Handheld pipetting device

Abstract

The invention relates to a pipetting device with a touch screen and a system with such a pipetting device. The operating concept of the pipetting device provides that values of pipetting parameters can be set by a user on at least one input screen page, actuation of a control element leads to the display of an output screen page and the initiation of a pipetting process defined by the pipetting parameters, and touching of an individual input field of the output screen page leads back to the input screen page.

Description

Technical Field

[0001] The present invention relates to a handheld pipetting device, a system for exchanging data between the handheld pipetting device and an external device, and computer program code that can be implemented by the handheld pipetting device. Background Technology

[0002] These handheld pipettes are commonly used in medical, biological, biochemical, chemical, and other laboratories. They are used in the laboratory to transport and transfer small volumes of fluid samples, especially for precise sample measurement. The two known types of these handheld pipettes differ in the corresponding physical principles of liquid absorption or dispensing. One type measures liquid using an air cushion principle, while the other uses a direct squeeze principle. The first type is called an air cushion pipette, and the second type is called a direct squeeze pipette.

[0003] Cushion pipettes use a piston-cylinder system for actual measurements. The cushion separates the sample drawn into the plastic tip from the piston inside the pipette. As the piston slides upward, a negative pressure is created in the tip, causing the liquid to rise into the tip. The cushion, moved by the piston, acts like an elastic spring, holding the liquid volume in the tip at the spring. In handheld pipettes operating on the direct squeeze principle, a tip with an integrated piston is used as the transfer container. The piston is connected to the piston rod of the metering device during the pipetting process and undertakes the actual metering. Because the piston can replace the entire internal volume of the tip in this case, virtually no cushion is formed between the sample drawn and the piston tip. The term "piston-stroke pipette" also refers to two types of handheld pipettes: cushion pipettes and direct squeeze pipettes.

[0004] Some handheld pipetting devices have piston systems that are manually driven, while others are electrically driven. Electrically driven handheld piston-stroke pipettes can often be controlled by at least one pipetting program to perform at least one pipetting process automatically or semi-automatically.

[0005] Handheld pipettes are designed for single-handed use by human users. However, there are also automated laboratory devices with robotic gripping arms that mimic the movements of a human hand to operate the handheld pipette and are designed for operation and use.

[0006] In pipetting devices, the amount of sample expelled by individual manipulation corresponds to the amount of sample aspirated into the device. However, it is also possible to specify that the sample volume absorbed corresponding to multiple expulsions is then expelled sequentially. Furthermore, there is a difference between single-channel and multi-channel pipetting devices. Single-channel pipetting devices contain only one expulsion / absorption channel, while multi-channel pipetting devices contain multiple expulsion / absorption channels, which in particular allow for the parallel expulsion or aspiration of multiple samples.

[0007] The handheld pipetting device described within the scope of this invention is a handheld computer-controlled piston-stroke pipette with an electric piston actuator, also known as a handheld electric pipetting device or a handheld electric piston-stroke pipette.

[0008] An example of a handheld electronic pouch pipette in the prior art is from Eppendorf AG of Hamburg, Germany. and Plus; an example of a handheld electronic dispenser is from Eppendorf GmbH in Hamburg, Germany. E3 and E3x.

[0009] Compared to non-electric pipetting devices, electric pipetting devices offer numerous advantages because they can perform multiple functions in a simple manner. In particular, electric pipetting devices simplify the execution of specific, program-controlled pipetting processes by automating or semi-automating them. Typical pipetting parameters used to control these processes with the aid of appropriate pipetting programs involve the volume of liquid aspirated or expelled, their sequence and number of repetitions, and, if necessary, their time parameters when allocating these processes over time. Electric pipetting devices can be configured to operate in one or more operating modes. Operating modes can specify a set of parameters of the pipetting device that automatically queries, sets, and / or uses one or more pipetting parameters that influence or control the pipetting process of the device.

[0010] Handheld pipetting devices are known, in which a touch-sensitive screen is used to allow users to input pipetting parameters, thereby enabling the pipetting process of the handheld pipetting device to be performed at least partially automatically.

[0011] Document EP2814612B1 describes a pipetting device with one or more touchscreens, which are defined almost entirely by touch and controlled by the user. The potential of using multiple touchscreens is illustrated, but whether such a pipette is ergonomically usable remains ultimately questionable. Summary of the Invention

[0012] The objective of this invention is to provide a handheld pipetting device with an effective and ergonomic operating procedure.

[0013] The present invention addresses this task, particularly by means of the pipetting apparatus according to claim 1. Preferred designs are the subject of the dependent claims and are further apparent from the description.

[0014] This invention relates to a handheld pipetting device for pipetting samples of at least one liquid state.

[0015] It has a connection section for connecting at least one pipette.

[0016] The device includes electrically controlled moving elements for aspirating at least one sample into at least one pipette, for holding the sample in at least one pipette, and for discharging the sample from at least one pipette during the pipetting process.

[0017] A touch-sensitive screen with user-defined pipetting parameters for inputting values, wherein a set of parameters for at least one pipetting parameter defines the pipetting process.

[0018] The device includes an electrical control unit programmed to control a moving element based on at least one pipetting parameter from a parameter set, and at least one operating element that initiates the pipetting process defined by the parameter set by user manipulation. Further features of the pipetting device according to the invention will become apparent from the following description and claims.

[0019] The advantage of handheld electric pipetting devices (hereinafter referred to as pipetting devices) lies in the electronic configurability of the automated or semi-automated pipetting process within these devices. The challenge lies in finding an operating method that provides users with an intuitive, efficient, and ergonomic working experience among these devices, which offer an unpredictable number of functions, configuration possibilities, and programmability. The inventors have developed an operating method that addresses this task by leveraging multiple inventions, including those described in the present claims.

[0020] When referring to automated pipetting processes, the meaning will always be semi-automated, unless the context contradicts this. Generally, any user activity that triggers at least one automated pipetting process by manipulating the operating elements of a pipetting device also constitutes executing an automated pipetting process. A semi-automated pipetting process for a specific application scenario may, for example, require the user to initiate at least one sub-process by manipulating the operating elements, in addition to starting a pipetting process divided into multiple sub-processes. An automated pipetting process for a specific application scenario can be defined in a particular embodiment of the pipetting device by a set of pipetting parameters that the user sets before initiating the automated pipetting process using the user interface of the pipetting device, and / or accepts pipetting parameters from default settings and / or loads pipetting parameters from memory. The user interface of these embodiments of the pipetting device typically has selection options, such as an operating wheel or a list of selectable boxes on a touchscreen, by which a so-called "operating mode" can be selected, representing a specific application scenario, or a complete set of pipetting parameters belonging to this specific application scenario can be selected in that operating mode, and these pipetting parameters can be set by the user before initiating the relevant automated pipetting process. The automated pipetting process is then performed according to the predetermined pipetting procedure based on this operating mode.

[0021] In a preferred embodiment, the pipetting device or data processing apparatus is programmed to allow the user to manually define an automated pipetting process by selecting pipetting parameters, and thus, in particular, to define a set of pipetting parameters (a set of pipetting parameters) for the user-defined pipetting process. This set of pipetting parameters may partially or completely correspond to a predetermined set of pipetting parameters for an operating mode. The pipetting parameters of the pipetting process preferably relate to or quantify the volume to be pipetted in the step of aspirating the sample into a pipette connected to a piston-stroke pipette or in the step of discharging the sample from this pipette, possibly the sequence and number of repetitions of these steps, and time parameters that may be allocated over time for these processes, particularly the time variations of these processes, especially the speed and / or acceleration of aspirating or discharging the sample. In this embodiment, the automated pipetting process is performed according to a pipetting program defined entirely according to these user-defined pipetting parameters.

[0022] The handheld pipetting device according to the invention is preferably configured to perform at least one pipetting process based on at least one or at least two or at least three pipetting parameters, particularly for use in at least one predetermined operating mode according to a predetermined parameter set of the pipetting device or in a user-defined parameter set. In one operating mode, it is preferred to set separate parameter sets (pipetting parameter groups) for pipetting parameters, wherein the pipetting parameters in the parameter group may be unselectable by the user or may be at least partially selectable by the user and may be supplemented with further pipetting parameters.

[0023] A typical pipetting process involves, according to a pipetting procedure, the aspiration of a specific volume of sample from the starting container into a pipetting container, particularly a pipetting tip, connected to a piston-stroke pipette, and / or the dispensing, particularly the metered dispensing, into a target container. The pipetting process can preferably be controlled by at least one, two, three, or preferably more pipetting parameters, which can influence or define the pipetting process or its function or components in a desired manner.

[0024] The pipetting parameters used to control the pipetting process preferably relate to or quantify the volume of sample to be pipetted in the step of aspirating the sample into a pipetting container connected to a piston-stroke pipette or in the step of discharging the sample from this pipetting container, possibly the sequence and number of repetitions of these steps, and time parameters that may be allocated over time for these processes, particularly the time variations of these processes, particularly the speed and / or acceleration of aspirating or discharging the sample, or the number of pre-wetting steps and optionally the volumes aspirated and discharged here, respectively.

[0025] These pipetting parameters are preferably selected at least partially and preferably entirely by the user, particularly through at least one operating element of the user interface device of a piston-stroke pipette or an external data processing device.

[0026] The pipetting process is preferably defined explicitly by or through a set of pipetting parameters. This set of pipetting parameters is preferably at least partially and preferably entirely selected and / or input by the user, particularly through the operating mechanism of the pipetting device or an external data processing device.

[0027] However, it is possible that the pipetting process cannot be definitively determined by the set of pipetting parameters; in such cases, the pipetting device is particularly configured to, or the data processing device is programmed to, automatically supplement the set of pipetting parameters, in particular, based on the (selected) pipetting parameters with at least one additional pipetting parameter. It is possible and preferred that at least one pipetting parameter is not determined by the user, but rather predetermined by the pipetting device, for example, in such a way that the parameter set is stored therein, for example, in a data memory known in advance, or is automatically derived.

[0028] Preferably, at least one pipetting parameter is set to determine the number of directly consecutive or indirectly consecutive pipetting volumes. Preferably, at least one pipetting parameter is set to determine the number of aspiration and / or discharge steps, and preferably, the associated pipetting volume, associated pipetting speed and / or pipetting acceleration and / or associated time interval between the steps are also determined.

[0029] Typical pipetting parameters for user-defined pipetting processes can be manually defined, as can be seen from the following description of typical application scenarios for automated pipetting processes:

[0030] A typical application scenario for setting up a semi-automatic process in a pipetting device is the dispensing of the volume absorbed into the pipetting container (pipette tip or separator tip) (referred to as "DIS"). For arbitrary partial dispensing, such as dispensing 1 ml of total sample from a pipette into ten target containers on a microtiter plate, the user needs to position the pipette above the storage container containing the sample liquid to be dispensed, insert the pipette tip into the storage liquid, absorb the starting volume by manipulating the operating element, trigger the reverse stroke by manipulating the operating element, thereby bringing the system into the defined initial position, positioned above the first target container, and then initiate the electric dispensing of the metered 0.1 ml volume by manipulating the operating element, moving and positioning the pipette above the next target container on the microtiter plate, and then initiating the electric dispensing of the metered 0.1 ml volume again by manipulating the operating element. After the automatic dispensing process of electrically dispensing 0.1 ml of sample (a total of 10 steps of partial dispensing), these manually executed dispensing processes (positioning, triggering) are repeated eight more times. After pre-setting pipetting parameters that include one, more, or all of the following pipetting parameters, the fractional volume is dispensed quantitatively: the total volume of sample to be dispensed, the fractional volume of sample to be dispensed, and / or the number of dispensing steps used to dispense the same fractional volume, the sample absorption rate and / or a sample dispensing rate that may differ therefrom, the volume of the backstroke, and the volume of the overstroke. The dispensing function is particularly suitable for rapidly filling the microtiter pan with reaction liquid and can be used, for example, for performing ELISA (Enzyme-Linked Immunosorbent Assay).

[0031] The preferred application scenario involves "automatic dispensing" (ADS) of samples. Preferred operating parameters include: the volume of a single sample, relating to the volume of liquid transferred during one of multiple dispensing steps; the number of dispensing steps; the duration of time intervals, according to which dispensing steps are automatically performed sequentially at constant time intervals, which can be determined as time intervals or, for example, as a delay between the end and start of consecutive dispensing steps; the rate of sample absorption; and the rate of sample dispensing. This dispensing function is also more convenient for filling microtiter pans because the user does not need to repeatedly trigger dispensing steps by manipulation, such as pressing a button, but rather dispensing is time-controlled after automatic dispensing is initiated. The operation of a program belonging to this set of pipetting parameters enables automatic dispensing to be completed under conditions where the corresponding program is completed at least without interruption of manipulation of the control element, such as by continuously holding down a button. This is advantageous, for example, in a series of dispensings or reactions over a long period, where precise attention to the time window is required. The automatic dispensing function is even more convenient for filling microtiter plates, because the user does not have to trigger a separate dispensing step, but the dispensing step is performed automatically, which can be used, for example, to perform ELISA.

[0032] The preferred application scenario involves sample pipetting. Relevant pipetting parameters include: the volume of the sample to be pipetted; the rate of sample absorption; and the rate of sample ejection.

[0033] The preferred application scenario involves "pipette action followed by mixing" (P / Mix) of samples. Preferred pipetting parameters include: the volume of sample to be aspirated and / or dispensed; the mixing volume; the number of mixing cycles; the rate of sample aspiration; and the rate of sample dispensing. The "pipette action followed by mixing" function is recommended, for example, for pipetting very small volumes. If a volumetric volume < 10 μL is selected, it is recommended to spray this volume into the corresponding reaction solution. This is possible by automatically initiating the mixing motion after dispensing the liquid. The mixing volume and mixing cycle are predefined. An application of this operating mode is, for example, dispensing the remaining liquid in the pipette container, particularly the pipette tip, which is heavier than water due to its physical properties, and then rinsing it off with the liquid already supplied from the pipette container or pipette tip. Another application is to immediately mix the dispensed liquid with the supplied liquid. This operating mode is particularly advantageous, for example, when adding DNA to a PCR mixture.

[0034] The preferred application scenario involves "multiple absorptions" of samples, also known as "reverse separations" or "ASPs" for extraction. The relevant pipetting parameters preferably include: the volume of sample to be aspirated; the number of samples; the absorption rate; and the discharge rate. The function is used for multiple absorptions and discharges of liquid volume. Multiple fillings of the pipette container in a single process are not specified. The rate is the same for all samples. The design preferably involves the following scenario: starting from the base position, the pipetting device absorbs one fractional volume by manipulating a first operating device. After the last fractional volume is absorbed, the pipetting device preferably issues a warning, which preferably requires confirmation by the user manipulating a second operating device. Upon subsequent manipulation of the second operating device, the total volume is discharged again. For performing the first or second operation, the operating device preferably has at least two operating elements: one for inputting a "first" operation signal to the control device, and one for inputting a "second" operation signal to the control device. The operating device may particularly have a pressure plate, which is particularly pivotable about an axis perpendicular to the longitudinal axis of the pipetting device between a first signal trigger position for performing a first type of operation (“Wippe up”) and a second signal trigger position for performing a second type of operation (“Wippe down”).

[0035] The preferred application scenario involves sample "dilution," also known as "diluting." The relevant pipetting parameters preferably include: sample volume; bubble volume; diluent volume; absorption rate; and discharge rate. The maximum dilution volume = rated volume - (sample + bubble). This function is used to absorb the sample and diluent along with the bubble separation and discharge of the total volume. The rate is the same for all fractional volumes. In practice, the following is preferably observed: from the base position, the pipette first absorbs the diluent volume, then the bubble, and finally the sample. Each absorption is preferably triggered individually by manipulating the first operating device. The total volume is then discharged all at once.

[0036] The preferred application scenario involves "sequential dispensing" (SeqD) of samples. The relevant pipetting parameters preferably include: the number of samples (preferably up to a fixed, predetermined maximum number Nmax, preferably 5 ≤ Nmax ≤ 15, preferably Nmax = 10). This function is used for sequential dispensing of Nmax freely selectable volumes, and multiple fillings of the pipette are preferably not required. The speed is the same for all samples. The number of samples is preferably the dominant parameter for inputting a single volume. The pipette must preferably always check whether the maximum volume of the pipette is exceeded when inputting the volume, and issue a warning if necessary. After all parameters are input, the pipette absorbs the total volume after operating the first operating device and dispenses individual volumes after operating the second operating device. All further procedures preferably behave as in conventional dispensing.

[0037] The preferred application scenario involves "sequential pipetting" (SeqP) of samples. The relevant pipetting parameters preferably include: the number of samples (preferably up to a fixed, predetermined maximum number Nmax, preferably 5 ≤ Nmax ≤ 15, preferably Nmax = 10); the volume of a single sample; the absorption rate; and the dispensing rate. This function is used to pipette a maximum of Nmax freely selectable volumes, which are programmed and their order determined before initiation. The rate is the same for all samples, but it can also be set differently. The function's flow corresponds to the pipetting flow. The previously input volumes are processed in the programmed order. After dispensing, by manipulating an operating element, such as a button, it is determined whether the next sample should be absorbed or whether "blowout" should be performed before the next sample, i.e., using an overstroke to completely and safely blow away the sample still contained in the pipette container and / or whether the pipette container should be replaced.

[0038] The preferred application scenario involves "reverse pipetting" (rPip) of samples. Preferred pipetting parameters include: volume of a single sample; absorption rate; discharge rate; and counter activation. In this "rPip" function, a volume greater than the volume to be measured is absorbed. This is achieved by moving the piston downwards before liquid absorption, i.e., by a second operation, such as using a button or "plate down," until it enters a position below the overstroke of the piston during the blow-off phase, exceeding the piston's position during the pipetting stroke. Upon initiation of volumetric absorption, the pipetting device absorbs the blow-off volume and the set volume. To remove the gap in the discharge direction during drive, the pipetting device completes an additional stroke, which is immediately released. This is similar to dispensing, but preferably performed at maximum speed with automatic release of the discard stroke.

[0039] In the design of the "rPip" application scenario, the following scenario is preferred: First, the piston of the pipette (or dispensing tip) automatically moves towards the purging direction and remains in the lower position. Second, the first operating device is manipulated: the piston moves upward for the purging stroke and the stroke for the pipetting volume. Third, the second operating device is manipulated: the piston moves downward for the pipetting volume and stops before purging. Fourth, the second operating device is manipulated twice: the piston performs purging and remains in the lower position. As an alternative to the "fourth," the first operating device is manipulated: the piston moves upward for the pipetting stroke. The "rPip" mode is particularly suitable for pipetting plasma, serum, and other liquids with high protein content. The "pipettes" mode is particularly suitable for aqueous solutions. The "rPip" mode is particularly suitable for solutions containing wetting agents to minimize foam formation when dispensing into the target container. The liquid is especially accompanied by overstroke (purging volume) absorption. The overstroke here is typically not part of the dispensing volume and preferably does not dispense into the target container. Especially when reusing the same sample, the overstroke can be retained in the pipette tip. When using other liquids, it is preferable to discard the overstroke and / or preferably the pipette container.

[0040] The desired pipetting process is executed by optimizing the control program, particularly the control program, using a set of pipetting parameters. The control program can be configured as an electrical switching circuit of the control device, and / or as executable program code suitable for controlling the control device, which is capable of controlling the program code and preferably programmable.

[0041] The pipetting device or external data processing device is preferably configured to automatically check the user-inputted values ​​of the pipetting parameters (pipette parameter values) and compare them with the allowable range of the corresponding pipetting parameters. If the user-inputted pipetting parameter value is outside the allowable range, then either the input is not accepted, a warning is issued on the screen and / or audibly, or the value is set to a default value, which could be, for example, the minimum or maximum value or the last allowed input value, or an automatically corrected value is used.

[0042] The pipetting apparatus preferably has at least one touch-sensitive or non-touch-sensitive screen and / or preferably has a number of display pages (also called "screen pages") that are at least partially predefined and stored in the pipetting apparatus as display page data. The display pages can be displayed on one screen or distributed across multiple screens, preferably filling the screen. The screen surface is preferably substantially rectangular, but may also be square. In non-square rectangles, it is particularly preferred that the shorter side of the rectangle is arranged perpendicular to the longitudinal axis A of the pipetting apparatus. Side-by-side entries, especially columns, can be longer in this manner.

[0043] The data processing device is preferably programmed to display a graphical user interface (GUI) on a screen. In describing the GUI, the phrase "the data processing device is programmed to..." is omitted, and only the GUI and its operation are described. It is consistently mentioned that the data processing device is programmed to implement the corresponding GUI and its operation. Such implementation is routine for those skilled in the art.

[0044] The GUI includes several functions, and the data processing device is accordingly programmed to display at least a screen page (specifically, the "main screen"), displaying pipetting parameters of a parameter group on the screen page. Therefore, the data processing device is programmed to display a screen page, displaying pipetting parameters of a parameter group on the screen page. The phrase "displaying pipetting parameters on the screen" means displaying the currently set value of the pipetting parameter on the screen. Furthermore, descriptions of the pipetting parameters may be displayed, particularly textual descriptions, characteristic pictograms, or physical units of the parameters described by the pipetting parameters, if the pipetting parameter involves such physical units, for example, "μL" representing volume. However, those skilled in the art can also know or learn from the context which pipetting parameter the displayed value belongs to, even if no description is provided on the screen.

[0045] The data processing device is specifically programmed to display a screen page, i.e., a startup screen, also synonymously called the main screen (similar to the homepage of an internet browser). Preferably, a large number or multiple user inputs at the GUI are returned to this main screen. This main screen can be advantageously used to display the entire set of parameters for the pipetting process, either user-defined or adopted from pre-stored application scenarios, and to enable the setting of related pipetting parameters. The main screen is displayed, particularly immediately after the pipetting device is powered on, where it is possible that a purely informational page, such as company logo, device information, etc., is inserted before the main screen. Power-on can be achieved through user operation of the display or control elements, or through measurements by sensors, such as accelerometers, motion sensors, proximity sensors, etc. This main screen has proven to be the intuitive central point for the user to grasp the operation scheme of the pipetting device.

[0046] The main screen is preferably selected as the standard (default) option to display the pipetting parameters of the currently valid parameter set. Furthermore, the data processing device can be programmed to display one, more, or all of the following displays on the main screen:

[0047] • After the pipetting device is turned on, the pipetting parameters in the basic parameter group are displayed;

[0048] • After the pipetting device is turned on, the pipetting parameters of the last set basic parameter group are displayed;

[0049] • After the pipetting device starts, the pipetting parameters of the last set of basic parameters are displayed. The basic parameters are either at least partially or completely implemented, or only set but not implemented.

[0050] • After the pipette has been idle for a period of time, especially after a possible standby mode, the pipetting parameters of the basic parameter set can be displayed; this pipetting parameter set is particularly the set displayed after the pipette is powered on; "idle" may mean that no user operation or display touch has been detected on the device for a predefined time, either factory-set or user-defined, and / or the optional sensors of the pipette (e.g., accelerometer, motion sensor, proximity sensor) have not detected user movement and / or proximity. Standby mode can be automatically activated after a predetermined idle time.

[0051] • After the pipette has been idle for a period of time, especially after possible standby mode, the pipetting parameters of the last set basic parameter group can be displayed;

[0052] • After a period of inactivity of the pipetting device, especially after possible standby mode, the pipetting parameters of the last set of basic parameters can be displayed, which may have been at least partially or fully implemented, or set but not implemented.

[0053] The screen page preferably includes at least one first input window, which displays the value of at least one or exactly one first pipetting parameter from a parameter group, particularly a basic parameter group, which defines the pipetting process, particularly the basic pipetting process. The number of input windows displayed on the screen page preferably corresponds to the number of pipetting parameters in the parameter group. The basic parameter group preferably includes at least one or exactly one pipetting parameter, preferably at least two or exactly two pipetting parameters, preferably at least three or exactly three pipetting parameters, preferably at least four or exactly four pipetting parameters, preferably at least five or exactly five pipetting parameters, preferably at least up to ten or exactly up to ten pipetting parameters, or more pipetting parameters. The data processing device is particularly programmed to initiate a pipetting process belonging to the pipetting parameter group when the user manipulates one, particularly any, control element on the displayed screen or main screen.

[0054] The input window on the touch screen page, especially the first input window, preferably opens an input interface that allows the user to input the value of relevant pipetting parameters, especially at least one first pipetting parameter.

[0055] An input window refers to a marked input area on a screen page displayed on a touchscreen. Touching the input window represents input, and programming preferably initiates a subsequent action as a result of this touch, particularly displaying the input interface. It is possible that the detection area evaluated by the controlled program as the input to this input window is different from the marked area, for example, larger, but the marked area, i.e., the visible input window, preferably corresponds to the detection area. If the detection area is larger than the marked area, then an incorrectly located touch is also defined as input. If the detection area is smaller than the marked area, then the user is trained to correctly locate the touch on the input window, and the spacing between adjacent input windows decreases without increasing the number of incorrect locations, thus better utilizing the available surface for input / output. This fault-tolerant solution is acceptable or promotes user satisfaction as long as the touch does not collide with the detection area of ​​another input window or another input box on the screen page. The visible input window is preferably a substantially rectangular area, because by being a rectangle on a substantially rectangular display, the available surface is optimally used for input and output. However, this area can be different, for example: hexagonal, arc-shaped, polygonal, and / or rounded. The width b of the input window preferably extends over a portion x of the entire width B of the screen, particularly when viewed perpendicularly to the longitudinal axis A passing through the pipette. Here, preferably 0.8 < x < 1, preferably 0.9 < x < 1, preferably 0.95 < x < 1. Due to the large width of the input window, input is comfortable. Here, b = B * x.

[0056] The background of the input window is preferably light-colored, especially white, and the information displayed on it is dark-colored, especially blue or black. However, the opposite is also possible, for example, in the monitor's night mode, where the background is dark and the information is displayed brighter. Sufficient contrast with the background is preferred to ensure that the information is readable by the user under any common lighting conditions, from darkness to sunlight. The pipetting device preferably has a photosensitive light sensor. The control device, particularly the data processing device, is preferably configured or programmed to maintain a predetermined relationship between the screen brightness and the light intensity received by the light sensor. This may mean that the screen brightness increases when the intensity of external light increases and decreases, especially when the intensity of external light decreases. However, the screen brightness can also be constant, particularly predetermined at the factory, and can be automatically set according to further parameters, such as depending on the loaded application scenario or also depending on the loaded user profile and / or can be set by the user.

[0057] The screen page, particularly the main screen, preferably has at least one input box, which, when touched, allows the user to select at least one second pipetting parameter. Several advantageous solutions have been found in such pipetting devices to enable this input capability. In a first solution, the input box is located in a marked area at the edge of the screen page, particularly the main screen, especially in the lower or upper edge region, so as not to interrupt the list of input boxes preferably displayed there. This specific position of the input box relative to the input window displayed there then clarifies its specific function: to open a new screen (also: "selection screen") for selecting and / or deselecting a new pipetting parameter, which should be added to the current parameter group (or deselected). After the selection screen is closed, at least one selected pipetting parameter is added to the current parameter group and displayed on the screen page. In a second solution for selecting / deselecting pipetting parameters, the screen page has a size, particularly length or width, that exceeds the display area available on the screen for displaying the screen page. Input windows can be set in this area of ​​the screen that is not initially visible. Each input window contains a value or information describing the value of a pipetting parameter belonging to the input window, such as an on / off switch that displays a specific pipetting parameter, or in particular, an on / off switch for the function represented by that pipetting parameter.

[0058] The screen page can be larger than the display area available on the screen; in this case, the screen page can be scrollable, for example, scrollable vertically. However, the screen page can also be moved vertically in the following ways. That is, clicking on a screen area or swiping the screen based on a known input gesture causes the screen content to move up and down, resulting in an area of ​​the screen page that is below, above, or to the side of the currently displayed area of ​​the screen page.

[0059] The term "selection" specifically refers to activating a pipetting parameter based on a predetermined volume, which may be stored in the pipetting device's data storage. Activating the pipetting parameter can directly result in its addition to the current parameter group, but it can also be done through an interactive dialog that allows the user to confirm or prevent this addition. Correspondingly, "deselect" is defined: disabling the activated pipetting parameter and accordingly changing the user-defined user parameter group.

[0060] The data processing device is preferably programmed to process data after a user-selected pipetting parameter, particularly a second pipetting parameter, is detected.

[0061] • At least one, particularly a second, pipetting parameter is added to at least one first pipetting parameter of a parameter group, particularly a basic parameter group, so that together with the at least one first pipetting parameter, a pipetting parameter of a user parameter group is formed, which defines a user-defined pipetting procedure, and

[0062] • This option allows the user to view at least one second pipetting parameter on the screen, especially on the main screen.

[0063] Considered an independent invention, the data processing device of the pipetting apparatus is programmed to display a graphical user interface (GUI) on a screen, wherein the GUI includes at least the following: screen pages, particularly a main screen, displaying pipetting parameters of a parameter group on the screen pages, wherein the screen pages include at least one first input window that displays the value of at least one first pipetting parameter of the parameter group, particularly a basic parameter group, which defines the pipetting process, particularly the basic pipetting process, and touching the first input window opens an input interface that allows the user to... The user inputs a value for at least one first pipetting parameter, wherein the screen page has at least one input box, and touching the input box enables the user to select at least one second pipetting parameter. The data processing device is programmed to, upon detecting such a selection by the user, add at least one second pipetting parameter to at least one first pipetting parameter in a parameter group, particularly a basic parameter group, so that together with the at least one first pipetting parameter, a pipetting parameter in a user parameter group is formed, which defines a user-defined pipetting procedure, and this selection of at least one second pipetting parameter is displayed to the user on the screen page, particularly on the main screen.

[0064] This invention represents a particularly advantageous aspect of an inventive operating scheme for pipetting devices. Research on users reveals that, for a significant segment of users, the pipetting device enables the establishment of a more efficient workflow, in which users largely define their desired pipetting process according to their own wishes by supplementing existing, for example, proven or basic parameter sets with additional pipetting parameters, i.e., supplementing functions or features. This approach clearly achieves the goal most effectively—defining the individual's desired pipetting process. Especially when readily implementable basic parameter sets are displayed on the screen, particularly the main screen, it immediately provides a sense of operational accomplishment without requiring lengthy learning curves. Within a short learning time, users can find their way within the list of possible pipetting parameters and thus more effectively utilize the vast functional potential of the electric pipetting device. This is particularly suitable for a wide range of users who find it difficult to learn existing, more or less complex operating modes representing their application scenarios in known prior art pipetting devices and are content with the simplest operating mode. This new approach invites inexperienced users to learn the functions and provides ample flexibility for experienced users.

[0065] It should be noted that the method of defining user parameter groups does not exclude other, particularly more complex parameter groups set by user selection, such as those provided by separate screen pages. These parameter groups represent specific predefined application scenarios, and may be parameter groups stored by the user, or automatically stored parameter groups from a list of parameter groups used earlier in time (this list is also called parameter group history), or parameter groups that are statistically most frequently used, or parameter groups that are favorited by the user.

[0066] These individual screen pages form the components of the GUI. These screen pages are preferably displayed on the screen, like any other screen page, and particularly according to programs or program code stored in a data storage device, especially running programs or control programs. Examples of these screen pages that are preferably components of the GUI are as follows:

[0067] A preferred setting is a favorites screen page, which displays, in particular, one or more, optionally limited to a maximum total number M1, pipetting parameter groups created in advance by the user or loaded by the user from other screen pages, and marked as favorites by the user via input options, such as by touch input boxes. Input boxes can be located in menu bars and / or navigation bars, particularly at the edge of the screen, especially input boxes with star-shaped pictograms or other appearances.

[0068] Preferably, a history screen page is set up to display one or more pipetting parameter groups, optionally limited to a maximum total of M2. Each of these pipetting parameter groups is formed from historical pipetting parameter groups that have been implemented in the past and are stored automatically, mimicking historical pipetting procedures.

[0069] Preferably, a program group screen page is provided, displaying, in particular listing, one or more pipetting parameter groups, optionally limited to a maximum total number M3, created by the user through programming. This programming can be performed, particularly on a programming screen page, where the user progressively assembles program steps according to a predetermined flow of the pipetting process, defined by the pipetting parameters, within the modular system. This input is automatically checked for consistency by a control program or other program, thereby creating the corresponding programmed pipetting parameter groups, which are then added to the program group screen page according to the user's specifications and stored there. Programming can also be performed on an external data processing device, where the programmed pipetting parameter groups created externally are transmitted to the pipetting device via its communication device. Programming is performed, in particular, using a programming (macro) language implemented in the pipetting device, which can be appropriately provided by those skilled in the art, particularly through selectable input boxes, text descriptions, and pictograms in a GUI, which the user can progressively combine. However, it is preferable to generate a program (macro) code through a recording function, which can then be edited by the user, particularly on the programming screen page.

[0070] The preferred configuration is an automatic program group screen page, which displays, in particular, one or more, optionally limited to a maximum total number of M4, pipetting parameter groups. These groups are derived in advance by the recording function of the pipetting device from the setting steps of the pipetting parameters and / or the pipetting process, which are manually set and performed by the user, i.e., with substantially no user intervention, and are then stored, in particular, in a data storage device. The recording function is typically triggered by the user touching an input box that defines the recording function in the GUI, and terminated by the user touching an input box that defines the end of the recording function in the GUI. To create the steps of the desired pipetting procedure, starting from the main screen with any desired pipetting parameters, the values ​​of these pipetting parameters are determined, and the manipulator is manipulated to perform the absorption or dissipation of sample volume in a simulated or non-simulated manner in the desired way. This means that the motion element moved by the motor is either preferably unable to move or preferably able to move after the manipulator is manipulated. Through this "teaching" feature of the recording function, when users set up their pipettes and perform pipetting, relevant sets of pipetting parameters can be created and stored, especially without requiring the user to specify them using the programming (macro) language implemented in the pipetting device. However, it is preferable that the recording function generates program (macro) code, which can then be edited by the user, particularly on the programming screen page.

[0071] Preferably, a scenario screen page is provided, which displays, in particular, lists one or more pipetting parameter sets, optionally limited to a maximum total number of M5, which are provided by the manufacturer. These pipetting parameter sets can define one, more, or all of the application scenarios described at the beginning of this document. The corresponding pipetting parameter set is selected by touching an input box or input window, which represents the corresponding application scenario and carries an abbreviation name.

[0072] On one of the screen pages, a pipetting parameter group can be represented by an input box, particularly an input window, which can be touched by the user to change the corresponding pipetting parameter group into the current pipetting parameter group. The pipetting parameters of the pipetting parameter group are then displayed on the (main) screen page, particularly on the main screen, or on a separate screen page, as claimed. Directly transferring the pipetting parameter group to the central screen page, particularly the main screen, is also known as quick selection. When transferring to a separate screen page, input options can be set to create a new program with the pipetting parameters of the selected pipetting parameter group, edit the pipetting parameter group, and delete the pipetting parameter group or its components.

[0073] The total numbers M1, M2, M3, M4, and M5 can be selected or fixedly predetermined, for example, between 1 and 50, especially between 2 and 30, especially between 5 and 25.

[0074] The basic parameter set may include, in particular, three pipetting parameters: volume V, velocity v (a two-component, vector parameter: absorption / displacement), and the number of repetitions (such absorption or displacement) n. Volume is specifically the volume to be aspirated into or displaced from the pipette during a single absorption and / or displacement. For volume, it is preferable to also display information about the physical unit, such as mL or μL, in the input window. Velocity is specifically a vector value, containing two semantically related descriptions related to pipetting speed: the rate at which liquid is absorbed into the sample container and the rate at which liquid is displaced from the sample container. The velocity values ​​may be proportional to the rate of liquid exchange between the pipette and the environment (alternatively, non-proportional). The user-selectable velocity can be predetermined by velocity levels, which may be represented by ordinal numbers such as 1...10 or letters A...J or other symbols, where level 4 does not necessarily represent twice the velocity compared to level 2, but can represent twice the velocity. In particular, the basic parameter set is selected in such a way that it defines the pipetting process that can be performed, as is particularly true in the example (V, v, n) described above.

[0075] Preferably, the input box is configured as an additional button, particularly a single input box designed as an additional button. This additional button has a shape and / or color and / or background color that differs from the input window displayed on the screen and / or its edge position on the screen. Touching the additional button preferably prompts the display of a selection screen, rather than the main screen and a screen overlaid thereon (overlay), specifically a predetermined number of available pipetting parameters, stored in a data storage device, in the form of a selection list. This selection list contains information about selectable second pipetting parameters, particularly a brief description (for identifying the pipetting parameter), from which the user can select at least one second pipetting parameter.

[0076] Preferably, after selecting at least one second pipetting parameter, the selection screen or selection list is closed and the screen page, particularly the main screen, is displayed again. The screen page now displays at least one second input window in addition to at least one first input window. The second input window displays the selection and / or value of at least one second pipetting parameter, or information about that at least one second pipetting parameter representing that value. The phrase "at least one first input window" specifically means that, for example, exactly three "first input windows" can be set, and thus, if necessary, the added "at least one second input window" can be the fourth input window out of the four currently displayed input windows.

[0077] Preferably, when at least one second pipetting parameter can occupy a value that can be selected by the user, touching at least one second input window (within the selection screen / selection list or after closing the selection screen / selection list) will open an input interface that allows the user to enter the value of at least one second pipetting parameter.

[0078] According to the second solution for selecting further pipetting parameters for the current parameter set, it is preferable to display input boxes for quantities N≥1 on the screen, preferably input windows, especially as a scrollable or vertically movable list of input windows, wherein each input box is equipped with and displays information about the second pipetting parameter that can be selected by means of the input box, especially a brief description, pictogram and / or physical units.

[0079] Preferably, after the user selects at least one second pipetting parameter from a number of N input boxes, the selected and / or value of the at least one second pipetting parameter, or information representing that value, is displayed. Preferably, after at least one second pipetting parameter can occupy a value selectable by the user, the user touches at least one second input window currently displayed on the screen / main screen to allow the user to input a value for at least one second pipetting parameter.

[0080] The data processing device is preferably programmed to display a screen page, particularly a main screen, on a screen, the screen page including at least one first input window, the at least one first input window displaying the value of at least one first pipetting parameter, and touching the first input window opening an input interface that allows the user to input the value of at least one first pipetting parameter.

[0081] This input interface is preferably a screen area displaying a numeric keypad whose numeric keys can be individually touched and used by the user to input a sequence of numbers defining the value of at least one first pipetting parameter. The screen area can also be the screen area of ​​a new screen page replacing the current screen page. The input interface can also contain a scrollable selection list of possible numerical values ​​or other informational selectable boxes, such as an input scroll bar, or a side-by-side diagram containing multiple possible selectable numerical values. The input interface preferably has input boxes in which the user manipulates previously made value changes. The input interface preferably has input boxes in which input or value setting is interrupted. The input interface, preferably a screen page, especially the main screen, preferably has input boxes; touching this input interface will remove the last pipetting parameter, especially at least one second pipetting parameter, added to the parameter group from the parameter group, or undo the last change to the value of the pipetting parameter ("undo" function) or reset the parameter selection to the default selection, especially to the basic parameter group.

[0082] The input interface may include, in particular, a number box, at least one selection box for selection from a list, especially a drop-down menu, at least one selection wheel, and other devices to facilitate changes in the value of parameters, especially pipetting parameters, by touch of the screen.

[0083] The data processing device is preferably programmed to display information on the screen when the value of the pipetting parameter input by the user via the input interface is not allowed, and preferably...

[0084] • Display at least one correction button. Touching this correction button will either override the value entered by the user and perform at least one correction procedure. The correction procedure may have the following design options:

[0085] - Automatically set allowed values ​​instead of disallowed values;

[0086] - Select at least one as an alternative pipetting parameter and, in particular, assign it a user value or other suitable value;

[0087] -Undo user input and, in particular, enable re-entry;

[0088] and / or

[0089] • Output error messages;

[0090] and / or

[0091] • Ignore previous changes to the current value and retain the previous current value;

[0092] and / or

[0093] • Automatically deselect another uncombinable pipetting parameter that represents a function that cannot be combined.

[0094] The data processing device is preferably programmed to display screen pages, particularly the main screen, on a screen containing a list of substantially rectangular input windows, which are arranged vertically and extend substantially across the entire screen page. This optimally utilizes available surface area and makes operation ergonomic.

[0095] The data processing device is preferably programmed to display a start screen page (main screen) on the screen, particularly a screen page for displaying pipetting parameters for a set of parameters, and the start screen page is replaced by a second screen page by a lateral or vertical sliding gesture, and the start screen page is replaced by a third screen page by a lateral or vertical reverse sliding gesture. This does not preclude the possibility of displaying additional screen pages starting from the second or third screen page by other sliding gestures.

[0096] The data processing device is preferably programmed to make the second screen page have a list of input boxes, each input box carrying an abbreviated name, and wherein touching an input box loads a predetermined set of parameters that defines a predetermined pipetting procedure, wherein, in particular, after touching this input box, a screen page different from the startup screen page is displayed, or alternatively, the startup screen page with the input window containing the predetermined set of parameters is re-displayed.

[0097] Preferably, at least one screen page is provided, offering the following specific functions of the pipetting device: pipetting parameters for a target volume, which can be entered or changed via an input box; and the ability to continuously aspirate liquid into the pipetting container for an extended period until the target volume is reached by continuously manipulating the control element. Similarly, or alternatively, a specific function for discharging liquid at a target volume is optionally provided: liquid is continuously dispelled from the pipetting container for an extended period by continuously manipulating the control element until the target volume is reached. This imitation of the operation of a conventional mechanical pipette provides the user with additional control, such as the ability to interrupt the pipetting process for short periods and, in particular, controlled pipetting.

[0098] The data processing device is preferably programmed to make the third screen page have a list with input boxes, each input box carrying an abbreviated name, and wherein touching an input box loads one of the following parameter groups:

[0099] The parameter set used in the past and automatically stored in history defines the historical pipetting process;

[0100] A parameter group that represents a specific, predefined application scenario; a parameter group that is stored by the user.

[0101] The parameter set that is most frequently implemented in statistics;

[0102] Parameter groups that belong to the user-defined parameter group collection list;

[0103] A set of parameters is automatically created from each setting step or pipetting process manually set by the user, either through user programming or through the recording function of the pipetting device using program code (the program code can in particular be part of the control program of the pipetting device).

[0104] In particular, after touching this input box, a different screen page is displayed than the splash screen.

[0105] Alternatively, you can re-display the startup screen page with the input window containing the predefined parameter set.

[0106] The screen (also called a "monitor") is a touch-sensitive screen (also called a "touchscreen"). The screen is preferably a color monitor.

[0107] Touchscreens can be used as input media, while non-touchscreens can be used as output media for outputting information or can be combined with operating elements arranged next to the screen as input media. In particular, when the screen area notifies the function of the corresponding operating element, the operating element can then be configured as a so-called soft key, which can perform variable functions.

[0108] The screen is preferably rectangular. This is the best way to utilize the screen space when using input windows and / or information boxes that are displayed on the screen in a substantially rectangular shape.

[0109] The screen is preferably flat. This improves readability because users can choose the alignment angle that reflects the least light in the lab, while on a curved screen, light is captured and reflected to the user's eyes from a greater spatial angle.

[0110] The flat screen is preferably flush with a flat section of the front of the housing, with the screen positioned within the front of the housing. This facilitates touching the near-edge areas of the touchscreen, especially when the screen is surrounded and protected by the front of the housing.

[0111] According to a creative variation of the operating scheme, the data processing device is preferably programmed to display screen pages, particularly output screen pages, and especially a separate input area, also known as a special button. Touching this input area closes the output screen page and displays the input screen page or other screen pages on the screen. These other screen pages also allow editing of parameter values ​​contained in the pipetting parameter group. Touching the special button can also cause an interruption of the ongoing pipetting process, which may require confirmation from the user via a safety prompt. Terminating the completed pipetting process also results in the input screen page being re-displayed instead of the output screen page without touching the special button, where information about the successful execution of the pipetting process can be output before / after. When a pipetting sequence ("do") has begun, for example, when only a quick adjustment of the speed is needed, it is not necessarily the previous input screen page that people return to by means of the special button. It can be specified that after the pipetting process begins, not all parameter values ​​can be changed / corrected, but only specific parameter values ​​of the current pipetting parameter group can be changed / corrected.

[0112] Distinguishing between the input mode (“set”) represented by the input screen page and the output mode (“do”) defined by the output screen page is particularly effective in preventing unintentional changes to parameter values ​​during “do” mode, which could disrupt laboratory work and result in significant financial losses. On the other hand, switching from “set” mode to “do” mode via manipulation of the control elements provides users with greater comfort and intuitiveness. This also greatly contributes to ergonomics and efficient workflows. The input and output screen pages can be distinguished by one or more of the definitions mentioned below. These definitions particularly preferably relate to the state of the pipetting apparatus in which the pipetting process is initiated and the electrically controlled motion elements are moved; however, it is possible that the definitions are not applicable when a state of the pipetting apparatus exists in which the pipetting process is initiated but the electrically controlled motion elements are not moving. This creates the possibility, for example, in a multi-step pipetting process, after the completion of a pipetting step or after the completion of a sub-step in a multi-step pipetting process, displaying an output screen page that allows modification of pipetting parameters in a parameter group, but preferably not all pipetting parameters in the parameter group, all of which were previously changeable on the input screen, particularly on the input screen displayed shortly before initiating a pipetting step. It is reasonable, for example, to allow the user to modify one or more individual pipetting parameters during a multi-step pipetting process, especially those that do not have a critical impact on the successful execution of the pipetting process. Also known as pipetting velocity, aspiration and / or dispensing velocity can be a pipetting parameter that, when modified, will not necessarily change the outcome of the pipetting process, and therefore can be adapted to user needs during this period or between the final sub-steps of the pipetting process. In a possible definition:

[0113] The output screen page, but not the input screen page, preferably has an input box with a special button. Touching the input box can close (output) the screen page and display this input screen page or another input screen page on the screen.

[0114] When an output screen page has a special button, it is clear that an input screen page, especially the main screen, does not have a special button, because a special button is defined to close the output screen page that must be displayed at the moment.

[0115] The input screen page, but not the output screen page, preferably does not have an input box called an extra button. Touching this input box opens up the possibility for the user to change the amount of the pipetting parameters in the parameter group that will be displayed on the input screen page next. The input screen page, but not the output screen page, preferably has an input box called an extra button. Touching this input box displays a selection screen, which displays a predetermined number of available pipetting parameters, i.e., stored in a data storage device, in the form of a selection list. The selection list contains information about the second pipetting parameters that can be selected, especially their abbreviations (to identify the contents of the pipetting parameters). The user can select at least one second pipetting parameter from the available second pipetting parameters. Here, "first pipetting parameters" refers to those pipetting parameters that have already been displayed on the input screen page, and "second pipetting parameters" refers to those pipetting parameters added to the first pipetting parameters.

[0116] An input screen page, but not an output screen page, preferably has an input box that displays pipetting parameters, in particular their numerical values, and touching the input box will immediately, that is, in particular without significant delay and in particular without requiring further user action, open the input interface, which the user can use to change the values ​​of the displayed pipetting parameters.

[0117] The output screen page and / or subsequent output screen pages displayed on the output screen page preferably cannot change the pipetting parameters previously displayed on the input screen page and changeable by input, especially more than half of the pipetting parameters, especially all of the pipetting parameters. The output screen page and / or subsequent output screen pages displayed on the output screen page preferably cannot change the total number or a portion of the f pipetting parameters previously displayed on the input screen page and changeable by input (especially: f > 3 / 4 or f > 2 / 3 or f > 1 / 2 or f > 1 / 3 or f > 1 / 4) or at least one pipetting parameter.

[0118] The output screen page and / or subsequent output screen pages displayed on the output screen page preferably do not have the possibility, in particular, of changing, especially directly and / or indirectly, at least one predetermined pipetting parameter previously displayed on the input screen page and changeable by input. This at least one predetermined pipetting parameter is preferably selected from the following list of pipetting parameters:

[0119] {Volume, which is aspirated or expelled during the pipetting process; the number of steps in a pipetting process comprising multiple steps, particularly the total number, especially the number of pre-wetting steps in the pipetting process (greater than zero), wherein, during the pre-wetting step, liquid is aspirated into the pipetting container and expelled again, particularly to wet the inner surface of the pipetting container before the actual pipetting process begins; time parameters, particularly the duration of a step in a pipetting process or a multi-step pipetting process, or the waiting time between pipetting processes or between steps in a multi-step pipetting process; parameters relating to the automatic / non-automatic expulsion of the remaining volume remaining in the pipetting container after the pipetting process is performed (activating or disabling the "auto blow off" function); speed parameters relating to the speed of the pipetting process during the steps of a multi-step pipetting method, particularly a dispensing method, particularly the speed at which the sample volume is aspirated into / expelled from the pipetting container}

[0120] The volume of a pipette can be the volume aspirated into the pipette container during the pipetting process or during a step of a multi-step pipetting process, or it can be the volume discharged from the pipette container during the pipetting process or during a step of a multi-step pipetting process, especially the volume to be discharged during a multi-step separation process.

[0121] The output screen page or the output screen page displayed next, in particular, except for special buttons, preferably does not have an input box, especially not such an input box, touching the input box will cause a change in the content of the output screen page, especially a direct change and / or a change in the pipetting process that has been started, especially a direct change.

[0122] The output screen page, or the output screen page that is displayed next, preferably does not have an input box for changing one of the pipetting parameters that were displayed on the input screen page that was previously displayed and that could be changed by input there, except for special buttons.

[0123] The output screen page, or the output screen page displayed subsequently, preferably does not have input boxes for changing pipetting parameters, except for special buttons. Touching said input box enables the direct or indirect change of one or more pipetting parameters from a group of pipetting parameters entered via the input screen page, particularly for changing at least one predetermined pipetting parameter previously displayed on the input screen page and changeable by input, and / or for changing one of the pipetting parameters in an ongoing pipetting process. "Direct change" specifically means that the input interface opens immediately after touching the input box, where the user can change the value of the displayed pipetting parameter. "Indirect change" specifically means that an input screen page with at least one input box is first opened, and touching said at least one input box immediately opens the input interface, where the user can change the value of the displayed pipetting parameter.

[0124] Preferably, at least one, several, or all of the changeable pipetting parameters of the parameter group are set only on the input screen page, particularly the main screen, but not on the output screen page. Specifically, only one input screen page, but not the aforementioned / one output screen page, contains input boxes, particularly at least one first input window, which displays at least one first pipetting parameter of the parameter group, particularly the basic parameter group, which defines the pipetting process, particularly the basic pipetting process. Touching this first input window, i.e., without further user input immediately following the touch, opens an input interface allowing the user to input the value of at least one first pipetting parameter. These pipetting parameters of the parameter group can be selected, in particular, from the aforementioned list of possible "predetermined operating parameters".

[0125] The output screen page, but not the input screen page, preferably displays different content depending on the specific steps of the automated multi-step pipetting process that are taking place. In particular, it defines the values ​​of the pipetting parameters for the currently ongoing step, such as step i out of a total of N steps in the pipetting process, with a specific discharge rate v2 discharging a fractional volume Vt. This could be the case, for example, in the application scenario "Dis (pipette)".

[0126] The output screen page, but not the input screen page, preferably displays a progress indicator that contains information about the progress of the multi-step pipetting process, depending on the specific steps that are occurring during the automated multi-step pipetting process.

[0127] The output screen page, but not the input screen page, preferably depends on the step-by-step occurrence of the automated multi-step pipetting process and preferably displays a changeable display element, in particular a display wheel or display scroll bar, as will be explained below.

[0128] In particular, the above definition can distinguish between input screen pages and output screen pages.

[0129] The pipetting process can be initiated under different or predetermined initiation conditions. It can be initiated directly by (first) manipulating the control element, or, upon safety inquiry or for other reasons, by, if necessary, by a third manipulation of the control element, which differs from a touchscreen, immediately following the first manipulation (i.e., especially without touching a special button). The data processing device is preferably programmed to display an input screen page, particularly a main screen, of pipetting parameters for displaying and inputting a set of parameters, and, when a manipulation of at least one (different from the screen) control element is detected, to display an output screen page (referred to as "do") on the screen instead of the input screen page, displaying the pipetting parameters defined in the input screen page. Specifically, the pipetting process is initiated either triggered by such manipulation or by manipulation of the (different from the screen) control element immediately following such manipulation, or specifically when a manipulation of at least one control element prompts the display of the output screen page, or in a subsequent manipulation of one of these control elements, the pipetting process defined according to this set of pipetting parameters is initiated. The data processing device is preferably programmed to allow the user to select the activation conditions via a GUI input interface within the pipetting apparatus.

[0130] The input screen page is preferably different from the output screen page, especially any output screen page, preferably in their graphic representation; the output screen page preferably has other coloring and / or other arrangements of symbols and / or information boxes. The output screen page preferably displays different content step by step according to the automated multi-step pipetting process, especially the values ​​of the pipetting parameters currently defined for each step, such as dispensing a fractional volume Vt at a specific dispensing rate v2 in step i out of a total of N steps in the pipetting process. This can be the case, for example, in the application scenario "Dis (dispensing)". In particular, the scheme of distinguishing the input screen page and the output screen page through external distinguishability forms an important ergonomic advantage in operation, because the user can recognize with minimal effort whether he is in a pipetting process that may be interrupted, waiting for manipulation, or in a setting mode. The scheme of input screen page and output screen page therefore means that the pipetting device has an input mode and an output mode that are easily distinguishable to the user. The preferred method, which involves touching only a single input area or triggering an automatic return to the input screen, particularly the main screen, during the end of a pipetting process, allows the user to change parameter values ​​or reselect parameters. This separation particularly prevents unintentional changes to parameter values ​​while running in "do" mode, which could disrupt laboratory work and result in significant financial loss. On the other hand, switching from "set" mode to "do" mode by manipulating the control element provides significant user comfort and intuitiveness. This also greatly contributes to ergonomics and efficient workflow.

[0131] At least one control element is not, in particular, part of the touch-sensitive screen. The at least one control element is preferably designed as a button, i.e., a component designed to be activated by the user, particularly with the thumb, when the user holds the handheld pipette in a prescribed manner by encircling the housing, which in particular serves as a handle, and hereby placing the armrest of the housing on the index finger. The touchscreen is operated, in particular, by the fingers of the hand not holding the pipette.

[0132] The data processing device can be programmed to activate the unload button (for unloading pipette tips) of the pipette during the display of the output screen page, particularly in the output mode of the pipette, in some scenarios or in principle resulting in the display of the input screen page, particularly the main screen or other input screen page, instead of the output screen page and / or stopping or interrupting the pipetting process.

[0133] A pipetting procedure defined by the pipetting parameters of a parameter set can have multiple time stages, such as when a specific sequence of steps or sub-steps is repeated repeatedly or cyclically. When the pipetting process, for example, contains a sequence of 10 steps, the output screen page preferably displays, at each step, which of the 10 steps is being performed and / or how many steps remain. Additionally, the one or more pipetting parameters for the current (active) step can also be displayed. The active parameter settings are preferably displayed on the output screen page, so that it is obvious what will happen next when the manipulator is pressed, for example, pipetting step 3 with 150 μL and a speed X.

[0134] The output screen page preferably displays different content depending on the ongoing steps of the automated multi-step pipetting process, specifically defining the values ​​of the pipetting parameters for the currently running step, such as discharging a fractional volume Vt at a specific discharge rate v2 as step i out of a total of N steps in the pipetting process. This could be the case, for example, in the application scenario "Dis (pipetting)".

[0135] To visualize the progress of a multi-step pipetting process, the output screen preferably has display elements, particularly a single or multi-part output window. The display elements preferably show different content depending on the specific step of the automated multi-step pipetting process, specifically defining the values ​​of the pipetting parameters for the currently occurring step. The display elements occupy an area of ​​the output screen that can be changed or remains constant in size.

[0136] The first view of the display element in the first state is preferably different from the second view in the second state. In the first state, the display element displays step i (where i is a counting index, specifically for sequentially performed steps), and in the second state, the display element displays step i+1. The difference in views is that, in the first state, the counting index i, and in the second state, the counting index i+1, are displayed on the output screen page, particularly on the display element. Furthermore, the difference in views also lies in the different values ​​of the pipetting parameters used in the corresponding steps displayed on the output screen page, particularly on the display element, in the first and second states.

[0137] The display element preferably has a first output window, in which one or more values ​​of one or more pipetting parameters used in the currently performed step i are displayed. The display element preferably also has a second output window, in which one or more values ​​of one or more pipetting parameters used in the future step i+1 are displayed. This provides the user with a better overview and better control over the operation of the pipetting device. The display element preferably has another second output window or a third display window, in which one or more values ​​of one or more pipetting parameters used in the previous step i-1 are displayed. This again provides the user with a better overview and better control over the operation of the pipetting device. Similarly, further output windows with continuously planned future steps (e.g., i+2, i+3, etc., up to i=N) can be displayed at least partially and simultaneously. Similarly, further output windows with continuously planned past steps (e.g., i-2, i-3, etc., up to i=0) can be displayed at least partially and simultaneously.

[0138] The display element may, in particular, include one or more output windows, specifically a first output window and a second and / or a third output window, according to step i.

[0139] The display element preferably has at least the first output window, the second output window, and the third output window during step i. The first output window is preferably spatially arranged between the second and third output windows. In this arrangement, the display element is also referred to as a display wheel or display scroll bar. The display scroll bar preferably has three positions (e.g., center, left, right; or center, top, bottom), which can be occupied by the output windows of the corresponding steps. The progress of a multi-step pipetting process, counted by an exponent counter i, is shown by the rotation of the output windows of the display bar. For example, in a ten-step (N=10) pipetting process (e.g., a dispensing process), at the start of the pipetting process (i=1), the output window for step i=1 is in the middle position on the display bar, while the output window for step i=0 is absent; or it is present and displayed on the side (left, right, top, bottom) of the middle position, displaying information about the entire pipetting process or other information, or displaying no information; and the output window for the future step i=2 is on the side of the middle position and facing the first position (e.g., right, left, top, bottom). After step i=1 ends, the first output window switches from the middle position to a side position, and the second output window related to the currently ongoing step i=2 switches to the middle position, while the third output window related to the future step i=3 is re-displayed in another side position of the display bar.

[0140] Preferably, a progress indicator is displayed on the output screen page, particularly on the display element, and especially in at least one output window of the display element. The progress indicator contains information about the progress of the multi-step pipetting process. Specifically, it can display the count index i and the value N of the total number of sub-steps in the multi-step pipetting process, for example, in the form of text output "iofN" or "i / N". The progress indicator may additionally or alternatively include a non-numerical and graphical representation of the progress, particularly a progress bar, or a path representing the continuously occurring sub-steps 1...N, with the currently ongoing sub-step i highlighted graphically.

[0141] If the display element has multiple output windows according to the steps, such as in a display scroll bar, then it can be specified that the switching from the first view to the second view of the display element is shown animatedly. Furthermore, the lateral position of the display scroll bar can be shown in a shaded or highlighted manner to simulate or show three-dimensional objects (scrolls, wheels), and / or to simulate or show the viewing angle. This makes working with the pipetting device even more intuitive.

[0142] The data processing device is preferably programmed so that the pipetting apparatus has exactly one first and one second operating element, which can be operated separately from each other, particularly by operating the pressure plate. Relatedly, an unloading button can be provided for unloading the pipetting container, especially the pipetting tip. This makes operation intuitive and ergonomic.

[0143] The data processing device is preferably programmed to detect user manipulation of the control elements, particularly the first control element, and to initiate a pipetting process defined by a set of parameters based on the manipulation of the control elements. This may involve initiating the pipetting process directly after manipulating the control elements, or performing one or two intermediate processes before initiation, such as purging (i.e., removing residual liquid from the pipetting container by means of an overstroke), or pre-wetting the pipette tip by absorbing and discharging a pre-wetting volume of the sample once or multiple times before initiating further steps of the pipetting process, or a mixing step may occur, which specifies the absorption and discharging of a mixing volume before initiating further steps of the pipetting process.

[0144] The pipetting apparatus preferably has first and second operating elements, each being a separately arranged button. The pipetting apparatus preferably has an operating plate and first and second operating elements, which can be operated separately from each other by operating the operating plate in such a way that pressing a first pressure surface of the operating plate operates the first operating element and pressing a second pressure surface of the operating plate operates the second operating element, wherein the first and second pressure surfaces are tactilely distinguishable. The first and second pressure surfaces are distinguishable in particular by external features that are subsequently perceptible and distinguishable by touch: * the optional direction of the arching of the first and second pressure surfaces, particularly by making the first pressure surface concave and the second pressure surface convex; * the surface structure of the first and second pressure surfaces; * the material of the first and second pressure surfaces. In a predetermined operating state of the pipetting apparatus, for example, after activating the execution mode by pressing one of the operating elements in a setting mode, the first operating element particularly facilitates sample absorption, and the second operating element particularly facilitates sample dissipation. Alternatively, the second operating element particularly facilitates sample absorption, and the first operating element particularly facilitates sample dissipation.

[0145] The pipetting device preferably has a housing configured for a user to hold the pipetting device handle with one hand, and the housing has an axial section containing a piston extending along the longitudinal axis A of this axial section.

[0146] The pipetting device has first and second operating elements, which can be operated separately from each other by operating plates mounted on the platform surface of the pipetting device, particularly the thumb support surface. The platform surface is arranged at an angle of 80° < α < 180° to the longitudinal axis and preferably downwards. When the longitudinal axis of the pipetting device is arranged parallel to gravity, the direction "downwards" refers to the direction of gravity. The platform surface is arranged in such a way that the user's thumb rests on the thumb support surface with virtually no effort (the "optimal point" for the operating hand) when holding the pipetting device with one hand.

[0147] The pipetting device preferably has a housing, which is made of or constructed of plastic.

[0148] The platform surface is preferably perpendicular to a plane that extends through the longitudinal axis and is perpendicular to the screen surface.

[0149] The pipetting device preferably has a housing with: a moving element, particularly an axial section comprising a piston or piston rod, the moving element extending along the longitudinal axis of this axial section; and a head section having a front surface inclined relative to the longitudinal axis, the front surface having a screen surface and preferably formed by a frame surrounding the screen, wherein the screen occupies at least 70%, preferably at least 80%, or even at least 90% of the front surface; and

[0150] Specifically, the front of the frame is located in the first plane, and the screen is located in a second plane that is either consistent with or parallel to the first plane.

[0151] The pipetting apparatus preferably has a housing with a connection section for at least one pipette and an unloading button. The contact surface of the unloading button is movable into the housing along a path by pressing the button. The pipetting apparatus is configured to unload at least one pipette, particularly a pipette tip, upon reaching the end of this path, or to generate an electrical signal that triggers the unloading of at least one pipette, particularly a pipette tip. The unloading button may be spring-supported. Unloading can also be purely mechanical, wherein the energy required for unloading is applied by the user directly during unloading or indirectly through a tensioning spring element when mounting the pipette tip.

[0152] This invention also relates to a system for inputting pipetting parameters, comprising a handheld pipetting device according to the invention, and

[0153] External data processing devices, particularly smartphones or laptops, have external screens. These external screens are not integral parts of the pipetting apparatus. The data processing device is programmed to display an external input screen page (“set”) on the external screen, used for displaying and inputting pipetting parameters. The external input screen page is essentially identical in content to the pipetting apparatus's input screen page; that is, it has the same functionality as the pipetting apparatus's screen pages, especially the input screen page.

[0154] The system is configured to transmit pipetting parameters defined on an external data processing device to the pipetting device and use them there to define the pipetting process, and / or transmit pipetting parameters defined on the pipetting device to an external data processing device and store them there.

[0155] The present invention also relates to computer program code for providing an input screen page on the screen of a handheld pipetting device for pipetting at least one liquid sample and having: a connection section for connecting at least one pipette container; electrically controlled motion elements, particularly pistons, piston rods, or other elements for aspirating at least one sample into at least one pipette container, holding the sample in at least one pipette container, and discharging the sample from at least one pipette container during the pipetting process; and a touch-sensitive screen for inputting parameter values ​​that can be defined by the user, wherein a set of pipetting parameters completely defines the pipetting process, and wherein the pipetting device has an electrical control device programmed to control the motion element according to at least one pipetting parameter, the control device having a data processing device and at least one actuating element operable by the user's finger pressure, particularly thumb pressure, and actuating the actuating element to initiate the pipetting process defined by the parameter set.

[0156] Specifically, when the program code is run by the data processing device of the handheld pipetting device, the program code causes,

[0157] a) Display the input screen page (“set”) on the screen for displaying and inputting pipetting parameters for the parameter group.

[0158] b) When manipulation of at least one control element is detected, an output screen page (“do (execute)”) for displaying the pipetting parameters of the parameter set is displayed on the screen, and optionally: under such manipulation of the control element or the immediate following manipulation, the pipetting process is also initiated according to the current pipetting parameter set, and

[0159] c) A special button is displayed on the output screen page. Touching this special button will close the output screen page and display the input screen page on the screen.

[0160] Alternatively, when the program code is run by the data processing unit of the handheld pipetting device, the program code causes...

[0161] A graphical user interface (GUI) is displayed on a screen, wherein the GUI includes at least: a screen page, particularly a main screen, displayed on the screen page, and pipetting parameters of a parameter group of pipetting parameters, wherein the screen page includes at least one first input window, the first input window displaying the value of at least one first pipetting parameter of the parameter group, particularly a basic parameter group, the parameter group defining a pipetting procedure, particularly a basic pipetting procedure, and touching the first input window opens an input interface that allows a user to input the value of at least one first pipetting parameter, wherein the screen page has at least one input box, touching the input box enabling the user to select at least one second pipetting parameter, wherein a data processing device is programmed to add at least one second pipetting parameter to at least one first pipetting parameter of the parameter group, particularly the basic parameter group, after detecting such a user selection, so as to form, together with the at least one first pipetting parameter, the pipetting parameters of the user parameter group, the pipetting parameters defining the user-defined pipetting procedure, and displaying such selection of at least one second pipetting parameter to the user on the screen page, particularly the main screen.

[0162] The pipetting apparatus or external data processing device preferably has a data storage device. This data storage device preferably has a data memory, particularly a hardware data memory, particularly a non-volatile data memory, particularly an EPROM or FLASH memory. The data storage device may also have a volatile data memory.

[0163] The electrical control device of the pipetting apparatus or external data processing device, also abbreviated as control device, preferably has a data processing device, especially a central processing unit (CPU). The data processing device may include a microcontroller. The control device preferably has a microcontroller. The control device preferably has at least one storage device or data memory for storing data, particularly pipetting parameters and / or one or more computer programs or computer program code.

[0164] The control device preferably includes at least one control software or control program that uses the at least one pipetting parameter to automatically perform at least one function of the pipetting process, or a part of the pipetting process, or the pipetting process itself. The control software or control program is implemented, particularly by the data processing unit of the control device, and especially by the CPU of the data processing unit. The control software or control program is stored, in particular, in the device's data storage device. This data storage device is preferably a non-volatile memory.

[0165] Pipettes or external data processing devices can incorporate sensor devices, such as sensors for detecting ambient parameters, particularly temperature, humidity, or pressure, and sensors for the current of the piston-driven motor in the pipette. The motor current can be used, in particular, to determine the viscosity of the liquid being pipetted, and thus to identify the liquid. The sensor devices can also be configured to perform measurements that determine parameters, particularly pipetting parameters, particularly the type of pipette connected to the pipette, and particularly the maximum filling volume of the pipette, especially the pipette tip. The pipette or external data processing device can be configured to automatically determine at least one pipetting parameter based on the measurements from the sensor devices. This improves the optimization of the pipetting parameters required for accurate pipetting.

[0166] The pipetting equipment and / or external data processing equipment preferably operate independently of the power grid. The corresponding equipment may in particular be equipped with a rechargeable power source, such as one or more batteries. In this case, the equipment may have a charging interface connected to the rechargeable power source.

[0167] Pipettes are primarily disposable products and are preferably made of plastic. Depending on the maximum required liquid volume, different pipette tips can be used with piston-stroke pipettes. Typical rated volumes for commercially available pipette tips are, for example, 10 μL, 20 μL, 100 μL, 200 μL, 300 μL, 1000 μL, 1250 μL, 2500 μL, 5 mL, and 10 mL (μL: microliter; mL: milliliter). Pipettes typically have a tapered container extending longitudinally along its longitudinal axis, with a liquid exchange opening at the lower end and a tapered and tubular, upward-opening end section at the upper end, which can be fitted, in particular, into the connecting section of a pipetting device configured as a working cone, such as an air-cushion pipette. Liquid is drawn into the pipette tip by negative pressure within its internal space. In the case of a pipette device configured as an air-cushion pipette, this negative pressure is generated by the movement of a piston-like moving element within the pipette tip, creating a negative pressure above the sample in the air chamber. The internal space of the pipette tip is connected to the pipetting channel of the piston-stroke pipette in a pipetting position, also known as the fitting position (where the pipette tip is connected to the connecting section of the piston-stroke pipette). This pipetting channel is loaded with negative / overpressure by an electrically movable piston cylinder within the hollow cylindrical piston chamber of the piston-stroke pipette.

[0168] Dispensing pipette tips are used in direct squeezers, where there is essentially no air cushion between the piston and the liquid sample during pipetting. The piston is an integral part of the dispensing pipette tip. This tip has a container portion with a spout that acts as a piston cylinder, and a container opening into which the piston fits, allowing it to be movably positioned within the piston cylinder and to replace the entire volume of liquid drawn in its final position. When connecting the dispensing pipette tip to a pipetting device configured as a direct squeezer, the container portion is connected to the pipetting device via a screw-on connection section, and the piston is connected to the moving element via a coupling device. Dispensing pipette tips are typically disposable and preferably made of plastic. Different dispensing pipette tips are used with direct squeezers depending on the maximum required liquid volume. Typical rated volumes of commercially available dispensing pipette tips are, for example, 100 μL, 200 μL, 500 μL, 1 mL, 2.5 mL, 5 mL, 10 mL, 25 mL, and 50 mL.

[0169] This invention relates to a handheld pipetting device, a data processing device that works in conjunction with such a pipetting device, a system, and a computer program or computer program code that can be stored, in particular, on a data storage medium. Possible and preferred designs for any of these subjects are derived from the description of all designs for the other subjects, with the feasibility of designing a handheld piston-stroke pipette particularly evident from the description of methods, especially external data processing devices, systems, and computer programs. Attached Figure Description

[0170] Further preferred designs of the handheld piston-stroke pipette according to the method of the present invention, the data processing device, the system, and the computer program cooperating with this method, will be derived from the following description of the embodiments in conjunction with the accompanying drawings. Identical components of the embodiments are indicated substantially by the same reference numerals unless otherwise stated or can be deduced from the context.

[0171] In the picture:

[0172] Figure 1a An embodiment of the pipetting device according to the invention, herein a cushion pipette, is shown in a schematic side view;

[0173] Figure 1b It shows Figure 1a Details of the operating plate 1 of the pipetting device;

[0174] Figure 1c It shows Figure 1a A view of the pipetting apparatus after it has been slightly rotated about the longitudinal axis A;

[0175] Figure 1dShown in the stereoscopic side view Figure 1a Details of the pipetting device, featuring a visible touchscreen;

[0176] Figure 1e The system according to the invention is illustrated schematically according to an embodiment;

[0177] Figure 2a Two figures illustrating the head region of the pipetting device according to the invention, according to an embodiment, demonstrate the functionality of the GUI of the pipetting device to switch between two main types of screen pages, namely, between an input screen page and an output screen page.

[0178] Figure 2b An input screen page for the GUI is shown, and below this input screen page are symbolically shown the control elements of the pipetting device, starting from the input screen page (“set”). The input screen page is replaced by an output screen page by manipulating the control elements, and the output screen page or its contents change continuously during the dispensing pipetting process (“Dis”) shown here.

[0179] Figure 2c The GUI input screen page is shown, with a list of abbreviations for the currently selected pipetting parameter group. The list of abbreviations is implemented as "tags" arranged at the top edge of the screen, with each tag showing the abbreviation of the selected pipetting parameter. The user can thus see the selected pipetting parameters even if he / she does not see the entire (scrollable) selection list.

[0180] Figure 2d The diagram shows the GUI's input screen pages, particularly the main screen, and the parameter selection screen page. When a single input box on the input screen page is touched, the parameter selection screen page is overlaid on top of the input screen page.

[0181] Figure 2e During the multi-step dispensing process, the output screen pages of the pipetting device according to the invention, as described in the embodiment, are shown in the first state of step i=2 and the second state of step i=3.

[0182] Figure 2f The output screen page of the pipetting device according to the invention, as described in the embodiment, is shown during the multi-step dispensing process.

[0183] Figure 3a Two figures illustrating the head region of the pipetting device according to the invention, as described in the embodiment, illustrate further functionality of the pipetting device's GUI, namely, adding further pipetting parameters or functions to the current parameter group from the main screen via a selection list in the selection screen.

[0184] Figure 3b Two diagrams illustrating the head region of the pipetting device according to the invention, as described in the embodiment, further demonstrate the functionality of the pipetting device's GUI, namely, adding further pipetting parameters or functions to the current parameter group starting from the main screen with scrollable content or a scrollable selection list.

[0185] Figure 4 The functionality of the GUI of the pipetting device according to the invention is illustrated by means of multiple illustrations of the screen of the pipetting device according to the embodiment, namely, switching between the display of different screen pages.

[0186] Figure 5a The screen of the pipetting device according to the invention, according to an embodiment, illustrates the function of the GUI of the pipetting device, namely, setting pipetting parameter values ​​by means of an input mask.

[0187] Figure 5b Two figures of the screen of the pipetting device according to the invention, as described in the embodiment, illustrate the functionality of the GUI of the pipetting device, namely, calling up a history list of pipetting parameters or using an optional menu bar with an input box for input screen pages or an information box used as a navigation aid and not as an input box.

[0188] Figure 6 The screen of the pipetting device according to the invention, according to an embodiment, illustrates the functionality of the GUI of the pipetting device, namely, selecting a predetermined set of parameters representing a specific application scenario.

[0189] Figure 7a Two figures on the screen of the pipetting device according to the invention, according to an embodiment, illustrate the function of the GUI of the pipetting device, namely, marking the current parameter group as a favorite, the current parameter is then stored as a favorite and, in particular, displayed as a selectable list item in the favorites screen page, i.e., as a corresponding informational input window.

[0190] Figure 7b Two figures of the screen of the pipetting device according to the invention according to an embodiment illustrate the function of the GUI of the pipetting device, namely, the input window representing the collection parameter group in the collection screen page has an input box, touching the input box transmits the parameters of the collection parameter group to a separate screen, and then the separate screen is displayed, in which the parameter values ​​and / or parameter selections of the collection parameter group can be changed.

[0191] Figure 8a Together with 8b, and with the aid of a series of diagrams of a screen with the control elements of the pipetting device according to the invention shown below (symbolically), the functionality of the GUI of the pipetting device is shown, i.e., defining the pipetting parameters of the pipetting process defined by the user through the recording function of the pipetting device.

[0192] Figure 9 The functionality of the GUI of the pipetting device is illustrated by a series of diagrams of a screen with the control elements shown below (symbolically) of the pipetting device according to the invention in accordance with an embodiment, namely, selecting and editing parameter groups created by the user through the recording function for changing purposes. Detailed Implementation

[0193] Figure 1a A handheld pipetting device according to the invention is shown for pipetting at least one liquid sample, here being an air cushion pipetting device 1. This pipetting device has:

[0194] For connecting at least one pipette container 19, here the connection section 2 for a pipette tip.

[0195] A piston 3 is an electrically controlled moving element, in this case, for aspirating at least one sample into at least one pipette 19, holding the sample in at least one pipette 19, and discharging the sample from at least one pipette during the pipetting process.

[0196] A touch-sensitive screen 4 on the front 14a of the head section 14 of the pipetting device is provided for inputting parameter values ​​that can be defined by the user, wherein the set of pipetting parameters completely defines the pipetting process. The electrical control unit 5 includes a data processing unit 6, a data storage unit 7, and a communication unit 8 for wireless communication with external data processing devices. The data processing unit is programmed to control the motion element 3 according to at least one pipetting parameter.

[0197] There are exactly two operating elements (synonyms: manipulation elements) 9a and 9b, which can be operated by the user via the operating plate 10. Each of these manipulation elements can be used to switch the pipetting device from input mode ("set") to output mode ("do"), in which input screen pages 100, 100' are displayed on the screen, for example... Figure 1d The main screen shown, in output mode, displays the output screen page. This advantageous aspect of the operating scheme also benefits from further... Figure 2a , 2b Please explain further with reference to button 4. The activation of the unloading button 15 and the "Power on / off" button (not shown) of the pipetting device will not cause switching between "set" and "do" modes. This is achieved through the use of the additional button, also referred to herein as the "additional button". Figure 1d The input box 101' with a "+" sign can process a list of pipetting parameters belonging to the parameter group.

[0198] The operating plate has: a lower, recessed section 10b, which, when operated, activates button 9b and, in particular, facilitates sample ejection; and an upper, convex section 10a, which, when operated, activates button 9a and, in particular, facilitates sample absorption. The operating plate rests on a platform formed by the housing sections, with the operating plate forming an angle of approximately α = 130-140° with the longitudinal axis A of the pipette. Due to the handrail 16 arranged perpendicular to the longitudinal axis beside the platform, the pipette rests ergonomically in the hand, allowing the thumb to rest on the plate 10 when at rest, as the hand posture allows the thumb to support itself at the "sweetspot." A screen 4 is arranged in the head housing section 14 of the pipette.

[0199] The pipetting apparatus has an electric motor 18, which is powered by a battery 17 and causes the piston rod or piston 3 to move within the piston cylinder 12, resulting in suction or discharge pressure in the pipetting channel 13. Precise measurement is possible through electronic control. An unloading button 15 is provided, which, via the pipetting apparatus's unloading sleeve, allows the pipetting tip 19 to be unloaded from the connecting section 2. The data processing unit is specifically programmed to interrupt the ongoing pipetting process when the unloading button 15 is activated and replace any output screen pages that may still be displayed with input screen pages 100, 100'.

[0200] The pipetting process, defined according to the current parameter set, is initiated by the user operating either of the two control elements 9a and 9b. The GUI enables the selection of pipetting parameters defining the desired semi-automatic pipetting process and the setting of these parameters, thus implementing the specific operating scheme according to the invention. This operating scheme is illustrated in the following figures.

[0201] Data processing device 6 is programmed (see) Figure 2aThe screen 4 displays input screen pages 100 and 100' ("set", see the contents of the rectangle enclosed in dashed lines) for displaying and inputting pipetting parameters for a set of parameters. When manipulation of at least one of the manipulation elements 9a or 9b is detected, an output screen page 200 ("do") for displaying the pipetting parameters for the set of parameters defined in the input screen pages is displayed on screen 4. Furthermore, when such manipulation of at least one of the manipulation elements is detected, or when one of the manipulation elements is subsequently manipulated (according to optional safety prompts), a pipetting process defined according to this set of pipetting parameters is initiated. The output screen page 200, or another output screen page displayed after the output screen page 200, has an input area at the lower edge of the screen designed as a special button 201 (labeled with the information "back"), which, when touched, closes the output screen page 200 and displays the input screen page 100 or another screen page, particularly the input screen page, on screen 4. In particular, when a second operation is performed on one of the control elements 9a and 9b (different from the screen) immediately following the first operation, the pipetting process defined according to the current pipetting parameter set is initiated.

[0202] The other screen pages may specifically enable editing of parameter values ​​contained in the pipetting parameter group. When the pipetting sequence ("do") has begun, for example, if only a rapid speed adjustment is needed, then it is not necessarily the previous input screen page 100. It can be specified that after the pipetting process begins, not all parameter values ​​can be changed / corrected, but only specific parameter values ​​of the current pipetting parameter group can be changed / corrected.

[0203] The difference between input screen page 100 and output screen page 200 lies in their representation of graphics and / or text or numbers, particularly coloring: the input boxes of input screen page 100 are mostly displayed in black (letters, numbers, input box color) against a light or white background, while the display boxes of output screen page 200 are mostly displayed in brown against a light or white background. The black input box 101 (also known as the auxiliary button) that invokes the selection screen for choosing pipetting parameters on the input screen is absent on the output screen page.

[0204] The output screen page 200 preferably displays different content according to the specific steps of the automated multi-step pipetting process, especially the values ​​of the pipetting parameters currently defined for those steps, such as discharging a specific volume Vt at a specific discharge rate v2 as step i out of a total of N steps in the pipetting process. This can be, for example, in... Figure 2bThe application scenario "Dis (dispensing)" shown is as follows.

[0205] exist Figure 2b The first image shows an input screen page 100_1, which contains a set of pipetting parameters for partially automated operation of the dispensing process. An additional button 101_1, graphically slightly modified from the additional button 101, similarly enables processing of the pipetting parameter list. Therefore, according to the invention, the screen page has an input box, i.e., the additional button here, which, when touched, allows the user to select at least one second pipetting parameter. Operation of the control element, i.e., the switch 9a of the operating plate 10 or the first pressure surface 10a here, imports the pipetting apparatus from the "set" mode to the "do" mode, now displaying the output screen page 200_1, which includes an additional button 201_1, graphically modified from the additional button 201, but otherwise functioning similarly. After the extraction process is performed, for example, after a 2-second time interval (during which 360 μL of solution is extracted into the pipette within 2 seconds), the output screen page 200_1 displays the output screen for the first dispensing volume step of dispensing 120 μL. Manipulating the control element, in this case, manipulating the second pressure surface 10b of the operating plate 10, pushes the dispensing volume out; any further manipulation of the pressure surface 10b results in the next dispensing step. The dispensing steps are counted by an exponential counter i = 1…3, and the progress display i / N (i = 1…3; N = 3) shows the progress of the semi-automatic dispensing process in the output box of the output screen page. To allow the user to have a more intuitive understanding of the progress, a variable display element can be used, for example, in… Figure 2e and 2f The display scroll bar is shown in the image. Output screen page 200_1 does not have this changeable display element; the output window is always in the same position on output screen page 200_1, with only the display of parameter values ​​and progress changing.

[0206] Figure 2eIn the multi-step dispensing process, in the first state of step i=2 (left side of the figure) and in the second state of step i=3 (right side of the figure), the output screen page 200' of the pipetting device is shown. The output screen page has a variable display element 203' designed to display a scroll bar. In the variable display element with at least one output window, the position of at least one output window within the display element can be changed. The display scroll bar 203' has a central output window 203a' that displays: the pipetting parameter "partial discharge volume", a value of 200 μl for the dispensing process with (N=6) steps; the discharge rate "8"; and a digital progress indicator ("2 / 6"). Above and adjacent to the middle output window 203a' is the upper output window 203b', which displays "Dispense 200 μL" for the previous discharge step (i=1). Below and adjacent to the middle output window 203a' is the lower output window 203c', which displays "Dispense 200 μL" for the discharge step (i=3) immediately following the current step i=2. The same output screen page 200' is shown on the right side of the figure, during the next discharge step accompanying i=3. Above and adjacent to the middle output window 203a' is an upper output window 203b', which displays "Dispense 200μL" for the previous dispensing step (i=2). Below and adjacent to the middle output window 203a' is a lower output window 203c', which displays "Dispense 200μL" for the dispensing step (i=4) immediately following the current step i=3. The transition of the view of display element 203' from i=2 to i=3 (from left to right) can be animated to show the dynamics of the progress. The changeable display elements make the perception of multi-stage pipetting processes and the operation of the pipetting device more intuitive. In the case of the final dispensing step (i=N; here i=6), the position 203c' below the display bar either displays information about reaching the end, other information, or nothing, or the corresponding output window 203c' is not even displayed. A similar situation can be set for the upper output window 203b' in the first row sub-step i=1, and the upper output window then, for example, does not display anything or is omitted.

[0207] The display scroll bar has a horizontal axis of rotation, while the output window position switches vertically. A vertical or tilted axis of rotation is also possible.

[0208] Figure 2fIn a multi-step (M=32) pipetting process, the output screen page 200″ of the pipetting device is shown in a state where step i=8. A display bar 203″ is also shown here, having a middle output position or output window 203a″, an upper output window 203b″, and a lower output window 203c″, which function similarly to the display bar 203′. Furthermore, the output screen page 200″ has additional functions achieved through further output and input boxes. The output screen page preferably does not have input boxes, which display the values ​​of the pipetting parameters, and touching these input boxes in subsequent steps allows the pipetting parameters to be changed, as is possible in the current embodiment. The pipetting parameters cannot be changed in the "Do (Setting)" mode, which is preferably present during the display of the output screen page; this can only be achieved through intermediate steps, and not all parameters in the parameter group are changeable. For example, it may be possible to change the rate of liquid discharge / absorption during the ongoing multi-step pipetting process.

[0209] The output screen page 200″ has an input box located at the edge, in this case, the lower right corner. It displays the word "Pause" and provides a pause function. Touching this input box pauses a multi-step pipetting process, for example, after completing a dispensing step N=3 at i=1, which is also the eighth step in a programmed pipetting process of 32 steps. For cases where this eighth step must be repeated due to user error, an input box with an exclamation mark and a circular arrow allows the pipetting process to be repeated. Therefore, according to GUI logic, this input box does not display the values ​​of the pipetting parameters, and touching it allows changing the pipetting parameters in the next step.

[0210] In these embodiments of pipetting devices, the "touch" input field always results in a direct effect, meaning that the effect occurs without significant delay and preferably without displaying an additional screen page, such as a noticeably delayed information page also known as a "waiting page," between the time of touch and the time of effect display (e.g., opening the input interface). However, there may also be GUI scenarios where such an intervening information page is meaningful.

[0211] As in Figure 2fAs shown, in a multi-step (M=32 here) pipetting process, a progress bar may be meaningful, and the progress can be graphically displayed, also numerically (“8 / 32”). The note “Protocol Lisa 250” in output window 222″ indicates that a pipetting process with a user-defined name “Lisa 250” is executed and simultaneously recorded, for example, a personalized programmable process, stored, for example, in the pipetting device's protocol file. Special button 201″, as is typically defined, causes the output screen page 200″ to close. Generally, not every output window is an input window, and therefore does not have an input box; touching an input box triggers a function, and therefore no input is possible.

[0212] The preferred implementation of a solution that distinguishes between the input and output screens through external differentiation offers significant ergonomic advantages during operation, as the user can easily determine whether they are in a potentially interrupted, awaiting pipetting process or in a setting mode. The input and output screen solution thus means that the pipetting device offers easily distinguishable input and output modes for the user. Preferably, changing parameter values ​​or reselecting parameters is possible simply by touching a separate input area (a special button) or ending the pipetting process (ending the process automatically returns to the input screen, particularly the main screen). This separation particularly prevents unintentional changes to parameter values ​​while operating in "do" mode, which could ruin laboratory work and result in significant financial loss. On the other hand, switching from "set" mode to "do" mode by manipulating the control element provides great user comfort and intuitiveness. This also greatly contributes to ergonomics and efficient workflows. Output screen pages (e.g., 200) are preferably designed such that the display boxes or windows contained within them, such as output window 203, are purely informational and therefore do not function as input boxes, and touching them, in particular, does not produce any action, especially not activating any input options. This does not apply to the separate operation box of the output screen page, here a special button 201, which, when touched, cancels the output mode and causes the input screen page to be displayed on the screen, and in particular may end the currently ongoing pipetting process or procedure.

[0213] The pipetting device 1 has exactly one first actuating element 9a and a second actuating element 9b, which can be operated separately from each other via the operating plate 10. The data processing unit 6 is programmed to detect the operation of the first or second actuating element 9a or 9b by the user and initiate a pipetting process defined by a set of parameters.

[0214] The pipetting device has an operating plate 10 and a first operating element 9a and a second operating element 9b, which can be operated separately from each other via the operating plate 10 in such a way that pressing the first pressure surface 10a of the operating plate 10 operates the first operating element 9a and pressing the second pressure surface 10b of the operating plate operates the second operating element 9b, wherein the first and second pressure surfaces are tactilely distinguishable. The first pressure surface 10a is convex (= outwardly arched), and the second pressure surface 10b is concave. The user can thus touch the desired operating element or desired side (pressure surface) of the operating plate without visual control, making operation intuitive and ergonomic.

[0215] The pipetting device 1 has a housing 11, which serves as a handle for the user to hold the device with one hand. The housing has an axial section 11 containing a moving element 3 extending along the longitudinal axis A of this axial section. An operating plate is mounted at a thumb support surface, which is arranged at an angle of 80° < α < 180° to the longitudinal axis, preferably at an angle of α = 100°-150°, preferably 130°, relative to the longitudinal axis, and particularly inclined downwards. "Downwards" refers to the orientation of the pipetting device with a vertically oriented longitudinal axis A and a pipette tip 19 pointing in the direction of gravity. The angled arrangement of the platform section of the operating plate provides an ergonomically designed thumb support surface. The thumb support surface is arranged with the longitudinal axis as its starting point and is positioned perpendicular to a plane extending through the longitudinal axis A and perpendicular to the plane of the screen 4. The platform section, with reference to the longitudinal axis, is also advantageously positioned at the same height as the armrest, which is also ergonomically sound.

[0216] The head section 14 has a front surface 14a that is inclined relative to the longitudinal axis A. This front surface is formed by the surface of the screen 4 and the frame surrounding the screen, wherein the screen occupies approximately 80% of the front surface. The frame front surface 14a is located in a first plane, and the flat screen 4 is located in a second plane that coincides with the first plane. This allows the user to easily touch the edge areas of the screen, thus optimizing the use of the available surface of the touchscreen 4. Simultaneously, the screen edges are not exposed and are protected by the frame front surface 14a.

[0217] The housing 11 has a connection section 2 (working cone) for at least one pipette 19 and an unloading button 15. The contact surface of the unloading button can be moved into the housing along a stroke by pressing the unloading button. The pipetting device is configured to unload the pipette, particularly the pipette tip, when the end of this stroke is reached, or to generate an electrical signal that triggers the unloading of at least one pipette.

[0218] Figure 5aThe data processing device is programmed to display screen page 102 on the screen, the screen page including at least one first input window 103, here 103a, 103b, 103c, at least one first input window displaying the value of at least one first pipetting parameter (here: 103a: V = 120 μL, 103b: v = (v1, v2), with discharge rate v1 = 8 levels, absorption rate = 8 levels; number of steps n = 3). Touching the first input window opens an input interface that allows the user to input the value of at least one first pipetting parameter. This input interface is a screen area, in particular displaying a numeric keypad. The numeric keys of the keypad can be individually touched and used by the user to input a sequence of numbers that defines the value of at least one first pipetting parameter. The input windows are here white rectangular areas of the screen, visible through corresponding diagrams or in contrast to a gray background, and extend across almost the entire width B of screen 4 with their width b. This results in advantageous ergonomics. While this applies to the input window, it does not necessarily apply to all input boxes on the input screen page; see [link / reference]. Figure 1d The input interface is located in the screen area of ​​the new screen page 100a, where... Figure 5a The values ​​are shown on the right and overlaid on screen page 100. When the input windows 103b and 103c for the relevant pipetting parameters v = (v1, v2) and n are opened, similar screen areas 100b and 100c are opened. Alternatively, when the absolute number of replacements should be set to divide the total volume V (e.g., by dividing into multiple sub-steps or sub-volumes via a dispensing step), the screen area correspondingly includes input boxes in a list of possible fractions f = 0.1 to 1.0.

[0219] Figure 3a The data processing device 6 is particularly preferably programmed to display a screen page 100 on screen 4, which is designed here as the main screen, for displaying pipetting parameters of a parameter group. This screen page includes at least one first input window 103 (here, three input windows 103a, 103b, 103c) that displays the value of at least one first pipetting parameter of the basic parameter group (here: V, v = (v1, v2), n). Touching the at least one first input window opens an input interface. Figure 5aFor example, a screen area with a numeric keypad on screen page 100a allows the user to input the value of at least one first pipetting parameter. Screen page 100 includes an input box 101; touching this input box causes a display, on a separate screen page 110, of a selection list containing brief descriptions of further selectable pipetting parameters (here, qm, rev, st, abo, etc.) (here, "quick mix", "reverse", "step time", "auto blow"). The user selects at least one second pipetting parameter (e.g., qm, rev, st, or abo) from a list of parameters such as "off (automatic blow-off)". This second pipetting parameter complements at least one first pipetting parameter from a basic parameter set, defining the pipetting parameters that determine the pipetting process. After selecting at least one second pipetting parameter, the selection list is closed and screen page 100 is displayed again. This screen page now displays at least one second input window in addition to at least one first input window 103. The at least one second input window displays the value of at least one second pipetting parameter (e.g., qm, rev, st, or abo). Touching the second input window opens an input interface 100d, allowing the user to input the value of at least one second pipetting parameter.

[0220] As an alternative to the display of alternative screen pages 110 (which show selectable parameters, and from which users return to the main screen 100 after selecting / deselecting the desired parameters via touch input window 104), it is possible to... Figure 3b As shown, the content of the main screen is expanded, for example, by extending downwards and by scrolling (vertically interacting or tapping on the operation box 105) into area 106, or also by other areas, in which possible pipetting parameters are listed and can be selected / activated, and their values ​​can then be edited.

[0221] The invention represents a particularly advantageous aspect of an inventive operating scheme for pipetting devices. Research on users reveals that, for a significant segment of users, the pipetting device enables the establishment of a more efficient workflow. In this device, users largely define their desired pipetting process according to their own wishes by supplementing existing, for example, proven or basic parameter sets with additional pipetting parameters—that is, adding functions or features. This approach clearly achieves the goal most effectively: defining the desired pipetting process. Especially when readily implementable basic parameter sets are displayed on the screen, particularly the main screen, it immediately provides a sense of operational accomplishment without requiring lengthy learning curves. Within a short learning time, users can find their way within the list of possible pipetting parameters and thus more effectively utilize the vast functional potential of the electric pipetting device. This is particularly suitable for a wide range of users who find it difficult to learn existing, more or less complex operating modes representing their application scenarios in known pipetting devices of the prior art and are content with the simplest operating mode. This novel approach invites inexperienced users to learn the functions and provides ample flexibility for experienced users.

[0222] The data processing device 6 is preferably programmed to display information on the screen when the value of the pipetting parameter input by the user through the input interfaces 100a, 100b, 100c, and 100d is not allowed, and preferably...

[0223] • Display at least one correction button. Touching this correction button will automatically perform at least one correction process, replacing the value entered by the user. The correction process can have the following design options:

[0224] - Automatically set allowed values ​​instead of disallowed values;

[0225] - Select at least one of the alternative pipetting parameters and, in particular, the value assigned to the user or other suitable value;

[0226] -Cancel user input and, in particular, allow re-entry;

[0227] and / or

[0228] • Output error messages;

[0229] and / or

[0230] • Ignore previous changes to the current value and retain the previous current value;

[0231] and / or

[0232] • Automatically deselect another uncombinable pipetting parameter that represents a function that cannot be combined.

[0233] The data processing device 6 is preferably programmed to display screen page 100 on screen 4, the screen page displaying a list of input windows 103a, 103b, 103c, the input windows extending substantially across the entire screen page.

[0234] Figure 4 The data processing device 6 is programmed to display a startup screen page 100 on screen 4, which is replaced by a second screen page 120 by a lateral swipe gesture and by a third screen page 130 by a lateral reverse swipe gesture. The second screen page 120 (see...) Figure 6 The third screen page 130 has a list of input boxes, each carrying an abbreviation (e.g., an input window with the abbreviation "measure volume"), and touching an input box loads a predefined set of parameters that defines a predefined pipetting procedure, wherein, in particular, another screen page 120a is displayed after touching this input box; and wherein, in particular, the third screen page 130 has a list of input boxes, each carrying an abbreviation (e.g., an input window with the abbreviation "150μL steps 6"), and touching an input box loads a previously used and automatically saved historical set of parameters that defines a historical pipetting procedure, wherein, in particular, other screen pages are displayed after touching this input box.

[0235] exist Figure 1e The diagram illustrates a system 300 for inputting pipetting parameters, comprising a handheld pipetting device 1 and an external data processing device 50. The external data processing device has an external screen 51 and a data processing unit 52, which is programmed to display an external input screen page on the external screen to display and input pipetting parameters for a set of parameters. The content of the external input screen page and the input screen page of the pipetting device are substantially the same. The system is configured to transmit pipetting parameters defined on the external data processing device to the pipetting device and use them there to define the pipetting process.

[0236] Figure 7a Two figures on the input screen page 100_3 of the pipetting apparatus according to the embodiment illustrate the function of the pipetting apparatus's GUI, namely, marking the current parameter group as a favorite. The current parameter group is then stored as a favorite and, in particular, displayed as an optional list entry in the favorites screen page, i.e., as a corresponding informational input window. The input window, correspondingly marked with a favorite symbol (small star), detects user touch, and due to the user touch, the pipetting parameter group defined in the input screen page 100_3 is stored as a favorite, which is indicated by a color change of the favorite symbol.

[0237] Figure 7b The functionality of the pipetting device's GUI is illustrated using two screen pages of the pipetting device according to the embodiment. Specifically, an input window labeled "Favorite Parameter Group" has an input box in the Favorite Screen Page 121. Touching this input box transmits the parameters of the Favorite Parameter Group to the main screen, i.e., Input Screen Page 100_4, which is then displayed. In this Input Screen Page, the parameter values ​​and / or parameter selections of the Favorite Parameter Group can be changed.

[0238] Figure 8a Together with 8b, and with the aid of a series of diagrams of a screen with the control elements of the pipetting device according to the invention shown below (symbolically), the functionality of the GUI of the pipetting device is illustrated, namely, defining the pipetting parameters of the user-defined pipetting process through the recording function of the pipetting device. Figure 8a The user-executed programming process begins on a screen page titled "Programs" and described as an "Automatic Programs Group Screen Page." Another program can be created using the "+" input box on this screen page. Then, on the next screen page, an input box for "Record" or "Record" is provided; touching this input box initiates the recording function or recording. Simultaneously, a separate "Record Mode" for the pipette is activated, in which, in one example, manipulating the control elements (9a, 9b) does not cause the piston 3 to move electrically; more precisely, the pipetting process is only simulated (though this can also be performed non-simulated). The pipetting process is only simulated, and the program steps are recorded. One feature of the recording function is that the manipulators 9a and 9b used only for sample absorption and discharge, along with the touchscreen and its input window 103 for setting pipetting parameter values, are required on the input screen page 100″. Programming is not required. During recording, a status bar on the screen displays the information "Recording…". Additionally, an input box with a stop symbol is provided to stop recording. The automatically assigned name "Program 2" is displayed as an input window in the program list on the screen page "Programs"; touching it allows editing the program, particularly changing its name.

Claims

1. A handheld pipetting device for pipetting at least one liquid sample, comprising a connection section for connecting at least one pipetting container, an electrically driven motion element for aspirating at least one sample into at least one pipetting container, holding the sample in at least one pipetting container, and discharging the sample from at least one pipetting container during the pipetting process, and a touch-sensitive screen for inputting values ​​of pipetting parameters that can be defined by a user, wherein, A set of at least one pipetting parameter defines a pipetting process, and includes an electrical control device with a data processing device programmed to control a motion element according to at least one pipetting parameter of the parameter set. The data processing device is also programmed to control a motion element according to at least one pipetting parameter of the parameter set, and includes at least one operating element that, when manipulated by a user, initiates the pipetting process defined by the parameter set. The data processing device is characterized by being programmed to display a graphical user interface (GUI) on a screen, wherein the GUI includes at least the following: displaying a screen page on the screen, displaying the pipetting parameters of the parameter set on the screen page, wherein the screen page includes at least one first input window displaying the value of at least one first pipetting parameter of a basic parameter set, the basic parameter set defining a basic pipetting process, and touching the at least one first input window opens an input interface allowing the user to input the value of at least one first pipetting parameter. The screen page has at least one... One less input box is provided. Touching the at least one input box enables the user to select at least one second pipetting parameter. The data processing device is programmed to add at least one second pipetting parameter to at least one first pipetting parameter in a basic parameter group after detecting such a user selection, so that together with the at least one first pipetting parameter, the pipetting parameters of the basic parameter group are formed. The pipetting parameters define a user-defined pipetting process, and the selection of at least one second pipetting parameter is displayed to the user on a screen page. After the selection of at least one second pipetting parameter is completed, the selection list is closed and a screen page is displayed. This screen page now displays at least one second input window in addition to at least one first input window. The second input window displays the selection and / or value of at least one second pipetting parameter, and touching the at least one second input window opens an input interface that allows the user to input the value of at least one second pipetting parameter.

2. The handheld pipetting device according to claim 1, wherein, An input box is set on the screen page. Touching the input box causes a predetermined number of available pipetting parameters to be displayed in the form of a selection list. The selection list contains information about the second pipetting parameters that can be selected. The user selects at least one second pipetting parameter from the selection list.

3. The handheld pipetting device according to claim 1, wherein, The screen page displays an N ≥ 1 number of input boxes, wherein each input box is equipped with and displays information about a second pipetting parameter that can be selected by means of the input box, wherein after the user selects at least one second pipetting parameter from the N number of input boxes, the selection and / or value of at least one second pipetting parameter is displayed, wherein in the case that at least one second pipetting parameter occupies a value that can be selected by the user, touching at least one second input window allows the user to input the value of at least one second pipetting parameter.

4. The handheld pipetting device according to claim 1, wherein, The data processing device is programmed to display a screen page on a screen, the screen page including at least one first input window, the at least one first input window displaying the value of at least one first pipetting parameter, and touching the at least one first input window opening an input interface that allows a user to input the value of the at least one first pipetting parameter, wherein the input interface is a screen area displaying a numeric keypad, the numeric keys of which can be individually touched and used by the user to input a sequence of numbers that defines the value of the at least one first pipetting parameter.

5. The handheld pipetting device according to any one of the preceding claims, wherein, The data processing device is programmed to display information on the screen and at least one correction button when the value of a pipetting parameter input by the user via the input interface is not allowed. Touching the correction button will either automatically perform at least one correction process instead of the value input by the user, the correction process having the following design options: - automatically setting an allowed value instead of the allowed value; - selecting at least one alternative pipetting parameter as the pipetting parameter and assigning it the user's value or other suitable value; - canceling the user's input and enabling re-input; and / or outputting an error message; and / or ignoring changes to the previous current value and retaining the previous current value; and / or automatically deselecting another uncombinable pipetting parameter representing an uncombinable function.

6. The handheld pipetting device according to any one of claims 1-4, wherein, The data processing device is programmed to display a screen page on the screen, the screen page displaying a list of input windows that extend across the entire width of the screen page.

7. The handheld pipetting device according to any one of claims 1-4, wherein, The data processing device is programmed to display a startup screen page on the screen, which is a screen page for displaying pipetting parameters of a parameter set. The startup screen page is replaced by a second screen page via a lateral pointing swipe gesture and by a third screen page via a lateral reversing swipe gesture. The second screen page has a list of input boxes, each carrying an abbreviation. Touching an input box loads a predefined parameter set that defines a predefined pipetting procedure. After touching this input box, the startup screen page with the predefined parameter set is re-displayed. The third screen page has a list of input boxes, each carrying an abbreviation. Touching an input box loads a previously used and automatically stored historical parameter set that defines a historical pipetting procedure. After touching this input box, the startup screen page with the historical parameter set is re-displayed.

8. The handheld pipetting device according to any one of claims 1-4, wherein, The data processing device is programmed to display an input screen page (100; 100') on the screen for displaying and inputting pipetting parameters of a parameter set, and when manipulation of at least one manipulator is detected, to display an output screen page (200) on the screen instead of the input screen page for displaying the pipetting parameters of the parameter set defined on the input screen page, and to initiate a pipetting process defined by the pipetting parameter set when such manipulation of at least one manipulator is detected or when one of these manipulators is subsequently manipulated, wherein the output screen page, or the output screen page to be displayed subsequently, has a special button that, when touched, closes the output screen page and displays the input screen page or another input screen page on the screen.

9. The handheld pipetting device according to any one of claims 1-4, wherein, The data processing device is programmed to implement a recording function, wherein the GUI has at least one input box for starting and / or ending recording, and after starting, records the steps of the pipetting procedure for performing a user-defined pipetting process, wherein the user performs these steps by manipulating the at least one manipulator and by entering values ​​of the pipetting parameters in one or more input screen pages.

10. The handheld pipetting device according to any one of claims 1-4, wherein, The pipetting device has an operating plate and first and second operating elements, which can be operated separately from each other by means of the operating plate, such that pressing a first pressure surface of the operating plate operates the first operating element and pressing a second pressure surface of the operating plate operates the second operating element, wherein the first and second pressure surfaces are tactilely distinguishable.

11. The handheld pipetting device according to any one of claims 1-4, wherein, The pipetting device has a housing configured for a user to hold the handle of the pipetting device with one hand, and the housing has an axial section including a piston extending along the longitudinal axis of the axial section, and wherein the pipetting device has first and second actuating elements that can be operated separately from each other by means of an operating plate mounted at a thumb support surface that is arranged at an angle of 80 < α < 180° with respect to the longitudinal axis and is inclined downward.

12. The handheld pipetting device according to any one of claims 1-4, wherein, The pipetting device has a housing with an axial section including a piston and a head section, the piston extending along the longitudinal axis of the axial section, and the head section having a front face inclined relative to the longitudinal axis, the front face being formed by the surface of the screen and a frame surrounding the screen, wherein the screen occupies at least 80% of the front face; and wherein the front face of the frame is in a first plane and the screen is in a second plane that is consistent with or parallel to the first plane.

13. The handheld pipetting device according to any one of claims 1-4, wherein, The pipetting device has a housing with a connection section for at least one pipette and an unloading button. The contact surface of the unloading button can move into the housing along a path by pressing the unloading button. The pipetting device is configured to unload the pipette from the connection section or generate an electrical signal that triggers the unloading of the at least one pipette when the end of the path is reached.

14. A system for inputting pipetting parameters, comprising: a handheld pipetting device according to any one of the preceding claims, and an external data processing device having an external screen and a data processing unit, the data processing unit being programmed to display an external input screen page "set" for displaying and inputting a set of pipetting parameters on the external screen, wherein... The external input screen page and the pipetting device input screen page are identical in content. The system settings are used to transmit the pipetting parameters defined on the external data processing device to the pipetting device and to define the pipetting process there.

15. A computer-readable storage medium having stored thereon computer program code for providing an input screen page on the screen of a handheld pipette for pipetting at least one liquid sample and having: a connection section for connecting at least one pipette container; Electrically controlled motion element for aspirating at least one sample into at least one pipette and holding the sample in at least one pipette during a pipetting process, and for discharging the sample from at least one pipette; The device includes a touch-sensitive screen for inputting user-defined pipetting parameters, wherein a set of pipetting parameters fully defines the pipetting process, and wherein the pipetting device has an electrical control unit with a data processing device programmed to control a motion element according to at least one pipetting parameter; and at least one actuating element operable by the user's finger pressure, which initiates the pipetting process defined by the parameter set, wherein when the program code is executed by the data processing device of the handheld pipetting device, the program code causes a) the display of a screen page for displaying the pipetting parameters of the parameter set, b) the screen page containing at least one first input window displaying the value of at least one first pipetting parameter of a basic parameter set defining a basic pipetting process, and touching the at least one first input window opens an input interface allowing the user to input at least one first pipetting parameter. c) The screen page has at least one input box, and touching the at least one input box enables the user to select at least one second pipetting parameter, wherein the data processing device is programmed to, after detecting such a user selection, add at least one second pipetting parameter to at least one first pipetting parameter of a basic parameter group so that together with the at least one first pipetting parameter, a pipetting parameter of a user parameter group is formed, the pipetting parameter defining a user-defined pipetting procedure, and displaying such selection of at least one second pipetting parameter to the user on the screen, wherein after the selection of at least one second pipetting parameter is completed, the selection list is closed and the screen page is displayed, the screen page now displaying at least one second input window in addition to at least one first input window, the second input window displaying the selection and / or value of at least one second pipetting parameter, and touching at least one second input window opens an input interface, the input interface enabling the user to input the value of at least one second pipetting parameter.

Images