Protease activity sensors and methods of using the same
Asymmetric bi-labile cyclic peptide nanoparticles with AND-gate logic enhance protease detection specificity by requiring simultaneous protease activity, addressing the limitations of existing biocircuit technologies and improving tumor antigen sensing and immune response monitoring.
WO2026085494A2 Publication Date: 2026-04-23GEORGIA TECH RES CORP +3
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Patent Information
- Application Number
- PCT/US2025/051553
- Authority / Receiving Office
- WO · WO
- Patent Type
- Applications
- Current Assignee / Owner
- Priority Date
- 2024-10-17
- Filing Date
- 2025-10-17
- Publication Date
- 2026-04-23
AI Technical Summary
Technical Problem
Existing biocircuit technologies for protease detection in cells lack specificity and sensitivity, particularly in distinguishing between different proteases and requiring co-localized proteases for accurate detection.
Method used
Development of protease activity sensors with asymmetric bi-labile cyclic peptides anchored to nanoparticles, implementing AND-gate logic that require simultaneous cleavage by two different proteases for activation, enhancing specificity and sensitivity.
Benefits of technology
The sensors provide precise detection of multiple proteases by requiring co-localized protease activity, improving specificity and reducing false positives, and are applicable in biomedical applications such as tumor antigen sensing and immune response monitoring.
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