Subtilase variants

By modifying Bacillus subtilis enzymes with specific amino acids, the enzyme stability and washing performance in liquid detergents were improved, solving the problem of enzyme activity loss in existing technologies and achieving better washing results.

CN107002058BActive Publication Date: 2026-01-27NOVOZYMES AS
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Patent Information

Application Number
CN201580065712.4
Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
Priority Date
2014-12-15
Filing Date
2015-12-14
Publication Date
2026-01-27
Estimated Expiration
2036-03-20

AI Technical Summary

Technical Problem

There is still room for improvement in the stability and washing performance of enzymes in existing liquid detergents, especially the problem of activity loss of wild-type Bacillus subtilis enzymes during storage has not been effectively solved.

Method used

Variant enzymes with specific amino acid sequences identical to the parent Bacillus subtilis enzyme were developed. Their stability and washing performance in liquid detergents were improved by introducing substitutions, deletions, or insertions of amino acid residues at specific positions.

Benefits of technology

This study achieved improved stability and washing performance of the variant enzyme in liquid detergents, enhancing the enzyme's storage stability and washing effect.

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Abstract

The present invention relates to novel protease variants exhibiting improved stability and or improved wash performance in liquid detergents. The variants of the invention are suitable for use in, for example, cleaning or detergent compositions, such as laundry detergent compositions and dishwashing compositions, including automatic dishwashing compositions. The invention also relates to isolated DNA sequences encoding the variants, expression vectors, host cells, and methods for producing and using the variants of the invention.
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