Chiral synthesis of tertiary alcohols
By reacting phenyl ketones or pyridyl ketones with zinc reagents and chiral ligands under BF3·OEt2 catalysis, the problems of low enantiomeric purity and yield in the preparation of chiral tertiary alcohols in the prior art have been solved, and high-purity tertiary alcohols have been prepared efficiently.
CN114829343BActive Publication Date: 2026-06-26RECURIUM IP HLDG LLC
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Patent Information
- Application Number
- CN202080086586.1
- Authority / Receiving Office
- CN · China
- Patent Type
- Patents(China)
- Current Assignee / Owner
- Priority Date
- 2020-06-11
- Filing Date
- 2020-11-12
- Publication Date
- 2026-06-26
- Estimated Expiration
- 2040-11-12
AI Technical Summary
Technical Problem
Existing technologies are difficult to efficiently prepare chiral tertiary alcohols with high enantiomeric purity, and also produce a large number of byproducts.
Method used
Tertiary alcohols or their salts are prepared by mixing optionally substituted phenyl ketones or pyridyl ketones with zinc reagents and chiral ligands, using BF3·OEt2 as a catalyst.
Benefits of technology
This method enables the preparation of chiral tertiary alcohols with high yield and high enantiomeric purity, while reducing unwanted byproducts.
✦ Generated by Eureka AI based on patent content.
Abstract
Disclosed herein are methods for preparing tertiary alcohols from optionally substituted phenyl ketones or optionally substituted pyridyl ketones, the methods comprising the use of chiral ligands and boron trifluoride etherate. The tertiary alcohols can be used to prepare synthetic forms of natural products and / or drugs.
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