Antiallergic gel for nasal use and preparation method thereof

Abstract

The present invention relates to an anti-allergic gel for nose containing sodium hyaluronate and a preparation method thereof. The product is composed of paraffin, vaseline, lanolin and sodium hyaluronate. The gel of the present invention is used to relieve seasonal or perennial inhalable allergic rhinitis and dry nose symptoms, such as pollen, dust and dust mites. The product is easy to carry and easy to use, and no preservatives are added in the ingredients, so it is highly safe.

Description

Technical Field

[0001] The invention relates to the technical field of anti-allergic agents, and in particular to an anti-allergic gel for nose and a preparation method thereof. Background Art

[0002] Allergic rhinitis is allergic rhinitis. Allergens are antigens that induce specific IgE antibodies and react with them. They mostly come from animals, plants, insects, fungi or other allergic substances. Allergens are mainly divided into inhaled allergens and food allergens.

[0003] Treatments for allergic rhinitis include: 1. Drug therapy, such as antihistamines, glucocorticoids, anti-leukotriene drugs, and other important drugs. The efficacy may vary between different patients. There is no long-term sustained efficacy after discontinuation of the drug, so maintenance treatment is required for persistent allergic rhinitis; 2. Immunotherapy, which induces clinical and immune tolerance, has long-term effects, and can prevent the development of allergic diseases. Allergen-specific immunotherapy is commonly used for subcutaneous injection and sublingual administration. The course of treatment is divided into a dose accumulation phase and a dose maintenance phase, and the total course of treatment is not less than 2 years; 3. Surgical treatment, the indications are that the symptoms of nasal congestion have not improved after drug or immunotherapy, there are obvious signs, and the quality of life is affected; the nasal cavity has obvious anatomical variations, accompanied by functional disorders; surgical treatment is not a routine method for the treatment of allergic rhinitis; 4. Avoid contact with strain allergens. This method is simple and effective, but inhaled allergens are difficult to avoid using conventional methods.

[0004] Based on the above problems, there is a need to develop an allergen barrier that is easy to use, simple and effective. The domestically produced Mabijing is a water-based gel with low adhesion. Summary of the invention

[0005] In view of the problems existing in the prior art, the purpose of the present invention is to provide an anti-allergic gel for nasal use with excellent performance. By utilizing its extremely strong viscosity and physical adsorption effect, inhaled allergens such as dust and pollen can be isolated to play a role in isolating allergens. The product is composed of an oily gel and a moisturizing ingredient, oil-dispersed sodium hyaluronate, which has strong adhesion and can moisturize the nasal cavity.

[0006] The objective of the present invention is achieved through the following technical solutions:

[0007] The first aspect of the present invention provides an antiallergic gel for nasal use, characterized in that it comprises the following components in parts by weight: 40-62 parts of solvent, 20-28 parts of paraffin, 10-30 parts of vaseline, 0.01-0.2 parts of hyaluronic acid, and 1.9-3 parts of lanolin.

[0008] Preferably, the weight proportion of the solvent is 40, 42, 45, 50, 55, 58 or 60 parts; the weight proportion of the paraffin is 20, 21, 22, 23, 24, 25, 26, 27 or 28 parts; the weight proportion of the vaseline is 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29 or 30 parts; the weight proportion of the hyaluronic acid is The weight parts of the lanolin are 0.01, 0.02, 0.03, 0.04, 0.05, 0.06, 0.07, 0.08, 0.09, 0.1, 0.11, 0.12, 0.13, 0.14, 0.15, 0.16, 0.17, 0.18, 0.19 or 0.2 parts; the weight parts of the lanolin are 1.9, 2.0, 2.1, 2.2, 2.3, 2.4, 2.5, 2.6, 2.7, 2.8, 2.9 and 3 parts.

[0009] Preferably, the paraffin wax is selected from one or more of solid paraffin wax and microcrystalline wax.

[0010] Preferably, the solvent is selected from liquid paraffin, and the liquid paraffin is liquid light paraffin.

[0011] Preferably, the vaseline is selected from white vaseline or yellow vaseline.

[0012] Preferably, the anti-allergic gel for nasal use further comprises peppermint oil.

[0013] The second aspect of the present invention provides a method for preparing an antiallergic gel for nasal use, comprising the following steps:

[0014] 1) Add vaseline, solid paraffin and lanolin to liquid paraffin, heat to 75-85°C, and stir until all the solids are dissolved to obtain a first solution;

[0015] 2) Cooling the first solution to 55-65° C., adding sodium hyaluronate, and stirring evenly to obtain the nasal antiallergic gel.

[0016] Preferably, the sodium hyaluronate is oil-dispersed sodium hyaluronate.

[0017] Preferably, the step 2) comprises: cooling the first solution to 55-65° C., adding oil-dispersed sodium hyaluronate and peppermint oil, and stirring evenly to obtain the anti-allergic gel for nasal use.

[0018] Preferably, the oil-dispersed sodium hyaluronate is made from sodium hyaluronate and vegetable oil by a special process, and the main active ingredient sodium hyaluronate is uniformly dispersed in the oil in the form of microspheres.

[0019] Compared with the prior art, the beneficial effects of the present invention are:

[0020] The anti-allergic gel for nose provided by the present invention utilizes its extremely strong physical adsorption effect to isolate inhaled allergens such as dust and pollen, thereby isolating allergens. The product is an oily gel and contains a moisturizing component, oil-dispersed sodium hyaluronate. It has strong adhesion and can moisturize the nasal cavity, effectively relieving and preventing allergic rhinitis.

[0021] The nasal anti-allergic gel provided by the invention has a simple preparation process, is easy to use, is simple and effective, has no side effects, and can significantly improve the quality of life of patients. BRIEF DESCRIPTION OF THE DRAWINGS

[0022] Figure 1A This is a picture of the nasal cavity after cleaning;

[0023] Figure 1B This is the nasal examination picture of the blank control group after one week;

[0024] Figure 1C This is the nasal examination picture of experimental group 1 one week later;

[0025] Figure 1D This is the nasal examination picture of experimental group 2 one week later;

[0026] Figure 1E This is the nasal examination picture of experimental group 3 one week later;

[0027] Figure 1F This is the nasal examination picture of experimental group 4 one week later. DETAILED DESCRIPTION

[0028] The following examples will further illustrate the present invention, but are not intended to limit the scope of the present invention. Any modifications and changes made by those skilled in the art without departing from the spirit of the present invention are within the scope of the present invention.

[0029] Embodiment 1

[0030] This embodiment provides an anti-allergic gel for nasal use, which comprises the following components by weight: 40 parts of liquid paraffin, 20 parts of solid paraffin, 10 parts of vaseline, 0.01 parts of hyaluronic acid, and 0.2 parts of lanolin. The vaseline is selected from white vaseline or yellow vaseline.

[0031] This embodiment further provides a method for preparing an antiallergic nasal gel, comprising the following steps:

[0032] 1) Add vaseline, solid paraffin and lanolin to liquid paraffin, heat to 75-85°C, and stir until all the solids are dissolved to obtain a first solution;

[0033] 2) Cooling the first solution to 55-65° C., adding oil to disperse sodium hyaluronate, and stirring evenly to obtain the nasal antiallergic gel.

[0034] Embodiment 2

[0035] The present embodiment provides an anti-allergic gel for nasal use, which comprises the following components by weight: 58 parts of liquid paraffin, 23 parts of solid paraffin, 15 parts of vaseline, 0.02 parts of oil-dispersed hyaluronic acid, 3 parts of lanolin, and 0.03 parts of peppermint oil. The vaseline described in the present embodiment is selected from white vaseline or yellow vaseline.

[0036] This embodiment further provides a method for preparing an antiallergic nasal gel, comprising the following steps:

[0037] 1) Add vaseline, solid paraffin and lanolin to liquid paraffin, heat to 75-85°C, and stir until all the solids are dissolved to obtain a first solution;

[0038] 2) Cooling the first solution to 55-65° C., adding oil-dispersed sodium hyaluronate and peppermint oil, and stirring evenly to obtain the nasal antiallergic gel.

[0039] Embodiment 3

[0040] The present embodiment provides an anti-allergic gel for nasal use, which comprises the following components by weight: 60 parts of liquid paraffin, 20 parts of solid paraffin, 18 parts of vaseline, 0.1 parts of oil-dispersed hyaluronic acid, 1.9 parts of lanolin, and 0.01 parts of peppermint oil. The vaseline described in the present embodiment is selected from white vaseline or yellow vaseline.

[0041] This embodiment further provides a method for preparing an antiallergic nasal gel, comprising the following steps:

[0042] 1) Add vaseline, solid paraffin and lanolin to liquid paraffin, heat to 75-85°C, and stir until all the solids are dissolved to obtain a first solution;

[0043] 2) Cooling the first solution to 55-65° C., adding oil-dispersed sodium hyaluronate and peppermint oil, and stirring evenly to obtain the nasal antiallergic gel.

[0044] Embodiment 4

[0045] This embodiment provides an anti-allergic gel for nasal use, which comprises the following components by weight: 62 parts of liquid paraffin, 22 parts of solid paraffin, 16 parts of vaseline, and 0.1 parts of oil-dispersed hyaluronic acid. The vaseline in this embodiment is selected from white vaseline or yellow vaseline.

[0046] This embodiment further provides a method for preparing an antiallergic nasal gel, comprising the following steps:

[0047] 1) Add vaseline and solid paraffin into liquid paraffin, heat to 75-85°C, and stir until all the solids are dissolved to obtain a first solution;

[0048] 2) Cooling the first solution to 55-65° C., adding oil to disperse sodium hyaluronate, and stirring evenly to obtain the nasal antiallergic gel.

[0049] Effectiveness evaluation:

[0050] 1. Experimental purpose: To test the ability of the nasal cavity to adhere to dust by simulating the dust concentration in the air and verify the effectiveness of the product.

[0051] 2. Instruments: laptop computer, nasal endoscope

[0052] 3. Sample: the products described in Example 1, Example 2, Example 3 and Example 4.

[0053] 4. Experimental subjects: 5 Bama Xiang pigs were divided into five groups: blank control group, experimental group 1, experimental group 2, experimental group 3, and experimental group 4.

[0054] 5. Experimental methods:

[0055] 1) Sample preparation: taking the products prepared in Example 1, Example 2, Example 3 and Example 4 of the present invention;

[0056] 2) Rinse the pigs’ nasal cavity with saline and use an endoscope to detect nasal symptoms after cleaning;

[0057] 3) The products prepared in Example 1, Example 2, Example 3 and Example 4 were evenly applied to one nostril of Experimental Group 1, Experimental Group 2, Experimental Group 3 and Experimental Group 4 for one week, and the other nostril was not treated;

[0058] 4) Take an equal amount of powder to simulate a high dust concentration environment in the air, and use a nasal endoscope to detect the dust adsorption effect.

[0059] 6. Experimental results:

[0060] Experimental results reference Figure 1A-1F , Figure 1A This is a picture of the nasal cavity after cleaning, showing that the inner wall of the nasal cavity is clean and smooth; Figure 1B This is the nasal cavity test picture of the blank control group after one week, showing a small amount of dust adhering to the inner wall; Figure 1C This is the nasal examination picture of experimental group 1 one week later, showing that a layer of dust adheres to the inner wall of experimental group 1; Figure 1D This is the nasal examination picture of experimental group 2 one week later, showing that a layer of dust adheres to the inner wall of experimental group 2; Figure 1EThis is the nasal examination picture of experimental group 3 one week later, showing that a layer of dust adheres to the inner wall of experimental group 3; Figure 1F This is the nasal examination picture of experimental group 4 one week later, showing that a layer of dust adheres to the inner wall of experimental group 4;

[0061] 7. Experimental data analysis:

[0062] Image-Pro Plus was used to calculate the dust adhesion area (Area) and integrated optical density (IOD) of the four products, which reflects the adhesion performance of the products:

[0063] Table 1 Analysis data of dust adhesion to nasal cavity area

[0064] Product Name Dust adhesion area Integrated optical density Experimental Group 1 47112.7±3511.9 17390.7±1234.7 Experimental Group 2 42312.7±3612.5 16190.7±1524.5 Experimental Group 3 33356.7±3732.8 15807.7±2754.3 Experimental Group 4 37448.7±3381.5 16266.3±1811.1 Blank control 9126.0±486.1 3873.0±135.9

[0065] 8. Experimental conclusion:

[0066] from Figure 1A-1F It can be seen intuitively that most of the dust that enters the nasal cavity after applying the product is adhered to the nasal cavity, while only a small amount of dust in the nasal cavity without applying the product is attached to the inner wall of the nose by the nasal cilia and nasal secretions, indicating that the adhesion of the nasal cavity to dust is significantly increased after applying the product. Table 1 shows the data of the image analyzed by Image-Pro, and the area and integrated optical density of dust adhering to the nasal cavity are calculated. The area and integrated optical density of dust adsorbed by this product are much greater than those of the blank control, indicating that this product has extremely strong adhesion, and can achieve the effect of reducing the entry of adsorbed particles into the nasal cavity through adhesion, and relieve allergic reactions caused by allergic rhinitis and allergic asthma.

[0067] The above contents are further detailed descriptions of the present invention in combination with specific preferred embodiments, and it cannot be determined that the specific implementation of the present invention is limited to these descriptions. For ordinary technicians in the technical field to which the present invention belongs, several simple deductions or substitutions can be made without departing from the concept of the present invention, which should be regarded as falling within the protection scope of the present invention.

Claims

1. An antiallergic gel for nasal use, characterized in that: The composition is composed of the following components by weight: 40 parts of liquid paraffin, 20 parts of solid paraffin, 10 parts of vaseline, 0.01 parts of hyaluronic acid, and 0.2 parts of lanolin; the hyaluronic acid is oil-dispersed sodium hyaluronate; the preparation method of the anti-allergic gel for nose comprises the following steps: (1) Add vaseline, solid paraffin and lanolin to liquid paraffin, heat to 75-85°C, and stir until all the solids are dissolved to obtain a first solution; (2) Cooling the first solution to 55-65° C., adding oil to disperse sodium hyaluronate, and stirring evenly to obtain the nasal antiallergic gel.

2. The antiallergic gel for nasal use according to claim 1, characterized in that: The liquid paraffin is liquid light paraffin.

3. The antiallergic gel for nasal use according to claim 1, characterized in that: The vaseline is selected from white vaseline or yellow vaseline.

4. A method for preparing the antiallergic gel for nasal use as claimed in claim 1, characterized in that: The following steps are involved: (1) Add vaseline, solid paraffin and lanolin to liquid paraffin, heat to 75-85° C., and stir until all the solids are dissolved to obtain a first solution; (2) Cooling the first solution to 55-65° C., adding oil-dispersed sodium hyaluronate, and stirring evenly to obtain the nasal antiallergic gel.

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