Target-tissue-specific antigen-binding molecule

Antigen-binding molecules with concentration-dependent activity address the challenge of target tissue specificity, enabling effective therapy on cancer or inflamed tissues while reducing side effects on normal tissues.

AU2023229507B2Pending Publication Date: 2026-07-23CHUGAI PHARMA CO LTD
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Patent Information

Authority / Receiving Office
AU · AU
Patent Type
Applications
Current Assignee / Owner
CHUGAI PHARMA CO LTD
Filing Date
2023-09-12
Publication Date
2026-07-23

AI Technical Summary

Technical Problem

Existing antibody pharmaceuticals face challenges in achieving target tissue-specific cytotoxic activity while minimizing side effects on normal tissues due to antigen expression in both cancer and normal cells, and there is a lack of techniques for reversible action at lesion sites without systemic effects.

Method used

Development of antigen-binding molecules with varying antigen-binding activity based on the concentration of target tissue-specific compounds, such as kynurenine or its precursors, allowing for selective binding and action at lesion sites like cancer or inflamed tissues.

Benefits of technology

The antigen-binding molecules provide targeted therapeutic effects on cancer or inflamed tissues while minimizing side effects on normal tissues by varying binding activity based on tissue-specific metabolite concentrations.

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Abstract

The present inventors discovered that the above-mentioned problems can be solved by producing antigen-binding molecules that contain an antigen-binding domain whose 5 antigen- binding activity varies depending on the concentration of a target tissue-specific compound. Use of antigen-binding molecules of the present invention enables various diseases that originate from a target tissue to be treated in a manner specific to the target tissue. 20 23 22 95 07 1 2 Se p 20 23 TARGET-TISSUE-SPECIFIC ANTIGEN-BINDING MOLECULE 12 Sep 2023 2023229507
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Citation Information

Patent Citations

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    WO2009125825A1

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    WO2011038302A2