Antibacterial polymeric monomer containing halogenated imidazolium salt and preparation method and application of antibacterial polymeric monomer

By developing antibacterial polymerizable monomers containing halogenated imidazole salt structures, the problems of lack of antibacterial activity in acrylate bone cement and reduced mechanical properties of antibiotic bone cement have been solved, and the effect of imparting long-lasting antibacterial properties to acrylate bone cement has been achieved.

CN107162981AActive Publication Date: 2017-09-15SOUTH CHINA UNIV OF TECH
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Patent Information

Application Number
CN201710370647.7
Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
Filing Date
2017-05-23
Publication Date
2017-09-15
Estimated Expiration
2037-05-23

AI Technical Summary

Technical Problem

Existing acrylic bone cement lacks antibacterial activity, resulting in the need for revision surgery after infection, which increases patient pain and burden, and antibiotic-containing bone cement has problems with reduced mechanical properties and drug resistance.

Method used

Develop antibacterial polymerizable monomers containing halogenated imidazole salt structures, prepared through the reaction of N-hydroxyalkyl imidazole with isocyanylethyl methacrylate and alkyl halides, to generate antibacterial methacrylate monomers for partial replacement Methyl methacrylate gives bone cement long-lasting antibacterial properties.

Benefits of technology

The antibacterial polymerizable monomer significantly improves the antibacterial performance in acrylic bone cement, can participate in the curing process, prevent infection, and does not affect the mechanical properties of the bone cement.

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Abstract

The invention discloses an antibacterial polymeric monomer containing a halogenated imidazolium salt structure and a preparation method and application of the antibacterial polymeric monomer. The antibacterial polymeric monomer containing the halogenated imidazolium salt structure can be used as an antibacterial additive of acrylic bone cement. The monomer has the characteristics that the acrylic bone cement can be endowed with very high antibacterial property, the influence on curing time of the self-coagulating acrylic bone cement is small, the dough time of the bone cement can be significantly shortened, and meanwhile, the bone cement containing the monomer is good in mechanical property.
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