A tissue shearing instrument for cell separation

Abstract

The present invention relates to the technical field of sample processing, and discloses a tissue shearing instrument for cell separation, comprising a base plate, a shearing table horizontally slidably arranged on the base plate, and a mounting plate located above the shearing table, wherein the mounting plate is longitudinally movable, and a shearing mechanism is installed at the bottom of the mounting plate. A first driving mechanism for driving the mounting plate to reciprocate longitudinally is installed on one side of the base plate, and a second driving mechanism for driving the shearing table to slide horizontally is also provided on one side of the base plate. The first driving mechanism and the second driving mechanism are connected by a linkage mechanism, so that when the mounting plate moves longitudinally, the shearing table reciprocates in the horizontal direction. The present invention can place the cell tissue to be sheared on the shearing table, and the shearing mechanism is driven to reciprocate by the mounting plate, so that the tissue can be effectively sheared. At the same time, the shearing table can make the shearing more thorough and improve the work efficiency when the horizontal reciprocating motion occurs.

Description

Technical Field

[0001] The invention relates to the technical field of sample processing, and in particular to a tissue shearing instrument for cell separation. Background Art

[0002] In laboratory scientific research and production, it is often necessary to shear block tissue into cell tissue. During the shearing process, there is often a problem of poor shearing effect due to the large volume of tissue samples. The shearing process often uses some mechanisms with electric shearing functions, which generally cut by rotating the tool. The existing equipment lacks a structure that shears the tissue by moving the tool up and down, and it is not convenient to increase or decrease the tool according to needs. At the same time, it also does not have the function of shearing tissue cells into multiple small segments at one time. For this reason, a tissue shearing instrument for cell separation is proposed. Summary of the invention

[0003] The object of the present invention is to provide a tissue shearing instrument for cell separation to solve the problems raised in the above background technology.

[0004] To achieve the above object, the present invention provides the following technical solutions:

[0005] A tissue shearing instrument for cell separation comprises a bottom plate, a shearing workbench horizontally slidably arranged on the bottom plate, and a mounting plate located above the shearing workbench. The mounting plate is longitudinally movable, and a shearing mechanism is installed at the bottom of the mounting plate.

[0006] A first driving mechanism for driving the mounting plate to reciprocate in the longitudinal direction is installed on one side of the bottom plate, and a second driving mechanism for driving the shearing workbench to slide horizontally is also provided on one side of the bottom plate.

[0007] The first driving mechanism and the second driving mechanism are connected through a linkage mechanism so that when the mounting plate moves longitudinally, the shearing workbench reciprocates in the horizontal direction.

[0008] Furthermore, a support rod is fixed to the top surface of the base plate, a top plate located above the mounting plate is fixed to the top of the support rod, a guide rod is fixed to the bottom surface of the top plate, a guide hole for sliding fit of the guide rod is opened on the mounting plate, and a return spring is installed on the outer side of the guide rod, and one end of the return spring is connected to the mounting plate.

[0009] Furthermore, the first driving mechanism has a longitudinally arranged turntable, a power mechanism driving the turntable to rotate, and a shift block fixed on the outer ring surface of the turntable. The turntable rotates so that the shift block shifts the mounting plate downward, and the shift block is separated from the mounting plate when the shearing mechanism is working, and then the mounting plate moves up and resets.

[0010] Furthermore, the guide rod is arranged at an inclined angle with respect to the vertical direction, and a blocking plate for resisting the shifting block is fixed on the outer side of the mounting plate.

[0011] Furthermore, the power mechanism includes a vertical plate fixed on the bottom plate, and a motor installed on the vertical plate, and the output shaft of the motor is drivingly connected to the turntable.

[0012] Furthermore, the second driving mechanism includes a connecting rod and a rotating disk, wherein the rotating disk is horizontally arranged, a central shaft is coaxially installed at the bottom of the rotating disk, the bottom end of the central shaft is rotatably connected to the bottom plate, a pin is eccentrically installed on the disk surface of the rotating disk, one end of the connecting rod is rotatably connected to the shearing workbench, and the other end of the connecting rod is rotatably connected to the pin.

[0013] Furthermore, the connecting rod is a telescopic rod, and the connecting rod includes rod one, rod two and a length adjustment mechanism, wherein the length adjustment mechanism includes a connecting rod, a screw sleeve, and a central telescopic rod, one end of the central telescopic rod is fixed to rod one, and the other end of the central telescopic rod is slidably inserted into rod two, the screw sleeve is spirally sleeved on the outside of the central telescopic rod, one side of the screw sleeve is connected to rod two through a plurality of connecting rods, and an annular groove is coaxially opened on the side of the screw sleeve, and the annular groove is slidably connected to one end of each connecting rod.

[0014] Furthermore, the linkage mechanism includes a horizontally arranged driven shaft and bevel gear 1 and bevel gear 2. The driven shaft and the rotating shaft of the motor are connected through a transmission mechanism. Bevel gear 1 is installed on the driven shaft, bevel gear 2 is coaxially installed on the rotating disk, and bevel gear 1 and bevel gear 2 are meshed for transmission.

[0015] Furthermore, the shearing mechanism includes a mounting groove opened at the bottom of the mounting plate, and a plurality of shearing knives are installed in the mounting groove along the length direction, and two adjacent shearing knives are slidably connected to the inner wall of the mounting groove, and the remaining shearing knives are fixed to the inner wall of the mounting groove, and a width adjustment mechanism is provided in the mounting groove to adjust the distance between two adjacent shearing knives slidably connected to the mounting groove.

[0016] Further, the width adjustment assembly includes several groups of adjustment units and a power source, the adjustment unit includes two connecting plates respectively fixed on the adjacent sides of the two shearing knives, the two connecting plates are symmetrically provided with guide grooves, and the distance between the two guide grooves gradually increases from top to bottom, the adjustment unit also includes a horizontally arranged cross bar, the two ends of the cross bar are respectively fixed with driving columns, the two driving columns are respectively slidably arranged in the two guide grooves, and a push-pull rod is also fixed in the middle of the cross bar;

[0017] The power source comprises a driving member fixed in the installation groove, a movable plate which is slidably connected with the inner wall of the installation groove along the longitudinal direction is fixed on the telescopic end of the driving member, and the movable plate is fixed with each of the push-pull rods.

[0018] The beneficial effects of the present invention are:

[0019] The present invention designs a base plate, a shearing workbench horizontally slidably arranged on the base plate, and a mounting plate located above the shearing workbench. The mounting plate is longitudinally movable, and a shearing mechanism is installed at the bottom of the mounting plate. A first driving mechanism for driving the mounting plate to reciprocate longitudinally is installed on one side of the base plate, and a second driving mechanism for driving the shearing workbench to slide horizontally is also provided on one side of the base plate. The first driving mechanism and the second driving mechanism are connected by a linkage mechanism so that when the mounting plate moves longitudinally, the shearing workbench reciprocates in the horizontal direction.

[0020] Through the above structure, the present invention can place the cell tissue to be sheared on the shearing workbench, and drive the shearing mechanism to reciprocate through the mounting plate, so that the tissue can be effectively sheared. At the same time, the shearing workbench can reciprocate horizontally, which can make the shearing more complete and thorough, thereby improving work efficiency. BRIEF DESCRIPTION OF THE DRAWINGS

[0021] The drawings described herein are used to provide a further understanding of the present invention and constitute a part of this application. The exemplary embodiments of the present invention and their descriptions are used to explain the present invention and do not constitute an improper limitation of the present invention. In the drawings:

[0022] Figure 1 It is a front view of the overall structure of the present invention;

[0023] Figure 2 For the present invention Figure 1 Side view of the middle structure;

[0024] Figure 3 For the present invention Figure 1 A magnified view of point B;

[0025] Figure 4 For the present invention Figure 1 A magnified image of point A;

[0026] Figure 5 It is a schematic diagram of the connection structure between the shearing workbench and the second driving mechanism in Example 1 of the present invention;

[0027] Figure 6 A schematic diagram of the connection structure between the shearing workbench and the second driving mechanism in Embodiment 2 of the present invention;

[0028] Figure 7 For the present invention Figure 6 Enlarged view of center C.

[0029] In the figure: bottom plate 1, shearing workbench 2, support rod 3, guide rod 4, mounting plate 5, vertical plate 6, motor 7, dial block 8, turntable 9, blocking plate 10, active disk 11, top plate 12, placement slot 13, shear knife 14, connecting rod 15, rotating disk 16, rod 17, rod 2, mounting slot 19, driving member 20, movable plate 21, push-pull rod 22, connecting plate 23, driving column 24, knife handle 25, cross bar 26, guide slot 27, transmission mechanism 28, driven shaft 29, bevel gear 1 30, bevel gear 2 31, pin 32, center shaft 33, connecting rod 34, screw sleeve 35, center telescopic rod 36. DETAILED DESCRIPTION

[0030] The following will be combined with the drawings in the embodiments of the present invention to clearly and completely describe the technical solutions in the embodiments of the present invention. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention.

[0031] Embodiment 1:

[0032] See also Figure 1-7 This embodiment proposes a tissue shearing instrument for cell separation, including a base plate 1, a shearing workbench 2 horizontally slidably arranged on the base plate 1, and a mounting plate 5 located above the shearing workbench 2. The mounting plate 5 is longitudinally movable, and a shearing mechanism is installed at the bottom of the mounting plate 5.

[0033] In the present invention, a first driving mechanism for driving the mounting plate 5 to reciprocate in the longitudinal direction is installed on one side of the base plate 1, and a second driving mechanism for driving the shearing table 2 to slide horizontally is also provided on one side of the base plate 1.

[0034] The first driving mechanism and the second driving mechanism are connected through a linkage mechanism, so that when the mounting plate 5 moves longitudinally, the shearing table 2 reciprocates in the horizontal direction.

[0035] Furthermore, a support rod 3 is fixed to the top surface of the bottom plate 1, a top plate 12 located above the mounting plate 5 is fixed to the top of the support rod 3, a guide rod 4 is fixed to the bottom surface of the top plate 12, a guide hole for sliding fit of the guide rod 4 is provided on the mounting plate 5, and a return spring is installed on the outer side of the guide rod 4, one end of the return spring is connected to the mounting plate 5. The above structure enables the mounting plate 5 to slide along the guide rod 4. The operation is stable and reliable.

[0036] In an optional embodiment of the present invention, further, the first driving mechanism includes a turntable 9 longitudinally arranged, a power mechanism for driving the turntable 9 to rotate, and a shift block 8 fixed on the outer ring surface of the turntable 9. The turntable 9 rotates so that the shift block 8 shifts the mounting plate 5 downward, and the shift block 8 is separated from the mounting plate 5 when the shearing mechanism is working, and then the mounting plate 5 moves up and resets.

[0037] In an optional embodiment of the present invention, further, the guide rod 4 is arranged at an inclined angle with respect to the vertical direction, and a blocking plate 10 for resisting the shifting block 8 is fixed to the outer side of the mounting plate 5 .

[0038] When the above mechanism is working, the turntable 9 rotates, and when the shift block 8 and the blocking plate 10 collide with each other, the mounting plate 5 is driven to move downward, thereby performing shearing. Due to the inclined setting of the guide rod 4, after the mounting plate 5 moves downward to a certain position, the blocking plate 10 and the shift block 8 are separated. At this time, the mounting plate 5 returns to its initial position upward under the action of the return spring, and the cell tissue is cut in this reciprocating manner.

[0039] In an optional embodiment of the present invention, further, the power mechanism includes a vertical plate 6 fixed on the base plate 1 , a motor 7 installed on the vertical plate 6 , and an output shaft of the motor 7 is drivingly connected to the turntable 9 .

[0040] In an optional embodiment of the present invention, further, the second driving mechanism includes a connecting rod 15 and a rotating disk 16, wherein the rotating disk 16 is horizontally arranged, a central shaft 33 is coaxially installed at the bottom of the rotating disk 16, the bottom end of the central shaft 33 is rotatably connected to the bottom plate 1, a pin shaft 32 is eccentrically installed on the disk surface of the rotating disk 16, one end of the connecting rod 15 is rotatably connected to the shearing workbench 2, and the other end of the connecting rod 15 is rotatably connected to the pin shaft 32.

[0041] In an optional embodiment of the present invention, further, the linkage mechanism includes a horizontally arranged driven shaft 29 and a bevel gear 1 30 and a bevel gear 2 31. The driven shaft 29 and the rotating shaft of the motor 7 are connected through a transmission mechanism 28. The transmission mechanism can be a belt transmission mechanism or a gear rack transmission mechanism. The bevel gear 1 30 is installed on the driven shaft 29, and the bevel gear 2 31 is coaxially installed on the rotating disk 16, and the bevel gear 1 30 and the bevel gear 2 31 are meshed for transmission.

[0042] In an optional embodiment of the present invention, further, the shearing mechanism includes a mounting groove 19 provided at the bottom of the mounting plate 5, a plurality of shearing knives 14 are installed in the mounting groove along the length direction, and two adjacent shearing knives 14 are slidably connected to the inner wall of the mounting groove 19, and the remaining shearing knives 14 are fixed to the inner wall of the mounting groove 19, and a width adjustment mechanism is provided in the mounting groove 19 to adjust the distance between two adjacent shearing knives 14 slidably connected to the mounting groove 19. The portion of the shearing knife 14 extending into the mounting groove is a knife handle 25.

[0043] In an optional embodiment of the present invention, further, the width adjustment assembly includes a plurality of adjustment units and a power source, the adjustment unit includes two connecting plates 23 respectively fixed on the adjacent sides of the two shearing knives 14, the two connecting plates 23 are symmetrically provided with guide grooves 27, and the distance between the two guide grooves 27 gradually increases from top to bottom, the adjustment unit also includes a horizontally arranged cross bar 26, the two ends of the cross bar 26 are respectively fixed with driving columns 24, the two driving columns 24 are respectively slidably arranged in the two guide grooves 27, and the middle part of the cross bar 26 is also fixed with a push-pull rod 22;

[0044] The power source includes a driving member 20 fixed in the installation slot 19, and a movable plate 21 is fixed to the telescopic end of the driving member 20 and is slidably connected to the inner wall of the installation slot 19 in the longitudinal direction, and the movable plate 21 is fixed to each of the push-pull rods 22. The driving member 20 can be an electric push rod.

[0045] Embodiment 2:

[0046] Please refer to Figure 6 as well as Figure 7 Different from Example 1, in this embodiment, further, the connecting rod 15 is a telescopic rod, and the connecting rod 15 includes a rod 17, a rod 2 18 and a length adjustment mechanism, wherein the length adjustment mechanism includes a connecting rod 34, a screw sleeve 35, and a central telescopic rod 36, one end of the central telescopic rod 36 is fixed to the rod 17, and the other end of the central telescopic rod 36 is slidably inserted in the rod 2 18, the screw sleeve 35 is spirally sleeved on the outer side of the central telescopic rod 36, one side of the screw sleeve 35 is connected to the rod 2 18 through a plurality of connecting rods 34, and an annular groove is coaxially opened on the side of the screw sleeve 35, and the annular groove is slidably connected to one end of each connecting rod 34.

[0047] By means of the connecting rod 15 with adjustable length, the range of reciprocating motion of the shearing table 2 in the horizontal direction is changed under the drive of the rotating disk 16, so that the shearing mechanism on the mounting plate can shear tissue cells at different positions on the shearing table 2, making the shearing more sufficient and thorough, and improving the shearing effect.

[0048] Although embodiments of the present invention have been shown and described, it will be appreciated by those skilled in the art that various changes, modifications, substitutions and variations may be made to the embodiments without departing from the principles and spirit of the present invention, and that the scope of the present invention is defined by the appended claims and their equivalents.

Claims

1. A tissue shearing instrument for cell separation, characterized in that: It comprises a base plate (1), a shearing workbench (2) horizontally slidably arranged on the base plate (1), and a mounting plate (5) located above the shearing workbench (2), wherein the mounting plate (5) is movably arranged longitudinally, and a shearing mechanism is installed at the bottom of the mounting plate (5); A first driving mechanism for driving the mounting plate (5) to move reciprocatingly in the longitudinal direction is installed on one side of the base plate (1), and a second driving mechanism for driving the shearing workbench (2) to slide horizontally is also provided on one side of the base plate (1); The first driving mechanism and the second driving mechanism are connected by a linkage mechanism, so that when the mounting plate (5) moves longitudinally, the shearing workbench (2) reciprocates in the horizontal direction; The first driving mechanism comprises a longitudinally arranged rotating disk (9), a power mechanism for driving the rotating disk (9) to rotate, and a shifting block (8) fixed on the outer annular surface of the rotating disk (9); the rotating disk (9) rotates so that the shifting block (8) shifts the mounting plate (5) downward, and the shifting block (8) is separated from the mounting plate (5) when the shearing mechanism is working, and the mounting plate (5) then moves upward and resets; The second driving mechanism comprises a connecting rod (15) and a rotating disk (16), wherein the rotating disk (16) is arranged horizontally, a central shaft (33) is coaxially mounted on the bottom of the rotating disk (16), the bottom end of the central shaft (33) is rotatably connected to the bottom plate (1), a pin shaft (32) is eccentrically mounted on the disk surface of the rotating disk (16), one end of the connecting rod (15) is rotatably connected to the shearing workbench (2), and the other end of the connecting rod (15) is rotatably connected to the pin shaft (32); The linkage mechanism comprises a horizontally arranged driven shaft (29) and a bevel gear 1 (30) and a bevel gear 2 (31); the driven shaft (29) and the rotating shaft of the motor (7) are connected via a transmission mechanism (28); the bevel gear 1 (30) is mounted on the driven shaft (29); the bevel gear 2 (31) is coaxially mounted on the rotating disk (16); and the bevel gear 1 (30) and the bevel gear 2 (31) are meshed for transmission.

2. A tissue shearing instrument for cell separation according to claim 1, characterized in that: A support rod (3) is fixed to the top surface of the bottom plate (1), a top plate (12) located above the mounting plate (5) is fixed to the top of the support rod (3), a guide rod (4) is fixed to the bottom surface of the top plate (12), a guide hole for slidingly engaging the guide rod (4) is provided on the mounting plate (5), and a return spring is installed on the outer side of the guide rod (4), one end of the return spring is connected to the mounting plate (5).

3. A tissue shearing instrument for cell separation according to claim 2, characterized in that: The guide rod (4) is arranged at an inclined angle with respect to the vertical direction, and a blocking plate (10) for resisting against the shifting block (8) is fixed on the outer side of the mounting plate (5).

4. A tissue shearing instrument for cell separation according to claim 1, characterized in that: The power mechanism comprises a vertical plate (6) fixed on the bottom plate (1), and a motor (7) mounted on the vertical plate (6); the output shaft of the motor (7) is drivingly connected to the rotating disk (9).

5. A tissue shearing instrument for cell separation according to claim 1, characterized in that: The connecting rod (15) is a telescopic rod, and the connecting rod (15) comprises a rod 1 (17), a rod 2 (18) and a length adjustment mechanism, wherein the length adjustment mechanism comprises a connecting rod (34), a screw sleeve (35) and a central telescopic rod (36), one end of the central telescopic rod (36) is fixed to the rod 1 (17), the other end of the central telescopic rod (36) is slidably inserted into the rod 2 (18), the screw sleeve (35) is spirally sleeved on the outer side of the central telescopic rod (36), one side of the screw sleeve (35) is connected to the rod 2 (18) through a plurality of connecting rods (34), and a side surface of the screw sleeve (35) is coaxially provided with an annular groove, and the annular groove is slidably connected to one end of each connecting rod (34).

6. A tissue shearing instrument for cell separation according to claim 5, characterized in that: The shearing mechanism comprises a mounting groove (19) provided at the bottom of the mounting plate (5), wherein a plurality of shearing knives (14) are mounted in the mounting groove along the length direction, and two adjacent shearing knives (14) are slidably connected to the inner wall of the mounting groove (19), and the remaining shearing knives (14) are fixed to the inner wall of the mounting groove (19), and a width adjustment mechanism is provided in the mounting groove (19) to adjust the distance between two adjacent shearing knives (14) slidably connected to the mounting groove (19).

7. A tissue shearing instrument for cell separation according to claim 6, characterized in that: The width adjustment mechanism comprises a plurality of adjustment units and a power source. The adjustment unit comprises two connecting plates (23) respectively fixed on adjacent sides of two shear blades (14). The two connecting plates (23) are symmetrically provided with guide grooves (27), and the distance between the two guide grooves (27) gradually increases from top to bottom. The adjustment unit also comprises a horizontally arranged cross bar (26). Drive columns (24) are respectively fixed at both ends of the cross bar (26). The two drive columns (24) are respectively slidably arranged in the two guide grooves (27), and a push-pull rod (22) is also fixed in the middle of the cross bar (26). The power source comprises a driving member (20) fixed in the mounting groove (19), a movable plate (21) is fixed at the telescopic end of the driving member (20) and is slidably connected to the inner wall of the mounting groove (19) in the longitudinal direction, and the movable plate (21) is fixed to each of the push-pull rods (22).

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