Membrane fusion compounds for delivery of biologically active molecules
By designing membrane-fused compounds to form nanoparticles, the problem of low permeability of active agent molecules during intracellular transfection was solved, achieving efficient delivery and protection of cells and enhancing the delivery effect of active agents.
CN117105811BActive Publication Date: 2025-12-12NITTO DENKO CORP
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Patent Information
- Application Number
- CN202311077520.8
- Authority / Receiving Office
- CN · China
- Patent Type
- Patents(China)
- Current Assignee / Owner
- Priority Date
- 2017-11-06
- Filing Date
- 2018-11-06
- Publication Date
- 2025-12-12
- Estimated Expiration
- 2038-11-06
AI Technical Summary
Technical Problem
In existing technologies, active agent molecules suffer from low cell penetration when transfected into cells, especially for molecules that are sensitive in serum or other biological environments, making effective delivery and distribution difficult.
Method used
Nanoparticles with membrane fusion properties are formed by designing amphiphilic molecular structures as shown in chemical formulas I to XI, thereby improving cell permeability and delivering active agents.
Benefits of technology
It improves the transfection efficiency of active agent molecules into cells, achieves protection of the biological environment, and enhances the delivery effect of active agents.
✦ Generated by Eureka AI based on patent content.
Abstract
The present application relates to membrane fusion compounds for the delivery of biologically active molecules. The invention includes membrane fusion compounds, compositions thereof, and methods of use. The membrane fusion compounds can be used to manufacture nanoparticle compositions for use in biopharmaceuticals and therapeutics. More particularly, the present invention relates to compounds, compositions, and methods for providing nanoparticles incorporating or encapsulating active agents for the delivery and distribution of the active agents to cells, tissues, organs, and subjects.
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