Mouse mandibular advancement orthosis device and method for constructing mandibular condyle osteogenesis model

Abstract

The present invention relates to the technical field of mandibular orthoses for animal experiments, and in particular to a mandibular advancement orthoses device for mice and a method for constructing a mandibular condyle osteogenesis model. The advancement orthoses device comprises: a traction member and a correction member, wherein the traction member is arranged at the maxillary incisor of the mouse and is used to hang an elastic member; the correction member is arranged at the mandibular incisor of the mouse and is connected to the traction member via an elastic member, and the elastic member pulls the correction member to protrude the mouse's mandible. The device can not only effectively advance the mouse's mandible, but also keep the mouse's mandible in a continuously protruding state, and can best simulate the state of a person wearing a mandibular advancement orthoses device, thereby solving the problems of other mandibular advancement orthoses devices having an unsustainable advancement time, easy falling off, or being inconvenient for eating when worn.

Description

Technical Field

[0001] The present invention belongs to the technical field of mandibular orthopedics for animal experiments, and in particular relates to a mandibular advancement orthopedic device for mice and a method for constructing a mandibular condyle osteogenesis model. Background Art

[0002] Mandibular retraction not only affects facial aesthetics but also leads to malocclusion, affects the patient's feeding, and even in severe cases, reduces the volume of the airway, causing respiratory problems. During the peak growth and development period of children, mandibular retraction can be effectively treated by wearing a mandibular advancement appliance. However, much remains unknown about the growth and development of the mandible. The construction of a suitable animal experimental model is the cornerstone for further in-depth research on mandibular growth and development, and can provide a theoretical basis for further treatment of mandibular retraction.

[0003] Currently, experimental animal models for mandibular advancement are primarily based on rats or rabbits, and experimental devices are often simply modified versions of mandibular advancement appliances used in humans. However, due to significant differences in oral conditions between humans and rats or rabbits, mandibular advancement devices often suffer from issues such as inconsistent advancement, high shedding rates, and significant impact on the animals' feeding habits.

[0004] Mice offer advantages such as high reproductive capacity, reasonable price, and small size. Furthermore, mice are easily genetically modified and can simulate nearly any human disease or condition, making them an excellent experimental animal model. However, due to the small size of the mouse oral cavity, constructing experimental models within the oral cavity is challenging. Installing a mandibular advancement device and simulating mandibular advancement within the mouse oral cavity is even more challenging. Consequently, no mandibular advancement device currently exists that meets the requirements of being suitable for mouse oral wear, ensuring a sustained advancement time, reducing appliance shedding rates, and not interfering with the mouse's feeding habits. Summary of the Invention

[0005] The present invention aims to solve at least one of the technical problems existing in the prior art. To this end, the present invention provides a rodent mandibular advancement correction device and a method for constructing a mandibular condyle osteosynthesis model.

[0006] To achieve the above objectives, the present invention provides the following technical solution: a rodent mandibular advancement correction device, comprising:

[0007] A traction member, the traction member being provided at the maxillary incisor of the mouse, the traction member being bent by a first bending member to form a first pulling portion and a first retaining portion, the first retaining portion being bonded to the maxillary incisor of the mouse, and the first pulling portion being directed toward the outside of the mouse's oral cavity;

[0008] The corrective piece is arranged at the mandibular incisor of the mouse, and the corrective piece is connected to the traction piece through an elastic piece. The elastic piece pulls the corrective piece to make the mouse's mandible protrude. The corrective piece is bent by a second bending piece to form a second retaining portion, a connecting piece and a second pulling portion. The second retaining portion is bonded to the mandibular incisor of the mouse, and the second pulling portion is formed by bending the two ends of the connecting piece. The second pulling portion is located on the outside of the buccal gums of the mandibular molars in the mouse's mouth.

[0009] Compared with the existing technology, this device can not only effectively advance the mouse's mandible, but also keep the mouse's mandible in a continuously protruding state, which can best simulate the state of a person wearing a mandibular advancement appliance, and solve the problems of other mandibular advancement orthotic devices such as discontinuous advancement time, easy falling off, or inconvenience in eating when worn.

[0010] More specifically, in the above technical solution, both end portions of the first bent member are located at the first pulling portion, the two end portions are intersecting and closely arranged, and both end portions are facing inward.

[0011] To be more specific, in the above technical solution, the longitudinal cross-section of the first retaining portion is circular, and the diameter of the first retaining portion is 1.8 to 2.2 mm, the longitudinal cross-section of the first pulling portion is elliptical, and the length of the longitudinal plane of the first pulling portion is 1.8 to 2.2 mm, and the width of the transverse plane of the first pulling portion is 0.8 to 1.2 mm.

[0012] More specifically, in the above technical solution, the longitudinal cross-section of the second retaining portion is circular, and the diameter of the second retaining portion is 1.8-2.2 mm, and the longitudinal cross-section of the second pulling portion is circular, and the diameter of the second pulling portion is 0.8-1.2 mm.

[0013] More specifically, in the above technical solution, the connecting member includes bilateral first connecting rods and bilateral second connecting rods, and the length of the first connecting rods is 1.8-2.2 mm, and the length of the second connecting rods is 2.8-3.2 mm.

[0014] To be more specific, in the above technical solution, the transverse cross-section of the second retaining portion forms an angle of 115° to 125° with the connecting member, the longitudinal cross-section of the second retaining portion forms an angle of 115° to 125° with the connection point of the first connecting rod, and the angle of the connection point of the first connecting rod and the second connecting rod is 155° to 165°.

[0015] More specifically, in the above technical solution, the distance between the starting points of the first connecting rods on both sides is 2.8-3.2 mm, and the distance between the second pulling parts on both sides is 6.8-7.2 mm.

[0016] A method for constructing a mandibular condyle osteogenic model comprises the following steps:

[0017] Step 1: Bend the traction member and the correction member, and hang the elastic member into the second pulling part;

[0018] Step 2: The mice were generally anesthetized and a light-cured resin-reinforced glass ionomer orthodontic adhesive was prepared;

[0019] Step 3: Bonding the traction piece to the maxillary incisor of the mouse;

[0020] Step 4: Bond the orthodontic device to the mandibular incisor of the mouse;

[0021] Step 5: Stretch the elastic member toward the outside of the mouse's mouth and hang it into the first pulling part to complete the installation of the mandibular advancement orthosis device.

[0022] Compared with the existing technology, this method not only facilitates the installation of mandibular advancement orthotic devices in mice, but also uses light-cured resin-reinforced glass ionomer orthodontic adhesives to avoid the traction parts and the correction parts from falling off, reducing the shedding rate of the correction device and improving the stability and success rate of the mandibular advancement experiment; and after the second retention part and the first retention part are bonded to the corresponding incisor, the second pulling part is located on the outside of the buccal gums of the mandibular molars in the mouse's mouth, and the first pulling part is located on the outside of the mouse's oral cavity, so that the advancement orthotic device will not affect the mouse's eating; in addition, since the elastic part continues to play a role, the mouse's mandible is continuously in a protruding state, which can best simulate the state of a person wearing a mandibular advancement orthotic device.

[0023] To be more specific, in the above technical solution, the specific operation of step three is: clean the maxillary incisor, and after drying, dip the first retention part in light-curing resin-reinforced glass ionomer orthodontic adhesive, and insert it into the incisor from bottom to top along the incisal edge of the maxillary incisor, adjust the position of the traction part in the upper jaw of the mouse's mouth, so that the first pulling part faces the outside of the mouse's mouth and is placed symmetrically, and then use a dental light curing lamp to perform a light curing reaction so that the first retention part is bonded to the maxillary incisor.

[0024] To be more specific, in the above technical solution, the specific steps of step four are: clean the mandibular incisor, and after drying, dip the second retention part in light-curing resin-reinforced glass ionomer orthodontic adhesive, and insert it into the incisor from top to bottom along the incisal edge of the mandibular incisor, adjust the position of the orthodontic component in the mouse's mandible, so that the bilateral connecting parts are placed symmetrically, and the second pulling part is located on the buccal and gingival side of the mandibular first molar in the mouse's mouth, and then use a dental light curing lamp to perform a light curing reaction to bond the second retention part to the mandibular incisor.

[0025] The beneficial effects of the present invention are:

[0026] (1) The mandibular advancement correction device designed by the present invention can not only effectively guide the mouse's mandible, but also keep the mouse's mandible in a continuously protruding state, which can best simulate the state of a person wearing a mandibular advancement correction device. At the same time, it solves the problems of other mandibular advancement correction devices such as unsustainable leading time, easy falling off, or inconvenience in eating when worn.

[0027] (2) The mandibular advancement correction device designed by the present invention is cleverly designed and easy to install; the traction part and the correction part can be formed by bending Australian wire, which reduces the cost of constructing the animal experimental model.

[0028] (3) The method for constructing the mandibular condyle osteogenesis model used in the present invention adopts a light-cured resin-reinforced glass ionomer orthodontic adhesive to avoid the detachment of the traction part and the correction part, thereby reducing the detachment rate of the correction device and improving the stability and success rate of the mandibular advancement experiment; and after the second retaining part and the first retaining part are bonded to the corresponding incisor, the second pulling part is located on the outside of the buccal gum of the mandibular molar in the mouse's mouth, and the first pulling part is located on the outside of the mouse's oral cavity, so that the advancement correction device will not affect the mouse's eating; in addition, since the elastic part continuously works, the mouse's mandible is continuously in a protruding state, which can best simulate the state of a person wearing a mandibular advancement correction device.

[0029] (4) The mandibular advancement correction device and the method for constructing a mandibular condyle osteogenic model designed by the present invention have wide applicability. The mandibular advancement correction device can be scaled up in proportion to the size of the oral cavity of a rat or rabbit, thereby solving the problems of other mandibular advancement correction devices, such as unsustainable advancement time, easy falling off, or difficulty in eating when worn. BRIEF DESCRIPTION OF THE DRAWINGS

[0030] Figure 1 This is a schematic diagram of the side view of the structure of the rodent mandibular advancement correction device installed according to the present invention;

[0031] Figure 2 This is a schematic diagram of the top view of the corrective component in the present invention when it is installed;

[0032] Figure 3 This is a schematic diagram of the top view of the traction member in the present invention;

[0033] Figure 4 Schematic diagram of the top view of the correction component in the present invention;

[0034] Figure 5 Schematic diagram of the side view of the correction component in the present invention.

[0035] In the figure: 1. traction member; 11. first bending member; 12. first pulling portion; 13. first retaining portion; 2. correction member; 21. second bending member; 22. second retaining portion; 23. connecting member; 231. first connecting rod; 232. second connecting rod; 24. second pulling portion; 3. elastic member; 4. maxillary incisor; 5. mandibular incisor. DETAILED DESCRIPTION

[0036] The following will clearly and completely describe the technical solutions in the embodiments of the present invention in conjunction with the accompanying drawings. Obviously, the implementation regulations described are only part of the embodiments of the present invention, not all of the embodiments. All other embodiments obtained by ordinary technicians in this field based on the embodiments of the present invention without making any creative efforts shall fall within the scope of protection of the present invention.

[0037] In the description of the present invention, it should be understood that descriptions involving orientations, such as up, down, front, back, left, right, etc., indicating orientations or positional relationships, are based on the orientations or positional relationships shown in the accompanying drawings. They are only for the convenience of describing the present invention and simplifying the description, and do not indicate or imply that the device or element referred to must have a specific orientation, be constructed and operated in a specific orientation. Therefore, they cannot be understood as limitations on the present invention.

[0038] Example 1

[0039] See also Figure 1-5 The present invention proposes a mandibular advancement correction device for mice, including a traction member 1 and a correction member 2. The traction member 1 is placed on the maxillary incisor 4 of the mouse's mouth, and the correction member 2 is placed on the mandibular incisor 5 of the mouse's mouth. An elastic member 3 is connected between the traction member 1 and the correction member 2. The elastic force of the elastic member 3 pulls the mandibular advancement forward. On the one hand, it can keep the mouse's mandible in a continuously protruding state, thereby achieving the effect of correcting the mouse's mandibular condyle and better simulating the state of a person wearing a mandibular advancement correction device; on the other hand, it solves the problems of other mandibular advancement correction devices, such as discontinuous advancement time, easy falling off, or inconvenience in eating when worn.

[0040] The elastic member 3 is an elastic leather ring commonly used in orthodontic clinics. The elastic leather ring is circular in a relaxed state, and the diameter of the circle is Inches, the maximum effective force of the elastic ring is 2.0Oz.

[0041] like Figure 1-3As shown, in some embodiments, the traction member 1 is bent by a first bending member 11 to form a first pulling portion 12 and a first retaining portion 13, the first retaining portion 13 is bonded to the maxillary incisor 4 of the mouse, the first pulling portion 12 faces the outside of the mouse's oral cavity, the first bending member 11 is bent to form an "8" shape, and one side is the first pulling portion 12, and the other side is the first retaining portion 13, after cleaning the maxillary incisor 4 and waiting for it to dry, the first retaining portion 13 is dipped in light-curing resin reinforced glass ion orthodontic adhesive, and inserted from bottom to top along the cutting edge of the maxillary incisor 4, the position of the traction member 1 in the maxillary of the mouse's oral cavity is adjusted so that the first pulling portion 12 faces the outside of the mouse's oral cavity and is symmetrically placed, and then a dental light curing lamp is used to make the light-curing resin reinforced glass ion orthodontic adhesive undergo a light-curing reaction on the maxillary incisor 4, so that the first retaining portion 13 is bonded to the maxillary incisor 4.

[0042] like Figure 1-3 As shown, in some embodiments, both end portions of the first bent member 11 are located at the first pulling portion 12, and the two end portions are intersecting and tightly arranged, and both end portions are facing inward. By intersecting and tightly arranged the two end portions of the first pulling portion 12, the elastic leather ring is easily hooked into the first pulling portion 12 and is not easy to fall out. During the mandibular advancement process, the elastic leather ring can be prevented from detaching from the first pulling portion 12.

[0043] like Figure 3 As shown, in some embodiments, the longitudinal cross-section of the first retaining portion 13 is circular, and the diameter of the first retaining portion 13 is A, the longitudinal cross-section of the first pulling portion 12 is elliptical, and the length of the longitudinal plane of the first pulling portion 12 is B, and the width of the transverse plane of the first pulling portion 12 is C.

[0044] Among them, parameter A is 1.8~2.2mm, parameter B is 1.8~2.2mm, and parameter C is 0.8~1.2mm.

[0045] like Figure 1-2 and Figure 4As shown, in some embodiments, the orthodontic piece 2 is bent by a second bending piece 21 to form a second retaining portion 22, a connecting piece 23 and a second pulling portion 24. The second retaining portion 22 is bonded to the mandibular incisor 5 of the mouse. The second pulling portion 24 is formed by bending the two ends of the connecting piece 23. The second pulling portion 24 is located on the outer side of the buccal gum of the mandibular molar in the mouse mouth. The second pulling portion 24 is used to hang the elastic member 3. After cleaning the mandibular incisor 5 and drying, the second retaining portion 22 is bonded to the mandibular incisor 5 ... The part 22 is dipped in light-curing resin reinforced glass ionomer orthodontic adhesive and inserted from top to bottom along the cutting edge of the mandibular incisor 5. The position of the orthodontic component 2 in the mouse's mandible is adjusted, and the bilateral connecting parts 23 are placed symmetrically so that the second pulling part 24 is located on the buccal gingival side of the mandibular first molar in the mouse's mouth. Then, a dental light-curing lamp is used to make the light-curing resin reinforced glass ionomer orthodontic adhesive undergo a light-curing reaction on the mandibular incisor 5, so that the second retaining part 22 is bonded to the mandibular incisor 5.

[0046] like Figure 1-2 and Figure 4 As shown, in some embodiments, the second pulling portion 24 is formed by bending the two ends of the connecting member 23, and the second pulling portion 24 is circular. The other end of the elastic ring is easily hooked into the second pulling portion 24 and is not easy to fall out. During the mandibular advancement process, the elastic ring can be prevented from being separated from the second pulling portion 24. The first pulling portion 12 pulls the second pulling portion 24 through the elastic member 3, thereby pulling the mouse mandibular advancement.

[0047] The first bent part 11 and the second bent part 21 are both made of Australian wire, and both end surfaces of the Australian wire are circular with a diameter of 0.016".

[0048] like Figure 4-5 As shown, in some embodiments, the longitudinal cross-section of the second retaining portion 22 is circular, and the diameter of the second retaining portion 22 is D, the longitudinal cross-section of the second pulling portion 24 is circular, and the diameter of the second pulling portion 24 is I.

[0049] Among them, parameter D is 1.8~2.2mm, and parameter I is 0.8~1.2mm.

[0050] like Figure 4-5 As shown, in some embodiments, the connecting member 23 includes a first connecting rod 231 on both sides and a second connecting rod 232 on both sides, and the length of the first connecting rod 231 is G, and the length of the second connecting rod 232 is H.

[0051] Among them, parameter G is 1.8~2.2mm, and parameter H is 2.8~3.2mm.

[0052] like Figure 4-5As shown, in some embodiments, the transverse cross-section of the second retaining portion 22 forms an angle a with the connecting member 23, the longitudinal cross-section of the second retaining portion 22 forms an angle b with the connection between the first connecting rod 231, and the first connecting rod 231 forms an angle c with the second connecting rod 232.

[0053] Among them, parameter a is 115°~125°, parameter b is 115°~125°, and parameter c is 155°~165°.

[0054] like Figure 4 As shown, in some embodiments, the distance between the starting points of the first connecting rods 231 on both sides is E, and the distance between the second pulling parts 24 on both sides is F.

[0055] The parameter E is 2.8~3.2mm, and the parameter F is 6.8~7.2mm.

[0056] Example 2

[0057] See Figure 1-5 As shown, the present invention proposes a method for constructing a mandibular condyle osteogenic model, comprising the following steps:

[0058] Step 1: Bend the traction member 1 and the correction member 2, and hang the elastic member 3 into the second pulling portion 24;

[0059] The traction member 1 is bent by the following steps: the Australian wire is first bent into a circular shape with a diameter of 2.0 mm, namely the first retaining portion 13. After the upper and lower parts are crossed, the free ends on both sides are further bent into an elliptical shape, namely the first pulling portion 12. The first retaining portion 13 and the first pulling portion 12 intersect and overlap with each other, and the two ends of the first pulling portion 12 are arranged to intersect and fit together, both ends facing inward. Once the elastic ring is hung in the first pulling portion 12, the intersection and fit of the first pulling portion 12 can prevent the elastic ring from detaching.

[0060] Among them, the orthodontic component 2 is bent by the following steps: the Australian wire is first bent into a circle with a diameter of 2.0 mm, namely the second retaining portion 22. The Australian wires intersect in the middle and extend symmetrically horizontally by 3.0 mm. Then, they are bent in the horizontal direction to form an angle of 120°, and then bent into a connecting member 23. The connecting member 23 is bent in the vertical direction to form an angle of 120°, thereby forming a first connecting rod 231 with a length of 2.0 mm. The first connecting rod 231 is further bent in the vertical direction to form an angle of 160°, thereby forming a second connecting rod 232 with a length of 3.0 mm; both ends of the connecting member 23 are bent back to form a circle with a diameter of 1.0 mm to obtain a second pulling portion 24. The second pulling portion 24 can allow the elastic leather ring to be hung in and is not easy to fall out when performing its function in the mouse's mouth. The first connecting rod 231 and the second connecting rod 232 are both close to the buccal mucosal surface of the bilateral mandibular bones of the mouse, and the second pulling portion 24 is located on the buccal gingival side of the mandibular first molar in the mouse's oral cavity;

[0061] Among them, the traction piece 1 and the correction piece 2 are both Australian wires commonly used in orthodontic clinics, and the end faces of the Australian wires are both circular with a diameter of 0.016";

[0062] The elastic member 3 is an elastic leather ring commonly used in orthodontic clinics. The elastic leather ring is circular in a relaxed state, and the diameter of the circle is Inches, the maximum effective force of the elastic ring is 2.0Oz.

[0063] Step 2: The mice were generally anesthetized and a light-cured resin-reinforced glass ionomer orthodontic adhesive was prepared;

[0064] Among them, the light-curing resin-reinforced glass ionomer orthodontic adhesive is prepared in a powder-to-liquid mass ratio of 3:1; it needs to be freshly prepared before each use. If it is not used for more than 1 minute after preparation at room temperature, it needs to be discarded; the dosage of light-curing resin-reinforced glass ionomer orthodontic adhesive used in the first retention part 13 or the second retention part 22 of each mouse is 20-25 μL; the trade name of the light-curing resin-reinforced glass ionomer orthodontic adhesive used is light-curing orthodontic bonding cement (GC Fuji / ORTHO LC).

[0065] Step 3: Use a cotton swab dipped in 75% alcohol to clean the maxillary incisor 4. After drying, dip the first retaining part 13 in light-curing resin-reinforced glass ionomer orthodontic adhesive and insert it from bottom to top along the incisal edge of the maxillary incisor 4. Adjust the position of the traction member 1 in the upper jaw of the mouse's mouth so that the first pulling part 12 faces the outside of the mouse's mouth and is placed symmetrically. Then use a dental light curing lamp to perform a light curing reaction so that the first retaining part 13 is bonded to the maxillary incisor 4.

[0066] The dosage of the light-curable resin-reinforced glass ionomer orthodontic adhesive used in the first retention portion 13 in mice was 20 μL;

[0067] Among them, the wavelength of the dental curing light used is 470nm, and the adhesive needs to be irradiated from multiple directions for a total time of 20 to 30 seconds.

[0068] Step 4: Use a cotton swab dipped in 75% alcohol to clean the mandibular incisor 5. After it dries, dip the second retaining part 22 in light-curing resin-reinforced glass ionomer orthodontic adhesive and insert it from top to bottom along the incisal edge of the mandibular incisor 5. Adjust the position of the orthodontic device 2 in the mandibular of the mouse so that the bilateral connecting parts 23 are symmetrically placed and the second pulling part 24 is located on the buccal and gingival side of the mandibular first molar of the mouse. Then, use a dental light curing lamp to perform light curing reaction so that the second retaining part 22 is bonded to the mandibular incisor 5.

[0069] The dosage of the light-curable resin-reinforced glass ionomer orthodontic adhesive used in the second retention portion 22 in mice was 20 μL;

[0070] Among them, the wavelength of the dental curing light used is 470nm, and the adhesive needs to be irradiated from multiple directions for a total time of 20 to 30 seconds.

[0071] Step 5: Stretch the elastic member 3 toward the outside of the mouse's oral cavity and hang it into the first pulling portion 12 to complete the installation of the mandibular advancement correction device.

[0072] Among them, the force value of the elastic leather ring in the working state measured by the dynamometer commonly used in orthodontic clinical practice is 8 to 10g.

[0073] The present invention proposes the principle of constructing a mandibular condyle osteogenesis model: when the mandible leads forward, the mandibular condyle slides out of the articular fossa, resulting in increased activity of the pterygoid muscle. Continuous mechanical stimulation increases the force on the mandibular condyle, thereby promoting the activation of local growth factors and causing adaptive changes in the morphology and structure of the mandibular condyle. This will promote endochondral ossification of the mandibular condyle and trigger new bone formation in the mandibular condyle. The present invention proposes constructing a mandibular condyle osteogenesis model-mediated mandibular condyle osteogenesis, which is mainly located in the posterior part of the mandibular condyle head because this part is subjected to more mechanical traction, resulting in adaptive remodeling of the condylar cartilage.

[0074] In summary, through Example 1 and Example 2, the mandibular advancement correction device of Example 1 can not only effectively guide the mouse mandible, but also keep the mouse mandible in a continuously protruding state, which can better simulate the state of a person wearing a mandibular advancement correction device, and solve the problems of other mandibular advancement correction devices such as unsustainable leading time, easy falling off, or inconvenience in eating when worn; the method for constructing the mandibular condyle osteogenesis model of Example 2 not only facilitates the installation of the mandibular advancement correction device in mice, but also uses a light-cured resin reinforced glass ionomer orthodontic adhesive to The traction member 1 and the correction member 2 are prevented from falling off, thereby reducing the falling rate of the correction device and improving the stability and success rate of the mandibular advancement experiment. After the second retaining portion 22 and the first retaining portion 13 are bonded to the corresponding incisors, the second pulling portion is located outside the buccal gum of the mandibular molar in the mouse's mouth, and the first pulling portion is located outside the mouse's oral cavity, so that the correction device will not affect the mouse's eating. In addition, because the elastic member continuously functions, the mouse's mandible is continuously in a protruding state, which can best simulate the state of a person wearing a mandibular advancement appliance. The mandibular advancement correction device designed by the present invention and the method for constructing a mandibular condyle osteogenesis model have wide applicability. The mandibular advancement correction device can be proportionally enlarged according to the size of the rat or rabbit's oral cavity, solving the problems of other mandibular advancement correction devices such as inconsistent leading time, easy falling off, or difficulty in eating when worn.

[0075] In the description of the present invention, "several" means one or more, "many" means more than two, "greater than," "less than," and "exceed" are understood to exclude the number itself, while "above," "below," and "within" are understood to include the number itself. The use of "first" and "second" in the description is solely for the purpose of distinguishing technical features and should not be construed as indicating or implying relative importance, implicitly specifying the number of the indicated technical features, or implicitly specifying the order of the indicated technical features.

[0076] While embodiments of the present invention have been shown and described, it will be appreciated by those skilled in the art that various changes, modifications, substitutions, and variations may be made to these embodiments without departing from the principles and spirit of the invention, and that the scope of the invention is defined by the appended claims and their equivalents.

Claims

1. A rodent mandibular advancement orthosis device, characterized by: include: A traction member, the traction member being provided at the maxillary incisor of the mouse, the traction member being bent by a first bending member to form a first pulling portion and a first retaining portion, the first retaining portion being bonded to the maxillary incisor of the mouse, and the first pulling portion being directed toward the outside of the mouse's oral cavity; The corrective piece is arranged at the mandibular incisor of the mouse, and the corrective piece is connected to the traction piece through an elastic piece. The elastic piece pulls the corrective piece to make the mouse's mandible protrude. The corrective piece is bent by a second bending piece to form a second retaining portion, a connecting piece and a second pulling portion. The second retaining portion is bonded to the mandibular incisor of the mouse, and the second pulling portion is formed by bending the two ends of the connecting piece. The second pulling portion is located on the outside of the buccal gums of the mandibular molars in the mouse's mouth.

2. The rodent mandibular advancement correction device according to claim 1, characterized in that: Both ends of the first bent part are located at the first pulling part, the two ends are intersecting and closely arranged, and both ends face inwards.

3. The rodent mandibular advancement correction device according to claim 2, characterized in that: The longitudinal cross-section of the first retaining portion is circular, and the diameter of the first retaining portion is 1.8~2.2mm. The longitudinal cross-section of the first pulling portion is elliptical, and the length of the longitudinal plane of the first pulling portion is 1.8~2.2mm. The width of the transverse plane of the first pulling portion is 0.8~1.2mm.

4. The rodent mandibular advancement correction device according to claim 1, characterized in that: The longitudinal cross-section of the second retaining portion is circular, and the diameter of the second retaining portion is 1.8-2.2 mm. The longitudinal cross-section of the second pulling portion is circular, and the diameter of the second pulling portion is 0.8-1.2 mm.

5. The rodent mandibular advancement correction device according to claim 1, characterized in that: The connecting member includes a first connecting rod on both sides and a second connecting rod on both sides, wherein the length of the first connecting rod is 1.8-2.2 mm, and the length of the second connecting rod is 2.8-3.2 mm.

6. The rodent mandibular advancement correction device according to claim 5, characterized in that: The transverse cross-section of the second retaining portion forms an angle of 115°~125° with the connecting member, the longitudinal cross-section of the second retaining portion forms an angle of 115°~125° with the connection point of the first connecting rod, and the angle of the connection point of the first connecting rod and the second connecting rod is 155°~165°.

7. The rodent mandibular advancement correction device according to claim 6, characterized in that: The distance between the starting points of the first connecting rods on both sides is 2.8-3.2 mm, and the distance between the second pulling parts on both sides is 6.8-7.2 mm.

8. A method for constructing a mandibular condyle osteosynthesis model, comprising the rodent mandibular advancement orthosis device according to any one of claims 1 to 7, characterized in that: The steps include: Step 1: Bend the traction member and the correction member, and hang the elastic member into the second pulling part; Step 2: The mice were generally anesthetized and a light-cured resin-reinforced glass ionomer orthodontic adhesive was prepared; Step 3: Bonding the traction piece to the maxillary incisor of the mouse; Step 4: Bond the orthodontic device to the mandibular incisor of the mouse; Step 5: Stretch the elastic member toward the outside of the mouse's mouth and hang it into the first pulling part to complete the installation of the mandibular advancement orthosis device.

9. The method for constructing a mandibular condyle osteogenic model according to claim 8, wherein: The specific operation of step three is as follows: clean the maxillary incisor, and after it dries, dip the first retention part in light-curing resin-reinforced glass ionomer orthodontic adhesive, and insert it into the incisor from bottom to top along the incisal edge of the maxillary incisor. Adjust the position of the traction part in the upper jaw of the mouse's mouth so that the first pulling part faces the outside of the mouse's mouth and is placed symmetrically. Then use a dental light curing lamp to perform a light curing reaction so that the first retention part is bonded to the maxillary incisor.

10. The method for constructing a mandibular condyle osteogenic model according to claim 8, wherein: The specific steps of step four are as follows: clean the mandibular incisor, and after it dries, dip the second retention part in light-curing resin-reinforced glass ionomer orthodontic adhesive, and insert it into the incisor from top to bottom along the incisal edge of the mandibular incisor. Adjust the position of the orthodontic component in the mouse's mandible so that the bilateral connecting parts are placed symmetrically and the second pulling part is located on the buccal and gingival side of the mandibular first molar in the mouse's mouth. Then use a dental light curing lamp to perform a light curing reaction so that the second retention part is bonded to the mandibular incisor.

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