A non-phospholipid lipid membrane modified yeast microcapsule carrier, its preparation method and application

By modifying yeast microcapsule carriers with non-phospholipid lipid membranes, the problems of mucosal adhesion and short drug release cycle of oral drug carriers in yeast cells were solved, achieving drug stability in gastric juice and sustained release effect in the intestine, thus improving drug utilization.

CN116271083BActive Publication Date: 2026-01-30DALIAN UNIV OF TECH
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Patent Information

Application Number
CN202211600024.1
Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
Filing Date
2022-12-13
Publication Date
2026-01-30
Estimated Expiration
2042-12-13

AI Technical Summary

Technical Problem

Existing oral drug delivery systems for yeast cells suffer from low mucosal adhesion, low drug load, and short drug release cycles, resulting in excessive drug loss in gastric juice and low utilization in the intestine.

Method used

A yeast microcapsule carrier was modified with a non-phospholipid lipid membrane. Saccharomyces cerevisiae microcapsules were prepared by ethanol dehydration. After loading the drug, the microcapsules were modified with a cationic lipid membrane, including cholesterol and octadecylamine, to form a non-phospholipid cationic lipid membrane coating, which endowed the carrier with acid stability and pH responsiveness.

Benefits of technology

It improves the stability of the drug in gastric juice and the sustained-release effect in the intestine, enhances the oral bioavailability of the drug, promotes the absorption of the drug in the intestinal environment, and solves the problems of drug loss and uneven release in acidic environments.

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Abstract

This invention discloses a non-phospholipid lipid membrane-modified yeast microcapsule carrier, its preparation method, and its application, belonging to the field of drug carrier technology. The invention obtains yeast microcapsules through ethanol dehydration, adsorbs and loads drugs to obtain drug-loaded yeast microcapsules, and then modifies these drug-loaded yeast microcapsules with a cationic lipid membrane to obtain yeast microcapsules modified with a non-phospholipid cationic lipid membrane coating. The non-phospholipid lipid membrane-modified yeast microcapsule carrier prepared by this invention possesses the acid stability, pH responsiveness, and ion responsiveness of cationic lipid membranes. It successfully solves the problems of poor stability, excessive drug loss in gastric juice, and low bioavailability of drugs such as berberine hydrochloride due to their ineffective retention in the intestine, thus improving the oral bioavailability of drugs such as berberine and promoting drug absorption in the intestinal environment. This provides a new approach for the research and development and use of drugs with low bioavailability in oral formulations.
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