Processes for the preparation of azoxystrobin using DABCO as a catalyst and novel intermediates used in the processes

By using DABCO as a catalyst in the preparation process of azoxystrobin, the problem of large catalyst dosage is solved, production costs and environmental pollution are reduced, productivity is increased, and environmental benefits are achieved.

CN102126955BInactive Publication Date: 2012-12-12SYNGENTA IP
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Patent Information

Application Number
CN201010583801.7
Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
Priority Date
2005-04-26
Filing Date
2006-04-13
Publication Date
2012-12-12
Estimated Expiration
Not applicable · inactive patent

AI Technical Summary

Technical Problem

When preparing the strobilurin fungicide azoxystrobin in the prior art, a large amount of catalyst is used, resulting in high production costs and environmental pollution problems.

Method used

Using 1,4-diazabicyclo[2.2.2]octane (DABCO) as the catalyst, by reacting with 2-cyanophenol or its salt in the presence of 0.1 to 2 mol% DABCO, the catalyst dosage can be reduced and the yield can be increased. Rate.

Benefits of technology

It significantly reduces the amount of catalyst, reduces production costs and environmental pollution, increases the yield of azoxystrobin, and achieves environmental benefits.

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Abstract

The present invention relates to a process for preparing a compound of formula (IV) where W is the methyl ( E )-2-(3-methoxy)acrylate group, which comprises the steps of: (i) reacting the compound of formula (IV) where W is the methyl 2-(3,3-dimethoxy)propanoate group with a reagent that will protect the hydroxyl group of that compound from reaction during subsequent demethanolysis; (ii) eliminating methanol from the hydroxyl-protected compound formed in step (i); and (iii) removing the hydroxyl-protecting group formed in step (i) to form a compound of formula (IV) where W is the methyl ( E )-2-(3-methoxy)acrylate group.
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