A photoacoustic diagnosis and treatment nasopharyngeal endoscope and nasopharyngeal endoscope device

Abstract

The present invention discloses a photoacoustic diagnosis and treatment nasopharyngeal mirror and a nasopharyngeal mirror device, wherein the photoacoustic diagnosis and treatment nasopharyngeal mirror comprises a multi-wavelength laser, a pulse laser and a nasopharyngeal mirror body, the nasopharyngeal mirror body comprises a probe, an optical fiber bundle extending from a proximal end to a distal end is arranged in the probe, a first light outlet is arranged at the distal end of the probe, an inner cavity is arranged at the proximal end of the nasopharyngeal mirror body, the inner cavity comprises a laser transmission area and an imaging area, a dichroic mirror for forming a laser beam is arranged in the laser transmission area, a first focusing lens, a first reflector, a second reflector and a beam splitter are also arranged in the laser transmission area, the first focusing lens, the first reflector, the second reflector, the beam splitter and the optical fiber bundle are arranged in sequence along the optical path of the laser beam, the imaging area is used to obtain transmitted light, and a second light outlet is arranged on the nasopharyngeal mirror body for outputting transmitted light, and the photoacoustic diagnosis and treatment nasopharyngeal mirror can realize monitoring and treatment of tissue areas.

Description

Technical Field

[0001] The present invention is used in the field of medical equipment, and in particular relates to a photoacoustic diagnosis and treatment nasopharyngeal mirror and a nasopharyngeal mirror device. Background Art

[0002] The incidence of nasopharyngeal carcinoma has obvious regional differences. The number of new nasopharyngeal carcinoma cases in China accounts for more than 40% of the world's total. The peak age of nasopharyngeal carcinoma is between 40 and 50 years old, which can easily cause a major impact on the family and bring a heavy disease burden. Clinical diagnosis and treatment practice shows that the five-year survival rate of early nasopharyngeal carcinoma after treatment can reach more than 90%, while the five-year survival rate of mid-to-late stage nasopharyngeal carcinoma is less than 50%. However, since early nasopharyngeal carcinoma patients basically have no symptoms, more than 70% of nasopharyngeal carcinoma patients have already progressed to the mid-to-late stage when they first visit the doctor. Therefore, promoting early diagnosis and treatment of nasopharyngeal carcinoma is the key to improving the prognosis of nasopharyngeal carcinoma.

[0003] Nasopharyngeal carcinoma is prone to occur in the top and posterior walls of the nasopharynx and the pharyngeal recess, which is directly connected to the outside world through the nasal cavity, which provides a natural basis for the development of laparoscopic technology. Based on this feature, the gold standard for clinical diagnosis of nasopharyngeal carcinoma is to perform tissue biopsy by clinicians under the guidance of electronic nasopharyngeal endoscopes, and then pathological diagnosis by pathologists. Because the sampling is more traumatic, the sampled tissue is small, and it depends on the naked eye observation under the microscope, about 10% of patients fail to diagnose at the first sampling. Doctors and patients need to face the choice of sampling again or multiple times, or follow-up observation, which is easy to delay the disease. In addition, nasopharyngeal biopsy is difficult to detect early nasopharyngeal carcinoma, especially carcinoma in situ, because the surface symptoms of the nasopharyngeal mucosa of early nasopharyngeal carcinoma are not obvious. Under the existing electronic nasopharyngeal endoscope, it is difficult to directly distinguish these early symptoms with the naked eye. In general, nasopharyngeal biopsy strictly relies on the clinical experience of clinicians and medical devices such as nasopharyngeal endoscopes. The development of non-invasive or minimally invasive diagnostic technology is of great significance for the early diagnosis and treatment of nasopharyngeal carcinoma.

[0004] In terms of other imaging-assisted diagnosis of tumors, traditional imaging methods are limited by imaging depth and resolution, or by expensive detection equipment and time-consuming detection. They cannot be quickly applied to the identification of early lesions and timely screening of cancer. There are also problems such as ionizing radiation and allergy to exogenous contrast agents. Therefore, a new imaging method with no ionizing radiation, no exogenous contrast agents, and high resolution is urgently needed in current diagnosis, which can be used for imaging diagnosis of nasopharyngeal carcinoma and long-term monitoring during subsequent cancer treatment.

[0005] In terms of tumor treatment, radiotherapy or combined radiotherapy and chemotherapy are the main means of treating nasopharyngeal carcinoma. The main reason for the failure of nasopharyngeal carcinoma treatment is the occurrence of recurrence and metastasis. Compared with traditional treatment methods, laser-based laser medicine has achieved rapid development. Nasopharyngeal carcinoma is directly connected to the outside world through the nasal cavity, and the optical fiber is thin and controllable. Nasopharyngeal carcinoma can be said to be a natural model for laser medicine. Photoacoustic therapy is a new treatment method that guides nanochemical drugs to focus on the deep area of ​​the tumor through laser, increases the concentration of nanomedicine in the target area, and thus achieves precise targeted treatment. Compared with continuous light irradiation, the heat diffusion is very small due to the use of a second laser to irradiate the drug area, which realizes a precise treatment method of "pointing and hitting" and avoids thermal damage to normal tissues. Photoacoustic imaging is a new imaging technology based on a second laser, which combines the high resolution of optical imaging and the high penetration of acoustic imaging, making photoacoustic imaging have the advantages of in situ high resolution and deep imaging, which is very suitable for nasopharyngeal carcinoma with unclear early mucosal symptoms. Summary of the invention

[0006] The purpose of the present invention is to solve at least one of the technical problems existing in the prior art, and to provide a photoacoustic diagnosis and treatment nasopharyngeal endoscope and a nasopharyngeal endoscope device, wherein the photoacoustic treatment nasopharyngeal endoscope can monitor the tumor tissue area and treat the tumor tissue, thereby realizing integrated diagnosis and treatment.

[0007] The technical solution adopted by the present invention to solve its technical problem is:

[0008] A photoacoustic diagnosis and treatment nasopharyngoscope comprises a multi-wavelength laser, a pulse laser and a nasopharyngoscope body, wherein the nasopharyngoscope body comprises a probe, wherein an optical fiber bundle extending from a proximal end to a distal end is arranged in the probe, wherein a first light outlet is arranged at the distal end of the probe, wherein an inner cavity is arranged at the proximal end of the nasopharyngoscope body, wherein the inner cavity comprises a laser transmission area and an imaging area, wherein the multi-wavelength laser and the pulse laser are both connected to the nasopharyngoscope body through the laser transmission area, wherein a dichroic mirror for forming a laser beam is arranged in the laser transmission area, wherein the dichroic mirror is arranged at an intersection position of the optical paths of the multi-wavelength laser and the pulse laser, wherein a first focusing lens for focusing the laser beam, and a first reflector, a second reflector and a beam splitter, which are all used to reflect the laser beam, are further arranged in the laser transmission area, wherein the first focusing lens, the first reflector, the second reflector, the beam splitter and the optical fiber bundle are arranged in sequence along the optical path of the laser beam, wherein the imaging area is used to obtain the transmitted light emitted from the beam splitter, wherein a second light outlet for outputting the transmitted light is arranged on the nasopharyngoscope body, and wherein the second light outlet is located in the imaging area.

[0009] Preferably, a first light entrance and a second light entrance are provided on the main body of the nasopharyngeal mirror, the first light entrance and the second light entrance are located on both sides of the dichroic mirror, a second focusing lens, a first optical fiber and a first collimator are provided between the multi-wavelength laser and the first light entrance, a fiber coupler, a second optical fiber and a second collimator are provided between the pulse laser and the second light entrance, and both the first collimator and the second collimator are focus-adjustable collimators.

[0010] Preferably, the second reflector is a MEMS mirror.

[0011] Preferably, a third focusing lens and a transducer are provided at the distal end of the probe, the transducer is provided on the inner wall of the probe, and a light-transmitting acoustic reflector is provided between the transducer and the third focusing lens.

[0012] Preferably, a fourth focusing lens is provided on the second light outlet.

[0013] The present invention also provides a nasopharyngeal endoscope device, including an image sensor and a photoacoustic diagnostic nasopharyngeal endoscope. Since the photoacoustic diagnostic nasopharyngeal endoscope has been described in detail in the previous text, it will not be repeated here. The image sensor is connected to the nasopharyngeal endoscope body through the second light outlet.

[0014] Preferably, the nasopharyngeal endoscope device comprises a signal amplifier, and a signal transmission line is provided between the signal amplifier and the transducer.

[0015] Preferably, the nasopharyngeal endoscope device comprises an acquisition card, and the acquisition card is connected to the signal amplifier.

[0016] Preferably, the nasopharyngeal endoscope device comprises a controller, and the controller is connected to the multi-wavelength laser and the pulse laser.

[0017] Preferably, the nasopharyngeal endoscope device comprises a computer, and the computer is connected to the acquisition card, the image sensor and the controller.

[0018] One of the above technical solutions has at least one of the following advantages or beneficial effects: the photoacoustic diagnostic nasopharyngeal endoscope can perform photoacoustic treatment on tumor tissue by using lasers generated by multi-wavelength lasers and pulsed lasers. The optical fiber bundle of the photoacoustic diagnostic nasopharyngeal endoscope is a flexible structure, which can image and treat curved and narrow areas. By adopting a dichroic mirror, photoacoustic imaging and photoacoustic treatment can share the same optical path. The use of a spectrometer simultaneously realizes the collection of photoacoustic treatment and image information. The second reflector can scan and image the monitored tissue area to obtain the morphological characteristics of the tissue in the nasal cavity. The photoacoustic diagnostic nasopharyngeal endoscope can realize the integration of diagnosis and treatment.

[0019] Additional aspects and advantages of the present invention will be given in part in the following description and in part will be obvious from the following description, or will be learned through practice of the present invention. BRIEF DESCRIPTION OF THE DRAWINGS

[0020] The above and / or additional aspects and advantages of the present invention will become apparent and easily understood from the description of the embodiments in conjunction with the following drawings, in which:

[0021] Figure 1 is a schematic structural diagram of a nasopharyngeal mirror body according to an embodiment of the present invention;

[0022] Figure 2 It is a schematic structural diagram of a nasopharyngeal endoscope device according to an embodiment of the present invention. DETAILED DESCRIPTION

[0023] This section will describe in detail the specific embodiments of the present invention. The preferred embodiments of the present invention are shown in the accompanying drawings. The purpose of the accompanying drawings is to supplement the description of the text part of the specification with graphics, so that people can intuitively and vividly understand each technical feature and the overall technical solution of the present invention, but it cannot be understood as a limitation on the scope of protection of the present invention.

[0024] In the present invention, if directions (up, down, left, right, front and back) are described, it is only for the convenience of describing the technical solution of the present invention, and does not indicate or imply that the technical features referred to must have a specific orientation, be constructed and operate in a specific orientation. Therefore, it cannot be understood as a limitation of the present invention.

[0025] In the present invention, "several" means one or more, "multiple" means more than two, "greater than", "less than", "exceed" and the like are understood to exclude the number itself; "above", "below", "within" and the like are understood to include the number itself. In the description of the present invention, if there is a description of "first" or "second", it is only used for the purpose of distinguishing technical features, and cannot be understood as indicating or implying relative importance or implicitly indicating the number of the indicated technical features or implicitly indicating the order of the indicated technical features.

[0026] In the present invention, unless otherwise clearly defined, the words "set", "install", "connect" and the like should be understood in a broad sense, for example, they can be directly connected or indirectly connected through an intermediate medium; they can be fixedly connected or detachably connected or integrally formed; they can be mechanically connected or electrically connected or able to communicate with each other; they can be the internal connection of two elements or the interaction relationship between two elements. Those skilled in the art can reasonably determine the specific meanings of the above words in the present invention in combination with the specific content of the technical solution.

[0027] See also Figure 2The embodiment of the present invention provides a photoacoustic diagnosis and treatment nasopharyngeal mirror, comprising a multi-wavelength laser 100, a pulse laser 200 and a nasopharyngeal mirror body 300, wherein the nasopharyngeal mirror body 300 has a probe 310, see Figure 1The probe 310 is provided with an optical fiber bundle 311 extending from the proximal end to the distal end. The optical fiber bundle 311 is a flexible structure and serves as a scanning structure during the inspection process. Compared with the traditional hard nasopharyngeal endoscope, it can image and treat curved and narrow areas. The use of the optical fiber bundle 311 can effectively extend the working distance, has higher applicability, and can be used for a variety of surgeries. The distal end of the probe 310 is provided with a first light outlet 312. When the probe 310 corresponds to the monitored tissue area, the light beam output from the first light outlet 312 can perform laser treatment on the area. The proximal end of the nasopharyngeal endoscope body 300 is provided with an inner cavity 320. The inner cavity 320 includes a laser transmission area 321 and an imaging area 322. The multi-wavelength laser 100 and the pulse laser 200 are both connected to the laser transmission area 321 through the laser transmission area 321. The nasopharyngeal mirror body 300 is connected, and a dichroic mirror 330 for forming a laser beam is provided in the laser transmission area 321. The dichroic mirror 330 is provided at the intersection of the optical paths of the multi-wavelength laser 100 and the pulse laser 200. The first laser emitted by the multi-wavelength laser 100 can be used for imaging, and the second laser emitted by the pulse laser 200 can be used for treatment. The first laser is reflected by the dichroic mirror 330 to form reflected light, and the second laser is transmitted by the dichroic mirror 330 to form transmitted light. The reflected light and the transmitted light overlap through the dichroic mirror 330 to form a laser beam. The dichroic mirror 330 allows photoacoustic imaging and photoacoustic therapy to share an optical path. The laser transmission area 321 is also provided with a first focusing lens 340 for focusing the laser beam, and a second focusing lens 340 for reflecting the laser beam is provided. The first reflector 350, the second reflector 360 and the beam splitter 370 of the laser beam, the first focusing lens 340, the first reflector 350, the second reflector 360, the beam splitter 370 and the optical fiber bundle 311 are sequentially arranged along the optical path of the laser beam. When working, the laser beam is incident on the first focusing lens 340, and the first focusing lens 340 can focus the laser beam so that the laser beam can be incident on the optical fiber bundle 311. Then, the laser beam is reflected by the first reflector 350, the second reflector 360 and the beam splitter 370 in sequence, and is incident on the optical fiber bundle 311. It is output from the first light outlet 312 to irradiate the tissue area, excites the tissue to generate an ultrasonic signal, thereby realizing photoacoustic treatment of the tissue area. The imaging area 322 is used to obtain the ultrasonic signal from the beam splitter. The transmitted light emitted by the mirror 370, the laser beam is incident on the tissue area through the optical fiber bundle 311 to form reflected light, the reflected light is incident on the spectroscope 370 through the optical fiber bundle 311 to form transmitted light and enters the imaging area 322, the nasopharyngeal mirror body 300 is provided with a second light outlet 313 for outputting the transmitted light, the second light outlet 313 is located in the imaging area 322, the image information of the tissue area corresponding to the first light outlet 312 on the probe 310 can be obtained through the second light outlet 313, the spectroscope 370 can be used to realize photoacoustic therapy and image information collection at the same time, when performing nasopharyngeal monitoring, as the probe 310 moves, the plane scanning image of the monitored tissue area can be realized from the first light outlet 312, so as to obtain the morphological characteristics of the tissue in the nasal cavity,During photoacoustic therapy, nanoparticles can be highly aggregated in the tumor area in a short time. At the same time, nanoparticles can be excited and release heat, so that the treatment area is locally heated up, thereby achieving the effect of killing tumor cells. Compared with traditional treatment methods, the integrated photoacoustic therapy nasopharyngeal mirror of the present invention has the characteristics of minimally invasive, high efficiency, information integration, high resolution, and integrated diagnosis and treatment. It is suitable for the diagnosis of various cavities and abdominal cancers, and provides accurate imaging and treatment methods for carcinogenesis.

[0028] In some embodiments, since the wavelengths of the first laser emitted by the multi-wavelength laser 100 and the second laser emitted by the pulse laser 200 are different, by selecting a dichroic mirror 330 with an appropriate cutoff frequency, the second laser can be transmitted while reflecting the first laser, thereby combining the first laser and the second laser. Preferably, the dichroic mirror 300 is a long-wave pass dichroic mirror with a cutoff frequency of 550 nm.

[0029] See also Figure 1 The nasopharyngeal mirror body 300 is provided with a first light inlet 314 and a second light inlet 315, and the first light inlet 314 and the second light inlet 315 are located on both sides of the dichroic mirror, see Figure 2 A second focusing lens 110, a first optical fiber and a first collimator 120 are provided between the multi-wavelength laser 100 and the first light inlet 314. A fiber coupler 210, a second optical fiber and a second collimator 220 are provided between the pulse laser 200 and the second light inlet 315. In some embodiments, the first collimator 120 and the second collimator 220 are both adjustable-focus collimators. Preferably, the multi-wavelength laser 100 is an OPO laser 100. It is understandable that other lasers capable of generating imaging wavelengths may be used. When in use, the first laser emitted by the OPO laser 100 enters the first optical fiber through the second focusing lens 110, and enters the nasopharyngeal endoscope body 300 through the first collimator 120. The pulse laser 200 emits a first laser beam. The second laser enters the single-mode optical fiber through the optical fiber coupler 210, and enters the nasopharyngeal endoscope body 300 through the second collimator 220, wherein the addition of the adjustable-focus collimator can realize the confocal point of photoacoustic imaging and photoacoustic therapy. Since the pulsed laser 200 and the OPO laser 100 output light wavelengths are different, the difference between the imaging wavelength and the treatment wavelength causes dispersion when passing through the same lens, resulting in the non-confocal of the imaged tissue area and the treated tissue area. By using the adjustable-focus collimator, the position of the focus of the light spot incident on the monitored tissue area is changed, thereby achieving the confocal point of the imaged tissue area and the treated tissue area, and enabling photoacoustic therapy to be performed after imaging the same position. In some embodiments, the first optical fiber and the second optical fiber are both single-mode optical fibers.

[0030] In some embodiments, the second laser wavelength emitted by the pulse laser 200 is 532nm, the first laser wavelength emitted by the OPO laser 100 is 850nm, the first laser wavelength range that the OPO laser 100 can output is 400nm to 2500nm, and the pulse width is 5ns to 50ns.

[0031] Preferably, see Figure 1 The second reflector 360 is a MEMS mirror. When in use, the laser beam is reflected to the surface of the MEMS mirror through the first reflector 350. By controlling the deflection angle of the MEMS mirror, the scanning range of the MEMS mirror can be adjusted. It can be understood that the second reflector 360 can be a galvanometer scanning mirror, but compared with the galvanometer scanning mirror, the MEMS mirror can reduce the main volume of the nasopharyngeal mirror and reduce the mass of the nasopharyngeal mirror. At the same time, the MEMS mirror has a high reflectivity to the incident light.

[0032] See also Figure 1 A third focusing lens 380 and a transducer 316 are provided at the distal end of the probe 310. The transducer 316 is provided on the inner wall of the probe 310. A light-transmitting reflective mirror 317 is provided between the transducer 316 and the third focusing lens 380. The laser beam focused by the third focusing lens 380 can perform laser treatment on the tissue area that needs treatment. After the laser beam is irradiated onto the tissue area, reflected light is generated. The light-transmitting reflective mirror 317 can reflect the photoacoustic echo signal in the reflected light, and the photoacoustic echo signal is received by the transducer 316. In some embodiments, the transducer 316 is a high-frequency ultrasonic transducer. The main frequency of the high-frequency ultrasonic transducer is 40M and the bandwidth is 80%.

[0033] See also Figure 1 A fourth focusing lens 390 is disposed on the second light outlet 313 , and the fourth focusing lens 390 can focus the transmitted light of the imaging area 322 , and the focused light is emitted through the second light outlet 313 .

[0034] The embodiment of the present invention also provides a nasopharyngeal endoscope device, see Figure 2 , including an image sensor 600 and a photoacoustic diagnosis and treatment nasopharyngeal mirror. The image sensor 600 is connected to the nasopharyngeal mirror body 300 through the second light outlet 313. When in use, the probe 310 is moved to obtain the image information of the tissue area corresponding to the first light outlet 312 through the image sensor 600 to achieve scanning imaging. The image sensor 600 can also monitor the temperature information through the reflected light to realize real-time monitoring of the temperature change of the tissue area. During the treatment process, the treatment process and effect can be evaluated according to the temperature information changes of the monitored tissue area, thereby realizing the integration of temperature measurement and diagnosis.

[0035] See also Figure 2The photoacoustic diagnostic and therapeutic nasopharyngeal endoscope also includes a signal amplifier 400. A signal transmission line is provided between the transducer 316 and the signal amplifier 400. The signal transmission line is a coaxial cable. The signal amplifier 400 can emit a light signal to facilitate subsequent data collection. In some embodiments, the amplification gain of the signal amplifier 400 is 50dB.

[0036] See also Figure 2 The photoacoustic diagnosis and treatment nasopharyngeal endoscope also includes an acquisition card 500, which is connected to the signal amplifier 400 to realize data collection.

[0037] See also Figure 2 The photoacoustic diagnostic and therapeutic nasopharyngeal endoscope also includes a controller 700, which is connected to the multi-wavelength laser 100 and the pulse laser 200. The controller 700 can control the multi-wavelength laser 100 and the pulse laser 200 to generate laser by generating a trigger signal.

[0038] See also Figure 2 The photoacoustic diagnostic nasopharyngeal endoscope also includes a computer 800, which is connected to the image sensor 600, the acquisition card 500, the image sensor 600 and the controller 700. The computer 800 can display the image and temperature information collected by the image sensor 600 in real time, and reconstruct the photoacoustic image with the data collected by the acquisition card 500 and the image sensor 600.

[0039] The steps for using the photoacoustic nasopharyngeal endoscope are:

[0040] Step 1: Align the first light outlet 312 on the probe 310 of the photoacoustic diagnosis and treatment nasopharyngeal endoscope with the tissue area that needs to be monitored in the nasopharynx;

[0041] Step 2: triggering system, generating a trigger signal through the controller 700, controlling the OPO laser 100 to emit a first laser, controlling the pulse laser 200 to emit a second laser, the first laser enters the single-mode optical fiber through the second focusing lens 110, and then enters the nasopharyngeal endoscope body 300 through the first collimator 120, the second laser is coupled into the single-mode optical fiber by the optical fiber coupler 210, and then enters the nasopharyngeal endoscope body 300 through the second collimator 220, the first laser and the second laser are combined by the dichroic mirror 330, the combined laser beam is focused by the first focusing lens 340, and is reflected by the first reflector 350 to reach the surface of the MEMS mirror 360, the deflection angle of the MEMS mirror 360 can be adjusted to change the scanning range, the laser beam is reflected by the beam splitter 370 and then incident on the optical fiber bundle 311, and is focused by the third focusing lens 380, and is incident on the tissue area from the first light outlet 312 of the probe 310;

[0042] Step 3: Data Collection

[0043] 1. Photoacoustic data acquisition: The laser beam is incident on the tissue area through the optical fiber bundle to form reflected light. After the reflected light passes through the light-transmitting reflective mirror 317, the acoustic signal therein is reflected to the transducer 316. The acoustic signal is received by the transducer 316 and converted into an electrical signal, and enters the signal amplifier 400 through the coaxial cable. The amplified electrical signal is collected by the acquisition card 500 and sent to the computer 800, thereby realizing the acquisition of photoacoustic data;

[0044] 2. Temperature data acquisition: The reflected light reflected by the tissue area is received by the first light outlet 312 of the probe 310. The reflected light is incident on the spectroscope 370 via the optical fiber bundle 311 to form transmitted light. The transmitted light enters the image sensor 600 and is converted into a digital signal by the image sensor 600. The electrical signal enters the computer 800 through the data line.

[0045] 3. Image processing: The computer 800 uses the collected data for reconstruction of photoacoustic images and real-time display of temperature information.

[0046] In the description of this specification, the description with reference to the terms "example", "embodiment" or "some embodiments" etc. means that the specific features, structures, materials or characteristics described in conjunction with the embodiment or example are included in at least one embodiment or example of the present invention. In this specification, the schematic representation of the above terms does not necessarily refer to the same embodiment or example. Moreover, the specific features, structures, materials or characteristics described can be combined in any one or more embodiments or examples in a suitable manner.

[0047] Of course, the invention is not limited to the above-mentioned embodiments, and those skilled in the art may make equivalent modifications or substitutions without violating the spirit of the invention, and these equivalent modifications or substitutions are all included in the scope defined by the claims of this application.

Claims

1. A nasopharyngeal endoscope device, characterized in that: The invention comprises an image sensor and a photoacoustic diagnosis and treatment nasopharyngoscope, wherein the photoacoustic diagnosis and treatment nasopharyngoscope comprises a multi-wavelength laser, a pulse laser and a nasopharyngoscope body, wherein the nasopharyngoscope body has a probe, wherein an optical fiber bundle extending from a proximal end to a distal end is arranged in the probe, wherein a first light outlet is arranged at the distal end of the probe, wherein an inner cavity is arranged at the proximal end of the nasopharyngoscope body, wherein the inner cavity comprises a laser transmission area and an imaging area, wherein the multi-wavelength laser and the pulse laser are both connected to the nasopharyngoscope body through the laser transmission area, wherein a dichroic mirror for forming a laser beam is arranged in the laser transmission area, wherein the dichroic mirror is arranged at the intersection of the optical paths of the multi-wavelength laser and the pulse laser, wherein a first focusing lens for focusing the laser beam, a first reflecting mirror for reflecting the laser beam, a second reflecting mirror for reflecting the laser beam and a beam splitter for reflecting or transmitting the laser beam are also arranged in the laser transmission area, wherein the first focusing lens, the first reflecting mirror, the second reflecting mirror, the beam splitter and the optical fiber bundle are arranged in sequence along the optical path, wherein the imaging area is used to obtain the transmitted light emitted from the beam splitter, and wherein a There is a second light outlet for outputting transmitted light, the second light outlet is located in the imaging area, a third focusing lens and a transducer are provided at the distal end of the probe, the transducer is arranged on the inner side wall of the probe, a light-transmitting acoustic mirror is arranged between the transducer and the third focusing lens, a fourth focusing lens is arranged on the second light outlet, the image sensor is connected to the nasopharyngeal mirror body through the second light outlet, a first light inlet and a second light inlet are arranged on the nasopharyngeal mirror body, the first light inlet and the second light inlet are located on both sides of the dichroic mirror, a second focusing lens, a first optical fiber and a first collimator are arranged between the multi-wavelength laser and the first light inlet, a fiber coupler, a second optical fiber and a second collimator are arranged between the pulse laser and the second light inlet, the first collimator and the second collimator are both adjustable focus collimators, the second reflector is a MEMS mirror, the dichroic mirror is a long-wave pass dichroic mirror, and its cut-off frequency is 550nm, the second laser wavelength emitted by the pulse laser is 532nm, and the first laser wavelength emitted by the multi-wavelength laser is 850nm.

2. The nasopharyngeal endoscope device according to claim 1, characterized in that: It comprises a signal amplifier, and a signal transmission line is arranged between the signal amplifier and the transducer.

3. The nasopharyngeal endoscope device according to claim 2, characterized in that: It includes an acquisition card, and the acquisition card is connected to the signal amplifier.

4. The nasopharyngeal endoscope device according to claim 3, characterized in that: A controller is included, and the controller is connected to the multi-wavelength laser and the pulse laser.

5. The nasopharyngeal endoscope device according to claim 4, characterized in that: It comprises a computer, and the computer is connected with the acquisition card, the image sensor and the controller.

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