A multi-stage positioning controllable vascular closure device and delivery system

Abstract

The application discloses a multi-stage positioning controllable blood vessel closure device and a delivery system, which comprises a blood vessel closure device and a delivery device. The blood vessel closure device comprises a sealing part and an anchoring part. The sealing part comprises a diaphragm and a connecting rod. The connecting rod has a first end and a second end in the axial direction. A plurality of connecting parts are arranged between the first end and the second end in the axial direction of the connecting rod. The diaphragm is arranged between the first end and one of the connecting parts close to the first end. The delivery device comprises a handle and a rod-shaped assembly. The rod-shaped assembly comprises a pushing part, an anchoring part and a releasing part. Under the action of the handle, the pushing part releases the diaphragm and ensures that the state of the diaphragm is fully open. The releasing part realizes the separation of the blood vessel closure device and the delivery device. The blood vessel closure device can realize multi-stage positioning of the closure device, so that the blood vessel walls with different thicknesses can be clamped between the anchoring part and the diaphragm, and the blood vessel walls can be reliably attached and closed at the damaged parts.

Description

TECHNICAL FIELD

[0001] The present application relates to the technical field of medical devices, in particular to a multi-stage positioning controllable blood vessel closure device. BACKGROUND

[0002] Cardiovascular and cerebrovascular diseases are the top killer of mankind, and interventional surgery has become the main treatment method due to its small trauma and good effect. Data shows that in 2020, the number of patients treated by single coronary intervention in China was 968,651, ranking first in the world. Vascular closure refers to the fact that a cavity hole is generated at the vascular puncture point during cardiovascular minimally invasive diagnosis and interventional surgery, and the cavity hole must be closed after the surgery to prevent blood loss. Under normal circumstances, vascular closure can be achieved in four ways, namely manual compression, closure auxiliary device, surgical suturing and vascular closure device.

[0003] Manual compression hemostasis is the most traditional and currently the most commonly used method of arterial hemostasis. Its advantages lie in low cost and relative reliability. When other methods of hemostasis fail, this method is still needed to solve and remedy. Of course, its disadvantages are also quite prominent. It is not only time-consuming and labor-intensive, but also exacerbates the patient's pain. The compression hemostasis time after extubation is about 25 minutes. In addition, after compression hemostasis, the patient needs to be pressed and bandaged for 6-12 hours and stay in bed for 18-24 hours. In the case of obese patients or puncture sites that are too high or too low, compression difficulties, local hematoma, pseudoaneurysm, arteriovenous fistula, vagal reflex and lower extremity venous thrombosis may occur. However, for large-diameter blood vessels, suturing and closure devices are required. In particular, for valve implantation surgery, in 2019, the number of patients with tricuspid regurgitation, mitral regurgitation, aortic regurgitation and aortic stenosis in China was 9.1 million, 10.3 million, 3.8 million and 4.3 million respectively. According to Frost & Sullivan data, the number of vascular closure surgeries in China increased from 107,500 in 2015 to 274,300 in 2019, and is expected to further increase to 3,782,100 in 2030.

[0004] However, the structure of the current vascular closure device has the problems of residual foreign body due to the non-degradable stent part, poor adhesion of the occlusion part to the inner wall of the blood vessel, poor clinical closure effect, complicated operation and long learning curve for doctors. Therefore, the structure of the vascular closure device urgently needs to be updated.

[0005] In addition, the current vascular closure device can usually only adapt to blood vessels with a certain thickness of the wall. When different thicknesses of the blood vessel wall need to be occluded, different vascular closure devices need to be configured. Therefore, the application range of a single vascular closure device is narrow.

[0006] In the use of a vascular closure device, a corresponding delivery system needs to be used. For a large-diameter vascular closure device, the corresponding delivery system is relatively large and cumbersome. For example, the handle structure of a Proglide suture type closure device is complex, multiple operation steps are required, and the doctor's requirements are high, which requires a long learning curve. Even the delivery handle of a conventional vascular closure device has a series of problems, such as the difficulty in operating each component on the handle, the easy misoperation, the size of the handle not meeting the ergonomic design, and the handle being unable to accurately position the displacement distance of the internal catheter. These problems increase the risk in surgery. Therefore, it is necessary to develop a delivery handle with simple operation and simple steps to reduce the risk of surgery. SUMMARY

[0007] The technical problem to be solved by the present application is to overcome the defects in the prior art that the single vascular closure device has a narrow application range and the delivery system cannot accurately position and release the implant, and to provide a multi-stage positioning controllable vascular closure device and a delivery system.

[0008] The present application solves the above technical problems by the following technical solutions:

[0009] A multi-stage positioning controllable vascular closure device comprises a vascular closure device and a delivery device. The vascular closure device comprises a sealing member and an anchoring part. The sealing member comprises a diaphragm and a connecting rod. The connecting rod has a first end and a second end in the axial direction. A plurality of connecting parts are arranged between the first end and the second end in the axial direction of the connecting rod. The diaphragm is arranged between the first end and one of the connecting parts close to the first end.

[0010] The delivery device comprises a handle and a rod-shaped component. The rod-shaped component comprises a pushing part, an anchoring part and a releasing part.

[0011] The rod-shaped component is configured to be driven by the handle to switch the sealing member from a folded state in the pushing part to an unfolded state outside the pushing part and keep the unfolded state. The sealing member is used to seal the puncture on the blood vessel in the unfolded state.

[0012] The rod-shaped component is further configured to be driven by the handle to move the anchoring part along the axial direction of the connecting rod until one of the connecting parts is connected to the sealing member to clamp the blood vessel wall between the anchoring part and the diaphragm. The releasing part is used to release the vascular closure device from the delivery device under the action of the handle.

[0013] In the present scheme, the pushing part supports the released membrane, which can well guarantee the opening and closing state of the membrane in the body, avoiding the abnormal release of the membrane caused by blood flow or incorrect operation. Since the number of connecting parts is multiple, the anchoring part can be connected with the corresponding connecting part according to the thickness of the blood vessel wall, so that multi-stage positioning of the occluder can be realized, and the blood vessel wall of different thicknesses can be clamped between the anchoring part and the membrane. Through the above structure, the application range of the vascular occlusion device is wider, which can be applied to blood vessels of different individuals and different parts. In addition, through the cooperation of the rod-shaped assembly and the handle, the anchoring part can be more reliably connected with the connecting part, and the blood vessel wall can be more reliably clamped between the anchoring part and the membrane, so that the membrane can be more reliably attached to the blood vessel wall and seal the damaged part.

[0014] Preferably, a foldable skeleton structure is attached to the membrane.

[0015] The membrane, the skeleton structure and the anchoring part are made of elastic material; and / or the skeleton structure is made of material with shape memory characteristics.

[0016] In the present scheme, the membrane is more gently and naturally stretched, and the membrane and the anchoring part made of elastic material are less likely to cause damage to human tissues, providing a better experience for patients. The skeleton structure is made of material with shape memory characteristics, so that the skeleton can return to the memory position, thereby driving the membrane to unfold, so that the membrane can cover the puncture on the blood vessel.

[0017] Preferably, the skeleton structure includes a plurality of skeletons, and the plurality of skeletons are arranged at intervals on the periphery of the connecting rod and are arc-shaped so that the membrane is umbrella-shaped when unfolded.

[0018] In the present scheme, the plurality of skeletons are arc-shaped and fixed at intervals on the periphery of the connecting rod to support and control the shape and unfolding state of the membrane. The interval between the plurality of skeletons makes the membrane present an umbrella-shaped morphology when unfolded, so that it can better fit and close the cross section of the blood vessel, achieving a reliable closing effect. At the same time, the shape of each skeleton is also designed to be arc-shaped or curved, and the membrane will unfold according to the shape of the arc or curve, which can make the membrane better fit on the inner wall of the blood vessel, reduce the phenomenon of failed occlusion and blood leakage, and make the vascular occlusion device better adapt to the pressure state inside the blood vessel, thereby minimizing the damage and invasion to the blood vessel wall and reducing the risk of complications and the discomfort of patients.

[0019] Preferably, the side of the skeleton away from the membrane is provided with a corrugated structure and / or a special-shaped hole.

[0020] In the scheme, the side of the skeleton away from the membrane is the side in contact with the blood vessel wall, and the corrugated structure and / or the heterogeneous holes provided thereon are more conducive to cell climbing and endothelialization, and can make the blood vessel heal faster.

[0021] Preferably, a plurality of the connecting portions are arranged at intervals along the axial direction of the connecting rod.

[0022] Alternatively, a plurality of the connecting portions are formed by a threaded structure provided on the outer wall surface of the connecting rod, and the anchoring portion and the connecting portion are threadedly connected.

[0023] In the scheme, a plurality of connecting portions are arranged at intervals, and multi-stage positioning can be achieved with a relatively simple structure. The connecting portion is a thread on the outer side wall of the connecting rod and can be arranged to extend from the second end to the membrane. The anchoring portion and the connecting portion are threadedly connected, the distance between the anchoring portion and the membrane can be infinitely adjusted, and the blood vessel closure device can better adapt to blood vessels of different thicknesses. The distance between the anchoring portion and the membrane is not too large, which leads to poor closure effect, or the distance between the anchoring portion and the membrane is too small, which leads to the situation that the blood vessel is clamped and damaged.

[0024] Preferably, the anchoring portion comprises a main body and a claw, the main body is connected with the plugging piece, the number of the claw is a plurality, a plurality of the claw is arranged at intervals along the circumference of the main body and extends towards the membrane, so that the blood vessel wall is clamped between the claw and the membrane.

[0025] In the scheme, the anchoring portion is provided with a claw extending towards the membrane. When the blood vessel wall is clamped between the claw and the membrane, the claw applies a force to the blood vessel wall towards the membrane, so that the membrane is more closely attached to the blood vessel wall, and the closure effect is better.

[0026] Preferably, the closer further comprises a pulling structure, the connecting rod is connected with the pulling structure at one end away from the plugging piece, the pulling structure is provided with a pulling line, and the pulling line is used to adjust the position and angle of the plugging piece outside the body.

[0027] In the scheme, the connecting rod is connected with the plugging piece, the pulling structure is provided on the connecting rod, the pulling line is provided on the pulling structure, the plugging piece is pulled outside the body through the pulling line, the position and angle of the plugging piece are adjusted, the plugging piece can be aligned with the puncture port on the plugging blood vessel in the blood vessel, the anchoring portion is pushed under the action of the anchoring portion by pulling the pulling line outside, the anchoring portion is engaged with the adipose tissue of the outer wall of the blood vessel, so that the blood vessel is clamped in the middle by the plugging piece and the anchoring portion, the anchoring portion, the blood vessel and the plugging piece form a sandwich structure, and the effect of blood vessel closure is improved.

[0028] Preferably, the connecting rod comprises a primary connecting rod and a secondary connecting rod fixedly connected, wherein the primary connecting rod is connected with the pulling wire structure, and the secondary connecting rod is fixedly connected with the blocking piece.

[0029] In the scheme, the primary connecting rod is connected with the pulling wire structure, and the secondary connecting rod is fixedly connected with the blocking piece, that is, one end of the connecting rod is connected with the blocking piece, and the other end of the connecting rod is connected with the pulling wire structure, so that the position adjustment of the blocking piece can be realized by pulling the pulling wire.

[0030] Preferably, a protrusion is arranged at the joint of the primary connecting rod and the secondary connecting rod, the anchor portion can move from a first position to a second position relative to the connecting rod, the anchor portion is sleeved on the primary connecting rod when the anchor portion is in the first position, and the anchor portion moves to the secondary connecting rod by overcoming the protrusion when the anchor portion moves to the second position.

[0031] Preferably, the pulling wire structure has two structures which are symmetrically arranged on both sides of the connecting rod, and two through holes are arranged on the connecting rod for mounting the pulling wire structure.

[0032] In the scheme, two pulling wire structures are arranged, the two structures are symmetrically arranged on both sides of the connecting rod, and two through holes are arranged on the connecting rod for mounting the pulling wire structure, so that two pulling wires can be conveniently arranged, the structure is more stable by using two pulling wires, and the whole closing structure is prevented from tilting to one side due to excessive force on one side, so that the blocking fails, the two pulling wires are tied together outside the body, and the whole closing operation is completed by cutting the knot after the puncture port is closed.

[0033] Preferably, the pushing part comprises a pushing catheter, the anchor part comprises an anchor catheter, and the release part comprises a release catheter, the pushing catheter, the anchor catheter and the release catheter are nested with each other, the pushing catheter is located at the outermost side, and the release catheter is located at the innermost side.

[0034] The release catheter is detachably connected with the closer, the pushing catheter is used for pushing the blocking piece to be delivered into the blood vessel, the blocking piece is in a folded state when the blocking piece is located in the pushing catheter, and the blocking piece is released to be in an unfolded state when the blocking piece is exposed from the pushing catheter.

[0035] The anchor catheter is nested between the pushing catheter and the release catheter, and the anchor catheter is used for pushing the anchor portion so that the anchor portion is fixed to the outer wall of the blood vessel.

[0036] Preferably, the releasing conduit is further provided with a releasing structure at the end connected with the closer, the releasing structure comprising at least two oppositely arranged spherical clamping pieces, the connecting rod being clamped between the at least two spherical clamping pieces and wrapped in the releasing conduit;

[0037] The releasing conduit is configured to make the at least two spherical clamping pieces pop open to release the closer when the releasing conduit pushes out of the anchoring conduit, so as to realize the separation of the closer from the delivery device.

[0038] Preferably, the occlusion piece, the connecting rod and the anchoring part are made of degradable polymer.

[0039] In this solution, the occlusion piece, the connecting rod and the anchoring part can be completely degraded in the human body, so as to ensure that the closer is gradually degraded and absorbed in the human body, thereby reducing the adverse effects on the human health.

[0040] Preferably, the handle comprises a housing and a power mechanism, the power mechanism being mounted on the housing.

[0041] The rod-shaped assembly comprises a first conduit, a second conduit and a third conduit, the power mechanism comprises a first propulsion device, a second propulsion device, a third propulsion device and a fourth rotating device, the first propulsion device being connected with the first conduit to drive the first conduit to move along the axial direction of the first conduit, the second propulsion device being connected with the second conduit to drive the second conduit to move along the axial direction of the second conduit, the third propulsion device being connected with the third conduit to drive the third conduit to move along the axial direction of the third conduit, and the fourth rotating device being connected with the third conduit to drive the third conduit to rotate around the central axis of the third conduit.

[0042] The first conduit, the second conduit and the third conduit are sequentially sleeved from outside to inside, and the third conduit is used for connecting the implant.

[0043] In the first state of the handle assembly, the implant is located in the first conduit, and the retraction of the first conduit can make the implant exposed.

[0044] In the second state, the reverse extension of the first conduit can make the implant fully expanded.

[0045] In the third state, the axial movement of the second conduit can make the implant fixed on the blood vessel.

[0046] In the fourth state, the rotation of the third conduit around the axial direction can make the implant in a pre-releasing state.

[0047] In the fifth state, axial movement of the third conduit can cause the implant to be released from the third conduit.

[0048] In the present scheme, the first conduit can be extended and retracted by axial movement of the first conduit driven by the first propulsion device. In use, the implant hidden in the first conduit is exposed by retraction of the first conduit in the first state, and the implant expands to some extent after being exposed, preparing for subsequent expansion. In the second state, the first conduit is extended and rests on the exposed implant, allowing the implant to expand fully. In the third state, the second conduit is moved by the second propulsion device, thereby fixing the implant on the blood vessel. In the fourth state, the third conduit is rotated by the fourth rotating device, causing the implant to enter a pre-release state, preparing for subsequent release. In the fifth state, the third conduit is moved by the third propulsion device, releasing the implant. Through the cooperation of the power mechanism in different states, the implant can be precisely retracted and fixed in the blood vessel. The handle assembly of the present scheme only needs five steps to fix the implant on the blood vessel, and the operation steps are simpler and more convenient for doctors to operate. The power mechanism and the conduits are one-to-one corresponding, making the operation smoother and reducing the operation error, thereby reducing the risk of surgery.

[0049] Preferably, the handle further comprises a feedback mechanism, the feedback mechanism comprising a switch plate and a plurality of positioning teeth that cooperate with each other.

[0050] The power mechanism comprises a rotating wheel, which is connected to the rod-shaped assembly. The rotating wheel rotates to drive the rod-shaped assembly to move. A plurality of positioning teeth are arranged on the rotating wheel and distributed circumferentially along the rotating wheel. Rotation of the rotating wheel can switch the switch plate between the plurality of positioning teeth.

[0051] In the present scheme, the number of times of switching by the positioning teeth can feedback the angle (number of turns) of rotation of the rotating wheel. Since the rotating wheel rotates to drive the rod-shaped assembly to move, the feedback mechanism can more accurately position and control the movement distance of the conduit.

[0052] Preferably, the positioning teeth are distributed on the inner circumferential surface of the rotating wheel.

[0053] In the present scheme, the switch plate and the positioning teeth of the feedback mechanism cooperate inside the rotating wheel, which is more reasonable in position and makes the overall structure more compact.

[0054] Preferably, the second propulsion device comprises a screw rod, and the rotating wheel and the screw rod are respectively provided with internal threads and external threads that cooperate with each other. The second conduit is fixed on the screw rod, and the rotating wheel rotates to drive the screw rod to move axially along the second conduit.

[0055] And / or, the handle further comprises a locking mechanism, which is arranged on the shell, and is used for locking and unlocking the third advancing device and / or the fourth rotating device.

[0056] In this scheme, the control of the second conduit is realized by the thread cooperation between the screw rod and the rotating member, and the second advancing device can more accurately control the movement of the second conduit, which is convenient for the doctor to operate. The locking and unlocking of the third advancing device and the fourth rotating device by the locking mechanism can avoid the implant from entering the pre-unlocking state or being unlocked in advance due to accidental touch, reduce the operation error, and ensure the accuracy of the implant release.

[0057] Preferably, the locking mechanism is distributed between the third advancing device and the fourth rotating device, and comprises a first locking member, which has a first locking position and a second locking position, the first locking position is used for locking the third advancing device, and the second locking position is used for locking the fourth rotating device, and the first locking member is switched between the first locking position and the second locking position to realize locking and unlocking.

[0058] In this scheme, the first locking member has two locking positions, which are respectively used for locking the third advancing device and the fourth rotating device. In addition, the first locking member can be conveniently switched between the two positions to realize the locking of the third advancing device and the unlocking of the fourth rotating device, or the unlocking of the third advancing device and the locking of the fourth rotating device, so that the doctor operates more conveniently.

[0059] Preferably, the locking mechanism further comprises a second locking member, which comprises a third locking position and an unlocking position, the third locking position is used for locking the third advancing device, and the second locking member is switched between the third locking position and the unlocking position to realize locking and unlocking.

[0060] In the scheme, the second locking member can lock the third advancing device, avoiding that the third advancing device is unlocked by mistake when the first locking member locks the fourth rotating device in the second locking position in the initial state; and before entering the pre-delivering state, the first locking member needs to be unlocked, and the third advancing device is controlled to make the third guide tube extend, so as to first release the restriction on the rotation of the implant; then, the first locking member is switched to the first locking position to unlock the fourth rotating device, and the third advancing device is locked at the same time, at this time, the fourth rotating device is controlled to make the third guide tube rotate, so as to make the implant enter the pre-delivering state; then, the first locking member is switched to the second locking position to unlock the third advancing device, and the fourth rotating device is locked at the same time, the third guide tube is moved by controlling the third advancing device, so that the implant is delivered; when one of the third advancing device and the fourth rotating device is operated, the other one is in the locked state, the operation error is reduced, and the first locking member and the second locking member cooperate to make the whole process only need to be switched three times (locked or unlocked three times), and the operation is simpler.

[0061] Preferably, the first advancing device, the second advancing device, the third advancing device and the fourth rotating device are sequentially distributed on the shell from the opening end of the handle to the tail end of the handle.

[0062] In the scheme, the first advancing device needs to extend and retract, and the adjustment range is large, while the fixation and delivery of the second advancing device, the third advancing device and the fourth rotating device are all small-range fine adjustment, the position distribution makes the handle more stable in the advancing process, and the balance is better, so that the handle can be more smoothly controlled, and the handle is more ergonomic.

[0063] The application further provides a delivery system comprising the above multi-stage positioning controllable vascular closure device.

[0064] The positive progress effect of the application is that: since the number of the connecting parts is multiple, the anchoring part can be connected with the corresponding connecting part according to the thickness of the blood vessel wall, multi-stage positioning of the closure device can be realized, and the blood vessel wall with different thicknesses can be clamped between the anchoring part and the diaphragm. Through the above structure, the application range of the vascular closure device is wider, and the vascular closure device can be applied to blood vessels of different individuals and different positions. In addition, through the cooperation of the rod-shaped assembly and the handle, the anchoring part can be more reliably connected with the connecting part, and the blood vessel wall can be more reliably clamped between the anchoring part and the diaphragm, so that the diaphragm can be more reliably attached to the blood vessel wall and seal the damaged part. BRIEF DESCRIPTION OF DRAWINGS

[0065] Figure 1 FIG. 1 is a structural schematic view of a vascular closure device in Embodiment 1 of the application.

[0066] Figure 2Another structural schematic view of the vascular closure device in Embodiment 1 of the present application.

[0067] Figure 3 Another structural schematic view of the vascular closure device in Embodiment 1 of the present application.

[0068] Figure 4 A structural schematic view of the anchor portion in Embodiment 1 of the present application.

[0069] Figure 5 A structural schematic view of another embodiment of the anchor portion in Embodiment 1 of the present application.

[0070] Figure 6 A structural schematic view of the membrane and the umbrella rib in Embodiment 1 of the present application.

[0071] Figure 7 A structural schematic view of another embodiment of the membrane and the umbrella rib in Embodiment 1 of the present application.

[0072] Figure 8 A structural schematic view of another embodiment of the membrane and the umbrella rib in Embodiment 1 of the present application.

[0073] Figure 9 A structural schematic view of another embodiment of the membrane and the umbrella rib in Embodiment 1 of the present application.

[0074] Figure 10 A structural schematic view of the connecting rod and the clamping portion in Embodiment 1 of the present application.

[0075] Figure 11 A structural schematic view of another embodiment of the connecting rod and the clamping portion in Embodiment 1 of the present application.

[0076] Figure 12 A structural schematic view of another embodiment of the connecting rod and the clamping portion in Embodiment 1 of the present application.

[0077] Figure 13 A structural schematic view of another embodiment of the connecting rod and the clamping portion in Embodiment 1 of the present application.

[0078] Figure 14 A structural schematic view of the connecting portion in Alternative Embodiment 1 of the present application.

[0079] Figure 15 A structural schematic view of the anchor portion in Alternative Embodiment 1 of the present application.

[0080] Figure 16 A structural schematic view of the anchor portion in the closure device of Embodiment 2 of the present application at a first position.

[0081] Figure 17 A structural schematic view of the anchor portion in the closure device of Embodiment 2 of the present application at a second position.

[0082] Figure 18 Schematic diagram (1) of the structure of the closure device according to embodiment 2 of the present invention when no anchoring portion is provided.

[0083] Figure 19 for Figure 18 Schematic diagram of the middle closer in another direction.

[0084] Figure 20 This is a schematic structural diagram of the anchoring portion in Example 2 of the present invention.

[0085] Figure 21 This is a schematic diagram of the anchoring portion in another direction in Example 2 of the present invention.

[0086] Figure 22 This is a structural schematic diagram (2) of the closure of Example 2 of the present invention when no anchoring portion is provided.

[0087] Figure 23 for Figure 20 Top view of the middle closer.

[0088] Figure 24 Schematic diagram (3) of the structure when no anchoring portion is provided in the closure of Example 2 of the present invention.

[0089] Figure 25 This is a schematic structural diagram of the conveyor according to embodiment 2 of the present invention.

[0090] Figure 26 Schematic diagram (four) of the structure when no anchoring portion is provided in the closure of embodiment 2 of the present invention.

[0091] Figure 27 for Figure 26 Schematic diagram of the middle closer in another direction.

[0092] Figure 28 Schematic diagram of the coordination between the delivery catheter and the release structure of Example 2 of the present invention.

[0093] Figure 29 This is a schematic structural diagram of the handle of Example 3 of the present invention.

[0094] Figure 30 This is a structural schematic diagram of the handle of Example 3 of the present invention (1).

[0095] Figure 31 Schematic diagram of the structure of the handle of embodiment 3 of the present invention (II)

[0096] Figure 32 This is a cross-sectional view (1) of the handle of embodiment 3 of the present invention.

[0097] Figure 33Sectional view of the handle of embodiment 3 of the present application (two)

[0098] Figure 34 Schematic diagram of the internal structure of the handle of embodiment 3 of the present application.

[0099] Figure 35 Schematic diagram of the structure of the rotating member and the push piece of embodiment 3 of the present application.

[0100] Figure 36 Schematic diagram of the assembly structure of the first locking member and the second locking member of the handle of embodiment 3 of the present application.

[0101] Figure 37 Schematic diagram of the structure of the anchor structure before fixation of embodiment 3 of the present application.

[0102] Figure 38 Schematic diagram of the structure of the anchor structure after fixation of embodiment 3 of the present application.

[0103] Figure 39 Schematic diagram of the structure of the connecting member of the implant of embodiment 3 of the present application.

[0104] Figure 40 Schematic diagram of the partial structure of the third catheter of embodiment 3 of the present application.

[0105] Figure 41 Flow chart of the use method of the handle of embodiment 3 of the present application.

[0106] Figure 42 Schematic diagram of the structure of the handle of embodiment 4 of the present application.

[0107] Figure 43 Schematic diagram of the partial structure of the vascular closure device of embodiment 5 of the present application.

[0108] Figure 44 Schematic diagram of the structure of the vascular closure device of embodiment 5 of the present application.

[0109] Explanation of reference signs:

[0110] Example 1

[0111] Sealing member 1; diaphragm 11; rib 12; first group of ribs 121; second group of ribs 122; connecting rod 13; connecting part 131; first end 132; second end 133; anchor part 2; main body 21; clamping jaw 22; blood vessel wall 3; clamping matching part 4.

[0112] Example 2 and Example 5

[0113] Sealing member 1; connecting rod 2; pull wire structure 3; anchoring portion 4; diaphragm 5; skeleton structure 6; primary connecting rod 7; secondary connecting rod 8; protrusion 9; anchoring ring 10; anchoring sheet 11; through hole 12; release structure 13; spherical clamping sheet 14; pushing catheter 15; releasing catheter 16; anchoring catheter 17; handle 18; rod-shaped component 19; handle 20.

[0114] Example 3 and Example 4

[0115] Shell 1; transparent area 11; first propulsion device 21; second propulsion device 22; rotating wheel 221; screw 222; paddle 223; positioning tooth 224; third propulsion device 23; fourth rotating device 24; mark 25; catheter 3; first catheter 31; second catheter 32; third catheter 33; block 331; tail end 41; open end 42; implant 5; connecting member 51; first limiting groove 511; second limiting groove 512; protrusion 513; anchoring structure 52; anchoring foot 521; locking mechanism 6; first locking member 61; first locking position 611; second locking position 612; first locking tongue 613; second locking tongue 614; second locking member 62; third locking position 621; third locking tongue 622. DETAILED DESCRIPTION

[0116] The present invention is further described below by way of examples, but the present invention is not limited to the scope of the examples.

[0117] Example 1

[0118] like Figures 1-3 、 Figures 6-9 As shown, this embodiment provides a blood vessel closure device comprising an occluding member 1 and an anchoring portion 2. The occluding member 1 comprises a diaphragm 11, on which are disposed ribs 12 made of an elastic material. The occluding member 1 is provided with a connecting portion 131, through which the anchoring portion 2 is connected to the occluding member 1, such that the blood vessel wall 3 is clamped between the anchoring portion 2 and the diaphragm 11. The ribs 12, diaphragm 11, and anchoring portion 2 are all made of an elastic material.

[0119] In this embodiment, the anchor portion 2 is connected to the connecting portion 131 on the occluding member 1 through the above-described structure, thereby clamping the blood vessel wall 3 between the anchor portion 2 and the diaphragm 11. The diaphragm 11 can adhere to the blood vessel wall 3 and seal the damaged area. In addition, because the diaphragm 11 is provided with ribs 12 made of elastic material, when the occluding member 1 is released within the blood vessel, the diaphragm 11 can be extended from its original curled state under the support of the ribs 12. Compared with diaphragms 11 without ribs 12, the extended diaphragm 11 has better stability and conformity to the inner wall of the blood vessel, thereby improving the operational stability of the blood vessel closure device.

[0120] As a preferred embodiment, the occlusion member 1 comprises a connecting rod 13, the connecting rod 13 comprises a first end 132 and a second end 133, a connecting portion 131 is arranged between the first end 132 and the second end 133, the diaphragm 11 and the umbrella rib 12 are arranged between the first end 132 and the connecting portion 131.

[0121] In the embodiment, through the above structure, the diaphragm 11 and the umbrella rib 12 are arranged between the first end 132 and the connecting portion 131, that is, the connecting portion 131 is arranged between the diaphragm 11 and the second end 133, the anchor portion 2 is connected with the connecting portion 131 to fix the diaphragm 11 on the side of the connecting rod 13 close to the first end 132, and the diaphragm 11 can be inserted into the blood vessel along with the first end 132 of the connecting rod 13, so that the operation is simple.

[0122] As a preferred embodiment, the number of the connecting portions 131 is five, and the five connecting portions 131 are uniformly arranged along the axial direction of the connecting rod 13 between the diaphragm 11 and the second end 133.

[0123] In the embodiment, since the five connecting portions 131 are arranged along the axial direction of the connecting rod 13, the anchor portion 2 can be connected with the corresponding connecting portion 131 according to the thickness of the blood vessel wall 3, so that the blood vessel wall 3 with different thicknesses can be clamped between the anchor portion 2 and the diaphragm 11. Through the above structure, the application range of the blood vessel closure device is wider, and the blood vessel closure device can be applied to blood vessels of different individuals and different positions. Of course, in other embodiments, the number of the connecting portions 131 can be more than five or less than four, as long as the different thicknesses of the blood vessels can be adapted.

[0124] As shown in FIG. 2, Figure 4 As a preferred embodiment, the anchor portion 2 comprises a main body 21 and a claw 22, the main body 21 is connected with the occlusion member 1, the number of the claws 22 is two, and the two claws 22 are symmetrically arranged on both sides of the main body 21 and extend toward the diaphragm 11, so that the blood vessel wall 3 is clamped between the claws 22 and the diaphragm 11.

[0125] In the embodiment, the anchor portion 2 is provided with the claw 22 extending toward the diaphragm 11, when the blood vessel wall 3 is clamped between the claw 22 and the diaphragm 11, the claw 22 applies a force to the blood vessel wall 3 toward the diaphragm 11, so that the diaphragm 11 is more closely attached to the blood vessel wall 3, and the closing effect is better. Of course, in other embodiments, the number of the claws 22 can be more than three, as shown in FIG. 3, Figure 5 When the number of the claws 22 is four, the claws 22 are uniformly arranged along the circumferential direction of the main body 21, so that a better clamping effect is achieved.

[0126] As a preferred embodiment, one side of the claw 22 facing the diaphragm 11 is arc-shaped.

[0127] Through the above structural form, the side of the clamping jaw 22 in contact with the blood vessel wall 3 is arc-shaped, which can avoid damage to the blood vessel wall 3 by the clamping jaw 22.

[0128] As a preferred embodiment, the clamping jaw 22 is made of elastic material.

[0129] In this embodiment, the clamping jaw 22 is made of elastic material, which can avoid damage to the blood vessel wall 3 by hard material, and on the other hand, the elastic material of the clamping jaw 22 can better apply force to the blood vessel wall 3 towards the membrane 11, so that the membrane 11 is more closely attached to the blood vessel wall 3.

[0130] As shown in Figure 6 As a preferred embodiment, the number of the ribs 12 is 2, and the two ribs 12 are arranged along the circumference of the membrane 11.

[0131] In this embodiment, the membrane 11 can be completely unfolded in the circumferential direction under the support of the interval arranged ribs 12, and the closing effect is better when occluding the blood vessel. As shown in Figures 7-9 Of course, in other embodiments, the number of the ribs 12 can be 3, 4 or even 8, as long as multiple ribs 12 are arranged along the circumference of the membrane 11 to completely unfold the membrane 11, which can achieve better attachment to the blood vessel wall 3.

[0132] As a preferred embodiment, the position of the rib 12 corresponds to the position of the clamping jaw 22.

[0133] In this embodiment, when the blood vessel wall 3 is clamped between the clamping jaw 22 and the membrane 11, the clamping jaw 22 applies force to the blood vessel wall 3 towards the membrane 11, and since the position of the rib 12 corresponds to the position of the clamping jaw 22, the blood vessel wall 3 is clamped between the clamping jaw 22 and the rib 12, and the membrane 11 is more closely attached to the blood vessel wall 3, achieving better closing effect. Of course, in other embodiments, when the number of the ribs 12 is multiple, it is only necessary that at least one rib 12 corresponds to the position of the clamping jaw 22, as long as the blood vessel wall 3 can be clamped between the clamping jaw 22 and the rib 12, so that the membrane 11 can be more closely attached to the blood vessel wall 3.

[0134] The application also provides a delivery structure, which comprises the above-mentioned blood vessel closure device, the occlusion member 1 comprises a connecting rod 13, the connecting rod 13 comprises a first end 132 and a second end 133, and the delivery device is used to deliver the blood vessel closure device to the blood vessel damage site. As shown in Figures 10 to 13, the second end 133 is provided with a clamping part, and the delivery device is provided with a clamping matching part 4, the clamping part and the clamping matching part 4 are matched by the structure of mutual clamping, and can be disengaged after the release catheter is separated. In this embodiment, before the vascular closure device enters the blood vessel damage, the delivery device is clamped together with the clamping part of the second end 133 through the clamping matching part 4, when the vascular closure device reaches the blood vessel damage position, the clamping matching part 4 and the clamping part are disengaged, and the vascular closure device can stay in the blood vessel of the human body. The anchor part 2 is connected with the connecting part 131 on the occlusion piece 1, can clamp the blood vessel wall 3 between the anchor part 2 and the diaphragm 11, and the diaphragm 11 can be attached to the blood vessel wall 3 and close the damage. In addition, since the umbrella rib 12 composed of elastic material is arranged on the diaphragm 11, when the occlusion piece 1 is released in the blood vessel, the diaphragm 11 can be stretched from the original crimping state under the support of the umbrella rib 12, compared with the diaphragm 11 without the umbrella rib 12, the stability of the diaphragm 11 and the attachment to the inner wall of the blood vessel are better.

[0135] Alternative embodiment 1

[0136] Reference Figures 14-15 , this embodiment is basically the same as embodiment 1, the difference is that the connecting part 131 is in the form of thread, and extends from the second end 133 to the diaphragm 11, and the anchor part 2 is threadedly connected with the connecting part 131.

[0137] In this embodiment, the connecting part 131 is a thread on the outer wall of the connecting rod 13 and extends from the second end 133 to the diaphragm 11, and the anchor part 2 is threadedly connected with the connecting part 131, so that the distance between the anchor part 2 and the diaphragm 11 can be infinitely adjusted, so that the vascular closure device can better adapt to blood vessels of different thicknesses, and the situation that the distance between the anchor part 2 and the diaphragm 11 is too large, resulting in poor closing effect, or the distance between the anchor part 2 and the diaphragm 11 is too small, resulting in the situation that the blood vessel is clamped and damaged. Of course, in other embodiments, the threaded connecting part 131 can also be arranged in multiple intervals similar to embodiment 1, so as to realize infinite adjustment at several gears.

[0138] Embodiment 2

[0139] As Figures 16-17As shown, the present application provides a vascular closure device, which comprises a closer, the closer comprises a blocking piece 1, a connecting rod 2 and an anchor part 4, the blocking piece 1 comprises a folded state and an unfolded state, and the blocking piece 1 blocks a puncture on the blood vessel in the unfolded state; the connecting rod 2 is connected with the blocking piece 1, and a pulling wire structure 3 is connected at one end of the connecting rod 2 away from the blocking piece 1, and a pulling wire is arranged on the pulling wire structure 3, which is used for adjusting the position and angle of the blocking piece 1 outside the body; the anchor part 4 is arranged on the connecting rod 2 and can move on the connecting rod 2 from the first position to the second position, so that the anchor part 4 is clamped on the outer wall of the blood vessel to realize the fixation of the closer. The connecting rod 2 is connected with the blocking piece 1, and the pulling wire structure 3 is arranged on the connecting rod 2, and the pulling wire is arranged on the pulling wire structure 3, so that the blocking piece 1 is pulled outside the body through the pulling wire, so that the position and angle of the blocking piece 1 are adjusted, and the blocking piece 1 can be aligned with the puncture on the blood vessel in the blood vessel; and by arranging the anchor part 4 on the connecting rod 2, the anchor part 4 is moved to the second position, and the anchor part 4 is clamped on the outer wall of the blood vessel to realize the fixation of the closer, and the closure of the blood vessel opening is completed; and by pulling the pulling wire outside, the anchor part 4 is pushed to be clamped with the adipose tissue of the outer wall of the blood vessel, so that the blood vessel is closed by the blocking piece 1 and the anchor part 4 in the middle, and the anchor part 4, the blood vessel and the blocking piece 1 form a sandwich structure, thereby improving the effect of vascular closure.

[0140] As shown, Figure 18 The blocking piece 1 comprises a diaphragm 5, and the diaphragm 5 is attached with a foldable framework structure 6; the framework structure 6 is made of a material with shape memory characteristics. The diaphragm 5 is attached with the foldable framework structure 6, and the framework structure 6 is made of a material with shape memory characteristics, so that the framework can return to the memory position, thereby driving the diaphragm 5 to unfold, so that the diaphragm 5 can cover the puncture on the blood vessel.

[0141] As shown, Figures 16-19 The connecting rod 2 comprises a primary connecting rod 7 and a secondary connecting rod 8 fixedly connected, wherein the primary connecting rod 7 is connected with the pulling wire structure 3, and the secondary connecting rod 8 is fixedly connected with the blocking piece 1. The primary connecting rod 7 is connected with the pulling wire structure 3, and the secondary connecting rod 8 is fixedly connected with the blocking piece 1, that is, one end of the connecting rod 2 is connected with the blocking piece 1, and the other end of the connecting rod 2 is connected with the pulling wire structure 3, so that the position adjustment of the blocking piece 1 is realized through the pulling wire.

[0142] As shown, Figure 19 The primary connecting rod 7 and the secondary connecting rod 8 are provided with a protrusion 9 at the joint, and when the anchor part 4 is at the first position, the anchor part 4 is sleeved on the primary connecting rod 7, as shown in Figure 1 When the anchor part 4 moves to the second position, the anchor part 4 moves to the secondary connecting rod 8 by overcoming the protrusion 9 under the action of the pushing force, as shown in Figure 17As shown. A protrusion 9 is provided at the junction of the primary connecting rod 7 and the secondary connecting rod 8. The protrusion 9 can act as a separator. Only when fixation is required, the anchoring part 4 is pushed to apply a thrust to the protrusion 9, so that the anchoring part 4 moves over the protrusion 9 to the secondary connecting rod 8 and reaches the second position, so that the anchoring part 4 fixes the blocking member 1.

[0143] like Figures 20-21 As shown, the anchoring portion 4 includes an anchoring ring 10 and anchoring sheets 11. The anchoring ring 10 has a sleeve hole that cooperates with the connecting rod 2, and the anchoring sheets 11 are arranged at intervals along the circumference of the anchoring ring 10. The sleeve hole that cooperates with the connecting rod 2 is provided in the anchoring ring 10 to facilitate the connection of the anchoring portion 4 to the connecting rod 2. The plurality of anchoring sheets 11 are arranged at intervals around the circumference of the anchoring ring 10, so that the anchoring sheets 11 are distributed around the circumference of the anchoring ring 10, which can provide a stronger anchoring force and a more stable connection, and prevent the anchoring portion 4 from sliding or falling off.

[0144] Preferably, the anchor sheet 11 is configured to engage with the adipose tissue surrounding the outer wall of the blood vessel and is elastic. The anchor sheet 11 is configured to engage with the adipose tissue surrounding the outer wall of the blood vessel to position the occluder on the outer wall of the blood vessel. The anchor sheet 11 is constructed of an elastic material, which allows for varying degrees of compression depending on the thickness of the blood vessel.

[0145] In this embodiment, if Figure 18 As shown, there are two pull-wire structures 3, which are symmetrically arranged on both sides of the connecting rod 2, and the two connecting rods 2 are provided with through holes 12 for installing the pull-wire structures 3. The two pull-wire structures 3 are symmetrically arranged on both sides of the connecting rod 2, and the two connecting rods 2 are provided with through holes 12 for installing the pull-wire structures 3. Two pulling wires can be set on each side. By using two pulling wires, the structure can be made more stable. By pulling the two pulling wires at the same time, it can be effectively prevented that the entire closed structure tilts to one side due to excessive force on one side, thereby causing occlusion failure. The two pulling wires outside the body will converge into one place to make a knot for fixing. After the puncture port is closed, the knot can be cut to complete the entire closing operation. Of course, in other embodiments, such as Figures 22-23 As shown, a pulling wire structure 3 can also be provided, and the pulling wire structure 3 is provided on the connecting rod 2, so that the position and angle of the positioning member can be adjusted by pulling the pulling wire, and the release can be achieved by shortening the pulling wire when release is required.

[0146] like Figure 18 As shown, the skeleton structure 6 includes a plurality of skeletons, which are arranged at intervals on the circumference of the connecting rod 2. The plurality of skeletons extend horizontally along the circumference of the connecting rod 2 and are arranged parallel to the diaphragm 5 when the diaphragm 5 is unfolded. Figure 24As shown, the multiple frames are curved, so that the diaphragm 5 forms an umbrella shape when deployed. The multiple frames are curved and fixed to the circumference of the connecting rod 2 at intervals to support and control the shape and deployment state of the diaphragm 5. Each frame is also designed to be curved or curved, and the diaphragm 5 will deploy in the shape of the curve or curve, allowing the vascular closure device to better adapt to the pressure state inside the blood vessel, thereby minimizing damage and invasion to the blood vessel wall, reducing the risk of complications and patient discomfort.

[0147] In a preferred embodiment, the side of the skeleton facing away from the diaphragm 5 is provided with a corrugated structure and / or irregularly shaped holes. The side of the skeleton facing away from the diaphragm 5 is the side in contact with the blood vessel wall, and the corrugated structure and / or irregularly shaped holes thereon are more conducive to cell climbing and endothelialization, thereby enabling faster blood vessel healing.

[0148] like Figure 25 As shown, the blood vessel closure device further includes a delivery device, which includes a push catheter 15 and a release catheter 16. The release catheter 16 is nested in the push catheter 15 and is detachably connected to the closure device. The release catheter 16 is used to deliver the occluding member 1 into the blood vessel. When the occluding member 1 is located in the push catheter 15, the occluding member 1 is in a folded state; when the occluding member 1 is exposed from the push catheter 15, the occluding member 1 is released and is in an unfolded state. The blood vessel closure device includes a conveyor, which includes a push catheter 15 and a release catheter 16. The release catheter 16 is detachably connected to the occluding member 1, and can conveniently convey the occluding member 1 from one end of the push catheter 15 to the other end located in the blood vessel under the drive of the release catheter 16, so that the occluding member 1 is conveyed into the blood vessel. When release is required, the release catheter 16 and the occluding member 1 are disassembled to release the occluding member 1; the release catheter 16 is nested in the push catheter 15. During the process of the release catheter 16 driving the occluding member 1 to move, when the occluding member is located in the push catheter 15, the push catheter 15 wraps the occluding member, so that the occluding member 1 is in a folded state; when the occluding member 1 is exposed from the push catheter 15, the occluding member 1 is released and is in an unfolded state.

[0149] Preferably, the vascular closure device further includes an anchoring catheter 17, which is nested between the push catheter 15 and the release catheter 16. The anchoring catheter 17 is used to push the anchoring portion 4, thereby securing the anchoring portion 4 to the outer wall of the blood vessel. Nesting the anchoring catheter 17 between the push catheter 15 and the release catheter 16 facilitates use of the anchoring catheter 17 to push the anchoring portion 4 and apply a thrust to the anchoring portion 4, thereby securing the anchoring portion 4 to the outer wall of the blood vessel.

[0150] The delivery device further comprises a handle 18, the push catheter 15, the push catheter and the release catheter 16 are connected with the handle 18 respectively, and the operation of the handle 18 controls the movement of the push catheter 15, the push catheter and the release catheter 16 respectively, so as to realize the control of the withdrawal and advancement of the push catheter 15, the push catheter and the release catheter 16.

[0151] Although the position and angle of the closure device are adjusted by the pull wire structure in this embodiment to accurately fit the puncture port, and the release of the closure device is realized by the pull wire when it is needed, the release of the closure device can also be realized by the release structure 13 in other embodiments, as shown in Figures 26-28 The end of the release catheter 16 connected with the closure device is also provided with the release structure 13, and the release structure 13 comprises two oppositely arranged spherical clamping pieces 14, the connecting rod 2 is clamped between the two spherical clamping pieces 14 and wrapped in the release catheter 16, when the release catheter 16 is withdrawn, the two spherical clamping pieces 14 are opened, and the closure device is released, wherein the structure of the two spherical clamping pieces 14 in the release catheter 16 is as shown in Figure 13

[0152] In this scheme, the two spherical clamping pieces 14 clamp the connecting rod 2 and are wrapped in the release catheter 16, during delivery, the connecting rod 2 is firmly clamped in the middle by the two spherical clamping pieces 14 and is wrapped inside the push catheter 15, when the closure device needs to be released, the release catheter 16 is withdrawn to release the closure device, so that the two spherical clamping pieces 14 are opened and the closure device is released, thereby realizing the accurate release of the closure device.

[0153] Preferably, the occlusive member 1, the connecting rod 2 and the anchor part 4 are all made of degradable polymer. The occlusive member 1, the connecting rod 2 and the anchor part 4 can all be completely degradable in the human body, which ensures that the closure device is gradually degraded and absorbed in the human body, thereby reducing the adverse effects on human health.

[0154] Embodiment 3

[0155] As shown in Figures 29-38 ​As shown, the embodiment discloses a handle assembly, the handle assembly comprising a handle and a catheter 3, the handle comprising a shell 1 and a power mechanism, the power mechanism being mounted on the shell 1; the catheter 3 comprising a first catheter 31, a second catheter 32 and a third catheter 33, the power mechanism comprising a first propulsion device 21, a second propulsion device 22, a third propulsion device 23 and a fourth rotating device 24, the first propulsion device 21 being connected with the first catheter 31 to drive the first catheter 31 to move along the axial direction of the first catheter 31, the second propulsion device 22 being connected with the second catheter 32 to drive the second catheter 32 to move along the axial direction of the second catheter 32, the third propulsion device 23 being connected with the third catheter 33 to drive the third catheter 33 to move along the axial direction of the third catheter 33, and the fourth rotating device 24 being connected with the third catheter 33 to drive the third catheter 33 to rotate around the central axis of the third catheter 33.

[0156] The first catheter 31, the second catheter 32 and the third catheter 33 are sequentially sleeved from outside to inside, and the third catheter 33 is used for connecting the implant 5; wherein, in a first state, the implant 5 is located in the first catheter 31, and the retraction of the first catheter 31 can make the implant 5 exposed; in a second state, the reverse extension of the first catheter 31 can make the implant 5 fully unfolded; in a third state, the axial movement of the second catheter 32 can make the implant 5 fixed on the blood vessel; in a fourth state, the axial rotation of the third catheter 33 can make the implant 5 in a pre-delivering state; and in a fifth state, the axial movement of the third catheter 33 can make the implant 5 delive from the third catheter 33.

[0157] In the embodiment, the first propulsion device 21 drives the first catheter 31 to move along the axial direction, so that the first catheter 31 can be extended and retracted; in use, the retraction of the first catheter 31 in the first state makes the implant 5 hidden in the first catheter 31 exposed, and the implant 5 expands to a certain extent after being exposed, which prepares for subsequent unfolding; in the second state, the first catheter 31 is extended and abuts against the exposed implant 5, so that the implant 5 can be fully unfolded; in the third state, the second propulsion device 22 drives the second catheter 32 to move, so that the implant 5 is fixed on the blood vessel; in the fourth state, the fourth rotating device 24 rotates and drives the third catheter 33 to rotate, so that the implant 5 is in a pre-delivering state, which prepares for subsequent delivery; and in the fifth state, the third propulsion device 23 drives the third catheter 33 to move, so that the implant 5 is delivered; through the cooperation of the power mechanism in different states, the implant 5 can be accurately received and released in the operation, and the fixation of the implant 5 in the blood vessel is maintained; the handle assembly only needs five steps to fix the implant 5 on the blood vessel, the operation steps are simpler, and the doctor is convenient to operate; the power mechanism and the catheter 3 are one-to-one corresponding respectively, the operation is smoother, the operation error is reduced, and the operation risk is reduced.

[0158] As Figures 29-35As shown, the handle assembly comprises a feedback mechanism, the feedback mechanism comprises a plurality of positioning teeth 224 and a switch plate 223 matched with each other; the power mechanism comprises a rotating wheel 221 connected with the catheter 3, the rotating wheel 221 rotates to drive the catheter 3 to move, the plurality of positioning teeth 224 are arranged on the rotating wheel 221 and distributed along the circumference of the rotating wheel 221, and the rotating wheel 221 rotates to switch the switch plate 223 between the plurality of positioning teeth 224.

[0159] In the embodiment, the number of times of switching by the positioning teeth 224 can feedback the angle (number of turns) of the rotating wheel 221 rotating, since the rotating wheel 221 rotating can drive the catheter 3 to move, so that the feedback mechanism can more accurately position and control the moving distance of the catheter 3.

[0160] Specifically, in the embodiment, the rotating wheel 221 is provided with a mark 25, and the shell 1 is provided with a pointer, the angle of the rotating wheel 221 rotating is determined by observing the mark 25 and the pointer, so as to determine the displacement of the corresponding catheter 3 moving, and the feedback mechanism and the form of the pointer and the mark 25 are used, so that the displacement of the catheter 3 moving can be more accurately controlled; the shell 1 is provided with a transparent area 11, the transparent area 11 is of transparent material, and the displacement of the first catheter 31 moving can be observed through the transparent area 11.

[0161] As shown in Figure 35 , the positioning teeth 224 are distributed on the inner circumferential surface of the rotating wheel 221. The switch plate 223 and the positioning teeth 224 of the feedback mechanism are matched in the rotating wheel 221, the position is more reasonable, and the overall structure is more compact. Of course, in other alternative embodiments, the positioning teeth 224 can also be arranged on the outer circumferential surface of the rotating wheel 221.

[0162] As shown in Figure 34 , the second propulsion device 22 comprises a screw rod 222, the rotating wheel 221 and the screw rod 222 are respectively provided with internal threads and external threads matched with each other, the second catheter 32 is fixed on the screw rod 222, and the rotating wheel 221 rotates to drive the screw rod 222 to move along the axial direction of the second catheter 32. The second catheter 32 is controlled by the thread cooperation between the screw rod 222 and the rotating wheel 221, the second propulsion device 22 can more accurately control the movement of the second catheter 32, and the doctor is convenient to operate.

[0163] As shown in Figure 32 and Figure 36 , the handle assembly further comprises a locking mechanism 6 arranged on the shell 1, the locking mechanism 6 is used for locking and unlocking the third propulsion device 23 and / or the fourth rotating device 24. By locking and unlocking the third propulsion device 23 and the fourth rotating device 24 through the locking mechanism 6, it is avoided that the implant 5 enters the pre-unlocking state or is unlocked in advance due to accidental touch, the operation error is reduced, and the accuracy of releasing the implant 5 is ensured.

[0164] As shown in Figure 36 , the locking mechanism 6 is distributed between the third advancing device 23 and the fourth rotating device 24, and the locking mechanism 6 comprises a first locking member 61, the first locking member 61 having a first locking position 611 for locking the third advancing device 23 and a second locking position 612 for locking the fourth rotating device 24, and the first locking member 61 is switched between the first locking position 611 and the second locking position 612 to lock and unlock.

[0165] In this embodiment, the first locking member 61 has two locking positions, which are respectively used for locking the third advancing device 23 and the fourth rotating device 24. In addition, the first locking member 61 can be conveniently switched between the two positions to realize the locking of the third advancing device 23 and the unlocking of the fourth rotating device 24, or the unlocking of the third advancing device 23 and the locking of the fourth rotating device 24, so that the operation of the doctor is more convenient.

[0166] As shown in Figure 36 , the locking mechanism 6 further comprises a second locking member 62, the second locking member 62 comprising a third locking position 621 for locking the third advancing device 23 and an unlocking position, and the second locking member 62 is switched between the third locking position 621 and the unlocking position to lock and unlock.

[0167] In this embodiment, the second locking member 62 can lock the third advancing device 23, so as to avoid that the third advancing device 23 is unlocked by mistake when the first locking member 61 is in the second locking position 612 to lock the fourth rotating device 24 in the initial state. In addition, before entering the pre-delivery state, the first locking member 61 needs to be unlocked, and the third advancing device 23 is controlled to make the third catheter 33 extend, so as to first release the restriction on the rotation of the implant 5. Then, the first locking member 61 is switched to the first locking position 611 to unlock the fourth rotating device 24, and the third advancing device 23 is locked at the same time, and the fourth rotating device 24 is controlled to make the third catheter 33 rotate, so as to make the implant 5 enter the pre-delivery state. Then, the first locking member 61 is switched to the second locking position 612 to unlock the third advancing device 23, and the fourth rotating device 24 is locked at the same time, and the third advancing device 23 is controlled to make the third catheter 33 move, so as to make the implant 5 be delivered. When one of the third advancing device 23 and the fourth rotating device 24 is operated, the other one is in the locked state, so as to reduce the operation error. In addition, the cooperation of the first locking member 61 and the second locking member 62 makes the whole process only need to be switched three times (locked or unlocked three times), and the operation is simpler.

[0168] Specifically, the first locking member 61 includes a first locking tongue 613 and a second locking tongue 614, the first locking tongue 613 is distributed at one end close to the third advancing device 23, and the second locking tongue 614 is distributed at one end close to the fourth rotating device 24, the third advancing device 23 and the fourth rotating device 24 are respectively provided with a locking seat (not shown in the figure) cooperating with the first locking tongue 613 and the second locking tongue 614 to realize locking, wherein the first locking member 61 moves to the side of the third advancing device 23, the first locking member 61 switches to the first locking position 611, at this time, the first locking tongue 613 cooperates with the locking seat of the third advancing device 23, so as to lock the third advancing device 23, and the second locking tongue 614 is away from the locking seat of the fourth rotating device 24, and the fourth rotating device 24 is unlocked; conversely, the first locking member 61 moves to the side of the fourth rotating device 24, that is, the fourth rotating device 24 is locked, and the third advancing device 23 is unlocked.

[0169] As shown in Figure 36 , the second locking member 62 includes a third locking tongue 622, and the locking principle is the same as that of the first locking member 61, and the difference lies in that the second locking member 62 is provided with a locking tongue only at one end close to the third advancing device 23.

[0170] As shown in Figure 30 , the first advancing device 21, the second advancing device 22, the third advancing device 23 and the fourth rotating device 24 are distributed in sequence on the housing 1 from the opening end 42 of the handle to the tail end 41 of the handle. The first advancing device 21 needs to be stretched out and retracted, and the adjustment range is large, while the fixation and release of the second advancing device 22, the third advancing device 23 and the fourth rotating device 24 are all small-range fine adjustment, and the position distribution makes the handle more stable in the advancing process, better balance, so as to be able to more smoothly control the handle, and the handle is more in line with ergonomics.

[0171] Specifically, in the embodiment, the first state is the initial state of the handle assembly, the third catheter 33 is connected to one end of the implant 5 inside the first catheter 31, so that the implant 5 is located in the first catheter 31; the second state is the implant 5 exposure state, that is, the implant 5 is exposed and has a certain degree of expansion but is not fully expanded; the third state is the implant 5 expansion state, at this time, the implant 5 has been fully expanded, and needs to be fixed to the blood vessel; the fourth state is the implant 5 fixation state, which needs to further make the implant 5 in the pre-release state; the fifth state is the implant 5 pre-release state, which needs to be released to release the implant 5.

[0172] As shown in Figure 37 and Figure 38As shown, the end of the second conduit 32 is connected with an anchoring structure 52, wherein the anchoring structure 52 has an anchoring leg 521, and the end of the second conduit 32 abuts against the end surface of the anchoring structure (the end away from the anchoring leg 521), in the third state, the second conduit 32 is extended to push the anchoring structure 52, so that the anchoring leg 521 is engaged with the adipose tissue of the outer wall of the blood vessel, at this time, the blood vessel is sandwiched by the implant 5 (the membrane structure) and the anchoring structure 52 to be closed, thereby fixing the implant 5 on the blood vessel.

[0173] As shown in Figure 39 and Figure 40 As shown, the end of the third conduit 33 has a clamping block 331, and the connecting piece 51 of the implant 5 includes a first limiting slot 511 and a second limiting slot 512, wherein the first limiting slot 511 is further provided with a protrusion 513, before the implant 5 enters the pre-delivery state, the clamping block 331 of the third conduit 33 is clamped in the first limiting slot 511, and the protrusion 513 limits the clamping block 331, limiting the rotation of the connecting piece 51. When the implant 5 is delivered, the third advancing device 23 extends the third conduit 33 so that the clamping block 331 is disengaged from the limitation of the protrusion 513, and the limitation of the rotation of the implant 5 is released, thereby entering the pre-delivery state; in the pre-delivery state, the fourth rotating device 24 rotates the third conduit 33, so that the clamping block 331 is rotated into the second limiting slot 512, at this time, the limitation of the clamping block 331 to the first limiting slot 511 of the connecting piece 51 is released; in the delivery state, the third advancing device 23 reverses the third conduit 33 to retract, and the clamping block 331 retreats along the second limiting slot 512, thereby releasing the implant 5.

[0174] As shown in Figure 41 The embodiment also discloses a use method of the handle assembly, which comprises the following steps:

[0175] Controlling the first advancing device 21 to retract the first conduit 31, so that the implant 5 is exposed from the first conduit 31;

[0176] Controlling the first advancing device 21 to reversely extend the first conduit 31, so that the implant 5 is fully unfolded;

[0177] Controlling the second advancing device 22 to move the second conduit 32, so that the implant 5 is fixed on the blood vessel;

[0178] Controlling the fourth rotating device 24 to rotate the third conduit 33, so that the implant 5 enters the pre-delivery state;

[0179] Controlling the third advancing device 23 to move the third conduit 33, so that the implant 5 is delivered from the third conduit 33.

[0180] In the embodiment, the method only needs five steps to fix the implant 5 on the blood vessel, the steps and teaching cycle are relatively short, easy to master and apply, greatly shorten the operation time and improve the operation safety.

[0181] In the embodiment, the step of fixing the implant 5 on the blood vessel further comprises the step of: controlling the second pushing device 22 to extend the second catheter 32, so as to fix the implant 5 on the blood vessel; of course, in other alternative embodiments, the step can also be fixed by retracting the second catheter 32 to fix the implant 5.

[0182] In the embodiment, the step of disengaging the implant 5 from the third catheter 33 further comprises the step of: controlling the third pushing device 23 to retract the third catheter 33, so as to disengage the implant 5 from the third catheter 33. Of course, in other alternative embodiments, the step can also be disengaged by extending the third catheter 33 to disengage the implant 5.

[0183] In the embodiment, between the step of fixing the implant 5 on the blood vessel and the step of entering the implant 5 into the pre-disengaging state, the step of: controlling the third pushing device 23 to extend the third catheter 33, so as to release the restriction on the rotation of the implant 5. By releasing the restriction on the rotation of the implant 5 first, and then entering the implant 5 into the pre-disengaging state, the doctor is prevented from mistakenly touching the fourth rotating device 24 to make the implant 5 enter the pre-disengaging state in advance. Of course, in other alternative embodiments, the protrusion 513 can also not be arranged in the connecting piece 51, so that the implant 5 can be directly entered into the pre-disengaging state without the need to release the restriction on the rotation of the implant 5 first.

[0184] In the embodiment, before the step of releasing the restriction on the rotation of the implant 5, the step of: switching the second locking piece 62 to the unlocking position is included.

[0185] Between the step of releasing the restriction on the rotation of the implant 5 and the step of entering the implant 5 into the pre-disengaging state, the step of: switching the first locking piece 61 to the first locking position 611 is included.

[0186] Between the step of entering the implant 5 into the pre-disengaging state and the step of disengaging the implant 5 from the third catheter 33, the step of: switching the first locking piece 61 to the second locking position 612 is included.

[0187] In the embodiment, the method only needs to switch the first locking piece 61 and the second locking piece 62 three times, and when one of the third pushing device 23 and the fourth rotating device 24 is operated, the other one can be guaranteed to be in the locking state, which avoids the mistake and ensures the accuracy, and simplifies the operation.

[0188] It should be noted that the implant in the embodiment corresponds to the occluding piece 1 in the embodiment 2.

[0189] Example 4

[0190] like Figure 42 As shown, the second propulsion device 22 and the third propulsion device 23 both adopt mechanical propulsion. The second propulsion device 22 and the third propulsion device 23 both include a pushing member and an inner rod. The pushing member and the inner rod are fixedly connected. The movement of the pushing member can drive the inner rod to move along its axial direction. The second catheter 32 and the third catheter 33 are respectively fixedly connected to the corresponding inner rods. The user pushes the external pushing member to drive the inner rod and the second catheter 32 and the third catheter 33 connected to the corresponding inner rods to move.

[0191] Specifically, in this embodiment, the inner rod is bonded to the pusher, and the second conduit 32 and the third conduit 33 are respectively bonded to the corresponding inner rod. Of course, in other alternative embodiments, the connection between the inner rod and the pusher and the second conduit 32, the third conduit 33 and the inner rod can also be a mechanical snap-fit ​​connection.

[0192] Example 5

[0193] like Figure 43 and Figure 44 As shown, this embodiment provides a multi-stage positioning controllable vascular closure device, which includes a vascular closure device and a delivery device. The vascular closure device and delivery device in this embodiment can each adopt any of the structures described in Embodiments 1 to 4 above. If certain structures in various embodiments have the same substantial function and structure, but differ in reference numerals and technical feature names, they should be considered to be the same.

[0194] In this embodiment, a vascular closure device includes an occluding member 1 and an anchoring portion 4. The occluding member 1 includes a diaphragm and a connecting rod 2. The connecting rod 2 has a first end and a second end along the axial direction. The connecting rod 2 is provided with multiple connecting portions, which are arranged axially between the first end and the second end. The diaphragm is disposed between the first end and one of the multiple connecting portions closest to the first end. The delivery device includes a handle 20 and a rod assembly 19, which includes a push portion, an anchoring portion, and a release portion. The rod assembly 19 is configured to, under the action of the handle 20, drive the occluding member 1 from a folded state within the push portion to an expanded state outside the push portion and maintain the expanded state. In the expanded state, the occluding member 1 is used to occlude a puncture in a blood vessel. The rod-shaped component 19 is further configured such that: under the action of the handle 20, the anchoring portion drives the anchoring portion 4 to move along the axial direction of the connecting rod 2 until it is connected to the occluding member 1 through one of the connecting portions so that the blood vessel wall is clamped between the anchoring portion 4 and the diaphragm 5; under the action of the handle 20, the releasing portion realizes the release and separation of the blood vessel closure device from the conveyor.

[0195] The pushing part supports the released membrane 5, which can well ensure the opening and closing state of the membrane 5 in the body, and avoid the abnormal release of the membrane 5 caused by blood flow or incorrect operation. Since the number of the connecting parts is multiple, the anchor part 4 can be connected with the corresponding connecting part according to the thickness of the blood vessel wall, so that multi-stage positioning of the occluder can be realized, and the blood vessel walls with different thicknesses can be clamped between the anchor part 4 and the membrane 5. Through the above structure, the application range of the vascular occlusion device is wider, and the device can be applied to blood vessels of different individuals and different parts. In addition, through the cooperation of the rod-shaped assembly 19 and the handle 20, the anchor part 4 can be more reliably connected with the connecting part, and the blood vessel wall can be more reliably clamped between the anchor part 4 and the membrane 5, so that the membrane 5 can be more reliably attached to the blood vessel wall and seal the damaged part.

[0196] The pushing part comprises a pushing catheter, the anchor part comprises an anchor catheter, and the release part comprises a release catheter, the pushing catheter, the anchor catheter and the release catheter are nested with each other, the pushing catheter is at the outermost side, and the release catheter is at the innermost side;

[0197] The release catheter is detachably connected with the occluder, the pushing catheter is used for pushing the occlusion piece 1 to be delivered into the blood vessel, and the occlusion piece 1 is in a folded state when the occlusion piece 1 is located in the pushing catheter; when the occlusion piece 1 is exposed from the pushing catheter, the occlusion piece 1 is released to be in an unfolded state;

[0198] The anchor catheter is nested between the pushing catheter and the release catheter, and the anchor catheter is used for pushing the anchor part 4 so that the anchor part 4 is fixed to the outer wall of the blood vessel.

[0199] The end of the release catheter connected with the occluder is further provided with a release structure, the release structure comprises at least two oppositely arranged spherical clamping pieces, the at least two spherical clamping pieces clamp the connecting rod 2 and are wrapped in the release catheter; the delivery catheter is configured such that when the release catheter pushes out the anchor catheter, the at least two spherical clamping pieces are popped open to release the occluder, so as to realize the separation of the occluder from the delivery device.

[0200] It should be noted that the pushing catheter in the embodiment corresponds to the first catheter 31 in the embodiment 3, the release catheter in the embodiment corresponds to the third catheter 33 in the embodiment 3, and the anchor catheter in the embodiment corresponds to the second catheter 32 in the embodiment 3.

[0201] In addition, the release structure is briefly described as follows: as described in Embodiment 2, the end of the release conduit connected with the occluder is also provided with a release structure, which includes at least two oppositely arranged spherical clamping pieces, the connecting rod is clamped between the at least two spherical clamping pieces, and is wrapped in the release conduit; the release conduit is configured to pop open the at least two spherical clamping pieces when the release conduit is pushed out of the anchor conduit, so as to release the occluder and achieve the separation of the occluder from the delivery device. That is, the release structure in Embodiment 2 is a flexible spherical structure at the distal end of the release conduit, which is wrapped outside the implant connection, while the release conduit is wrapped by the anchor conduit. However, in other alternative embodiments, the release structure can also be provided in other structures, such as the release conduit and the implant end part being respectively provided with male and female structures (such as tabs and clamping grooves). Of course, in another alternative embodiment, the implant can also be pulled directly in the way of the pull wire provided in Embodiment 2, and the release can be achieved by cutting off one end of the pull wire.

[0202] Although the specific embodiments of the present application are described above, those skilled in the art should understand that this is only an example, and the protection scope of the present application is defined by the appended claims. Those skilled in the art can make various changes or modifications to these embodiments without departing from the principles and essence of the present application, and these changes and modifications all fall within the protection scope of the present application.

Claims

1. A multistage positioning controllable vascular closure device comprising a vascular closure device and a delivery device, characterized in that, The blood vessel closure device comprises a closure member and an anchor part, the closure member comprises a membrane and a connecting rod, the connecting rod has a first end and a second end in the axial direction, a plurality of connecting parts are arranged on the connecting rod, and the plurality of connecting parts are arranged between the first end and the second end in the axial direction of the connecting rod, the membrane is arranged between the first end and one of the connecting parts close to the first end; The delivery device comprises a handle and a rod assembly, the rod assembly comprises a pushing part, an anchor part and a releasing part; The rod assembly is configured to switch the closure member from a folded state in the pushing part to an unfolded state out of the pushing part and keep the unfolded state under the action of the handle, and the closure member is used to close the puncture on the blood vessel in the unfolded state; The rod assembly is further configured to drive the anchor part to move along the axial direction of the connecting rod until one of the connecting parts is connected with the closure member to clamp the blood vessel wall between the anchor part and the membrane under the action of the handle; the releasing part realizes the release of the blood vessel closure device from the delivery device under the action of the handle; The handle comprises a shell and a power mechanism, and the power mechanism is mounted on the shell; The rod assembly comprises a first catheter, a second catheter and a third catheter, the power mechanism comprises a first propulsion device, a second propulsion device, a third propulsion device and a fourth rotating device, the first propulsion device is connected with the first catheter to drive the first catheter to move along the axial direction of the first catheter, the second propulsion device is connected with the second catheter to drive the second catheter to move along the axial direction of the second catheter, the third propulsion device is connected with the third catheter to drive the third catheter to move along the axial direction of the third catheter, and the fourth rotating device is connected with the third catheter to drive the third catheter to rotate around the central axis of the third catheter; The first catheter, the second catheter and the third catheter are sequentially sleeved from the outside to the inside, and the third catheter is used to connect the implant; In the first state, the implant is located in the first catheter, and the retraction of the first catheter can expose the implant; In the second state, the reverse extension of the first catheter can make the implant fully expand; In the third state, the axial movement of the second catheter can fix the implant on the blood vessel; In the fourth state, the axial rotation of the third catheter can make the implant in the pre-release state; In the fifth state, the axial movement of the third catheter can release the implant from the third catheter.

2. The multi-stage positioning controllable vascular closure device of claim 1, wherein, The membrane is attached with a foldable skeleton structure; The membrane, the skeleton structure and the anchor part are made of elastic material; and / or, the skeleton structure is made of material with shape memory property.

3. The multi-stage positioning controllable vascular closure device of claim 2, wherein, The skeleton structure comprises a plurality of skeletons, the plurality of skeletons are arranged at intervals on the periphery of the connecting rod, and the plurality of skeletons are arc-shaped to make the membrane in the shape of an umbrella when it is unfolded.

4. The multi-stage positioning controllable vascular closure device of claim 3, wherein, The skeleton is provided with a corrugated structure and / or a special-shaped hole on the side away from the diaphragm.

5. The multistage positioning controllable vascular closure device of claim 1, wherein, A plurality of the connecting portions are arranged at intervals along the axial direction of the connecting rod. Alternatively, a plurality of the connecting portions are formed by a threaded structure arranged on the outer wall surface of the connecting rod, and the anchoring portion and the connecting portion are threadedly connected.

6. The multi-stage positioning controllable vascular closure device of claim 1, wherein, The anchoring portion comprises a main body connected with the occlusion member and a plurality of clamping claws arranged at intervals along the circumference of the main body and extending towards the diaphragm, so that the blood vessel wall is clamped between the clamping claws and the diaphragm.

7. The multi-stage positioning controllable vascular closure device of claim 1, wherein, The closer further comprises a pulling structure, one end of the connecting rod away from the occlusion member is connected with the pulling structure, a pulling wire is arranged on the pulling structure, and the pulling wire is used for adjusting the position and angle of the occlusion member outside the body.

8. The multistage positioning controllable vascular closure device of claim 7, wherein, The connecting rod comprises a primary connecting rod and a secondary connecting rod fixedly connected, wherein the primary connecting rod is connected with the pulling structure, and the secondary connecting rod is fixedly connected with the occlusion member.

9. The multistage positioning controllable vascular closure device of claim 8, wherein, The primary connecting rod and the secondary connecting rod are provided with a protrusion at the joint, the anchoring portion can move from a first position to a second position relative to the connecting rod, the anchoring portion is sleeved on the primary connecting rod when the anchoring portion is in the first position, and the anchoring portion moves to the secondary connecting rod beyond the protrusion under the action of a pushing force when the anchoring portion moves to the second position.

10. The multistage positioning controllable vascular closure device of claim 7, wherein, The pulling structure has two and is symmetrically arranged on both sides of the connecting rod, and through holes for mounting the pulling structure are arranged on the two connecting rods.

11. The multistage positioning controllable vascular closure device of claim 1, wherein, The pushing portion comprises a pushing catheter, the anchoring portion comprises an anchoring catheter, the release portion comprises a release catheter, the pushing catheter, the anchoring catheter and the release catheter are nested with each other, the pushing catheter is at the outermost side, and the release catheter is at the innermost side. The release catheter is detachably connected with the closer, the pushing catheter is used for pushing the occlusion member to be delivered into the blood vessel, the occlusion member is in a folded state when the occlusion member is in the pushing catheter, and the occlusion member is released to be in an unfolded state when the occlusion member is exposed from the pushing catheter. The anchoring catheter is nested between the pushing catheter and the release catheter, and the anchoring catheter is used for pushing the anchoring portion, so that the anchoring portion is fixed to the outer wall of the blood vessel.

12. The multistage positioning controllable vascular closure device of claim 11, wherein, The end of the release catheter connected with the closer is further provided with a release structure, the release structure comprises at least two oppositely arranged spherical clamping pieces, the connecting rod is clamped between the at least two spherical clamping pieces and wrapped in the release catheter. The release catheter is configured to: when the release catheter pushes out the anchoring catheter, the at least two spherical clamping pieces are opened to release the closer, so that the closer is separated from the delivery device.

13. The multi-stage positioning controllable vascular closure device of claim 1, wherein, The occlusion member, the connecting rod and the anchoring portion are all made of a degradable polymer.

14. The multistage positioning controllable vascular closure device of claim 1, wherein, The handle further comprises a feedback mechanism comprising a plurality of positioning teeth and a tab matched with each other. The power mechanism comprises a rotating wheel connected with the rod-shaped assembly, the rotating wheel rotates to drive the rod-shaped assembly to move, a plurality of positioning teeth are arranged on the rotating wheel and distributed along the circumference of the rotating wheel, and the rotating wheel rotates to switch the dial between the plurality of positioning teeth.

15. The multistage positioning controllable vascular closure device of claim 14, wherein, The positioning teeth are distributed on the inner circumferential surface of the rotating wheel.

16. The multi-stage positionally controlled vascular closure device of claim 14, wherein, The second propulsion device comprises a screw rod, the rotating wheel and the screw rod are respectively provided with inner threads and outer threads matched with each other, the second conduit is fixed on the screw rod, and the rotating wheel rotates to drive the screw rod to move along the axial direction of the second conduit. And / or, the handle further comprises a locking mechanism arranged on the shell, the locking mechanism is used for locking and unlocking the third propulsion device and / or the fourth rotating device.

17. The multistage positioning controllable vascular closure device of claim 16, wherein, The locking mechanism is distributed between the third propulsion device and the fourth rotating device, the locking mechanism comprises a first locking member, the first locking member has a first locking position and a second locking position, the first locking position is used for locking the third propulsion device, the second locking position is used for locking the fourth rotating device, and the first locking member switches between the first locking position and the second locking position to lock and unlock.

18. The multi-stage positionally controlled vascular closure device of claim 17, wherein, The locking mechanism further comprises a second locking member, the second locking member comprises a third locking position and an unlocking position, the third locking position is used for locking the third propulsion device, and the second locking member switches between the third locking position and the unlocking position to lock and unlock.

19. The multistage positioning controllable vascular closure device according to any one of claims 1-18, wherein, The first propulsion device, the second propulsion device, the third propulsion device and the fourth rotating device are sequentially distributed on the shell from the opening end of the handle to the tail end of the handle.

20. A delivery system characterized by, It comprises the multi-stage positioning controllable blood vessel closure device according to any one of claims 1-19.

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