Respiration-associated modulation of cardiac contractility force

By using an implantable cardiac device to detect respiratory parameters and set the timing and intensity of cardiac contractility modulation stimulation, the problems of pain and discomfort in cardiac contractility modulation therapy are solved. Precise synchronization between cardiac contractility modulation and respiratory cycle is achieved, improving treatment efficacy and patient comfort.

CN115697469BActive Publication Date: 2026-07-10IMPULSE DYNAMICS NV
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Patent Information

Application Number
CN202080101268.8
Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
Priority Date
2020-03-29
Filing Date
2020-10-22
Publication Date
2026-07-10
Estimated Expiration
2040-10-22

AI Technical Summary

Technical Problem

Existing technologies struggle to effectively integrate cardiac contractility regulation with respiratory phases or conditions, leading to patient pain and discomfort. Furthermore, the parameter settings for cardiac contractility regulation therapy are not precise enough.

Method used

By using an implanted cardiac device, sensors can detect respiratory parameters such as respiratory rate, inhalation and exhalation time, and the timing and intensity of cardiac contractility modulation stimulation can be set to ensure that stimulation is applied during the absolute refractory period of the cardiac cycle and when the diaphragm or phrenic nerve is furthest from the heart, thus reducing pain.

Benefits of technology

It achieves precise synchronization between cardiac contractility regulation stimulation and respiratory cycle, reducing patient pain and improving the effectiveness of cardiac contractility regulation therapy and patient comfort.

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Abstract

A system comprising: one or more sensors for detecting a parameter of a patient's respiratory cycle; and an implantable cardiac device comprising: at least one lead comprising one or more electrodes for applying a cardiac contractility modulation stimulation to a heart; and circuitry for controlling and activating the lead, the circuitry being programmed to set a parameter of the cardiac contractility modulation stimulation in dependence on the parameter of the respiratory cycle detected by the one or more sensors.
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