Tolazoline antigen, synthetic method and application in preparation of immunological detection kit

By preparing toluenethiazide antigen and coupling it with a macromolecular protein to prepare toluenethiazide colloidal gold test strip, the problems of cumbersome and costly toluenethiazide detection in the existing technology are solved, and rapid and accurate detection results are achieved.

CN116120429BActive Publication Date: 2026-07-24ASSURE TECH (HANGZHOU) CO LTD +1
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Patent Information

Application Number
CN202310075895.4
Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
Filing Date
2023-02-07
Publication Date
2026-07-24
Estimated Expiration
2043-02-07

AI Technical Summary

Technical Problem

Existing detection methods for toluenethiazide are cumbersome and costly, making them unsuitable for rapid diagnosis, especially for testing human body fluids or tissue samples.

Method used

A toluthiazide test strip was prepared by conjugating toluthiazide antigen with a macromolecular protein, and rapid detection was achieved using colloidal gold immunochromatography. The toluthiazide colloidal gold test strip was prepared by conjugating toluthiazide antigen with bovine serum albumin or bovine gamma globulin.

Benefits of technology

It enables rapid, accurate, and convenient detection of toluenethiazide, reduces detection costs, is suitable for initial screening of large batches of samples, provides reliable results, has high material safety, and is suitable for industrial production.

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Abstract

The present application relates to a kind of toluene thiazide antigens, its general structure is as follows: and the preparation method of toluene thiazide antigen, carboxyl is derived from succinic anhydride by toluene thiazide hapten, and is coupled to obtain by carboxyl and bovine serum albumin or bovine gamma globulin.The toluene thiazide antigen of the present application is synthesized in preparation process, and the material and catalyst used are ordinary products, so it is more practical, suitable for industrial production and can produce economic value;And, no chloroform is used, and toxicity is lower, more security.
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