plate reader (Dainippon Pharmaceutical Co., Ltd.). Then, the amount of Claudin was calculated based on the fluorescence intensity of the test group and the control group, and the relative values ​​of each test group were shown with the amount of Claudin in the control group set to 100.

[0051] The results of Test Example 2 are shown in Table 2. [Table 2] JPEG0007872973000002.jpg88126

[0052] As shown in Table 2, although it was confirmed that sodium dodecyl sulfate, a surfactant, reduces claudin, a protein involved in the skin's barrier function, the extract according to the present invention was confirmed to have the effect of suppressing damage to claudin caused by sodium dodecyl sulfate. On the other hand, this effect was not confirmed in comparative sample 1. From this, it is suggested that the extract according to the present invention 1 protects the skin barrier function from external stimuli and can provide preventive and ameliorative effects against rough skin, inflammation, atopic dermatitis, contact dermatitis, psoriasis, or seborrheic dermatitis.

[0053] Test Example 3. Evaluation Test of Water Retention Efficiency (i) Sample preparation Sample 1 of the present invention and comparative samples 1 and 2 were prepared with the following compositions. (1) Sample 1 of the present invention (cream) [component] Olive oil 5.0 Squalane 5.0 Jojoba oil 5.0 Jojoba wax 1.0 Shea butter 2.0 Behenyl alcohol 1.0 Stearyl alcohol 1.5 Candelilla wax 0.5 Extract from manufacturing example 3 2.0 Lactic acid fermented rice 3.0 Hydrogenated lecithin 2.0 Katamenkirinsai extract 2.0 Carboxyvinyl polymer 0.3 Sodium alginate 0.2 Glycerin 4.0 1,3-Butylene glycol 5.0 Methylparaben 0.1 Potassium hydroxide (appropriate amount) Purified water, in an amount that makes the total volume 100 parts (2) Comparative sample 1 (cream) [component] Olive oil 5.0 Squalane 5.0 Jojoba oil 5.0 Jojoba wax 1.0 Shea butter 2.0 Behenyl alcohol 1.0 Stearyl alcohol 1.5 Candelilla wax 0.5 1,3-Butylene glycol 5.6 Lactic acid fermented rice 3.0 Hydrogenated lecithin 2.0 Katamenkirinsai extract 2.0 Carboxyvinyl polymer 0.3 Sodium alginate 0.2 Glycerin 4.0 Methylparaben 0.1 Potassium hydroxide (appropriate amount) Purified water, in an amount that makes the total volume 100 parts (3) Comparative sample 2 (cream) [component] Olive oil 5.0 Squalane 5.0 Jojoba oil 5.0 Jojoba wax 1.0 Shea butter 2.0 Behenyl alcohol 1.0 Stearyl alcohol 1.5 Candelilla wax 0.5 Lactic acid fermented rice 3.0 Hydrogenated lecithin 2.0 Katamenkirinsai extract 2.0 Carboxyvinyl polymer 0.3 Sodium hyaluronate 0.02 Sodium alginate 0.2 Glycerin 4.0 1,3-Butylene glycol 5.0 Methylparaben 0.1 Potassium hydroxide (appropriate amount) Purified water, in an amount that makes the total volume 100 parts

[0054] (b) Test method The inner side of the left forearm of each subject (6 people in total: 4 men and 2 women, aged 20-50) was lightly washed with water. Next, a 1.5cm x 1.5cm test area was set up and acclimatized for 15 minutes in a room with constant temperature and humidity (20℃±2℃, 50%±5% humidity), and the initial stratum corneum moisture content was measured. From the following day, a skin irritation treatment with a 0.1% sodium lauryl sulfate aqueous solution was performed on the test area at 9:00 and 17:00. A 1.5cm x 1.5cm filter paper was placed on each test area, and a 0.1% SDS aqueous solution was dropped onto the entire filter paper to moisten it. This was left to stand for 3 minutes, after which the filter paper was removed and the area was lightly washed with water. After washing, Sample 1 of the present invention, and as comparison subjects, Comparative Sample 1 and Comparative Sample 2 were applied to the respective test areas. After 3 weeks, the inner side of the left forearm of each subject was lightly washed with water, acclimatized in the same manner as described above, and the stratum corneum moisture content was measured. The results were calculated using the average value of the change from an initial value of 0 for the six subjects.

[0055] The test results for Test Example 3 are shown in Table 3. [Table 3] JPEG0007872973000003.jpg45135

[0056] As shown in Table 3, Sample 1 of the present invention was confirmed to have a significant effect in improving the moisture content of the stratum corneum of skin that had become rough due to external stimuli. The effect of the extract according to the present invention was higher than that of comparative sample 1 which did not contain the extract according to the present invention, and it was also confirmed to be more effective than comparative samples which contained sodium hyaluronate, a known moisturizing ingredient, instead of the extract according to the present invention.

[0057] Prescription example 1. Lotion [Ingredients] Part Eucalyptus oil 0.2 Polyoxyethylene (5.5) cetyl alcohol 5.0 Extract from Production Example 1 2.0 Tocopherol acetate 0.02 Dipotassium glycyrrhizinate 0.5 Monoammonium glycyrrhizinate 0.5 Stearyl glycyrrhetinate 0.05 Isopropylmethylphenol 0.1 Align In 0.1 D-Pantothenyl alcohol 0.1 Salicylic acid 0.5 Urea 5.0 l-menthol 0.9 dl-menthol 0.2 1,3-Butylene glycol 5.0 Sodium citrate 0.2 Methylparaben 0.1 Hinokitiol 0.003 Photosensor No. 201 0.002 Purified water, in an amount that makes the total volume 100 parts

[0058] Prescription example 2. Lotion A lotion was obtained with the same composition as in Formulation Example 1, except that 2.0 parts of the extract from Manufacturing Example 2 were added to the ingredients of Formulation Example 1 instead of the extract from Manufacturing Example 1.

[0059] Prescription example 3. Lotion [Ingredients] Part Glyceryl caprylate 3.0 Polyglyceryl-10 laurate 3.0 Cetanol 2.0 Behenyl alcohol 2.0 Methylparaben 0.1 Extract from manufacturing example 3 2.0 Ascorbic acid 3.0 Glycyrrhizic acid 0.5 β-Glycyrrhetinic acid 0.05 Tocopherol nicotinate 0.1 Resorcinol 0.1 Zinc oxide 2.0 dl-camphor 0.5 Glycerin 2.0 1,3-Butylene glycol 5.0 Potassium hydroxide 0.5 Purified water, in an amount that makes the total volume 100 parts

[0060] Prescription example 4. Lotion [Ingredients] Part Jojoba oil 1.0 Polyoxyethylene (5.5) cetyl alcohol 5.0 Methylparaben 0.1 Extract from manufacturing example 3 2.0 Ascorbic acid glucoside 2.0 Tranexamic acid 2.0 ε-aminocaproic acid 0.1 Sulfur 0.2 Estradiol 0.1 Glycerin 5.0 1,3-Butylene glycol 5.0 Sodium citrate 0.2 Sodium metabisulfite 0.2 d-camphor 0.1 Purified water, in an amount that makes the total volume 100 parts

[0061] Prescription example 5. Lotion A lotion was obtained with the same composition as in Formulation Example 1, except that 2.0 parts of the extract from Manufacturing Example 4 were added to the ingredients of Formulation Example 4 instead of the extract from Manufacturing Example 3.

[0062] Prescription example 6. Emulsion [Ingredients] Part Squalane 5.0 Cyclopentasiloxane 1.0 Hexaran 3.0 Hexyldecyl isostearate 1.0 Caprylic / Capric Triglyceride 1.0 Polyglyceryl-10 laurate 5.0 Polyglyceryl-10 isostearate 5.0 Ascorbyl dipalmitate 15.0 Hydrogenated soy lecithin 1.5 Extract from manufacturing example 3: 1.0 Magnesium ascorbic acid phosphate salt 3.0 Arbutin 3.0 Potassium hydroxide 0.5 Glycerin 3.0 1,3-Butylene glycol 2.0 Carboxymethylcellulose 0.3 Xanthan gum 0.2 Tremella fuciformis polysaccharide 0.2 Sodium hyaluronate 0.01 Tocopherol acetate 0.3 Tocopherol nicotinate 0.1 Glycyrrhizic acid 0.1 Dipotassium glycyrrhizinate 0.1 Isopropylmethylphenol 0.1 Water-soluble collagen 1.0 Hydrolyzed collagen 1.0 Sodium hyaluronate 1.0 Purified water, in an amount that makes the total volume 100 parts

[0063] Prescription example 7. Emulsion An emulsion was obtained with the same composition as in Formulation Example 6, except that 2.0 parts of L-ascorbic acid-2-glucoside were used instead of 2.0 parts of magnesium ascorbic acid phosphate in Formulation Example 6.

[0064] Prescription example 8. Emulsion An emulsion was obtained with the same composition as in Formulation Example 6, except that 2.0 parts of tranexamic acid were used instead of 2.0 parts of magnesium ascorbic acid phosphate and 0.5 parts of potassium hydroxide in the components of Formulation Example 6.

[0065] Prescription example 9. Emulsion An emulsion was obtained with the same composition as in Formulation Example 6, except that 3.0 parts of nicotinamide were used instead of 2.0 parts of magnesium ascorbic acid phosphate and 0.5 parts of potassium hydroxide in Formulation Example 6.

[0066] Prescription example 10. Cream [Ingredients] Part Olive oil 5.0 Jojoba oil 5.0 Squalane 5.0 Hexyldecyl isostearate 5.0 Lauroyl glutamate di(octyldodecyl / phytosteryl / behenyl) 5.0 Glyceryl caprylate 1.0 Glyceryl stearate 1.0 Isostearyl glyceryl 3.0 γ-oryzanol 0.1 Behenyl alcohol 2.0 Palmitic acid 2.5 D-Panthenyl alcohol 3.0 Allantoin 0.1 Riboflavin 0.01 Resorcinol 0.1 Benzalkonium chloride 0.05 Urea 3.0 β-Glycyrrhetinic acid 0.1 Stearyl glycyrrhetinate 0.1 Ammonium glycyrrhizinate 0.1 Extract from Production Example 1 2.0 Lactic acid fermented rice 2.0 Hydrogenated lecithin 0.5 Hydrogenated lysolecithin 0.5 Oil-soluble ginseng extract 2.0 Xanthan gum 1.0 Zinc oxide 0.5 dl-camphor 0.3 l-menthol 0.5 Purified water, in an amount that makes the total volume 100 parts

[0067] Example 11. Pack [Ingredients] Part Dipropylene glycol 5.0 Polyoxyethylene (60) hydrogenated castor oil 5.0 Cetanol 3.0 Behenyl alcohol 3.0 Allantoin 0.1 Dipotassium glycyrrhizinate 0.1 Ammonium glycyrrhizinate 0.1 β-Glycyrrhetinic acid 0.1 Stearyl glycyrrhetinate 0.1 Salicylic acid 0.1 Tocopherol acetate 0.5 Tocopherol nicotinate 0.1 D-Pantothenyl alcohol 0.3 Resorcinol 0.1 Sulfur 2.0 Estradiol 0.002 Extract from manufacturing example 3: 1.0 Xanthan gum 2.0 Polyglyceryl-6 myristate 1.0 Potassium cocoyl glutamate 1.0 Hydrogenated lecithin 3.0 Hydroxylated lecithin 3.0 Purified water, in an amount that makes the total volume 100 parts

[0068] Prescription Example 12: Hair Shampoo [Ingredients] Part Sodium laureth sulfate 10.0 Glyceryl monostearate 1.0 Coconut oil fatty acid diethanolamide 2.0 Polyoxyethylene (40) hydrogenated castor oil 0.5 Benzalkonium chloride 1.0 Stearyl alcohol 2.0 Behenyl alcohol 2.0 Dimethicone 3.0 Extract from manufacturing example 3 2.0 Allantoin 0.1 Dipotassium glycyrrhizinate 0.1 Salicylic acid 0.1 Sodium salicylate 0.1 Tocopherol acetate 0.1 Pyrithione Zinc 0.3 Benzoic acid 0.2 Triclosan 0.2 Citric acid 0.1 Propylene glycol 2.0 Purified water, in an amount that makes the total volume 100 parts

[0069] Example 13. Hair Conditioner [Ingredients] Part Polyoxyethylene (10) hydrogenated castor oil 1.0 Distearyldimethylammonium chloride 1.5 Stearyltrimethylammonium chloride 2.0 Glyceryl 2-ethylhexanoate 1.0 Benzalkonium chloride 1.0 Cetanol 3.0 Stearyl alcohol 1.0 Extract from manufacturing example 3 2.0 Allantoin 0.1 Isopropylmethylphenol 0.1 Dipotassium glycyrrhizinate 0.1 Salicylic acid 0.1 Sulfur 0.5 Alkylisoquinolinium bromide solution (75%) 0.06 Pyrithione Zinc 0.3 Methylparaben 0.1 Triclosan 0.2 Resorcinol 0.1 Purified water, in an amount that makes the total volume 100 parts

[0070] Prescription Example 14. Cleansing Cosmetics [Ingredients] Part Potassium cocoyl glycine 5.0 Glycerin 10.0 Glyceryl caprylate 1.0 Sodium lauroyl aspartate 10.0 Extract from Production Example 1: 1.0 Cetanol 3.0 Myristyl alcohol 3.0 Isopropylmethyl alcohol 0.1 Allantoin 0.1 Sulfur 0.5 Glycyrrhizic acid 0.1 Dipotassium glycyrrhizinate 0.1 Monoammonium glycyrrhizinate 0.1 β-Glycyrrhetinic acid 0.05 Stearyl glycyrrhetinate 0.1 Salicylic acid 0.2 Tocopherol acetate 0.2 Triclosan 0.1 Trichlorocarbanide 0.5 Trichlorohydroxydiphenyl ether 0.2 Concentrated benzalkonium chloride solution 50 0.2 Benzalkonium chloride 0.1 Purified water, in an amount that makes the total volume 100 parts

[0071] Prescription Example 15: Sheet Mask A sheet mask is obtained by impregnating a nonwoven fabric with the following ingredients. [Ingredients] Part Extract from manufacturing example 3 2.0 Glycerin 3.0 1,3-Butylene glycol 2.0 L-ascorbic acid 2-glucoside 2.0 Methylparaben 0.2 Citric acid 0.1 Sodium citrate 0.3 Xanthan gum 1.0 Water-soluble collagen 1.0 Sodium hyaluronate 1.0 Seagrass extract 1.0 Rice extract hydrolyzate 1.0 Potassium hydroxide (appropriate amount) Purified water, in an amount that makes the total volume 100 parts

[0072] Prescription Example 16: Serum [Ingredients] Part Ethanol 2.0 Glycerin 5.0 1,3-Butylene glycol 5.0 Methylparaben 0.1 Hyaluronic acid hydrolysate 1.0 Lactic acid bacteria culture 1.0 Extract from manufacturing example 3 2.0 Citric acid 0.3 Sodium citrate 0.6 Purified water, in an amount that makes the total volume 100 parts

Claims

1. An epidermal barrier function maintenance agent containing an extract of white asparagus water or a mixed solvent of water and polyhydric alcohol as an active ingredient.

2. A humectant containing an extract of white asparagus water or a mixed solvent of water and polyhydric alcohol as an active ingredient.

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