Stable synergistic pesticidal composition

Abstract

The present invention relates to a stable synergistic pesticidal composition comprising A) a compound of Formula I, i.e., 2,4-dioxo-1-(pyrimidin-5-ylmethyl)-3-[3-trifluoromethyl)phenyl] -3,4-dihydro-2H-pyrido[1,2-a] pyrimidin-1-ium-3-ide or its agrochemically acceptable salts, esters and derivatives; B) acompound of Formula IT, i.e., N-methyl-N-nitro-N- [(tetrahydro-3-furanyl)methyl] guanidine or its agrochemically acceptable salts, esters and derivatives; and C) at least one strobilurin fungicide selected from pyraclostrobin, or trifloxystrobin, or picoxystrobin or its agrochemically acceptable salts, esters or its derivatives for effective control of various pests including but not limited to insect-pests, aphids, thrips etc. and a wide range of fungal pathogens and their associates diseases. Further, the present invention also relates to a process for preparation of such pesticidal composition for synergistic and efficacious control of various pests including insects-pests and fungal pathogens and their associated diseases.

Description

[0001] “STABLE SYNERGISTIC PESTICIDAL COMPOSITION”

[0002] FIELD OF THE INVENTION

[0003] The present invention relates to a stable synergistic pesticidal composition comprising A) a compound of Formula I, i.e., 2,4-dioxo-l-(pyrimidin-5-ylmethyl)-3-[3-trifluoromethyl)phenyl]- 3,4-dihydro-2H-pyrido[l,2-a]pyrimidin-l-ium-3-ide or its agrochemically acceptable salts, esters and derivatives; B) a compound of Formula II, i.e., N-methyl-N'-nitro-N"-[(tetrahydro-3-furanyl)methyl]guanidine or its agrochemically acceptable salts, esters and derivatives; and C) at least one strobilurin fungicide selected from pyraclostrobin, or trifloxystrobin, or picoxystrobin or its agrochemically acceptable salts, esters or its derivatives for effective control of various pests including but not limited to insect-pests, aphids, thrips etc. and a wide range of fungal pathogens and their associates diseases. Further, the present invention also relates to a process for preparation of such pesticidal composition for synergistic and efficacious control of various pests including insects -pests and fungal pathogens and their associated diseases.

[0004] BACKGROUND OF THE INVENTION

[0005] The increasing global population has led to an unprecedented demand for agricultural production. Further, modern crop production increasingly faces severe challenges due to infestation of combination of pests such as sap-feeding insect pests, plant- and leaf-hoppers, alongside fungal pathogens that proliferate under favourable environmental conditions. Consequently, the use of pesticides has become an indispensable need in agriculture to ensure higher yield, crop protection from pests, non-target effects, rapid environmental degradation, and inability of single mode active ingredients to address multi-pest infestations effectively.

[0006] However, the use of individual insecticidal and fungicidal compounds is well-established, their effectiveness is frequently undermined by pest resistance, non-target effects, rapid environmental degradation, and the inability of single -mode agents to address multi-pest infestations effectively. One major issue is the development of pest resistance; continuous application of a specific pesticide can lead to the emergence of resistant pest populations, rendering that pesticide ineffective over time. This phenomenon not only undermines pest management efforts but also contributes to the economic burden on farmers who must seek alternative solutions. Moreover, conventional pesticides can have detrimental effects on non-target organisms, including beneficial insects, wildlife, and human health. These concerns have prompted industry, farmers and consumers to seek alternatives that are both effective and environmentally friendly. Further, these limitations have driven the agrochemical industry to explore new strategies capable of delivering broad-spectrum, long-lasting control with reduced environmental impact. One such strategy involves employing synergistic combinations of pesticidal compounds wherein two or more active ingredients complement each other’s mode of action, thereby enhancing biological performance while reducing application rates and mitigating toxicity concerns. Such combinations are particularly valuable when they merge insecticides targeting different receptor pathways with fungicides that disrupt fungal respiration, resulting in multi -target activity against complex pest populations.

[0007] In line with the evolving needs, it is recognized that relying solely on single-mode insecticides or fungicides is often insufficient to achieve sustainable control of pest’s complex comprising insectpests and fungal pathogens. Therefore, the present invention discloses a synergistic stable pesticidal composition that could deliver rapid knock-down of insect-pests, strong suppression of fungal pathogens, and effective against all life stages of pests, and ensures reduced risk of resistance, and improved crop health.

[0008] Therefore, a stable synergistic pesticidal composition of the present invention aims to overcome the problems of the prior art and provides a stable synergistic pesticidal composition comprising bioactive amounts of comprising;

[0009] A compound of Formula I chemically known as 2,4-dioxo-l-(pyrimidin-5-ylmethyl)-3-[3- trifhioromethyl)phenyl]-3,4-dihydro-2H-pyrido[l,2-a]pyrimidin-l-ium-3-ide, is a fast-acting mesoionic insecticide. It inhibits the nicotinic acetylcholine receptor (nAChR), it shifts most nAChRs to a desensitized state, making them unable to respond to acetylcholine, the endogenous neurotransmitter. This reduces nervous system activity, resulting in lethargic poisoning. It is used for control of Rice hoppers (e.g. Nilaparvata lugens, Sogatella frucif era), Leafhoppers; Aphids and Cockroaches in Paddy & Rice etc.

[0010] While a compound of Formula II chemically known as N-methyl-N'-nitro-N"-[(tetrahydro-3- furanyl)methyl]guanidine is a neonicotinoid insecticide offers rapid and systemic control of a wide range of insects including but not limited to sap feeding insects. It is used to control a wide range of sucking pests by binding to nicotinic receptors in an insect's central nervous system, which overstimulates the receptors. This causes the insect's neurons to fire continuously, leading to paralysis and death. It is effective against pests such as but not limited to Whiteflies; Mealybugs; Thrips; Plant hoppers; Leafminers; Aphids, etc. It is suitable to use on crops such as Vegetables; Fruits; Turf; Rice crops; etc.

[0011] Further, strobilurin fungicides deliver potent Qol mediated disease control. Qol fungicides are excellent as preventive fungicides, because they all effectively kill germinating spores. All Qol fungicides share a common biochemical mode of action: they all interfere with energy production in the fungal cell. They block electron transfer at the site of quinol oxidation (the Qo site) in the cytochrome bcl complex, thus preventing ATP formation. These fungicides control an unusually wide array of fungal diseases, including diseases caused by water molds, downy mildews, powdery mildews, leaf spotting and blighting fungi, fruit rotters, and rusts. They are used on a wide variety of crops, including cereals, field crops, fruits, tree nuts, vegetables, turfgrasses, and ornamentals.

[0012] Various strobilurin fungicides are known in the art. They are also categorised as systemic and translaminar strobilurin fungicides. Each of the strobilurin fungicide has different effective activity against fungal pests. Out of the known strobilurin fungicides, the effective strobilurin fungicides are Pyraclostrobin, Trifloxystrobin, and Picoxystrobin as they have shown to have better fungal disease control in comparison to other strobilurin fungicides

[0013] Pyraclostrobin is broad-spectrum strobilurin used to control major plant pathogens in cereals and other crops. Pyraclostrobin works by inhibiting mitochondrial respiration, which disrupts cellular biochemical processes and stops fungal growth. Further, Trifloxystrobin is a strobilurin that works by interfering with the respiration of plant-pathogenic fungi. It does this by blocking the mitochondrial electron transport chain and inhibiting the production of energy in fungi. Moreover, Picoxystrobin’ s mode of action is to inhibit mitochondrial respiration in fungal cells by blocking electron transfer at the Qo centre of cytochrome bcl.

[0014] However, none of the prior art teaches or suggests that these structurally and functionally distinct actives — each operating through independent biological pathways — could be effectively coformulated in a single, stable composition. Therefore, the composition of present invention comprising the Compound of Formula I, the Compound of Formula II, and a strobilurin fungicide achieves (i) concurrent control of multiple pest classes, including but not limited to insect pests and fungal pathogens, (ii) improve overall crop health and vigour, and (iii) unexpectedly deliver synergistic biological efficacy. The present invention composition thus, provides enhanced and non-obvious technical effects not predictable from the individual actives or their known uses.

[0015] Thus, a stable synergistic pesticidal composition of the present invention aims to overcome the problems of the prior art and provides a stable synergistic pesticidal composition comprising comprising A) a compound of Formula I, i.e., 2,4-dioxo-l-(pyrimidin-5-ylmethyl)-3-[3- trifluoromethyl)phenyl] -3 ,4-dihydro-2H-pyrido [ 1 ,2-a]pyrimidin- 1 -ium-3 -ide or its agrochemically acceptable salts, esters and derivatives; B) a compound of Formula II, i.e., N- methyl-N'-nitro-N"-[(tetrahydro-3-furanyl)methyl]guanidine or its agrochemically acceptable salts, esters and derivatives; and C) at least one strobilurin fungicide selected from pyraclostrobin, or trifloxystrobin, or picoxystrobin or its agrochemically acceptable salts, esters or its derivatives for synergistic and effective control of various pests and wide range of pesticidal diseases.

[0016] The present invention satisfies the existing needs, as well as others, and generally overcomes the deficiencies found in the prior art. The synergistic pesticidal composition of the present invention is synergistic, efficacious, environmentally friendly, simple to formulate, stable and is safe to use.

[0017] The present invention also provides a novel method of preparing composition of present invention, which is stable as well as provide desired bio-efficacy, synergy. Embodiments of the present invention may therefore ameliorate one or more of the above-mentioned problems.

[0018] OBJECTIVES AND ADVANTAGES OF THE INVENTION

[0019] The principal objective of the present invention is to provide a novel and effective stable synergistic pesticidal composition that exhibits high efficacy and stability, providing comprehensive protection for crops and plants against a wide range of pests, including insect pests, fungus etc. responsible for various diseases caused by such pests.

[0020] Another objective of the present invention is to provide selective effectiveness while significantly reducing adverse effects on non-target organisms, particularly beneficial species, thus promoting ecological balance. Yet another objective of the present invention is to provide improved, stable and ready to use pesticidal composition that demonstrates superior synergistic efficacy compared to existing formulations, mixtures or compositions ensuring improved pest control.

[0021] It is yet another objective of the present invention to ensure effective management of pests by developing an improved broad spectrum stable synergistic pesticidal composition. Yet another objective of the present invention to provide a novel and effective stable synergistic pesticidal composition effectively targeting all life stages of major plant pathogens and promoting overall plant health and crop yield.

[0022] It is yet another objective of the present invention to provide a method and a stable synergistic pesticidal composition for controlling pests including insect-pests and fungal pathogens and diseases associated with such pests.

[0023] Yet another objective of the present invention is to provide a stable synergistic pesticidal composition and method for controlling various pests including sucking pests and fungi including associated diseases in plants, crops and plant propagation materials. Another objective of the present invention is to provide one shot application of novel and effective synergistic pesticidal composition for killing / controlling highly resistant pests including insect pests and fungus at lower application rates.

[0024] It is another objective of the present invention to provide a novel and effective synergistic pesticidal composition which is environmentally safe, possesses broad spectrum bio-efficacy, is non-phytotoxic and has improved stability during the desired shelf life at various temperature and pH conditions and has enhanced efficacy and penetration capacity and is economically more beneficial.

[0025] It is another objective of the present invention to provide a novel and effective stable synergistic pesticidal composition which further comprises additives, inert ingredients and / or adjuvants, for providing the enhanced stability, enhanced permeability, improved penetration capacity, uniform spray-ability, improved rain-fastness, enriched biotic factors, better flowability, enhanced spreading or coverage effect, effective storage stability, longer residual effect, improved uptake of active ingredients, and safer to the environment attributes to the composition of present invention.

[0026] It is another objective of the present invention is to provide a stable synergistic pesticidal composition that protects crop and the environmental damage. It is another objective of the present invention is to provide a novel and effective stable synergistic pesticidal composition that improves germination rate, increased plants stand count and plant health, which results in higher yield.

[0027] Another objective of the present invention is to provide a stable synergistic pesticidal composition comprising A) a compound of Formula I, i.e., 2,4-dioxo-l-(pyrimidin-5-ylmethyl)-3-[3- trifluoromethyljphenyl] -3 ,4-dihydro-2H-pyrido [ 1 ,2-a]pyrimidin- 1 -ium-3 -ide or its agrochemically acceptable salts, esters and derivatives; B) a compound of Formula II, i.e., N- methyl-N'-nitro-N"-[(tetrahydro-3-furanyl)methyl]guanidine or its agrochemically acceptable salts, esters and derivatives; and C) at least one strobilurin fungicide selected from pyraclostrobin, or trifloxystrobin, or picoxystrobin or its agrochemically acceptable salts, esters or its derivatives

[0028] Yet another objective of the present invention is to provide a process for the preparation of a stable synergistic pesticidal composition comprising 2,4-dioxo-l-(pyrimidin-5-ylmethyl)-3-[3- trifluoromethyljphenyl] -3 ,4-dihydro-2H-pyrido [ 1 ,2-a]pyrimidin- 1 -ium-3 -ide or its agrochemically acceptable salts, esters and derivatives; B) a compound of Formula II, i.e., N- methyl-N'-nitro-N"-[(tetrahydro-3-furanyl)methyl]guanidine or its agrochemically acceptable salts, esters and derivatives; and C) at least one strobilurin selected from pyraclostrobin, or trifloxystrobin, or picoxystrobin or its agrochemically acceptable salts, esters or its derivatives.

[0029] Some or all these and other objects of the invention can be achieved by way of the invention described hereinafter.

[0030] ADVANTAGES:

[0031] 1. The stable synergistic pesticidal composition is effective in protecting a wide range of crops, including fruits, vegetables, cereals, flowers and seeds against major plant diseases and shows no phytotoxicity effect and provide a stable synergistic pesticidal composition that shows technical advancement over the existing combination of pesticides and also proves to has an improved rain fastness. 2. The stable synergistic pesticidal composition ensures better control of plant / crop in a shorter period of time and shows to have decrease chances of resistance against pests associated diseases and shows to have an improved stability during the desired shelf life and promotes plant health and increases plant yield in the field.

[0032] 3. The stable synergistic pesticidal composition improves germination rate, increased plant stand count, lower cost of application, better cost-benefit ratio to the end user, reduced wear of equipment and loss caused by mechanical damage to the crop and soil.

[0033] 4. The stable synergistic pesticidal composition of the present invention results in significant lowering the count of pests such as rice hoppers (e.g., Nilaparvata lugens, Sogatella frucifera), leafhoppers, aphids, cockroaches, sucking pests, whiteflies, etc. The stable synergistic pesticidal composition of the present invention further helps in control of certain foliar, stem and root diseases by lowering count of pests such as Alternaria, Black root, Black spot, Botrytis, Downy mildew, etc. and resulted in significantly lower incidence of pesticidal diseases in various crops such as Rice, Vegetables including carrots, asparagus, cucurbits, vining peas, etc.

[0034] SUMMARY OF THE INVENTION

[0035] Accordingly, the main aspect of the present invention is to provide a stable synergistic pesticidal composition having high pests control efficacy.

[0036] Accordingly, the present invention relates to a stable synergistic pesticidal composition comprising:

[0037] A) Compound of Formula I, i.e., 2,4-dioxo-l-(pyrimidin-5-ylmethyl)-3-[3- trifluoromethyl)phenyl] -3 ,4-dihydro-2H-pyrido[ 1 ,2-a]pyrimidin- 1 -ium-3 -ide or its agrochemically acceptable salts, esters and derivatives;

[0038] B) Compound of Formula II, i.e., N-methyl-N'-nitro-N"-[(tetrahydro-3- furanyl)methyl]guanidine or its agrochemically acceptable salts, esters and derivatives; and

[0039] C) At least one strobilurin fungicide selected from Pyraclostrobin, Trifloxystrobin, or Picoxystrobin or its agrochemically acceptable salts, esters or its derivatives. In another aspect, the present invention provides a stable synergistic pesticidal composition comprising:

[0040] A) Compound of Formula I, i.e., 2,4-dioxo-l-(pyrimidin-5-ylmethyl)-3-[3- trifluoromethyl)phenyl] -3 ,4-dihydro-2H-pyrido[ 1 ,2-a]pyrimidin- 1 -ium-3 -ide or its agrochemically acceptable salts, esters and derivatives;

[0041] B) Compound of Formula II, i.e., N-methyl-N'-nitro-N"-[(tetrahydro-3- furanyl)methyl]guanidine or its agrochemically acceptable salts, esters and derivatives;

[0042] C) At least one strobilurin fungicide selected from Pyraclostrobin, Trifloxystrobin, or Picoxystrobin or its agrochemically acceptable salts, esters or its derivatives; and

[0043] D) One or more agrochemically acceptable excipients.

[0044] In another aspect, the present invention provides a stable synergistic pesticidal composition comprising:

[0045] A) Compound of Formula I, i.e., 2,4-dioxo-l-(pyrimidin-5-ylmethyl)-3-[3- trifluoromethyl)phenyl] -3 ,4-dihydro-2H-pyrido[ 1 ,2-a]pyrimidin- 1 -ium-3 -ide or its agrochemically acceptable salts, esters and derivatives;

[0046] B) Compound of Formula II, i.e., N-methyl-N'-nitro-N"-[(tetrahydro-3- furanyl)methyl]guanidine or its agrochemically acceptable salts, esters and derivatives;

[0047] C) At least one strobilurin fungicide selected from Pyraclostrobin, Trifloxystrobin, or Picoxystrobin or its agrochemically acceptable salts, esters or its derivatives; and

[0048] D) At least one or more additive.

[0049] In one another aspect, the present invention provides a stable synergistic pesticidal composition comprising:

[0050] A) Compound of Formula I, i.e., 2,4-dioxo-l-(pyrimidin-5-ylmethyl)-3-[3- trifluoromethyl)phenyl] -3 ,4-dihydro-2H-pyrido[ 1 ,2-a]pyrimidin- 1 -ium-3 -ide or its agrochemically acceptable salts, esters and derivatives; B) Compound of Formula II, i.e., N-methyl-N'-nitro-N"-[(tetrahydro-3- furanyl)methyl]guanidine or its agrochemically acceptable salts, esters and derivatives;

[0051] C) At least one strobilurin fungicide selected from Pyraclostrobin, Trifloxystrobin, or Picoxystrobin or its agrochemically acceptable salts, esters or its derivatives;

[0052] D) At least one or more additive selected from urea clathrate, Siloxane Polyalkyleneoxide Copolymer, tallow amine ethoxylate, ammonium sulphate, and epoxide soybean oil either alone or in combination thereof; and

[0053] E) One or more agrochemically acceptable excipients.

[0054] In one another aspect, the present invention provides a stable synergistic pesticidal composition comprising:

[0055] A) Compound of Formula I, i.e., 2,4-dioxo-l-(pyrimidin-5-ylmethyl)-3-[3- trifluoromethyl)phenyl] -3 ,4-dihydro-2H-pyrido[ 1 ,2-a]pyrimidin- 1 -ium-3 -ide or its agrochemically acceptable salts, esters and derivatives, in the range of 0.1-90% by weight of the composition;

[0056] B) Compound of Formula II, i.e., N-methyl-N'-nitro-N"-[(tetrahydro-3- furanyl)methyl]guanidine or its agrochemically acceptable salts, esters and derivatives, in the range of 0.1-90% by weight of the composition; and

[0057] C) At least one strobilurin fungicide selected from Pyraclostrobin, Trifloxystrobin, or Picoxystrobin or its agrochemically acceptable salts, esters or its derivatives in the range of 0.1-90% by weight of the composition.

[0058] A)

[0059] In another specific aspect, the present invention provides a stable synergistic pesticidal composition comprising:

[0060] A) Compound of Formula I, i.e., 2,4-dioxo-l-(pyrimidin-5-ylmethyl)-3-[3- trifhioromethyl)phenyl]-3,4-dihydro-2H-pyrido[l,2-a]pyrimidin-l-ium-3-ide or its agrochemically acceptable salts, esters and derivatives; B) Compound of Formula II, i.e., N-methyl-N'-nitro-N"-[(tetrahydro-3- furanyl)methyl]guanidine or its agrochemically acceptable salts, esters and derivatives; and

[0061] C) Pyraclostrobin or its agrochemically acceptable salts, esters or its derivatives.

[0062] In another specific aspect, the present invention provides a stable synergistic pesticidal composition comprising:

[0063] A) Compound of Formula I, i.e., 2,4-dioxo-l-(pyrimidin-5-ylmethyl)-3-[3- trifhioromethyl)phenyl]-3,4-dihydro-2H-pyrido[l,2-a]pyrimidin-l-ium-3-ide or its agrochemically acceptable salts, esters and derivatives;

[0064] B) Compound of Formula II, i.e., N-methyl-N'-nitro-N"-[(tetrahydro-3- furanyl)methyl]guanidine or its agrochemically acceptable salts, esters and derivatives; and

[0065] C) Trifloxystrobin or its agrochemically acceptable salts, esters or its derivatives.

[0066] In another specific aspect, the present invention provides a stable synergistic pesticidal composition comprising:

[0067] A) Compound of Formula I, i.e., 2,4-dioxo-l-(pyrimidin-5-ylmethyl)-3-[3- trifhioromethyl)phenyl]-3,4-dihydro-2H-pyrido[l,2-a]pyrimidin-l-ium-3-ide or its agrochemically acceptable salts, esters and derivatives;

[0068] B) Compound of Formula II, i.e., N-methyl-N'-nitro-N"-[(tetrahydro-3- furanyl)methyl]guanidine or its agrochemically acceptable salts, esters and derivatives; and

[0069] C) Picoxystrobin or its agrochemically acceptable salts, esters or its derivatives.

[0070] In yet another aspect, the present invention provides a process for preparation of the stable synergistic pesticidal composition comprising:

[0071] A) Compound of Formula I, i.e., 2,4-dioxo-l-(pyrimidin-5-ylmethyl)-3-[3- trifhioromethyl)phenyl]-3,4-dihydro-2H-pyrido[l,2-a]pyrimidin-l-ium-3-ide or its agrochemically acceptable salts, esters and derivatives;

[0072] B) Compound of Formula II, i.e., N-methyl-N'-nitro-N"-[(tetrahydro-3- furanyl)methyl]guanidine or its agrochemically acceptable salts, esters and derivatives; and C) At least one strobilurin fungicide selected from pyraclostrobin, or trifloxystrobin, or picoxystrobin or its agrochemically acceptable salts, isomers, esters or its derivatives.

[0073] In an aspect of the present invention, the present invention provides a stable synergistic pesticidal composition which further comprises additives and / or adjuvants, for providing the following attributes to the composition of present invention: a) enhanced stability, permeability, and spreading or coverage effect, b) improved penetration capacity, and improved rain-fastness, c) uniform spray-ability, storage stability, and longer residual effect, d) enriched biotic factors, and better flowability, e) improved uptake of active ingredients, and f) safer to the environment.

[0074] In another aspect, the present synergistic pesticidal composition is stable and has enhanced shelf life and effectively control wide range of pests including insects in various crops. In another aspect, the present invention provides a stable synergistic pesticidal composition which has enhanced efficacy and penetration capacity.

[0075] DETAILED DESCRIPTION OF THE INVENTION

[0076] In describing the embodiments of the invention, specific terminology is resorted for sake of clarity. However, it is not intended that the invention be limited to specific terms so selected and it is to be understood that each specific term includes all technical equivalents that operate in a similar manner to accomplish a similar purpose.

[0077] Discussed below are some representative embodiments of the present invention. The invention in its broader aspects is not limited to the specific details and representative methods.

[0078] All technical and scientific terms used herein have the same meanings as commonly understood by someone ordinarily skilled in the art to which the present subject matter belongs.

[0079] The terminology used, in the present disclosure, is only for the purpose of explaining a particular embodiment and such terminology shall not be considered to limit the scope of the present disclosure. As used in the present disclosure, the forms "a,” "an," and "the" may be intended to include the plural forms as well, unless the context clearly suggests otherwise. Thus, for example, reference to a composition containing “a compound” includes a mixture of two or more compounds. It should also be noted that the term “or” is generally employed in its sense including “and / or” unless the content clearly dictates otherwise.

[0080] The terms "comprise / comprises", "comprising", “including”, and “having” are open ended transitional phrases and therefore specify the presence of stated features, integers, steps, operations, elements, but do not forbid the presence or addition of one or more other features, integers, steps, operations, elements, components, and / or groups thereof. The particular order of steps disclosed in the method and process of the present disclosure is not to be construed as necessarily requiring their performance as described or illustrated. It is also to be understood that additional or alternative steps may be employed.

[0081] Variations or modifications to the composition of this invention, within the scope of the invention, may occur to those skilled in the art upon reviewing the disclosure herein. Such variations or modifications are well within the spirit of this invention.

[0082] The expression of various quantities in terms of “% or “%” means the percentage by weight, relative to the weight and “% w / v” means the percentage by weight relative to the volume of the total solution or composition unless otherwise specified.

[0083] The term “active ingredient” (a.i.) or “active agent” or “active” used herein refers to that component of the composition responsible for control of various diseases caused by various pests including but not limited to insect-pests and fungal pathogens at the same time.

[0084] The term “crop” shall include a multitude of desired crop plants or an individual crop plant growing at a locus. The term “synergistic”, as used herein, refers to the combined action of two or more active agents blended together and administered conjointly that is greater than the sum of their individual effects.

[0085] “Bioactive amounts” as mentioned herein means that amount which, when applied for treatment of crops, is sufficient to give effect in such treatment.

[0086] The term “control” means to inhibit the ability of pests including but not limited to insects-pests and fungal pathogens to survive, grow, feed and / or reproduce, or to limit the diseases related damages or loss in crop plants.

[0087] The term “health of a plant” or “plant health” is defined as a condition of the plant and / or its products. As a result of the improved health; yield, plant vigour, quality and tolerance to abiotic or biotic stress is increased. As a result, the health of a plant is increased even in the absence of pest or disease pressure.

[0088] Accordingly, in an especially preferred embodiment according to the invention, the health of a plant is increased both in the presence and absence of biotic or abiotic stress factors. An increase in plant vigor may for example result in an increased yield and / or tolerance to abiotic or biotic stress.

[0089] One indicator for the condition of the plant is the yield. “Yield” is to be understood as any plant product of economic value that is produced by the plant such as grains, fruits, vegetables, nuts, grains, seeds, wood (e.g., in the case of silviculture plants) or even flowers (e.g. in the case of gardening plants, ornamentals). The plant products may in addition be further utilized and / or processed after harvesting.

[0090] In another preferred embodiment of the invention, the yield of the plants treated according to the method of the invention, is increased synergistically.

[0091] In another especially preferred embodiment of the invention, the plant vigour of the treated plant is increased. In another preferred embodiment of the invention, the plant vigour of the plants treated according to the composition of the present invention is increased synergistically.

[0092] Another indicator for the condition of the plant is the “quality” of a plant and / or its products.

[0093] In an especially preferred embodiment of the invention, the quality of the treated plant is increased. In another preferred embodiment of the invention, the quality of the plants treated according to the method of the invention, is increased synergistically.

[0094] The term rain fastness refers to the ability of a substance to remain effective after being applied to a surface and then exposed to rainfall or irrigation. In other words, it measures how well the substance adheres to the target surface and resists being washed away by water. A low rain fastness indicates that it may be washed off or diluted by rainfall, reducing its efficacy.

[0095] The term "Increased uptake of active ingredient" refers to the enhanced absorption or penetration of the active component of a substance into the target organism or plant. This increased uptake can lead to greater effectiveness of the product in controlling various diseases caused by pests such as insect-pest and fungal pathogens at the same time. It may occur through various mechanisms, such as improved formulation, adjuvants that enhance penetration, or modifications to the active ingredient itself to facilitate absorption. Overall, increased uptake of the active ingredient results in improved performance of the product in achieving its intended purpose.

[0096] The term “benefit: cost” refers to a ratio used in a cost-benefit analysis to summarize the overall relationship between the relative costs and benefits of a proposed composition. If a treatment has a benefit-cost ratio greater than 1.0, the treatment is expected to deliver a positive and better outcome.

[0097] In one embodiment of the present invention, the yield of the treated plant is increased.

[0098] In another embodiment of the present invention, there is synergistic and efficacious control of various diseases caused by pests including but not limited to insects and fungal pathogens affecting the plants and crops.

[0099] Another embodiment of the present invention, includes within its scope, all possible salts, isomers, esters and derivatives of the active ingredients of the composition.

[0100] It is also to be understood that the terminology used herein is for the purpose of describing particular embodiments of the invention only and is not intended to limit the scope of the invention in any manner. The use of examples anywhere in this specification including examples of any terms discussed herein is illustrative only, and in no way limits the scope and meaning of the invention or of any exemplified term. Likewise, the invention is not limited to various embodiments given in this specification.

[0101] Unless otherwise defined, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this invention pertains.

[0102] The composition according to the present invention has a reduced or zero phytotoxicity with respect to agricultural crops. This results in the present invention effective and possible in the selective control of pests including insect-pests and fungal diseases.

[0103] It has been observed by the inventors of the present invention that the composition of present invention not only provides synergistic effect but also provides anti-aging effect to the crops or plants to which it is applied. In addition, the stable synergistic pesticidal composition of the present invention is effective against all developmental stages of insect-pests including egg, nymph, larva, pupa, and adult, and all life stages of fungal pathogens including spore, germination, mycelium and reproduction, etc

[0104] In an embodiment, the present invention provides a stable synergistic pesticidal composition comprising:

[0105] A) Compound of Formula I, i.e., 2,4-dioxo-l-(pyrimidin-5-ylmethyl)-3-[3- trifluoromethyl)phenyl] -3 ,4-dihydro-2H-pyrido[ 1 ,2-a]pyrimidin- 1 -ium-3 -ide or its agrochemically acceptable salts, esters and derivatives;

[0106] B) Compound of Formula II, i.e., N-methyl-N'-nitro-N"-[(tetrahydro-3- furanyl)methyl]guanidine or its agrochemically acceptable salts, esters and derivatives; and

[0107] C) At least one strobilurin fungicide selected from Pyraclostrobin, Trifloxystrobin, or picoxystrobin or its agrochemically acceptable salts, esters or its derivatives.

[0108] In another embodiment, the present invention provides a stable synergistic pesticidal composition comprising: A) Compound of Formula I, i.e., 2,4-dioxo-l-(pyrimidin-5-ylmethyl)-3-[3- trifluoromethyl)phenyl] -3 ,4-dihydro-2H-pyrido[ 1 ,2-a]pyrimidin- 1 -ium-3 -ide or its agrochemically acceptable salts, esters and derivatives;

[0109] B) Compound of Formula II, i.e., N-methyl-N'-nitro-N"-[(tetrahydro-3- furanyl)methyl]guanidine or its agrochemically acceptable salts, esters and derivatives;

[0110] C) At least one strobilurin fungicide selected from Pyraclostrobin, Trifloxystrobin, or Picoxystrobin or its agrochemically acceptable salts, esters or its derivatives; and

[0111] D) One or more agrochemically acceptable excipients

[0112] In another aspect, the present invention provides a stable synergistic pesticidal composition comprising:

[0113] A) Compound of Formula I, i.e., 2,4-dioxo-l-(pyrimidin-5-ylmethyl)-3-[3- trifluoromethyl)phenyl] -3 ,4-dihydro-2H-pyrido[ 1 ,2-a]pyrimidin- 1 -ium-3 -ide or its agrochemically acceptable salts, esters and derivatives;

[0114] B) Compound of Formula II, i.e., N-methyl-N'-nitro-N"-[(tetrahydro-3- furanyl)methyl]guanidine or its agrochemically acceptable salts, isomers, esters and derivatives;

[0115] C) At least one strobilurin fungicide selected from Pyraclostrobin, Trifloxystrobin, or Picoxystrobin or its agrochemically acceptable salts, esters or its derivatives; and

[0116] D) At least one or more additive.

[0117] In one another embodiment, the present invention provides a stable synergistic pesticidal composition comprising:

[0118] A) Compound of Formula I, i.e., 2,4-dioxo-l-(pyrimidin-5-ylmethyl)-3-[3- trifluoromethyl)phenyl] -3 ,4-dihydro-2H-pyrido[ 1 ,2-a]pyrimidin- 1 -ium-3 -ide or its agrochemically acceptable salts, esters and derivatives; B) Compound of Formula II, i.e., N-methyl-N'-nitro-N"-[(tetrahydro-3- furanyl)methyl]guanidine or its agrochemically acceptable salts, isomers, esters and derivatives; and

[0119] C) At least one strobilurin fungicide selected from Pyraclostrobin, Trifloxystrobin, or Picoxystrobin or its agrochemically acceptable salts, esters or its derivatives;

[0120] D) At least one or more additive selected from urea clathrate, Siloxane Polyalkyleneoxide CopolymerSiloxane Polyalkyleneoxide Copolymer, tallow amine ethoxylate, ammonium sulphate, and epoxide soybean oil either alone or in combination thereof; and

[0121] E) One or more agrochemically acceptable excipients.

[0122] In one another embodiment, the present invention provides a stable synergistic pesticidal composition comprising:

[0123] A) Compound of Formula I, i.e., 2,4-dioxo-l-(pyrimidin-5-ylmethyl)-3-[3- trifluoromethyl)phenyl] -3 ,4-dihydro-2H-pyrido[ 1 ,2-a]pyrimidin- 1 -ium-3 -ide or its agrochemically acceptable salts, esters and derivatives, in the range of 0.1-90% by weight of the composition;

[0124] B) Compound of Formula II, i.e., N-methyl-N'-nitro-N"-[(tetrahydro-3- furanyl)methyl]guanidine or its agrochemically acceptable salts, esters and derivatives, in the range of 0.1-90% by weight of the composition; and

[0125] C) At least one strobilurin fungicide selected from Pyraclostrobin, Trifloxystrobin, or Picoxystrobin or its agrochemically acceptable salts, esters or its derivatives in the range of 0.1-90% by weight of the composition.

[0126] In one another embodiment, the present invention provides a stable synergistic pesticidal composition comprising:

[0127] A) Compound of Formula I, i.e., 2,4-dioxo-l-(pyrimidin-5-ylmethyl)-3-[3- trifluoromethyl)phenyl] -3 ,4-dihydro-2H-pyrido[ 1 ,2-a]pyrimidin- 1 -ium-3 -ide or its agrochemically acceptable salts, esters and derivatives, in the range of 0.1-90% by weight of the composition; B) Compound of Formula II, i.e., N-methyl-N'-nitro-N"-[(tetrahydro-3- furanyl)methyl]guanidine or its agrochemically acceptable salts, esters and derivatives, in the range of 0.1-90% by weight of the composition;

[0128] C) At least one strobilurin fungicide selected from Pyraclostrobin, Trifloxystrobin, or Picoxystrobin or its agrochemically acceptable salts, esters or its derivatives in the range of 0.1-90% by weight of the composition; and

[0129] D) One or more agrochemically acceptable excipients.

[0130] In one another embodiment, the present invention provides a stable synergistic pesticidal composition comprising:

[0131] A) Compound of Formula I, i.e., 2,4-dioxo-l-(pyrimidin-5-ylmethyl)-3-[3- trifluoromethyl)phenyl] -3 ,4-dihydro-2H-pyrido[ 1 ,2-a]pyrimidin- 1 -ium-3 -ide or its agrochemically acceptable salts, esters and derivatives, in the range of 0.1-90% by weight of the composition;

[0132] B) Compound of Formula II, i.e., N-methyl-N'-nitro-N"-[(tetrahydro-3- furanyl)methyl]guanidine or its agrochemically acceptable salts, esters and derivatives, in the range of 0.1-90% by weight of the composition;

[0133] C) At least one strobilurin fungicide selected from Pyraclostrobin, Trifloxystrobin, or Picoxystrobin or its agrochemically acceptable salts, esters or its derivatives in the range of 0.1-90% by weight of the composition; and

[0134] D) At least one or more additives.

[0135] In one another embodiment, the present invention provides a stable synergistic pesticidal composition comprising:

[0136] A) Compound of Formula I, i.e., 2,4-dioxo-l-(pyrimidin-5-ylmethyl)-3-[3- trifhioromethyl)phenyl]-3,4-dihydro-2H-pyrido[l,2-a]pyrimidin-l-ium-3-ide or its agrochemically acceptable salts, esters and derivatives, in the range of 0.1-90% by weight of the composition; B) Compound of Formula II, i.e., N-methyl-N'-nitro-N"-[(tetrahydro-3- furanyl)methyl]guanidine or its agrochemically acceptable salts, esters and derivatives, in the range of 0.1-90% by weight of the composition;

[0137] C) At least one strobilurin fungicide selected from Pyraclostrobin, Trifloxystrobin, or Picoxystrobin or its agrochemically acceptable salts, esters or its derivatives in the range of 0.1-90% by weight of the composition;

[0138] D) At least one or more additive selected from urea clathrate, Siloxane Polyalkyleneoxide Copolymer, tallow amine ethoxylate, ammonium sulphate, and epoxide soybean oil either alone or in combination thereof, in the range of 0.01-20% by weight of the composition; and

[0139] E) One or more agrochemically acceptable excipients.

[0140] In another specific embodiment, the present invention provides a stable synergistic pesticidal composition comprising:

[0141] A) Compound of Formula I, i.e., 2,4-dioxo-l-(pyrimidin-5-ylmethyl)-3-[3- trifhioromethyl)phenyl]-3,4-dihydro-2H-pyrido[l,2-a]pyrimidin-l-ium-3-ide or its agrochemically acceptable salts, esters and derivatives;

[0142] B) Compound of Formula II, i.e., N-methyl-N'-nitro-N"-[(tetrahydro-3- furanyl)methyl]guanidine or its agrochemically acceptable salts, esters and derivatives; and

[0143] C) Pyraclostrobin or its agrochemically acceptable salts, esters or its derivatives;

[0144] In an embodiment, the present invention provides a stable synergistic pesticidal composition comprising:

[0145] A) Compound of Formula I, i.e., 2,4-dioxo-l-(pyrimidin-5-ylmethyl)-3-[3- trifhioromethyl)phenyl]-3,4-dihydro-2H-pyrido[l,2-a]pyrimidin-l-ium-3-ide or its agrochemically acceptable salts, esters and derivatives;

[0146] B) Compound of Formula II, i.e., N-methyl-N'-nitro-N"-[(tetrahydro-3- furanyl)methyl]guanidine or its agrochemically acceptable salts, esters and derivatives;

[0147] C) Pyraclostrobin or its agrochemically acceptable salts, esters or its derivatives; and D) One or more agrochemically acceptable excipients.

[0148] In an embodiment, the present invention provides a stable synergistic pesticidal composition comprising:

[0149] A) Compound of Formula I, i.e., 2,4-dioxo-l-(pyrimidin-5-ylmethyl)-3-[3- trifluoromethyl)phenyl]-3,4-dihydro-2H-pyrido[l,2-a]pyrimidin-l-ium-3-ide or its agrochemically acceptable salts, esters and derivatives;

[0150] B) Compound of Formula II, i.e., N-methyl-N'-nitro-N"-[(tetrahydro-3- furanyl)methyl]guanidine or its agrochemically acceptable salts, esters and derivatives;

[0151] C) Pyraclostrobin or its agrochemically acceptable salts, esters or its derivatives; and

[0152] D) One or more additives.

[0153] In a specific embodiment, the present invention provides a stable synergistic pesticidal composition comprising:

[0154] A) Compound of Formula I, i.e., 2,4-dioxo-l-(pyrimidin-5-ylmethyl)-3-[3- trifhioromethyl)phenyl]-3,4-dihydro-2H-pyrido[l,2-a]pyrimidin-l-ium-3-ide or its agrochemically acceptable salts, esters and derivatives;

[0155] B) Compound of Formula II, i.e., N-methyl-N'-nitro-N"-[(tetrahydro-3- furanyl)methyl]guanidine or its agrochemically acceptable salts, esters and derivatives; and

[0156] C) Pyraclostrobin or its agrochemically acceptable salts, esters or its derivatives;

[0157] D) At least one or additive selected from urea clathrate, Siloxane Polyalkyleneoxide Copolymer, tallow amine ethoxylate, ammonium sulphate, and epoxide soybean oil either alone or in combination thereof, and

[0158] E) One or more agrochemically acceptable excipients.

[0159] In another specific embodiment, the present invention provides a stable synergistic pesticidal composition comprising: A) Compound of Formula I, i.e., 2,4-dioxo-l-(pyrimidin-5-ylmethyl)-3-[3- trifluoromethyl)phenyl]-3,4-dihydro-2H-pyrido[l,2-a]pyrimidin-l-ium-3-ide or its agrochemically acceptable salts, esters and derivatives;

[0160] B) Compound of Formula II, i.e., N-methyl-N'-nitro-N"-[(tetrahydro-3- furanyl)methyl]guanidine or its agrochemically acceptable salts, esters and derivatives; and

[0161] C) Trifloxystrobin or its agrochemically acceptable salts, esters or its derivatives.

[0162] In another embodiment, the present invention provides a stable synergistic pesticidal composition comprising:

[0163] A) Compound of Formula I, i.e., 2,4-dioxo-l-(pyrimidin-5-ylmethyl)-3-[3- trifhioromethyl)phenyl]-3,4-dihydro-2H-pyrido[l,2-a]pyrimidin-l-ium-3-ide or its agrochemically acceptable salts, esters and derivatives;

[0164] B) Compound of Formula II, i.e., N-methyl-N'-nitro-N"-[(tetrahydro-3- furanyl)methyl]guanidine or its agrochemically acceptable salts, esters and derivatives;

[0165] C) Trifloxystrobin or its agrochemically acceptable salts, esters or its derivatives; and

[0166] D) One or more agrochemically acceptable excipients.

[0167] In another embodiment, the present invention provides a stable synergistic pesticidal composition comprising:

[0168] A) Compound of Formula I, i.e., 2,4-dioxo-l-(pyrimidin-5-ylmethyl)-3-[3- trifhioromethyl)phenyl]-3,4-dihydro-2H-pyrido[l,2-a]pyrimidin-l-ium-3-ide or its agrochemically acceptable salts, esters and derivatives;

[0169] B) Compound of Formula II, i.e., N-methyl-N'-nitro-N"-[(tetrahydro-3- furanyl)methyl]guanidine or its agrochemically acceptable salts, esters and derivatives;

[0170] C) Trifloxystrobin or its agrochemically acceptable salts, esters or its derivatives; and

[0171] D) At least one or more additives. In another embodiment, the present invention provides a stable synergistic pesticidal composition comprising:

[0172] A) Compound of Formula I, i.e., 2,4-dioxo-l-(pyrimidin-5-ylmethyl)-3-[3- trifluoromethyl)phenyl]-3,4-dihydro-2H-pyrido[l,2-a]pyrimidin-l-ium-3-ide or its agrochemically acceptable salts, esters and derivatives;

[0173] B) Compound of Formula II, i.e., N-methyl-N'-nitro-N"-[(tetrahydro-3- furanyl)methyl]guanidine or its agrochemically acceptable salts, esters and derivatives;

[0174] C) Trifloxystrobin or its agrochemically acceptable salts, esters or its derivatives;

[0175] D) At least one or more additive selected from urea clathrate, Siloxane Polyalkyleneoxide Copolymer, tallow amine ethoxylate, ammonium sulphate, and epoxide soybean oil either alone or in combination thereof, and

[0176] E) One or more agrochemically acceptable excipients.

[0177] In another specific embodiment, the present invention provides a stable synergistic pesticidal composition comprising:

[0178] A) Compound of Formula I, i.e., 2,4-dioxo-l-(pyrimidin-5-ylmethyl)-3-[3- trifhioromethyl)phenyl]-3,4-dihydro-2H-pyrido[l,2-a]pyrimidin-l-ium-3-ide or its agrochemically acceptable salts, esters and derivatives;

[0179] B) Compound of Formula II, i.e., N-methyl-N'-nitro-N"-[(tetrahydro-3- furanyl)methyl]guanidine or its agrochemically acceptable salts, esters and derivatives; and

[0180] C) Picoxystrobin or its agrochemically acceptable salts, esters or its derivatives.

[0181] In another embodiment, the present invention provides a stable synergistic pesticidal composition comprising:

[0182] A) Compound of Formula I, i.e., 2,4-dioxo-l-(pyrimidin-5-ylmethyl)-3-[3- trifhioromethyl)phenyl]-3,4-dihydro-2H-pyrido[l,2-a]pyrimidin-l-ium-3-ide or its agrochemically acceptable salts, esters and derivatives; B) Compound of Formula II, i.e., N-methyl-N'-nitro-N"-[(tetrahydro-3- furanyl)methyl]guanidine or its agrochemically acceptable salts, esters and derivatives;

[0183] C) Picoxystrobin or its agrochemically acceptable salts, esters or its derivatives; and

[0184] D) One or more agrochemically acceptable excipients.

[0185] In another embodiment, the present invention provides a stable synergistic pesticidal composition comprising:

[0186] A) Compound of Formula I, i.e., 2,4-dioxo-l-(pyrimidin-5-ylmethyl)-3-[3- trifhioromethyl)phenyl]-3,4-dihydro-2H-pyrido[l,2-a]pyrimidin-l-ium-3-ide or its agrochemically acceptable salts, esters and derivatives;

[0187] B) Compound of Formula II, i.e., N-methyl-N'-nitro-N"-[(tetrahydro-3- furanyl)methyl]guanidine or its agrochemically acceptable salts, esters and derivatives;

[0188] C) Picoxystrobin or its agrochemically acceptable salts, esters or its derivatives; and

[0189] D) At least one or more additives.

[0190] In another embodiment, the present invention provides a stable synergistic pesticidal composition comprising:

[0191] A) Compound of Formula I, i.e., 2,4-dioxo-l-(pyrimidin-5-ylmethyl)-3-[3- trifhioromethyl)phenyl]-3,4-dihydro-2H-pyrido[l,2-a]pyrimidin-l-ium-3-ide or its agrochemically acceptable salts, esters and derivatives;

[0192] B) Compound of Formula II, i.e., N-methyl-N'-nitro-N"-[(tetrahydro-3- furanyl)methyl]guanidine or its agrochemically acceptable salts, esters and derivatives;

[0193] C) Picoxystrobin or its agrochemically acceptable salts, esters or its derivatives;

[0194] D) At least one or more additive selected from urea clathrate, Siloxane Polyalkyleneoxide Copolymer, tallow amine ethoxylate, ammonium sulphate, and epoxide soybean oil either alone or in combination thereof, and

[0195] E) One or more agrochemically acceptable excipients. In yet another specific embodiment, the present invention provides a stable synergistic pesticidal composition comprising:

[0196] A) Compound of Formula I, i.e., 2,4-dioxo-l-(pyrimidin-5-ylmethyl)-3-[3- trifluoromethyl)phenyl] -3 ,4-dihydro-2H-pyrido[ 1 ,2-a]pyrimidin- 1 -ium-3 -ide or its agrochemically acceptable salts, esters and derivatives, in the range of 0.1-30% by weight of the composition;

[0197] B) Compound of Formula II, i.e., N-methyl-N'-nitro-N"-[(tetrahydro-3- furanyl)methyl]guanidine or its agrochemically acceptable salts, esters and derivatives, in the range of 0.1-50% by weight of the composition; and

[0198] C) At least one strobilurin fungicide selected from Pyraclostrobin, Trifloxystrobin, or Picoxystrobin or its agrochemically acceptable salts, esters or its derivatives in the range of 0.1-60% by weight of the composition.

[0199] In yet another embodiment, the present invention provides a process for preparation of the stable synergistic pesticidal composition comprising:

[0200] A) Compound of Formula I, i.e., 2,4-dioxo-l-(pyrimidin-5-ylmethyl)-3-[3- trifluoromethyl)phenyl] -3 ,4-dihydro-2H-pyrido [ 1 ,2-a]pyrimidin- 1 -ium-3 -ide or its agrochemically acceptable salts, esters and derivatives;

[0201] B) Compound of Formula II, i.e., N-methyl-N'-nitro-N"-[(tetrahydro-3- furanyl)methyl]guanidine or its agrochemically acceptable salts, esters and derivatives; and

[0202] C) At least one strobilurin fungicide selected from pyraclostrobin, or trifloxystrobin, or picoxystrobin or its agrochemically acceptable salts, esters or its derivatives.

[0203] In an embodiment, each individual row appearing in the table below represents the combinations of the present invention.

[0204] A compound of Formula I herein pertains to 2,4-dioxo-l-(pyrimidin-5-ylmethyl)-3-[3- trifluoromethyl)phenyl] -3 ,4-dihydro-2H-pyrido [ 1 ,2-a]pyrimidin- 1 -ium-3 -ide or its agrochemically acceptable salts, esters and derivatives; and A compound of Formula II herein pertains to N-methyl-N'-nitro-N"-[(tetrahydro-3- furanyl)methyl]guanidine or its agrochemically acceptable salts, esters and derivatives

[0205] According to embodiments of the present invention, the stable synergistic pesticidal composition results in an increased yield of the treated plant. Accordingly, there is synergistic and efficacious control of various pests, fungal and diseases caused by such pests affecting the plants and crops. The present invention includes within its scope, all possible salts, esters and derivatives of the active ingredients of the composition.

[0206] According to embodiments of the present invention, the stable synergistic pesticidal composition further optionally comprises additives, inert ingredients and / or adjuvants, for providing the following attributes to the composition of present invention: a) enhanced stability, permeability, and spreading or coverage effect b) improved penetration capacity, and storage stability, c) uniform spray-ability, and improved rain-fastness, d) enriched biotic factors, and better flowability, e) longer residual effect, and improved uptake of active ingredients, and f) safer to the environment.

[0207] In another embodiment of the present invention, the stable synergistic pesticidal composition of the present invention further comprises one or more agrochemically acceptable excipients including but not limited to the group comprising surfactant(s), dispersing agent(s), co-dispersant, anti-freezing agent(s), emulsifier(s) (anionic and non-ionic), anti-foaming agent / defoamer(s), wetting agent(s), antimicrobial / anti-bacterial agent(s), anti-caking agent , thickening agent / thickener(s), quick coating agent(s) or sticking agents / sticker(s), spreader(s), binder(s), pH- adjusting agent(s), anti-caking agent(s), adjuvant(s), filler(s) / suspension aid(s), colorant(s), carrier(s), buffering agent(s), polymer(s)rheology modifier(s), solvent(s), co-solvent(s) , biocide or a combination thereof. Additional components may also be included, e.g., protective colloids, carriers, adhesives, thixotropic agents, penetration agents, stabilisers, sequestering agents. More generally, the active materials can be combined with any solid or liquid carrier / additive, which complies with usual formulation techniques.

[0208] In yet another embodiment of the present invention, the present stable synergistic pesticidal composition can be formulated as one or more of Capsule suspension (CS), Dispersible concentrate (DC), Dustable powder (DP), Powder for dry seed treatment (DS), Emulsifiable concentrate (EC), Emulsifiable granule (EG), Emulsion water-in-oil (EO), Emulsifiable powder (EP), Emulsion for seed treatment (ES), Emulsion oil-in-water (EW), Flowable concentrate for seed treatment (FS), Granules (GR), Micro-emulsion (ME), Oil-dispersion (OD), Oil miscible flowable concentrate (OF), Oil miscible liquid (OL), Oil dispersible powder (OP), Suspension concentrate (SC), Suspension concentrate for direct application (SD), Suspo-emulsion (SE), Water soluble granule (SG), Soluble concentrate (SL), Spreading oil (SO), Water soluble powder (SP), Water soluble tablet (ST), Ultra-low volume (ULV) suspension, Tablet (TB), Ultra-low volume (ULV) liquid, Water dispersible granules (WG), Wettable powder (WP), Water dispersible powder for slurry seed treatment (WS), Water dispersible tablet (WT), a mixed formulation of CS and SC (ZC) or a mixed formulation of CS and SE (ZE) or a mixed formulation of CS and EW (ZW).

[0209] In yet another embodiment of the present invention, the invention further provides the process for preparation of the said pesticidal composition, wherein the said composition can be one or more of Capsule suspension (CS), Dispersible concentrate (DC), Dustable powder (DP), Powder for dry seed treatment (DS), Emulsifiable concentrate (EC), Emulsifiable granule (EG), Emulsion water- in-oil (EO), Emulsifiable powder (EP), Emulsion for seed treatment (ES), Emulsion oil-in-water (EW), Flowable concentrate for seed treatment (FS), Granules (GR), Micro-emulsion (ME), Oildispersion (OD), Oil miscible flowable concentrate (OF), Oil miscible liquid (OL), Oil dispersible powder (OP), Suspension concentrate (SC), Suspension concentrate for direct application (SD), Suspo-emulsion (SE), Water soluble granule (SG), Soluble concentrate (SL), Spreading oil (SO), Water soluble powder (SP), Water soluble tablet (ST), Ultra-low volume (ULV) suspension, Tablet (TB), Ultra-low volume (ULV) liquid, Water dispersible granules (WG), Wettable powder (WP), Water dispersible powder for slurry seed treatment (WS), Water dispersible tablet (WT), a mixed formulation of CS and SC (ZC) or a mixed formulation of CS and SE (ZE) or a mixed formulation of CS and EW (ZW).

[0210] In one embodiment, additives such as Siloxane Polyalkyleneoxide Copolymer or an organosilicone based powder adjuvant that can enhance the water absorption efficiency of hard-to-wet soils by increasing their water infiltration, drainage, water retention and hydrophilicity; tallow amine ethoxylate increases the biocompatibility in environmental applications and help in the interactions of active ingredients; ammonium sulphate help is resistant to leaching and helps the crop to utilize nitrogen efficiently; urea clathrate provides superior wetting and spray retention properties and serves as an excellent nitrogen source for crops and epoxide soybean oil provides increased active ingredient uptake and improved rain fastness to the composition; and epoxide soybean oil provides increased active ingredient uptake and improved rain fastness to the composition. The said additives are stable and hygroscopic resulting in an efficient uptake and functioning. In one embodiment, additives such as urea clathrate, Siloxane Polyalkyleneoxide Copolymer or organosilicone -based powder adjuvant super-wetter, tallow amine ethoxylate, ammonium sulphate, and epoxide soybean oil either alone or in combination thereof, present in the range of 0.01 - 20% by weight of the composition.

[0211] According to embodiments of the present invention, the present stable synergistic pesticidal composition can be applied to various crops and plants including but not limited to Paddy, Rice, Cotton, Brinjal, Tomato, Soybean, Groundnut, Corn, Banana, Chilli, Vegetables including carrots, asparagus, curcubits, fruiting vegetables, root vegetables (except radish), fruits including apples, pears, grapes, strawberries, Tropical crops, Turf, Cereals including wheat, barley, oats, forage & grain maize, triticale, winter and spring wheat, winter and spring barley (undersown with grass / clover), winter and spring oats; Oilseed rape, Sugarbeet, Potatoes, Vegetables including brassicas, carrot, beans, vining peas, Fruit including strawberry, blackcurrants and Ornamentals, etc.

[0212] According to embodiments of the present invention, the stable synergistic pesticidal composition provides synergistic and effective control against pests including, Brown plant hopper & White backed plant hopper, Brown plant hopper (Nilaparvata lugens), White backed plant hopper (Sogatella furcifera), American cockroach (Periplaneta americana), German Cockroach (Blattella germanica), Whitefly, Jassids, Aphids & Thrips, Leaf hopper, Green leaf hopper, Early blight, Frog eye leaf spot (Cercospora)& Alternaria leaf spot, Alternaria Leaf blight, Tikka disease, Turcicum leaf blight, Sigatoka leaf Spot, Anthracnose, Blast Disease, foliar, stem and root diseases by lowering count of pests such as Alternaria, Black root, Black spot, Botrytis, Downy mildew, Powdery mildew, Leaf spot, Rust, Rhizoctonia stem & root rot, Scab, Blossom blight rusts and mildews, Brown & yellow rusts, Leaf spot, Tan spot, Powdery mildew, Net blotch, Ear diseases & Sclerotinia, etc.

[0213] In yet another embodiment, the composition according to the invention can be applied to any and all developmental stages of pests, such as egg, nymph, larva, pupa, and adult and all developmental stages of fungi including spore germination, hyphal growth i.e mycelium and reproduction. The pests may be controlled by contacting the target pest, habitat, breeding ground or its locus with a bioactive amount of the novel and inventive composition of the present invention.

[0214] According to embodiments of the present stable synergistic pesticidal composition of the present invention can be applied to a plant / crop / soil by spraying, rubbing, atomizing, irrigating, evaporating, dusting, fogging, broadcasting, pouring, mist blowing, soil mixing, foaming, painting, spreading-on, drenching, dipping or drip irrigation, etc.

[0215] In yet another embodiment, the composition of the present invention can also comprise or may be applied together and / or sequentially with further active compounds. These further compounds can be selected from fertilizers or micronutrient donors or microorganisms or other preparations that influence plant growth, such as inoculants (e.g., a strain of nitrogen-fixing bacteria), and plant inducers.

[0216] Through the pesticidal composition of present invention, the number of applications to control wide range of pests appearing at the same time is minimised. The composition of present invention is highly safe to the user and to the environment. The composition also is cost-effective as it provides much greater simultaneous control and can be used in a variety of crops with a broader spectrum of protection.

[0217] The stable synergistic composition of present invention has very advantageous, curative, preventive and systemic pesticidal properties for protecting plants and crops. According to embodiments, the stable synergistic composition according to the present invention acts synergistically to control pests including but not limited to insect -pests and fungal pathogens in various crops.

[0218] Representative examples of the present composition of this invention are provided below and are not to be construed as limiting in any manner.

[0219] EXAMPLES: GENERAL RECIPE OF COMPOSITION OF PRESENT INVENTION:

[0220] A compound of Formula I herein pertains to 2,4-dioxo-l-(pyrimidin-5-ylmethyl)-3-[3- trifluoromethyl)phenyl] -3 ,4-dihydro-2H-pyrido [ 1 ,2-a]pyrimidin- 1 -ium-3 -ide or its agrochemically acceptable salts, esters and derivatives; and A compound of Formula II herein pertains to N-methyl-N'-nitro-N"-[(tetrahydro-3- furanyl)methyl]guanidine or its agrochemically acceptable salts, esters and derivatives

[0221] At least one strobilurin fungicide selected from pyraclostrobin, or trifloxystrobin, or picoxystrobin or its agrochemically acceptable salts, esters or its derivatives.

[0222]

[0223]

[0224] Example A: Compound of Formula 14% + Compound of Formula II 9.6% + Pyraclostrobin 16% EC FORMULATION PROCESS

[0225] 1. Solvent N-Methyl-2-pyrrolidone was charged into a clean and dry reactor, and stirred. 2. Compound of Formula I Technical, Compound of Formula II Technical, and Pyraclostrobin Technical were added to reactor, mixed well, and dissolved to obtain a clear solution.

[0226] 3. Emulsifier (blend of anionic and non-ionic) was added and mixed well to form an emulsifiable concentrate.

[0227] 4. Obtained product was filtered through a sparkler filter, and the filtrate was collected into another clean and dry vessel.

[0228] 5. The formulation was packed in QA-approved containers.

[0229] STABILITY DATA: Compound of Formula I 4% + Compound of Formula II 9.6% + Pyraclostrobin 16% EC

[0230] Example B: Compound of Formula I 5% + Compound of Formula II 9 % + Pyraclostrobin 15% WG MANUFACTURING PROCESS:

[0231] China clay was taken in the ribbon blender for mixing. To this, Silica ppt, Sodium Isopropyl Naphthalene Sulfonate, Sodium Lignosulphonate, Sodium salt of naphthalene sulfonate formaldehyde condensate, Sodium Polycarboxylate, Lactose monohydrate, Compound of Formula I Technical, Compound of Formula II Technical, Pyraclostrobin Technical were added and mixed well.

[0232] Mixing was continued until the material became completely homogenized. The premix was then passed through the Airjet mill at 6 to 7 kg / cm2of grinding pressure and a feeding rate of 100 to 150 kg / hr so as to obtain a particle size of D90 less than 10 microns. The ground material was collected in the post blender.

[0233] Extrusion process

[0234] Into the post blender, the solution of water and Polydimethylsiloxane emulsion was added by means of spraying, and a dough was prepared. This dough was mixed well to obtain a well- hydrated mass for extrusion. The dough was then allowed to pass through the screw valve fitted with the post blender and subsequently passed through the basket extruder.

[0235] Drying Process

[0236] The wet extruded granules were passed through the VFBG (vibro fluid bed drier), which had been brought to a consistent temperature of 50 °C prior to drying. The granules were then checked for moisture content, which was required to be not more than 3%. Once the parameter was set, the process was continued.

[0237] The dried granules were passed through a vibro sieve machine to separate any lumps or dust, and the desired size granules were collected and packed. STABILITY DATA: Compound of Formula I 5% + Compound of Formula II 9 % + Pyraclostrobin 15% WG

[0238] Example C: Compound of Formula I 6.5% + Compound of Formula II 16% + Trifloxystrobin 13% WP FORMULATION PROCESS:

[0239] 1. All required Technicals i.e Compound of Formula I Technical, Compound of Formula II Technical and Trifloxystrobin Technical and inert ingredients were mixed and then ground in air jet mill.

[0240] 2. The particle size was checked after grinding to ensure that it was less than 10 microns (D90).

[0241] 3. The ground powder was post-blended and mixed well.

[0242] Stability Data: Compound of Formula I 6.5% + Compound of Formula II 16% +

[0243] Trifloxystrobin 13% WP

[0244] Example D: Compound of Formula I 5.5% + Compound of Formula II 16.5 % + Trifloxystrobin 13% EC FORMULATION PROCESS 1. Into a clean and dry reactor, solvent N-Methyl-2-pyrrolidone was charged and stirring was started.

[0245] 2. Compound of Formula I Technical, Compound of Formula II Technical, and Trifloxystrobin Technical were added, mixed well, and dissolved to obtain a clear solution.

[0246] 3. Emulsifier (blend of anionic and non-ionic) was added and mixed well to form an emulsifiable concentrate.

[0247] 4. Obtained product was filtered through a sparkler filter, and the filtrate was collected into another clean and dry vessel.

[0248] 5. The formulation was packed in QA-approved containers.

[0249] STABILITY DATA: Compound of Formula I 5.5% + Compound of Formula II 16.5 % +

[0250] Trifloxystrobin 13% EC

[0251] Example E: Compound of Formula 16 % + Compound of Formula II 17 % + Trifloxystrobin

[0252] 12% SC FORMULATION PROCESS DM water and mixture of surfactants (Acrylic graft copolymer, Ethoxylated Fatty Alcohol), Epoxide Soybean Oil, Polyalkyleneoxide-modified Polydimethylsiloxane emulsion & Propylene Glycol (PG) were charged and further diluted with DM water. Then required Compound of Formula I Technical, Compound of Formula II Technical, and Trifloxystrobin Technical were mixed to obtain homogeneous mass at high shearing stirring. Obtained homogeneous mass was ground in Bead Mill. Grinding is carried out until a mean particle size of below 5 microns is obtained. Preparations of 0.2% gum solution - Take 100 g DM water add 0.2 g of 1,2- Benzisothiazolin-3-one, then xanthan gum is added with gradual stirring. After grinding, 2% aqueous solution of xanthan gum was added with stirring. Mixing is carried out to obtain final homogenous mixture. Obtained homogeneous mixture was checked for quality parameter.

[0253] STABILITY DATA: Compound of Formula I 6 % + Compound of Formula II 17 % +

[0254] Trifloxystrobin 12% SC

[0255] Example F: Compound of Formula I 4% + Compound of Formula II 9.6% + Picoxystrobin

[0256] 24% WG MANUFACTURING PROCESS:

[0257] China clay was taken in the ribbon blender for mixing. To this, Silica ppt, Sodium Isopropyl Naphthalene Sulfonate, Sodium Lignosulphonate, Sodium salt of naphthalene sulfonate formaldehyde condensate, Sodium Polycarboxylate, Lactose monohydrate, Compound of Formula I Technical, Compound of Formula II Technical, Picoxystrobin Technical were added and mixed well. Mixing was continued until the material became completely homogenized. The premix was then passed through the Airjet mill at 6 to 7 kg / cm2of grinding pressure and a feeding rate of 100 to 150 kg / hr so as to obtain a particle size of D90 less than 10 microns. The ground material was collected in the post blender. Extrusion process

[0258] Into the post blender, the solution of water and Polydimethylsiloxane emulsion was added by means of spraying, and a dough was prepared. This dough was mixed well to obtain a well- hydrated mass for extrusion. The dough was then allowed to pass through the screw valve fitted with the post blender and subsequently passed through the basket extruder. Drying Process

[0259] The wet extruded granules were passed through the VFBG (vibro fluid bed drier), which had been brought to a consistent temperature of 50 °C prior to drying. The granules were then checked for moisture content, which was required to be not more than 3%. Once the parameter was set, the process was continued. The dried granules were passed through a vibro sieve machine to separate any lumps or dust, and the desired size granules were collected and packed.

[0260] STABILITY DATA: Compound of Formula I 4% + Compound of Formula II 9.6 % + Picoxystrobin 24% WG

[0261] Example G: Compound of Formula I 6% + Compound of Formula II 8.5% + Picoxystrobin

[0262] 23% EC FORMULATION PROCESS

[0263] 1. Into a clean and dry reactor, solvent N-Methyl-2-pyrrolidone was charged and stirring was started.

[0264] 2. Compound of Formula I Technical, Compound of Formula II Technical, and Picoxystrobin Technical were added, mixed well, and dissolved to obtain a clear solution. 3. Emulsifier (blend of anionic and non-ionic) was added and mixed well to form an emulsifiable concentrate.

[0265] 4. The solution was filtered through a sparkler filter, and the filtrate was collected into another clean and dry vessel.

[0266] 5. The formulation was packed in QA-approved containers. STABILITY DATA: Compound of Formula I 6% + Compound of Formula II 8.5% +

[0267] Picoxystrobin 23% EC

[0268] Example H: Compound of Formula I 5% + Compound of Formula II 10 % + Picoxystrobin

[0269] 22% SC

[0270] FORMULATION PROCESS DM water and mixture of surfactants (Acrylic graft copolymer, Ethoxylated Fatty Alcohol), Epoxide Soybean Oil, Polyalkyleneoxide-modified Polydimethylsiloxane emulsion & Propylene Glycol (PG) were charged and further diluted with DM water.

[0271] Then required Compound of Formula I Technical, Compound of Formula II Technical, and Picoxystrobin Technical were mixed to obtain homogeneous mass at high shearing stirring. Obtained homogeneous mass was ground in Bead Mill. Grinding is carried out until a mean particle size of below 5 microns is obtained. Preparations of 0.2% gum solution - Take 100 g DM water add 0.2 g of 1,2- Benzisothiazolin-3-one, then xanthan gum is added with gradual stirring. After grinding, 2% aqueous solution of xanthan gum was added with stirring. Mixing is carried out to obtain final homogenous mixture. Obtained homogeneous mixture was checked for quality parameter.

[0272] STABILITY DATA: Compound of Formula I 5 % + Compound of Formula II 10 % +

[0273] Picoxystrobin 22% SC Evaluation of synergistic effect of stable synergistic pesticidal composition of the present invention

[0274] A synergistic effect of two or more products exists whenever the action of an active ingredient combination is greater than the sum of the actions of the individual components. Synergism was calculated by using Colby’s method (Weeds, vol. 15 No. 1 (Jan 1967), pp. 20-2.

[0275] The synergistic action expected for a given combination of two active components can be calculated as follows:

[0276] XY

[0277] E = (X + Y) -

[0278] 100

[0279] The synergistic action expected for a given combination of three active components can be calculated as follows:

[0280] (XY+YZ+XZ) (XYZ)

[0281] E = (X + Y + Z) - + -

[0282] 100 10000

[0283] Where:

[0284] E represents expected percentage of pesticidal control for the combination of the two or three active ingredients at defined doses (for example equal to x, y and z, respectively).

[0285] X is the percentage of pesticidal control observed by the Compound of Formula I at a defined dose (equal to x).

[0286] Y is the percentage of pesticidal control observed by the Compound of Formula II at a defined dose (equal to y).

[0287] Z is the percentage of pesticidal control observed by the compound (Pyraclostrobin / Trifloxystrobin / Picoxystrobin) at a defined dose (equal to z).

[0288] When the percentage of pesticidal control observed for the combination is greater than the expected percentage, there is a synergism effect.

[0289] Observed control (%)

[0290] Ratio = -

[0291] Expected control (%)

[0292] Ratio of O / E > 1, synergism observed

[0293] The present invention is illustrated by way of examples, the examples are meant for illustrative purposes and should not be construed as limiting. Experiment for Synergistic activity of synergistic pesticidal composition of present invention:

[0294] Example 1- Details of experiment on rice crop:

[0295] Field experiment for synergistic activity of Compound of Formula I + Compound of Formula 11+ Pyraclostrobin for the control of brown plant hopper and blast disease in rice crop was conducted.

[0296] To evaluate the synergistic effect, rice [Variety: Pusa Basmati 1] crop was sown in 5 m x 5 m plots maintaining 25 cm x 15 cm plant distance with three replications and in Randomized Block Design (RBD). The treatments were applied as foliar spray in the form of EC formulation @ 625 ml / ha. Each active component was applied twice in different ternary and binary compositions. Solo components were also taken for comparison. The treatment details are as under:

[0297] The treatments T1 to T28 were used as foliar application whereas no treatment was done for T29 control treatment. Two applications of each treatment were carried out at 15 -day intervals, initiated upon Economic Threshold Level (ETL) of insect pest and the initial appearance of disease symptoms in the experimental plots.

[0298] Observations of Nilaparvata lugens (brown plant hopper) were recorded before spraying and at 14 days after the first and second applications from randomly selected plants. The observations were recorded on the number of BPH (nymph and adults) present at the base of the rice plants on selected per 10 hills randomly for each plot. Observations on blast (causal organism : Pyricularia oryzae) disease severity assessment was carried out on a scale of 0 to 9 where: 0- No lesions visible (0%), 1- Small brown specks of pinhead size (<1%), 2- Small round to slightly elongated brown lesions with yellow halo (1-3%), 3- Few typical blast lesions (spindle-shaped with grey centers) (4-5%), 4- Lesions infecting 6-10% of leaf area, 5-Lesions more numerous, 11-25% leaf area affected, 6- Lesions coalescing, covering 26-50% of the leaf, 7- Lesions killing 51-75% of leaf area, 8- Most of the leaf area (>75%) affected, 9- All leaves dead (by examining five plants per plot). Percentage Disease Index was worked out using the formula, PDI = [Sum of all numerical rating / total number of observations taken x maximum disease score] x 100. The percent reduction in disease incidence and insect population was calculated over control. Based on the per cent reduction at 14 days after second spray in insect-pest population and disease severity, the Expected control was calculated and compared with Observed control. The results of the trial have been presented here under in Table 1A.

[0299] Table 1A: Synergistic effect of stable synergistic pesticidal composition of the present invention comprising Compound of Formula I + Compound of Formula n+ Pyraclostrobin against brown plant hopper and blast disease in rice crop

[0300] It is clearly evident from the data shown in above Table 1A for per cent insect and disease control in rice crop that the stable synergistic pesticidal composition of the present invention comprising Compound of Formula I + Compound of Formula 11+ Pyraclostrobin i.e., T1 to T4 are synergistic for pest populations with > 1 Colby’s Ratio. The binary composition of two fungicide / insecticide comprising (Compound of Formula I + Compound of Formula II, Compound of Formula I + Pyraclostrobin and Compound of Formula 11+ Pyraclostrobin) T5 to T16 show less efficacy and no synergistic effect for the control of brown plant hopper population and blast disease, as compared to synergistic pesticidal composition comprising Compound of Formula I + Compound of Formula 11+ Pyraclostrobin T1 to T4.

[0301] Experiment for Bio-efficacy evaluation of synergistic pesticidal composition of present invention:

[0302] For the ternary and binary compositions based on Compound of Formula I + Compound of Formula 11+ Pyraclostrobin evaluation under field conditions, the basic test composition as Compound of Formula I 4% + Compound of Formula II 9.6% + Pyraclostrobin 16% EC were prepared. For synergistic pesticidal composition, Compound of Formula I 4% + Compound of Formula II 9.6% + Pyraclostrobin 16% EC was used and for binary compositions, Compound of Formula 14% + Compound of Formula II 9.6% EC, Compound of Formula 14% + Pyraclostrobin 16% EC and Compound of Formula II 9.6% + Pyraclostrobin 16% EC were used. The solo formulations of Compound of Formula I 4% EC, Compound of Formula II 9.6% EC, Pyraclostrobin 16% EC were used for comparison. The other formulations namely Compound of Formula I 10% w / w SC, Compound of Formula II 70% WG and Pyraclostrobin 100g / l CS available in the market were also used for comparison.

[0303] Example 2: Evaluation of the stable synergistic pesticidal composition of the present invention on rice

[0304] The stable synergistic pesticidal composition of the present invention comprising Compound of Formula I 4% + Compound of Formula II 9.6% + Pyraclostrobin 16% EC was evaluated on rice crop variety Pusa Basmati 1 at a farmer field. The crop sowing was done in Randomized Block Design (RBD) with three replications maintaining a distance of 25 cm x 15 cm. The observations were recorded for the following objectives.

[0305] Objectives: 1. Bio-efficacy evaluation against brown plant hopper on rice crop.

[0306] 2. Bio-efficacy evaluation against blast disease on rice crop.

[0307] 3. Bio-efficacy evaluation based on per cent reduction in brown plant hopper population.

[0308] 4. Bio-efficacy evaluation based on percent reduction in blast disease severity.

[0309] 5. Bio-efficacy evaluation based on crop yield. 6. Phytotoxicity evaluation on rice crop.

[0310] Treatment details:

[0311] Methodology: The treatments T1 to T18 and T20 were used as foliar application whereas no treatment was done for T19 i.e., control treatment. All treatments were applied when pest population and disease reached ETL in the experimental plots.

[0312] Observations of Nilaparvata lugens (brown plant hopper) were recorded before spraying and at 14 days after the first and second applications from randomly selected plants. The observations were recorded on the number of BPH (nymph and adults) present at the base of the rice plants on selected per 10 hills randomly for each plot. Observations on blast (causal organism : Pyricularia oryzae) disease severity assessment was carried out on a scale of 0 to 9 where: 0- No lesions visible (0%), 1- Small brown specks of pinhead size (<1%), 2- Small round to slightly elongated brown lesions with yellow halo (1-3%), 3- Few typical blast lesions (spindle-shaped with gray centers) (4-5%), 4- Lesions infecting 6-10% of leaf area, 5-Lesions more numerous, 11-25% leaf area affected, 6- Lesions coalescing, covering 26-50% of the leaf, 7- Lesions killing 51-75% of leaf area, 8- Most of the leaf area (>75%) affected, 9- All leaves dead (by examining five plants per plot). Percentage Disease Index was worked out using the formula, PDI = [Sum of all numerical rating / total number of observations taken x maximum disease score] x 100. The per cent reduction in disease incidence and insect population was calculated over control. The crop yield was recorded at crop harvest. The observations for phytotoxicity on rice crop at 1, 3, 7, 10 and 14 days after 1stspray were also recorded. The data were subjected to statistical analysis of variance. Results are presented in Table 2A, 3A, 4A and 5A.

[0313] Results:

[0314] Table 2A: Field bio-efficacy evaluation of stable synergistic pesticidal composition of present invention comprising Compound of Formula I 4% + Compound of Formula II 9.6% + Pyraclostrobin 16% EC against brown plant hopper of rice crop

[0315]

[0316] Figures in parentheses are square root transformed values; NS= Non-significant

[0317] Table 2B: Field bio-efficacy evaluation of stable synergistic pesticidal composition of present invention comprising Compound of Formula I 4% + Compound of Formula 119.6% + Pyraclostrobin 16% EC against blast disease of rice crop

[0318] Figures in parentheses are angular transformed values; NS= Non-significant Table 2C: Field bio-efficacy evaluation of Compound of Formula I 4% + Compound of Formula 119.6% + Pyraclostrobin 16% EC based on yield of rice crop.

[0319] DAS - Days after crop sowing, q / ha= quintal per hectare Table 2D: Phytotoxicity evaluation of Compound of Formula 14% + Compound of Formula 119.6% + Pyraclostrobin 16% EC on rice crop

[0320] From the examples above, it is clearly seen that the stable synergistic pesticidal composition of the present invention is superior for controlling the Nilaparvata lugens (brown plant hopper) and blast disease (causal organism- Pyricularia oryzae) in rice at 14 days after 1st& 2ndspray (Table 2A and 2B) in rice crop as compared to the other pesticides such as Compound of Formula I 10% w / w SC, Compound of Formula 1170% WG and Pyraclostrobin 100g / l CS available in the market. The yield of rice crop also improved in the stable synergistic pesticidal comp as compared to binary and solo compositions (Table 2C).

[0321] The disclosed synergistic pesticidal composition comprising Compound of Formula I + Compound of Formula 11+ Pyraclostrobin EC @ 468.75, 625, 781.25 and 1250 ml / ha further showed no phytotoxicity in the rice crop even after 1, 3, 7, 10 and 14 days after 1stspray (Table 2D).

[0322] It is evident from the above data that the stable synergistic pesticidal composition of the present invention comprising Compound of Formula I + Compound of Formula 11+ Pyraclostrobin EC resulted in good control of Nilaparvata lugens (brown plant hopper) and blast disease (causal organism- Pyricularia oryzae) in rice with higher respective yields as compared to the reference standard products (binary compositions and solo products). Further, the composition of present invention is resulted synergistic.

[0323] Example 3- Details of experiment on Rice crop:

[0324] Field experiment for synergistic activity of Compound of Formula I + Compound of Formula II + Trifloxystrobin for the control of Brown Planthopper (BPH) {Nilaparvata lugens Stal) and Blast disease (Magnaporthe oryzae B. C. Couch) in Rice crops was conducted.

[0325] To evaluate the synergistic effect, Rice (Variety: HKR-127) crop was sown in 5 m x 5 m plots maintaining 25 x 15 cm plant distance with three replications and in Randomized Block Design (RBD). The treatments were applied as foliar spray in the form of WP formulation @ 375 ml / ha. Each active component was applied twice in different ternary and binary compositions. Solo components were also taken for comparison. The treatment details are as under: The treatments T1 to T28 were applied as foliar sprays, while T29 served as the untreated control. Two foliar applications were carried out at 15-day intervals, initiated upon the appearance of Rice plant in the experimental plots.

[0326] Field observations for Brown Planthopper (BPH) (Nilaparvata lugens Stal) and Blast disease Magnaporthe oryzae B. C. Couch) were recorded during the crop growth period. BPH population was assessed by counting the number of hoppers per hill from randomly selected plants in each plot. Blast incidence was recorded as the percentage of infected plants per plot, based on visual observation of typical lesions on leaves and panicles. Observations were taken from five randomly selected hills per replication, and the data were averaged for statistical analysis under uniform field conditions. Based on the percent reduction at 14 days after second spray in insect population and disease, expected control was calculated and compared with observed control. The results of the trial have been presented here under in Table 3 A.

[0327] Table 3A: Synergistic effect of stable synergistic pesticidal composition of the present invention comprising (Compound of Formula I + Compound of Formula II + Trifloxystrobin) against insect (Brown Planthopper) population and Blast disease in Rice crop.

[0328] It is clearly evident from the data shown in above Table 3A for per cent insect control in Rice crops that the stable synergistic pesticidal composition of the present invention comprising Compound of Formula I + Compound of Formula II + Trifloxystrobin i.e., T1 to T4 are synergistic for insect n disease control with > 1 Colby’s Ratio. The binary composition of two insecticide (Compound of Formula I + Compound of Formula II, Compound of Formula I + Trifloxystrobin and Compound of Formula II + Trifloxystrobin) T5 to T16 show less efficacy and no synergistic effect is shown, as compared to stable synergistic pesticidal composition comprising Compound of Formula I + Compound of Formula II + Trifloxystrobin T1 to T4.

[0329] Experiment for Bio-efficacy evaluation of stable synergistic pesticidal composition of present invention:

[0330] For the ternary and binary composition based on Compound of Formula I + Compound of Formula II + Trifloxystrobin evaluation under field conditions, the basic test composition as Compound of Formula I 6.5% + Compound of Formula II 16% + Trifloxystrobin 13% WP were prepared. For ternary composition, Compound of Formula I 6.5% + Compound of Formula II 16% + Trifloxystrobin 13% WP was used and for binary compositions, Compound of Formula I 6.5% + Compound of Formula II 16% WP, Compound of Formula I 6.5% + Trifloxystrobin 13% WP and Compound of Formula II 16% + Trifloxystrobin 13% WP were used. The solo formulations of these products were used for comparison. The other formulations namely Compound of Formula I 10% w / w SC, Compound of Formula II 70 % WG and Tebuconazole 50% + Trifloxystrobin 25% WG available in the market were also used for comparison.

[0331] Example 4: Evaluation of the stable synergistic pesticidal composition of the present invention on Rice

[0332] The stable synergistic composition of the present invention comprising Compound of Formula I 6.5% + Compound of Formula II 16% + Trifloxystrobin 13% was evaluated on Rice crop variety HKR-127. The crop sowing was done in Randomized Block Design (RBD) with three replications maintaining a distance of 25 cm x 15 cm. The observations were recorded for the following objectives.

[0333] Objectives:

[0334] 1. Bio-efficacy evaluation against Brown Plant Hopper (BPH) on Rice crop.

[0335] 2. Bio-efficacy evaluation against Blast disease on Rice crop.

[0336] 3. Bio-efficacy evaluation based on percent reduction in BPH population.

[0337] 4. Bio-efficacy evaluation based on percent reduction in Blast disease.

[0338] 5. Bio-efficacy evaluation based on crop yield.

[0339] 6. Phytotoxicity evaluation on Rice crop. Treatment details:

[0340] Methodology: The treatments T1 to T18 and T20 were used as foliar application whereas no treatment was done for T19 i.e., control treatment. All treatments were applied at the time of initiation of disease or when insect pest reach at ETL in the experimental plots.

[0341] Observations of Brown Planthopper (BPH) (Nilaparvata lugens Stal) and Blast disease (Magnaporthe oryzae B. C. Couch) were recorded during the crop growth period. BPH population was assessed by counting the number of hoppers per hill from randomly selected plants in each plot. Blast incidence was recorded as the percentage of infected plants per plot, based on visual observation of typical lesions on leaves and panicles. Observations were taken from five randomly selected hills per replication, and the data was averaged for statistical analysis under uniform field conditions. The percent reduction in insect population and disease were also calculated over control. The crop yield was recorded at crop harvest. The observations for phytotoxicity on Rice crop at 1, 3, 7, 10 and 14 days after 1stspray were also recorded. The data were subjected to statistical analysis of variance. Results are presented in Table 4A, 4B, 4B and 4D.

[0342] Results: Table 4A: Field bio-efficacy evaluation of stable synergistic pesticidal composition comprising

[0343] Compound of Formula I 6.5% + Compound of Formula II 16% + Trifloxystrobin 13% (WP) against BPH of Rice crop.

[0344]

[0345]

[0346] Table 4B: Field bio-efficacy evaluation of stable synergistic pesticidal composition comprising Compound of Formula I 6.5% + Compound of Formula II 16% + Trifloxystrobin 13% (WP) against Blast disease of Rice crop.

[0347] Table 4C: Field bio-efficacy evaluation of stable synergistic pesticidal composition comprising Compound of Formula 16.5% + Compound of Formula II 16% + Trifloxystrobin 13% (WP) based on yield of Rice crop.

[0348] Table 4D: Phytotoxicity evaluation of stable synergistic pesticidal composition comprising

[0349] Compound of Formula 16.5% + Compound of Formula II 16% + Trifloxystrobin 13% (WP) on Rice crop.

[0350] From the examples above, it is clearly seen that the stable synergistic pesticidal composition of the present invention is superior for controlling the pests such as BPH and Blast disease in Rice at 14 days after 1st& 2ndspray (Table 4A and 4B) as compared to the other pesticides such as Compound of Formula I 10% w / w SC, Compound of Formula II 70 % WG and Tebuconazole 50% + Trifloxystrobin 25% WG available in the market. The yield of Rice crop also improved in the synergistic pesticidal composition comprising Compound of Formula I + Compound of Formula II + Trifloxystrobin WP as compared to binary and solo compositions (Table 4C).

[0351] The stable synergistic pesticidal composition of present invention comprising Compound of

[0352] Formula I + Compound of Formula II + Trifloxystrobin WP @ 281.25, 375, 468.75 and 750 ml / ha further showed no phytotoxicity in the Rice crop even after 1, 3, 7, 10 and 14 days after 1stspray (Table 4D).

[0353] It is evident from the above data that the stable synergistic pesticidal composition of the present invention comprising Compound of Formula I + Compound of Formula II + Trifloxystrobin WP resulted in good control of BPH and Blast disease in Rice with higher respective yields as compared to the reference standard products (binary compositions and solo products). Further, the composition of present invention is resulted synergistic.

[0354] Example 5- Details of experiment on rice crop:

[0355] Field experiment for synergistic activity of Compound of Formula I + Compound of Formula II + Picoxystrobin for the control of brown plant hopper and blast disease in rice crop was conducted.

[0356] To evaluate the synergistic effect, rice [Variety: Pusa Basmati 1121] crop was sown in 5 m x 5 m plots maintaining 25 cm x 15 cm plant distance with three replications and in Randomized Block Design (RBD). The treatments were applied as foliar spray in the form of WG formulation @ 625 ml / ha. Each active component was applied twice in different ternary and binary compositions. Solo components were also taken for comparison. The treatment details are as under:

[0357] Experiment for Synergistic activity of pesticidal composition of present invention:

[0358] Example 5- Details of experiment on rice crop:

[0359] Field experiment for synergistic activity of Compound of Formula I + Compound of Formula II + Picoxystrobin for the control of brown plant hopper and blast disease in rice crop was conducted.

[0360] To evaluate the synergistic effect, rice [Variety: Pusa Basmati 1121] crop was sown in 5 m x 5 m plots maintaining 25 cm x 15 cm plant distance with three replications and in Randomized Block Design (RBD). The treatments were applied as foliar spray in the form of WG formulation @ 625 ml / ha. Each active component was applied twice in different ternary and binary compositions. Solo components were also taken for comparison. The treatment details are as under:

[0361] The treatments T1 to T28 were used as foliar application whereas no treatment was done for T29 control treatment. Two applications of each treatment were carried out at 15 -day intervals, initiated when pest population reached ETL and initial appearance of disease symptoms in the experimental plots.

[0362] Observations of Nilaparvata lugens (brown plant hopper) were recorded before spraying and at 14 days after the first and second applications from randomly selected plants. The observations were recorded on the number of BPH (nymph and adults) present at the base of the rice plants on selected per 10 hills randomly for each plot. Observations on blast (causal organism : Pyricularia oryzae) disease severity assessment was carried out on a scale of 0 to 9 where: 0- No lesions visible (0%), 1- Small brown specks of pinhead size (<1%), 2- Small round to slightly elongated brown lesions with yellow halo (1-3%), 3- Few typical blast lesions (spindle-shaped with gray centers) (4-5%), 4- Lesions infecting 6-10% of leaf area, 5-Lesions more numerous, 11-25% leaf area affected, 6- Lesions coalescing, covering 26-50% of the leaf, 7- Lesions killing 51-75% of leaf area, 8- Most of the leaf area (>75%) affected, 9- All leaves dead (by examining five plants per plot). Percentage Disease Index was worked out using the formula, PDI = [Sum of all numerical rating / total number of observations taken x maximum disease score] x 100. The percent reduction in disease incidence and pest population was calculated over control. Based on the percent reduction at 14 days after second spray in pest population and disease severity, the Expected control was calculated and compared with Observed control. The results of the trial have been presented here under in Table 5A. Table 5A: Synergistic effect of stable synergistic pesticidal composition of the present invention comprising Compound of Formula I + Compound of Formula II + Picoxystrobin against brown plant hopper and blast disease in rice crop

[0363] It is clearly evident from the data shown in above Table 5A for percent pest and disease control in rice crop that the stable synergistic pesticidal composition of the present invention comprising Compound of Formula I + Compound of Formula II + Picoxystrobin i.e. T1 to T4 are synergistic for controlling pest population and disease with > 1 Colby’s Ratio. The binary composition of two fungicide / insecticide (Compound of Formula I + Compound of Formula II, Compound of Formula I + Picoxystrobin and Compound of Formula II + Picoxystrobin) T5 to T16 is less efficacious and show no synergistic effect for the control of brown plant hopper population and blast disease, as compared to stable synergistic pesticidal composition of present invention comprising Compound of Formula I + Compound of Formula II + Picoxystrobin T1 to T4.

[0364] Experiment for Bio-efficacy evaluation of synergistic pesticidal composition of present invention:

[0365] For the ternary and binary compositions based on Compound of Formula I + Compound of Formula II + Picoxystrobin evaluation under field conditions, the basic test composition as Compound of Formula I 4% + Compound of Formula II 9.6% + Picoxystrobin 24% WG were prepared. For stable synergistic pesticidal composition comprising, Compound of Formula I 4% + Compound of Formula II 9.6% + Picoxystrobin 24% WG was used and for binary compositions, Compound of Formula I 4% + Compound of Formula II 9.6% WG, Compound of Formula I 4% + Picoxystrobin 24% WG and Compound of Formula II 9.6% + Picoxystrobin 24% WG were used. The solo formulations of Compound of Formula I 4% WG, Compound of Formula II 9.6% WG, Picoxystrobin 24% WG were used for comparison. The other formulations namely Compound of Formula I 10% w / w SC, Compound of Formula II 70% WG and Picoxystrobin 22.52% w / w SC available in the market were also used for comparison.

[0366] Example 6: Evaluation of the stable synergistic pesticidal composition of the present invention on rice

[0367] The stable synergistic pesticidal composition of the present invention comprising Compound of Formula I 4% + Compound of Formula II 9.6% + Picoxystrobin 24% WG was evaluated on rice crop variety Pusa Basmati 1121 at a farmer field. The crop sowing was done in Randomized Block Design (RBD) with three replications maintaining a distance of 25 cm x 15 cm. The observations were recorded for the following objectives.

[0368] Objectives:

[0369] 1. Bio-efficacy evaluation against brown plant hopper (BPH) on rice crop.

[0370] 2. Bio-efficacy evaluation against blast disease on rice crop.

[0371] 3. Bio-efficacy evaluation based on per cent reduction in brown plant hopper (BPH) population.

[0372] 4. Bio-efficacy evaluation based on percent reduction in blast disease severity.

[0373] 5. Bio-efficacy evaluation based on crop yield.

[0374] 6. Phytotoxicity evaluation on rice crop. Treatment details:

[0375] Methodology: The treatments T1 to T18 and T20 were used as foliar application whereas no treatment was done for T19 i.e., control treatment. All treatments were applied at the time of when pest population reached ETL in the experimental plots.

[0376] Observations of Nilaparvata lugens (brown plant hopper) were recorded before spraying and at 14 days after the first and second applications from randomly selected plants. The observations were recorded on the number of BPH (nymph and adults) present at the base of the rice plants on selected per 10 hills randomly for each plot. Observations on blast (causal organism : Pyricularia oryzae) disease severity assessment was carried out on a scale of 0 to 9 where: 0- No lesions visible (0%), 1- Small brown specks of pinhead size (<1%), 2- Small round to slightly elongated brown lesions with yellow halo (1-3%), 3- Few typical blast lesions (spindle-shaped with gray centers) (4-5%), 4- Lesions infecting 6-10% of leaf area, 5-Lesions more numerous, 11-25% leaf area affected, 6- Lesions coalescing, covering 26-50% of the leaf, 7- Lesions killing 51-75% of leaf area, 8- Most of the leaf area (>75%) affected, 9- All leaves dead (by examining five plants per plot). Percentage Disease Index was worked out using the formula, PDI = [Sum of all numerical rating / total number of observations taken x maximum disease score] x 100. The per cent reduction in disease incidence and insect population was calculated over control. The crop yield was recorded at crop harvest. The observations for phytotoxicity on rice crop at 1, 3, 7, 10 and 14 days after 1stspray were also recorded. The data were subjected to statistical analysis of variance. Results are presented in Table 6A, 6B, 6C and 6D. Results:

[0377] Table 6A: Field bio-efficacy evaluation of stable synergistic pesticidal composition of present invention comprising Compound of Formula I 4% + Compound of Formula II 9.6% + Picoxystrobin 24% WG against brown plant hopper of rice crop

[0378]

[0379] Figures in parentheses are square root transformed values; NS= Non-significant Table 6B: Field bio-efficacy evaluation of stable synergistic pesticidal composition of present invention comprising Compound of Formula 14% + Compound of Formula II 9.6% + Picoxystrobin 24% WG against blast disease of rice crop

[0380] Figures in parentheses are angular transformed values; NS= Non-significant

[0381] Table 6C: Field bio-efficacy evaluation of stable synergistic pesticidal composition of present invention comprising Compound of Formula I 4% + Compound of Formula II 9.6% + Picoxystrobin 24% WG based on yield of rice crop.

[0382] DAS - Days after crop sowing, q / ha= quintal per hectare

[0383] Table 6D: Phytotoxicity evaluation of Compound of Formula 14% + Compound of Formula

[0384] II 9.6% + Picoxystrobin 24% WG on rice crop

[0385] From the examples above, it is clearly seen that the synergistic pesticidal composition of the present invention is superior for controlling the Nilaparvata lugens (brown plant hopper) and blast disease (causal organism- Pyricularia oryzae) in rice at 14 days after 1st& 2ndspray (Table 6A and 6B) in rice crop as compared to the other pesticides such as Compound of Formula I 10% w / w SC, Compound of Formula II 70% WG and Picoxystrobin 22.52% w / w SC available in the market. The yield of rice crop also improved in the stable synergistic pesticidal composition of present invention comprising Compound of Formula I + Compound of Formula II + Picoxystrobin WG as compared to binary and solo compositions (Table 6C). The disclosed stable synergistic pesticidal composition of present invention comprising Compound of Formula I + Compound of Formula II + Picoxystrobin WG @ 468.75, 625, 781.25 and 1250 ml / ha further showed no phytotoxicity in the rice crop even after 1, 3, 7, 10 and 14 days after 1stspray (Table 6D).

[0386] It is evident from the above data that the stable synergistic pesticidal composition of the present invention comprising Compound of Formula I + Compound of Formula II + Picoxystrobin WG resulted in good control of Nilaparvata lugens (brown plant hopper) and blast disease (causal organism- Pyricularia oryzae) in rice with higher respective yields as compared to the reference standard products (binary compositions and solo products). Further, the composition of present invention is resulted synergistic.

[0387] From the above investigations, it will be observed that numerous modifications and variations can be effectuated without departing from the true spirit and scope of the novel concepts of the present invention. It is to be understood that no limitations with respect to the specific embodiments illustrated is intended or should be inferred. It should be understood that all such modifications and improvements have been deleted herein for the sake of conciseness and readability but are properly within the scope of the following claims.

Claims

AIM

1. A stable synergistic pesticidal composition comprising:A) Compound of Formula I, i.e., 2,4-dioxo-l-(pyrimidin-5-ylmethyl)-3-[3- trifluoromethyl)phenyl] -3,4-dihydro-2H-pyrido[ 1 ,2-a]pyrimidin- 1 -ium-3 -ide or its agrochemically acceptable salts, esters and derivatives;B) Compound of Formula II, i.e., N-methyl-N'-nitro-N"-[(tetrahydro-3- furanyl)methyl]guanidine or its agrochemically acceptable salts, esters and derivatives; andC) At least one strobilurin fungicide selected from Pyraclostrobin, Trifloxystrobin, or Picoxystrobin or its agrochemically acceptable salts, esters or its derivatives.

2. The stable synergistic pesticidal composition as claimed in claim 1, comprising:A) Compound of Formula I, i.e., 2,4-dioxo-l-(pyrimidin-5-ylmethyl)-3-[3- trifluoromethyl)phenyl] -3,4-dihydro-2H-pyrido[ 1 ,2-a]pyrimidin- 1 -ium-3 -ide or its agrochemically acceptable salts, esters and derivatives, in the range of 0.1-90% by weight of the composition;B) Compound of Formula II, i.e., N-methyl-N'-nitro-N"-[(tetrahydro-3- furanyl)methyl]guanidine or its agrochemically acceptable salts, esters and derivatives, in the range of 0.1-90% by weight of the composition; andC) At least one strobilurin fungicide selected from Pyraclostrobin, Trifloxystrobin, or picoxystrobin or its agrochemically acceptable salts, esters or its derivatives, in the range of 0.1 -90% by weight of the composition.

3. A stable synergistic pesticidal composition comprising:A) Compound of Formula I, i.e., 2,4-dioxo-l-(pyrimidin-5-ylmethyl)-3-[3- trifluoromethyl)phenyl] -3,4-dihydro-2H-pyrido[ 1 ,2-a]pyrimidin- 1 -ium-3 -ide or its agrochemically acceptable salts, esters and derivatives;B) Compound of Formula II, i.e., N-methyl-N'-nitro-N"-[(tetrahydro-3- furanyl)methyl]guanidine or its agrochemically acceptable salts, esters and derivatives; andC) At least one strobilurin fungicide selected from Pyraclostrobin, Trifloxystrobin, or Picoxystrobin or its agrochemically acceptable salts, esters or its derivatives.A) At least one or more additive.

4. A stable synergistic pesticidal composition comprising:A) Compound of Formula I, i.e., 2,4-dioxo-l-(pyrimidin-5-ylmethyl)-3-[3- trifluoromethyl)phenyl] -3,4-dihydro-2H-pyrido[ 1 ,2-a]pyrimidin- 1 -ium-3 -ide or its agrochemically acceptable salts, esters and derivatives, in the range of 0.1-90% by weight of the composition;B) Compound of Formula II, i.e., N-methyl-N'-nitro-N"-[(tetrahydro-3- furanyl)methyl]guanidine or its agrochemically acceptable salts, esters and derivatives, in the range of 0.1-90% by weight of the composition;C) At least one strobilurin fungicide selected from Pyraclostrobin, Trifloxystrobin, or Picoxystrobin or its agrochemically acceptable salts, esters or its derivatives in the range of 0.1-90% by weight of the composition; andD) At least one or more additive selected from urea clathrate, Siloxane Polyalkyleneoxide Copolymer, tallow amine ethoxylate, ammonium sulphate, and epoxide soybean oil either alone or in combination thereof, in the range of 0.01-20% by weight of the composition.

5. . The stable synergistic pesticidal composition as claimed in claims 1-4, which further comprises one or more agrochemically acceptable excipients.

6. . The stable synergistic pesticidal composition as claimed in claim 1 to 5, wherein agrochemically acceptable excipients comprises surfactant(s), dispersing agent(s), co -dispersant, anti-freezing agent(s), emulsifier(s)( (anionic and non-ionic), anti-foaming agent / defoamer(s), wetting agent(s), biocide / antimicrobial / anti-bacterial agent(s), thickening agent / thickener(s),quick coating agent(s) or sticking agents / sticker(s), spreader(s), binder(s), pH-adjusting agent(s), anti-caking agent(s), adjuvant(s), filler(s) / suspension aid(s), colorant(s) / colouring agent(s) / dye(s), carrier(s), stabilizer, buffering agent(s), polymer(s), safener(s), rheology modifier(s), solvent(s), co-solvent(s), or mixtures thereof.

7. . The stable synergistic pesticidal composition as claimed in any one of the claims 1 to 5, wherein the composition is in form of Emulsifiable concentrate (EC), Capsule suspension (CS), Dispersible concentrate (DC), Dustable powder (DP), Powder for dry seed treatment (DS), Emulsifiable granule (EG), Emulsion water-in-oil (EO), Emulsifiable powder (EP), Emulsion for seed treatment (ES), Emulsion oil-in-water (EW), Flowable concentrate for seed treatment (FS), Granules (GR), Wettable granules (WG) Micro-emulsion concentrate (MEC), Oil-dispersion (OD), Oil miscible flowable concentrate (OF), Oil miscible liquid (OL), Oil dispersible powder (OP), Suspension concentrate (SC), Suspension concentrate for direct application (SD), Suspo- emulsion (SE), Water soluble granule (SG), Soluble concentrate (SL), Spreading oil (SO), Water soluble powder (SP), Water soluble tablet (ST), Ultra-low volume (ULV) suspension, Tablet (TB), Ultra-low volume (ULV) liquid, Water dispersible granules (WG), Wettable powder (WP), Water dispersible powder for slurry seed treatment (WS), Water dispersible tablet (WT), a mixed composition of CS and SC (ZC) or a mixed composition of CS and SE (ZE) and a mixed composition of CS and EW (ZW).

8. . The stable synergistic pesticidal composition as claimed in claims 1 to 7, wherein the use of said composition promotes plant health, growth and increases plant yield in the field.

9. . A process for preparing a stable synergistic pesticidal composition comprising:A) Compound of Formula I, i.e., 2,4-dioxo-l-(pyrimidin-5-ylmethyl)-3-[3- trifluoromethyl)phenyl] -3,4-dihydro-2H-pyrido[ 1 ,2-a]pyrimidin- 1 -ium-3 -ide or its agrochemically acceptable salts, esters and derivatives;B) Compound of Formula II, i.e., N-methyl-N'-nitro-N"-[(tetrahydro-3- furanyl)methyl]guanidine or its agrochemically acceptable salts, esters and derivatives; andC) At least one strobilurin fungicide selected from Pyraclostrobin, Trifloxystrobin, or picoxystrobin or its agrochemically acceptable salts, esters or its derivatives.

10. . The process for preparing a stable synergistic pesticidal composition as claimed in claim 9, comprises the steps of: i) selecting and weighing the compounds of formula I, Hexythiazox, and Compound of Formula II, and at least one strobilurin fungicide selected from Pyraclostrobin, Trifloxystrobin, or picoxystrobin in predetermined synergistic proportions; ii) mixing the said active ingredients with one or more agrochemically acceptable carriers and / or excipients iii) optionally incorporating one or more surfactants, dispersing agents, wetting agents, suspending agents, stabilizers, defoamers, or binders to obtain a homogeneous mixture; and iv) processing the resulting mixture into a desired formulation type selected from or Emulsifiable concentrate (EC), Wettable powder (WP), Wettable granules (WG), Suspension concentrate (SC), Suspo-emulsion (SE), Micro-emulsion (ME), Emulsion for seed treatment (ES), , etc. by known techniques such as grinding, granulation, or high- shear homogenization, emulsification followed by drying, sieving, and packaging to obtain a physically and chemically stable synergistic composition suitable for agricultural application.

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