Contact lens case and detection method for detecting glucose content in tears

Abstract

The present invention provides a contact lens case for detecting glucose content in tears, belonging to the field of glucose detection technology, and comprising: a base, a circuit board, a test strip, and a display; when tears from the contact lens in the detection chamber drip onto the absorbent sheet through the detection hole, the circuit board receives the conductivity of the electrode group and controls the display reading. A detection method is also provided, which is applied to the contact lens case for detecting glucose content in tears. The beneficial effects of the present invention are: by wearing contact lenses for a short period of time and then placing them in the contact lens case, the current glucose level can be detected through tears, thus overcoming the problem of eye hypoxia caused by wearing contact lenses for a long time. At the same time, by replacing the absorbent paper on the test strip for each test, the detection device can be used repeatedly for testing.

Description

Technical Field

[0001] The invention belongs to the technical field of glucose detection, relates to a contact lens case for detecting the glucose content in tears, and also relates to a detection method. Background Art

[0002] To effectively monitor blood glucose levels in diabetic patients, portable home blood glucose meters and test strips are widely used. Current blood glucose testing methods primarily involve invasive or minimally invasive blood sampling, which causes significant pain for patients and carries the risk of viral infection through the bloodstream. Therefore, non-invasive blood glucose testing is urgently needed in diabetes treatment. The glucose content in tears correlates well with that in blood. Therefore, blood glucose levels can be indirectly inferred by measuring tear glucose, achieving the goal of non-invasive testing. Contact lenses with biosensors capable of detecting glucose levels in tears are now available on the market.

[0003] For example, an invention patent with publication number CN109239944A provides a contact lens capable of detecting the glucose content in tears and a preparation method. The contact lens comprises a gel matrix, the contact lens also comprising: platinum nanoparticles dispersed in the gel matrix. The platinum nanoparticles can act as a catalyst to accelerate the decomposition rate of hydrogen peroxide, that is, to increase the generation rate of oxygen and water; and a biosensor disposed in the gel matrix. The biosensor is provided with a glucose oxidation catalyst.

[0004] In summary, although some existing technical solutions can detect the glucose content in tears, long-term wearing of contact lenses can cause eye hypoxia. In addition, contact lenses are consumables with a service life of one day to six months. Each replacement is equivalent to discarding the original biosensor and replacing it with a new one. This technical method cannot reuse the detection device, is very impractical, and has a lot of room for improvement. Summary of the Invention

[0005] The purpose of the present invention is to address the above-mentioned problems existing in the prior art, and to provide a contact lens case for detecting the glucose content in tears, and also provide a detection method.

[0006] The object of the present invention can be achieved by the following technical solution: A contact lens case for detecting the glucose content in tears, comprising:

[0007] A base, which is provided with a detection cavity, a detection hole and a mounting groove, wherein the detection hole is connected to the detection cavity, and the detection cavity is used to place the contact lens;

[0008] a circuit board disposed in the base;

[0009] a test strip detachably connected to the mounting slot, the test strip being provided with an electrode group and a water-absorbing sheet, the electrode group being provided on a surface of the test strip, the water-absorbing sheet being detachably connected to the test strip and capable of covering an end of the electrode group, wherein when the test strip is inserted into the mounting slot, the circuit board is electrically connected to the electrode group and the water-absorbing sheet is located below the detection hole;

[0010] The display is electrically connected to the circuit board. When tears from the contact lens in the detection cavity drip into the absorbent sheet through the detection hole, the circuit board receives the conductivity of the electrode group and controls the display reading.

[0011] In the above-mentioned contact lens case for detecting the glucose content in tears, the test strip is a U-shaped structure arranged horizontally, the electrode group is distributed along the surface of the test strip and the two ends of the electrode group are respectively located at the upper and lower parts of the test strip, the absorbent sheet can cover the electrode group on the upper part of the test strip, and the circuit board can be electrically connected to the electrode group on the lower part of the test strip.

[0012] In the above-mentioned contact lens case for detecting the glucose content in tears, the test strip is also provided with a water-isolating sheet, which is arranged adjacent to the water-absorbing sheet and covers the upper part of the test strip together with the water-absorbing sheet. The base is also provided with a partition, and when the test strip is inserted into the mounting groove, the upper and lower parts of the test strip are separated by the partition.

[0013] In the above-mentioned contact lens case for detecting the glucose content in tears, it also includes a cover body, which is detachably connected to the base and can cover the detection cavity. The base is also provided with a first contact, which is electrically connected to the circuit board. The cover body is provided with a second contact and the display is provided on the cover body. The display is electrically connected to the second contact. When the second contact is electrically connected to the first contact, the display shows a number.

[0014] In the above-mentioned contact lens case for detecting the glucose content in tears, the base is further provided with a first positioning portion, and the cover is further provided with a second positioning portion. When the cover is connected to the base and the second positioning portion is aligned with the first positioning portion, the second contact is electrically connected to the first contact.

[0015] In the above-mentioned contact lens case for detecting the glucose content in tears, the base is further provided with a first attraction member, and the cover is further provided with a second attraction member. At least one of the first attraction member and the second attraction member is magnetic, and the first attraction member and the second attraction member attract each other so that the cover member is close to the base.

[0016] In the above-mentioned contact lens case for detecting the glucose content in tears, it also includes a battery cover, and the base is also provided with a battery cavity. The battery cover is detachably connected to the base and can cover the battery cavity. The opening of the battery cavity is provided with an unlocking groove along its axial direction and a locking groove along its circumference. The unlocking groove is connected to the locking groove. The battery cover is provided with a locking block, and the locking block can move along the unlocking groove and can move along the locking groove. When the locking block is located in the locking groove and away from the unlocking groove, the locking groove restricts the battery cover from being separated from the base.

[0017] In the above-mentioned contact lens case for detecting the glucose content in tears, the base is also provided with a cleaning chamber for cleaning the contact lenses.

[0018] A detection method, applied to the contact lens case for detecting the glucose content in tears, comprises the steps of:

[0019] S1: Before use, pull out the test strip and attach an absorbent sheet to the electrode group on top. Then, place the contact lens into the cleaning chamber for cleaning before the patient wears it.

[0020] S2: After wearing the contact lens for a period of time, place the contact lens into the test chamber and cover it with the cover. Tears will naturally drip into the absorbent sheet through the test hole. Observe the test results displayed on the monitor. After the test is completed, tear off the absorbent sheet on the electrode group.

[0021] In one of the above detection methods, in step S1, a catalyst is added in advance to the water-absorbing sheet to be attached to the electrode group to speed up the detection.

[0022] Compared with the prior art, the present invention has the following beneficial effects:

[0023] 1. After wearing contact lenses for a short time, put them into this contact lens case to detect the current glucose level through tears, overcoming the problem of eye hypoxia caused by wearing contact lenses for a long time. At the same time, the detection device can be used repeatedly for testing by replacing the absorbent paper on the test strip each time.

[0024] 2. The test strip is a U-shaped structure arranged horizontally. The absorbent sheet can cover the electrode group on the upper part of the test strip and the circuit board can be electrically connected to the electrode group on the lower part of the test strip to prevent tears from dripping directly onto the circuit board connection line. It also facilitates the installation of the test strip.

[0025] 3. The water-proof sheet set on the test strip can prevent tears from dripping onto the electrode group except the absorbent sheet. The partition set on the base can prevent tears from the upper part of the test strip from dripping to the lower part of the test strip and prevent tears from dripping onto the circuit board connection line.

[0026] 4. The first contact is electrically connected to the circuit board, the cover is provided with a second contact and the display is provided on the cover. When the second contact is electrically connected to the first contact, the display shows a number. The circuit is connected only when the cover is closed, saving power.

[0027] 5. The first positioning portion can be set as a positioning recess, and the second positioning portion can be set as a positioning protrusion. The positioning protrusion aligns with the positioning recess to position the cover body and the base for connection, and at the same time assists the second contact to be electrically connected to the first contact.

[0028] 6. The first attraction member and the second attraction member attract each other so that the cover body is close to the base. When the cover body and the base are close to a certain distance, the base can be automatically covered with the cover body due to the mutual attraction between the first attraction member and the second attraction member. BRIEF DESCRIPTION OF THE DRAWINGS

[0029] Figure 1 Exploded view of the contact lens case of the present invention.

[0030] Figure 2 This is an exploded view of the contact lens case of the present invention from another perspective.

[0031] Figure 3 It is a structural schematic diagram of the contact lens case of the present invention.

[0032] Figure 4 This is a schematic structural diagram of the contact lens case of the present invention from another perspective.

[0033] Figure 5 It is a top view of the contact lens case of the present invention.

[0034] Figure 6 for Figure 5 Schematic diagram of the cross section in the AA direction.

[0035] Figure 7 for Figure 5 Schematic cross-sectional view along the BB direction.

[0036] Figure 8 It is a structural schematic diagram of the base of the present invention.

[0037] Figure 9 It is a structural schematic diagram of the cover body of the present invention.

[0038] Figure 10 1 is an exploded view of the test strip of the present invention.

[0039] Figure 11 It is a schematic structural diagram of the test strip of the present invention.

[0040] In the figure, 100, base; 110, detection chamber; 120, detection hole; 130, mounting groove; 140, partition; 150, first contact; 160, first positioning portion; 170, first attraction member; 180, battery chamber; 181, unlocking groove; 182, locking groove; 190, cleaning chamber; 200, circuit board; 300, test strip; 310, electrode group; 311, working electrode; 312, counter electrode; 313, reference electrode; 320, absorbent sheet; 321, catalyst; 330, water-proof sheet; 400, cover; 410, second contact; 420, second positioning portion; 430, second attraction member; 500, battery cover; 510, locking block; 600, contact lens. DETAILED DESCRIPTION

[0041] The following are specific embodiments of the present invention and the accompanying drawings to further describe the technical solutions of the present invention, but the present invention is not limited to these embodiments.

[0042] It should be noted that all directional indications in the embodiments of the present invention (such as up, down, left, right, front, back, etc.) are only used to explain the relative position relationship, movement status, etc. between the various components under a certain specific posture (as shown in the accompanying drawings). If the specific posture changes, the directional indication will also change accordingly.

[0043] In addition, in the present invention, descriptions such as "first," "second," and "one" are for descriptive purposes only and should not be understood to indicate or imply their relative importance or implicitly specify the number of the technical features indicated. Therefore, a feature specified as "first" or "second" may explicitly or implicitly include at least one of such features. In the description of the present invention, "plurality" means at least two, such as two, three, etc., unless otherwise specifically defined.

[0044] In the present invention, unless otherwise specified or limited, the terms "connection" and "fixation" should be understood in a broad sense. For example, "fixation" can mean fixed connection, detachable connection, or integration; mechanical connection or electrical connection; direct connection or indirect connection through an intermediate medium; internal communication between two elements or interaction between two elements, unless otherwise specified. Those skilled in the art will be able to understand the specific meanings of the above terms in the present invention based on specific circumstances.

[0045] In addition, the technical solutions between the various embodiments of the present invention can be combined with each other, but it must be based on the fact that ordinary technicians in this field can implement it. When the combination of technical solutions is mutually contradictory or cannot be implemented, it should be deemed that such a combination of technical solutions does not exist and is not within the scope of protection required by the present invention.

[0046] The specific embodiments described herein are merely illustrative of the spirit of the present invention. Persons skilled in the art may make various modifications, additions, or substitutions to the described specific embodiments without departing from the spirit of the present invention or exceeding the scope of the appended claims.

[0047] like Figures 1-11 As shown, a contact lens case for detecting the glucose content in tears includes: a base 100, a circuit board 200, a test strip 300 and a display (not shown in the figure).

[0048] The base 100 is provided with a detection cavity 110 , a detection hole 120 and a mounting groove 130 . The detection hole 120 is communicated with the detection cavity 110 . The detection cavity 110 is used to place the contact lens 600 .

[0049] The circuit board 200 is disposed in the base 100 .

[0050] Among them, the test strip 300 is detachably connected to the mounting groove 130, and the test strip 300 is provided with an electrode group 310 and a water-absorbing sheet 320. The electrode group 310 is arranged on the surface of the test strip 300, and the water-absorbing sheet 320 is detachably connected to the test strip 300 and can cover the end of the electrode group 310. When the test strip 300 is inserted into the mounting groove 130, the circuit board 200 is electrically connected to the electrode group 310 and the water-absorbing sheet 320 is located below the detection hole 120.

[0051] Specifically, the electrode group 310 includes a working electrode 311 , a counter electrode 312 , and a reference electrode 313 , wherein the working electrode 311 is a glassy carbon electrode, the counter electrode 312 is a platinum electrode, and the reference electrode 313 is a silver chloride electrode.

[0052] The display is electrically connected to the circuit board 200. When tears from the contact lens in the detection cavity 110 drip into the absorbent sheet 320 through the detection hole 120, the circuit board 200 receives the conductivity of the electrode group 310 and controls the display reading.

[0053] In this embodiment, by wearing the contact lens 600 for a short time and then placing it in the contact lens case, the current glucose level can be detected through tears, thereby overcoming the problem of eye hypoxia caused by wearing the contact lens 600 for a long time. At the same time, by replacing the absorbent paper on the test strip 300 for each test, the detection device can be used repeatedly for testing.

[0054] like Figure 10 、 Figure 11As shown, based on the above embodiment, the test strip 300 is a U-shaped structure arranged horizontally, the electrode group 310 is distributed along the surface of the test strip 300 and the two ends of the electrode group 310 are respectively located at the upper and lower parts of the test strip 300, the absorbent sheet 320 can cover the electrode group 310 on the upper part of the test strip 300, and the circuit board 200 can be electrically connected to the electrode group 310 on the lower part of the test strip 300.

[0055] In this embodiment, the test strip 300 is a U-shaped structure arranged horizontally. The absorbent sheet 320 can cover the electrode group 310 on the upper part of the test strip 300 and the circuit board 200 can be electrically connected to the electrode group 310 on the lower part of the test strip 300 to prevent tears from dripping directly onto the connecting wires of the circuit board 200, while also facilitating the installation of the test strip 300.

[0056] like Figure 10 、 Figure 11 As shown, on the basis of the above embodiment, the test strip 300 is further provided with a water-isolating sheet 330, and the water-isolating sheet 330 is arranged adjacent to the water-absorbing sheet 320 and covers the upper part of the test strip 300 together with the water-absorbing sheet 320, and the base 100 is further provided with a partition 140, and when the test strip 300 is inserted into the mounting groove 130, the upper and lower parts of the test strip 300 are separated by the partition 140.

[0057] Specifically, the partition 140 and the water-isolating sheet 330 are also provided with water storage tanks, which can accumulate tears that accidentally drip and prevent them from continuing to slide off the plane.

[0058] In this embodiment, the waterproof sheet 330 provided on the test strip 300 can prevent tears from dripping onto the electrode group 310 other than the absorbent sheet 320, and the partition 140 provided on the base 100 can prevent tears from the upper part of the test strip 300 from dripping to the lower part of the test strip 300, and prevent tears from dripping onto the connecting wires of the circuit board 200.

[0059] like Figures 1-9 As shown, on the basis of the above embodiment, it also includes a cover body 400, which is detachably connected to the base 100 and can cover the detection cavity 110, and the base 100 is also provided with a first contact 150, and the first contact 150 is electrically connected to the circuit board 200, the cover body 400 is provided with a second contact 410 and the display is provided on the cover body 400, and the display is electrically connected to the second contact 410, and when the second contact 410 is electrically connected to the first contact 150, the display shows a number.

[0060] In this embodiment, the first contact 150 is electrically connected to the circuit board 200, the cover body 400 is provided with a second contact 410 and a display is provided on the cover body 400. When the second contact 410 is electrically connected to the first contact 150, the display shows a number. The circuit will be connected only when the cover body 400 is closed, saving power.

[0061] like Figure 6 、 Figure 8 、 Figure 9 As shown, on the basis of the above embodiment, the base 100 is further provided with a first positioning portion 160, and the cover body 400 is further provided with a second positioning portion 420. When the cover body 400 is connected to the base 100 and the second positioning portion 420 is aligned with the first positioning portion 160, the second contact 410 is electrically connected to the first contact 150.

[0062] In this embodiment, the first positioning portion 160 can be set as a positioning recess, and the second positioning portion 420 can be set as a positioning protrusion. The positioning protrusion aligns with the positioning recess to position the cover body 400 and connect it to the base 100, while assisting the second contact 410 to be electrically connected to the first contact 150.

[0063] Alternatively, the first positioning portion 160 may be configured as a positioning protrusion, and the second positioning portion 420 may be configured as a positioning recess.

[0064] like Figure 7 、 Figure 8 、 Figure 9 As shown, on the basis of the above embodiment, the base 100 is further provided with a first attraction member 170, and the cover body 400 is further provided with a second attraction member 430, at least one of the first attraction member 170 and the second attraction member 430 is magnetic, and the first attraction member 170 and the second attraction member 430 attract each other so that the cover body 400 is close to the base 100.

[0065] In this embodiment, the first attraction member 170 and the second attraction member 430 attract each other so that the cover body 400 is close to the base 100. When the cover body 400 and the base 100 are close to a certain distance, the first attraction member 170 and the second attraction member 430 attract each other and can automatically cover the base 100 with the cover body 400.

[0066] like Figure 1 、 Figure 2 、 Figure 4 、 Figure 6As shown, on the basis of the above embodiment, it further includes a battery cover 500, and the base 100 is further provided with a battery cavity 180. The battery cover 500 is detachably connected to the base 100 and can cover the battery cavity 180. The opening of the battery cavity 180 is provided with an unlocking groove 181 along its axial direction and a locking groove 182 along its circumference. The unlocking groove 181 is communicated with the locking groove 182. The battery cover 500 is provided with a locking block 510. The locking block 510 can move along the unlocking groove 181 and can move along the locking groove 182. When the locking block 510 is located in the locking groove 182 and away from the unlocking groove 181, the locking groove 182 restricts the battery cover 500 from being separated from the base 100.

[0067] In this embodiment, the unlocking slot 181 is connected to the locking slot 182 and forms an L-shaped structure. The locking block 510 can move along the unlocking slot 181 and can move along the locking slot 182. When the locking block 510 is located in the locking slot 182 and away from the unlocking slot 181, the locking slot 182 restricts the battery cover 500 from separating from the base 100, thereby realizing quick installation and locking of the battery cover 500.

[0068] like Figure 1 、 Figure 6 、 Figure 8 As shown, based on the above embodiment, the base 100 is further provided with a cleaning chamber 190 for cleaning the contact lens 600 .

[0069] In this embodiment, the cleaning chamber 190 is used to clean the contact lens 600, ensuring that the contact lens 600 can be kept moist before the user wears the contact lens.

[0070] like Figures 1-11 As shown, a detection method is applied to the contact lens case for detecting the glucose content in tears, comprising the steps of:

[0071] S1: Before use, remove the test strip 300 and attach the absorbent sheet 320 to the electrode group 310 on the top. Then, place the contact lens 600 into the cleaning chamber 190 for cleaning before the patient wears the lens.

[0072] S2: After wearing for a period of time, place the contact lens 600 into the detection cavity 110 and cover it with the cover 400. Tears will naturally drip into the absorbent sheet 320 through the detection hole 120. Observe the detection results displayed on the display. After the test is completed, tear off the absorbent sheet 320 attached to the electrode group 310.

[0073] In this embodiment, by wearing the contact lens 600 for a short time and then placing it in the contact lens case, the current glucose level can be detected through tears, thereby overcoming the problem of eye hypoxia caused by wearing the contact lens 600 for a long time. At the same time, by replacing the absorbent paper on the test strip 300 for each test, the detection device can be used repeatedly for testing.

[0074] like Figure 10 、 Figure 11 As shown, based on the above embodiment, in step S1, the catalyst 321 is added in advance to the absorbent sheet 320 that needs to be attached to the electrode assembly 310 to speed up the detection.

[0075] In this embodiment, the addition of the catalyst 321 can accelerate the chemical reaction between tears and the electrode assembly 310, thereby accelerating the detection.

Claims

1. A contact lens case for detecting glucose content in tears, characterized in that: include: A base, which is provided with a detection cavity, a detection hole and a mounting groove, wherein the detection hole is connected to the detection cavity, and the detection cavity is used to place the contact lens; a circuit board disposed in the base; a test strip detachably connected to the mounting slot, the test strip being provided with an electrode group and a water-absorbing sheet, the electrode group being provided on a surface of the test strip, the water-absorbing sheet being detachably connected to the test strip and capable of covering an end of the electrode group, wherein when the test strip is inserted into the mounting slot, the circuit board is electrically connected to the electrode group and the water-absorbing sheet is located below the detection hole; a display electrically connected to the circuit board, wherein when tears from the contact lens in the detection cavity drip into the absorbent sheet through the detection hole, the circuit board receives the conductivity of the electrode group and controls the display reading; The test strip is a U-shaped structure arranged horizontally, the electrode group is distributed along the surface of the test strip, and the two ends of the electrode group are respectively located at the upper and lower parts of the test strip. The absorbent sheet can cover the electrode group on the upper part of the test strip, and the circuit board can be electrically connected to the electrode group on the lower part of the test strip. The test strip is also provided with a water-isolating sheet, which is arranged adjacent to the water-absorbing sheet and covers the upper part of the test strip together with the water-absorbing sheet. The base is also provided with a partition, and when the test strip is inserted into the mounting groove, the upper and lower parts of the test strip are separated by the partition.

2. A contact lens case for detecting glucose content in tears according to claim 1, characterized in that: It also includes a cover body, which is detachably connected to the base and can cover the detection cavity. The base is also provided with a first contact, which is electrically connected to the circuit board. The cover body is provided with a second contact and the display is provided on the cover body. The display is electrically connected to the second contact. When the second contact is electrically connected to the first contact, the display shows a number.

3. A contact lens case for detecting glucose content in tears according to claim 2, characterized in that: The base is further provided with a first positioning portion, and the cover is further provided with a second positioning portion. When the cover is connected to the base and the second positioning portion is aligned with the first positioning portion, the second contact is electrically connected to the first contact.

4. A contact lens case for detecting glucose content in tears according to claim 3, characterized in that: The base is further provided with a first attraction member, and the cover is further provided with a second attraction member. At least one of the first attraction member and the second attraction member is magnetic. The first attraction member and the second attraction member attract each other so that the cover member is close to the base.

5. The contact lens case for detecting glucose content in tears according to claim 1, characterized in that: It also includes a battery cover, and the base is also provided with a battery cavity. The battery cover is detachably connected to the base and can cover the battery cavity. The opening of the battery cavity is provided with an unlocking groove along its axial direction and a locking groove along its circumference. The unlocking groove is connected to the locking groove. The battery cover is provided with a locking block, and the locking block can move along the unlocking groove and can move along the locking groove. When the locking block is located in the locking groove and away from the unlocking groove, the locking groove restricts the battery cover from being separated from the base.

6. The contact lens case for detecting glucose content in tears according to claim 1, characterized in that: The base is also provided with a cleaning cavity for cleaning contact lenses.

7. A detection method, characterized in that: The contact lens case for detecting glucose content in tears as claimed in any one of claims 1 to 6 comprises the following steps: S1: before use, the test strip is pulled out and an absorbent sheet is attached to the electrode group on the upper portion thereof, and then the contact lens is placed in a cleaning chamber for cleaning before being worn by the patient; S2: After wearing the contact lens for a period of time, place the contact lens into the test chamber and cover it with the cover. Tears will naturally drip into the absorbent sheet through the test hole. Observe the test results displayed on the monitor. After the test is completed, tear off the absorbent sheet on the electrode group.

8. A detection method according to claim 7, characterized in that: In step S1, a catalyst is added to the absorbent sheet to be attached to the electrode assembly in advance to speed up the detection.

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