A method for synthesizing fluopyram

2,3-Dichloro-5-trifluoromethylpyridine and o-trifluoromethylbenzoyl chloride are converted into fluopyram through a three-step reaction, which solves the problems of environmental pollution and too long reaction routes in the existing technology. , realizing the synthesis of fluopyram with high efficiency and high purity.

CN113429338BActive Publication Date: 2023-05-02CHINATECH (SHAANXI) MATERIALS IND CO LTD
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Patent Information

Application Number
CN202110549782.4
Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
Filing Date
2021-05-20
Publication Date
2023-05-02
Estimated Expiration
2041-05-20

AI Technical Summary

Technical Problem

The existing fluopyram synthesis method has the problems of environmental pollution, long reaction route, and poor atom economy.

Method used

2,3-Dichloro-5-trifluoromethylpyridine and o-trifluoromethylbenzoyl chloride are used as reaction raw materials, and commercially available 2-bromoethylamine hydrobromide is used as the starting raw material. Fluopyram is prepared by reaction, including reacting with o-tributanol in an alkaline solution Fluoromethylbenzoyl chloride reacts to produce cyclopropylamine-1-yl (2-(trifluoromethyl)phenyl)methanone, which is then reacted with 2,3-dichloro-5-trifluoromethylpyridine in the presence of alkyl lithium A nucleophilic reaction occurs under the conditions, and the pure product is finally obtained through liquid separation and washing.

Benefits of technology

The reaction route is simplified, the reaction yield is high, the product purity is high, the total yield is greater than 70%, and the product purity is greater than 95%, which has commercial value.

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Abstract

This invention provides a method for synthesizing fluopyram, using commercially available 2-bromoethylamine hydrobromide as a starting material. Under alkaline conditions, a self-nucleophilic substitution reaction is carried out to obtain cyclopropylamine. Cyclopropylamine then reacts with o-trifluorobenzoyl chloride to obtain the key intermediate cyclopropylamine-1-yl(2-(trifluoromethyl)phenyl) ketone. 2,3-Dichloro-5-trifluoromethylpyridine, after being treated with alkyllithium, reacts with cyclopropylamine-1-yl(2-(trifluoromethyl)phenyl) ketone to obtain fluopyram. This invention provides a three-step method for synthesizing fluopyram, with the first and second steps being a one-pot reaction. The reaction yield is high, the synthesis process is simple, and the product has high purity, possessing significant application value.
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