Marine antibacterial healing-promoting peptide and application thereof in preparation of wound infection prevention and treatment product

By optimizing the structure of marine antimicrobial healing peptides, the problems of antibiotic resistance and wound infection have been solved, achieving effective inhibition of Gram-negative and Gram-positive bacteria and rapid, high-quality wound repair.

CN116284251BActive Publication Date: 2026-02-06SOUTH CHINA SEA INST OF OCEANOLOGY CHINESE ACAD OF SCI
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Patent Information

Application Number
CN202310192305.6
Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
Filing Date
2023-03-02
Publication Date
2026-02-06
Estimated Expiration
2043-03-02

AI Technical Summary

Technical Problem

Existing antimicrobial drugs have resistance problems in the prevention and treatment of wound infections, and the overuse of traditional antibiotics leads to dysbiosis and superinfections. There is a need to develop new natural anti-infective drugs to improve the body's immunity and promote wound healing.

Method used

A marine antibacterial and healing-promoting peptide is provided. By replacing and deleting amino acids from the original peptide fragments, its structure is optimized to obtain 273 peptide fragments with significant antibacterial activity. These peptides are used to inhibit the growth of Gram-negative and Gram-positive bacteria and can be applied in wound infection prevention and healing products.

Benefits of technology

Marine antibacterial and healing peptides significantly inhibit the growth of various bacteria, promote cell proliferation and migration, reduce inflammatory responses, and improve the speed and quality of wound healing. They also have good biocompatibility and do not cause allergic reactions.

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Abstract

The application discloses a marine antibacterial and healing-promoting peptide and application thereof to preparation of a wound infection prevention and treatment product. Through site-directed mutagenesis and other methods, 273 peptide segments with more remarkable antibacterial and healing-promoting activity are preferably obtained. The antibacterial and healing-promoting peptide has broad-spectrum antibacterial activity, can rapidly increase membrane permeability, cause bacterial breakdown, and effectively inhibit growth of gram-negative bacteria such as Escherichia coli, Pseudomonas aeruginosa and Vibrio vulnificus and gram-positive bacteria such as Staphylococcus aureus. The antibacterial and healing-promoting peptide has good biocompatibility, no cytotoxicity, does not cause hemolysis, and can significantly promote cell proliferation and migration. In terms of prevention and treatment of wound infection, the antibacterial and healing-promoting peptide can effectively inhibit bacterial growth, reduce damage of toxins to the body, significantly reduce the level of pro-inflammatory factors, accelerate wound contraction, and improve the wound healing speed and repair quality. The antibacterial and healing-promoting peptide has a wide range of applications and can be applied to drugs and medical biomaterials, and has a very remarkable effect on prevention and treatment of wound infection.
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