Real-time fluorescent detection system for medical devices

By using a real-time fluorescent probe system and optical detection with fluorescent coating and fiber optic waveguides, the problem of surgical instrument positioning in minimally invasive spinal surgery has been solved, improving the accuracy and safety of the surgery and reducing the risk of injury.

CN114729888BActive Publication Date: 2026-03-24ACIES MEDICAL LLC
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
Filing Date
2020-12-04
Publication Date
2026-03-24

AI Technical Summary

Technical Problem

In current minimally invasive spinal surgery, surgical instruments are difficult to position precisely, leading to a high risk of iatrogenic injury. This is especially true when penetrating the spinal cord and nerve tissue, where the procedure relies on the operator's experience and anatomical landmark palpation, which introduces errors and variability, affecting the safety and effectiveness of the surgery.

Method used

A real-time fluorescent probe system, including a fluorescent coating and fiber optic waveguide, is used to optically detect target biomarkers (such as blood) and provide real-time feedback for precise placement of surgical instruments. The system utilizes the optical signals when the fluorescent probe comes into contact with biological tissue for localization.

Benefits of technology

It improves the precision and safety of surgical procedures, reduces the risk of iatrogenic injury, and enhances the effectiveness and reliability of minimally invasive surgery, especially in spinal and other minimally invasive surgical procedures.

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Abstract

A probe for real-time sensing of a target biomarker includes a needle, a luminescent probe located within an opening of the needle, a coating including a biomarker luminescent material in contact with biological tissue, and an ion depletion coating within the needle and adjacent to the coating. The disclosed probe can be used to sense blood in real-time during a medical procedure. Additionally, a biomarker detection system is disclosed that includes a biomarker luminescent material at or within a tip of a needle and a light coupler.
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