Novel insecticide target gene acting on insect and application of gene
By activating the diamondback moth adenosine receptor PxAdoR with the adenosine derivative HEA, we developed a diamondback moth insecticide targeting drug-resistant pests, solving the problems of traditional pesticide resistance and toxicological risks and achieving safe and efficient insecticide. Effect.
Patent Information
- Application Number
- CN201610113600.8
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- Filing Date
- 2016-02-29
- Publication Date
- 2017-09-05
- Estimated Expiration
- 2036-02-29
AI Technical Summary
The diamondback moth has developed significant resistance to existing pesticides, resulting in increased toxicological risks and ecological imbalance in the use of traditional pesticides, necessitating the development of new safe and effective pesticides.
The adenosine derivative N6-(2-hydroxyethyl)adenosine (HEA) isolated from Cordyceps sinensis is used as a potential insecticide to activate the diamondback moth adenosine receptor PxAdoR, inhibit its growth, and utilize adenosine Glycoside receptor agonists and inhibitors were used to screen suitable pesticide targets.
HEA significantly inhibits the growth and lethality of diamondback moth. The adenosine receptor inhibitor SCH58261 can counteract the lethal effect of HEA, providing a new insecticidal target and pesticide screening strategy, reducing the toxicity to beneficial insects and improving the ecological balance.