A flexible X-ray radiotherapy radiation dose measurement device

Abstract

The present invention relates to the technical field of radiation measurement in radiotherapy. The purpose is to be applicable to different X-ray radiation measurement scenarios through design. A flexible X-ray radiotherapy radiation dose measurement device is disclosed, which includes flexible protective layers arranged on both sides to support and protect the internal structure. Between the two flexible protective layers, there is a flexible radiation detection unit responsible for converting radiation into an electrical signal, and a flexible readout circuit for reading out the electrical signal generated by the flexible radiation detection unit. The flexible radiation detection unit includes a flexible scintillator material layer and a flexible photoelectric conversion layer. By adopting a flexible structure in the detector, the present invention has the characteristic of being flexibly deformable, enabling the detector to fit the human body surface and improving comfort. By adopting a plastic material in the support structure, the present invention has a memory characteristic, enabling the detector to conform to the human body and improving repeatability.

Description

Technical Field

[0001] The present invention relates to the technical field of radiation measurement in radiotherapy, and particularly to a flexible X-ray radiotherapy radiation dose measurement device. Background Art

[0002] There are many commonly used radiation measurement devices, including ionization chambers, matrix detectors, films, thermoluminescent dosimeters, and semiconductor detectors, etc. However, during in-vivo dose measurement in radiotherapy, ionization chambers, semiconductor detectors, and thermoluminescent dosimeters can only perform point dose verification. Films reflect two-dimensional dose distributions but cannot be measured in real time and are complex to operate. Matrix detectors and the like are relatively large in size and rigid, and it is not convenient to place them on the patient's body surface. In addition, in the field of radiation protection, such as for radiation workers and astronauts who need personal dose monitoring, often only 1-2 thermoluminescent dosimeters are used, making it difficult to accurately evaluate the dose received by an individual. And after use, a special instrument is also required for reading, with complex operations. Summary of the Invention

[0003] The purpose of the present invention is to propose a flexible X-ray radiotherapy radiation dose measurement device through design, which can be applied to different X-ray radiation measurement scenarios.

[0004] To achieve the above purpose, the present invention adopts the following technical solutions:

[0005] It includes flexible protective layers provided on both sides to support and protect the internal structure. Between the two flexible protective layers, there is a flexible radiation detection unit responsible for converting radiation into an electrical signal, and a flexible readout circuit for reading out the electrical signal generated by the flexible radiation detection unit. The flexible radiation detection unit includes a flexible scintillator material layer and a flexible photoelectric conversion layer.

[0006] Preferably, the flexible scintillator material layer includes a scintillator material and a flexible substrate, and the scintillator material includes perovskite materials.

[0007] Preferably, the flexible substrate includes any one or a combination of paper, nylon cloth, and flexible PET film.

[0008] Preferably, the perovskite material includes a perovskite scintillator, and the perovskite scintillator includes CsPbI 3 、CsPbI 2 Br、CsPbBr 3 、CsPbBr 2 Cl, any one or a combination of them.

[0009] Preferably, the material of the flexible photoelectric conversion layer includes MAPbI 3 、FAPbI 3 、FA 0.8MA 0.15 Cs 0.05 PbI 3 。

[0010] Preferably, the flexible readout circuit includes a wire for transmitting digital signals to a computer and a plurality of detection units uniformly arranged on the wire.

[0011] Compared with the traditional in-vivo dose measurement device, the advantages of the present invention are as follows:

[0012] 1. By adopting a flexible structure in the detector, the present invention has the characteristics of being flexible and deformable, enabling the detector to fit the human body surface and improving comfort.

[0013] 2. By adopting a plastic material in the support structure, the present invention has a memory characteristic, enabling the detector to conform to the human body and improving repeatability.

[0014] 3. By adopting a flexible circuit in the detector, the present invention can obtain dose signals online, enabling the detector to monitor the dose of human body irradiation in real time.

[0015] 4. By adopting a new type of radiation detection material in the detection unit, the present invention has the advantages of high sensitivity, high ray absorption coefficient, etc., enabling the detector to have higher resolution and providing richer and more accurate dose information. BRIEF DESCRIPTION OF THE DRAWINGS

[0016] Figure 1 is a schematic diagram of the usage scenario of the first flexible X-ray radiotherapy radiation dose measurement device;

[0017] Figure 2 is a schematic diagram of the structure of the first flexible X-ray radiotherapy radiation dose measurement device;

[0018] Figure 3 is a schematic diagram of the structure of the second flexible X-ray radiotherapy radiation dose measurement device B;

[0019] Figure 4 is Figure 3 a detailed enlarged structural schematic diagram of part a in

[0020] Figure 5 is a schematic diagram of the usage scenario of the second flexible X-ray radiotherapy radiation dose measurement device B.

[0021] In the figure:

[0022] A, the first flexible X-ray radiotherapy radiation dose measurement device, 1, the first flexible protective layer, 2, the first flexible radiation detection unit, 3, the first flexible readout circuit, 21, the first flexible scintillator material layer, 22, the first flexible photoelectric conversion layer, 31, the first wire, 32, the first detection unit;

[0023] B. Second flexible X-ray radiotherapy radiation dose measurement device, 4. Second flexible protective layer, 5. Second flexible radiation detection unit, 6. Flexible readout circuit, 7. Gas interface, 8. Foam particles, 51. Second flexible scintillator material layer, 52. Second flexible photoelectric conversion layer, 61. Second wire, 62. Second detection unit. Specific embodiments

[0024] Next, the technical solutions in the embodiments of the present invention will be clearly and completely described in conjunction with the accompanying drawings in the embodiments of the present invention. Obviously, the described embodiments are only a part of the embodiments of the present invention, rather than all the embodiments.

[0025] Embodiment 1

[0026] Referring to Figure 1 and Figure 2 , this embodiment is for in vitro measurement. The first flexible X-ray radiotherapy radiation dose measurement device A in this embodiment is a sheet-like structure as a whole, including the first flexible protective layer 1 arranged on both sides to support and protect the internal structure. The first flexible protective layer 1 is made of a synthetic polymer polyester board with a thickness of about 1.6 - 4.0 mm. It can be completely transparently softened when placed in hot water at 60 - 70 °C, and can be appropriately shaped at will. It can be completely hardened and shaped after being placed at room temperature for a few minutes. It has good X-ray permeability and will not cause attenuation to X-rays;

[0027] Between the two layers of the first flexible protective layer 1, there is a first flexible radiation detection unit 2 responsible for converting radiation into an electrical signal, and a first flexible readout circuit 3 for reading out the electrical signal generated by the flexible radiation detection unit. The first flexible radiation detection unit 2 includes a first flexible scintillator material layer 21 and a first flexible photoelectric conversion layer 22. The material of the first flexible photoelectric conversion layer 22 is MAPbI 3 , which converts visible light into an electrical signal;

[0028] The first flexible scintillator material layer 21 includes a first scintillator material and a first flexible substrate. The first scintillator material includes the perovskite material CsPbBr 3 , the first flexible substrate is a nylon cloth, and the first flexible readout circuit 3 includes a PET flexible interdigital electrode, a first wire 31 for transmitting digital signals to a computer, and a plurality of first detection units 32 uniformly arranged on the wire.

[0029] Clinically, when a doctor or technician locates a patient, the first flexible X-ray radiotherapy radiation dose measuring device A is softened in hot water, and then applied to the part of the patient that needs to be monitored and marked. After it cools and takes shape, it is sent to the CT room for scanning. When a physicist makes a treatment plan, the dose at the detector is calculated. During the patient's treatment, the detector is fixed according to the mark. During treatment, the dose received by the patient during irradiation is measured in real time, and the measured dose is compared with the calculated dose to determine whether the treatment plan is accurately executed.

[0030] The first flexible X-ray radiotherapy radiation dose measuring device A designed in this embodiment can also be applied to personal dose monitoring in the field of radiation protection:

[0031] Personal dose monitoring of radiation workers

[0032] It is applied to workers engaged in the mining, crushing, refining, enrichment, and component processing and manufacturing of natural uranium and thorium ores, the operation of plutonium and other transuranic elements, the operation of other radioactive substances, or radiation-related personnel such as those in radiology departments, interventional departments, and radiotherapy departments. The present invention can be made into clothing, gloves, etc., to monitor personal dose in real time and also has an alarm function.

[0033] Personal dose monitoring of astronauts

[0034] The present invention can be attached or sewn inside the spacesuit. By measuring the dose on the body surface, the dose distribution of each organ and tissue of the astronaut can be reconstructed, providing data support for evaluating the radiation risk of the astronaut.

[0035] Embodiment 2

[0036] Refer to Figures 3 - 5 In this embodiment, it is for in vitro measurement. The second flexible X-ray radiotherapy radiation dose measuring device B in this embodiment is generally spherical or a closed tubular structure at both ends, including a second flexible protective layer 4 provided on both the inner and outer sides to support and protect the internal structure between the two layers. The inside of the second flexible X-ray radiotherapy radiation dose measuring device B is filled with foam particles 8, which have good adsorption capacity and hardness and good plastic fixing performance. One end of the second flexible X-ray radiotherapy radiation dose measuring device B is provided with an air interface 7, which is made of plastic and is used for inflation and exhaust;

[0037] The second flexible protective layer 4 is made of synthetic polymer polyester board, with a thickness of about 1.6 - 4.0 mm. It can be completely transparently softened when placed in hot water at 60 - 70 °C, can be arbitrarily and appropriately shaped, and can be completely hardened and shaped after being placed at room temperature for a few minutes. It has good X-ray permeability and will not cause attenuation to X-rays;

[0038] A second flexible radiation detection unit 5 responsible for converting radiation into an electrical signal, and a second flexible readout circuit 6 for reading out the electrical signal generated by the flexible radiation detection unit are provided between two layers of the second flexible protective layer 4. The second flexible radiation detection unit 5 includes a second flexible scintillator material layer 51 and a second flexible photoelectric conversion layer 52. The material of the second flexible photoelectric conversion layer 52 is MAPbI 3 , which converts visible light into an electrical signal;

[0039] The second flexible scintillator material layer 51 includes a second scintillator material and a second flexible substrate. The second scintillator material includes a perovskite material MAPbI 3 . The second flexible substrate is a polyethylene nylon cloth. The second flexible readout circuit 6 includes a PET flexible interdigital electrode, a second wire 61 for transmitting a digital signal to a computer, and a plurality of second detection units 62 uniformly arranged on the second wire;

[0040] For pelvic radiotherapy, such as cervical cancer, prostate cancer, etc., the dose of the rectum needs to be strictly controlled. If the rectal dose is too high, it will cause rectal bleeding. This second flexible X-ray radiotherapy radiation dose measurement device B can be used to monitor the rectal dose, especially for precise photon radiotherapy and proton therapy. When in use, first evacuate the device. The device will change from deformable to rigid and non-deformable, and then be placed in the patient's rectum. Then inflate it to make it fit the patient's rectum, and then evacuate it again and make a mark. After the patient scans and locates the CT, the physicist makes a treatment plan based on the located CT and calculates the dose at the detector. When the patient is being treated, fix the detector according to the mark. During the treatment, the dose received by the patient during irradiation is measured in real time to determine whether the rectum is overdosed. At the same time, compare the measured dose with the calculated dose to determine whether the treatment plan is accurately executed.

[0041] In this embodiment, it is soft and deformable before evacuation and rigid and non-deformable after evacuation. When it is soft, it is placed in cavities such as the patient's oral cavity and rectum, and after stabilization, it is evacuated to make a personalized in-vivo dose measurement device for the patient. This not only ensures the patient's comfort but also can accurately detect the irradiation dose. The device can be positioned by using an accelerator-mounted CBCT or EPID.

[0042] The above is only a preferred specific embodiment of the present invention, but the protection scope of the present invention is not limited thereto. Any person skilled in the art within the technical scope disclosed by the present invention, according to the technical solution and inventive concept of the present invention, makes equivalent substitutions or changes, and all should be covered within the protection scope of the present invention.

Claims

1. A flexible X-ray radiotherapy radiation dose measurement device, characterized in that, it includes flexible protective layers provided on both sides for supporting and protecting the internal structure. The flexible protective layers are used to be affixed to the part of the patient that needs to be monitored. The flexibility and plasticity of the flexible protective layers are variable. A flexible radiation detection unit responsible for converting radiation into an electrical signal and a flexible readout circuit for reading out the electrical signal generated by the flexible radiation detection unit are provided between the two flexible protective layers. The flexible radiation detection unit includes a flexible scintillator material layer and a flexible photoelectric conversion layer. The flexible X-ray radiotherapy radiation dose measurement device as a whole is in a spherical or closed tubular structure at both ends, filled with foam particles inside and provided with a gas interface at one end.

2. The flexible X-ray radiotherapy radiation dose measurement device according to claim 1, characterized in that, the flexible scintillator material layer includes a scintillator material and a flexible substrate, and the scintillator material includes a perovskite material.

3. The flexible X-ray radiotherapy radiation dose measurement device according to claim 2, characterized in that, the flexible substrate includes any one or a combination of paper, nylon cloth, and flexible PET film.

4. The flexible X-ray radiotherapy radiation dose measurement device according to claim 2, characterized in that, The perovskite material includes a perovskite scintillator, and the perovskite scintillator includes CsPbI 3 , CsPbI 2 Br, CsPbBr 3 , CsPbBr 2 Cl, or any combination of one or more thereof.

5. The flexible X-ray radiotherapy radiation dose measurement device according to claim 1, characterized in that, The materials of the flexible optoelectronic conversion layer include MAPbI 3 , FAPbI 3 , FA 0.8 MA 0.15 Cs 0.05 PbI 3 .

6. The flexible X-ray radiotherapy radiation dose measurement device according to claim 1, characterized in that, the flexible readout circuit includes a wire for transmitting digital signals to a computer and a plurality of detection units uniformly arranged on the wire.

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