An outdoor emergency device

Abstract

This invention relates to an outdoor emergency device, comprising an intelligent module for monitoring actual temperature changes and a cold source configuration module for controlling the input and / or output of at least two refrigerants. The intelligent module is configured to adjust the phase and ratio of the refrigerants in the cold source configuration module based on the monitored actual temperature changes, so that the actual temperature is maintained at a preset temperature. In special circumstances such as energy shortages or outdoor emergency rescue scenarios, carrying medication for treatment places high demands on storage devices; that is, storage devices that can meet the differentiated low-temperature preservation requirements of drugs with different physicochemical properties and facilitate drug access are needed. Compared to existing emergency storage devices, most of which achieve low-temperature preservation through power-cooled devices using mobile power supplies, the device involved in this application can achieve temperature regulation based on an independent low-temperature preservation structure, improving the adaptability and specificity of the device for low-temperature preservation of different types of active materials.

Description

[0001] This invention is a divisional application of application number CN202310821433.2, filed on July 6, 2023, of the invention type, entitled "A Medical Storage and Transportation Device". Technical Field

[0002] This invention relates to the field of medical device technology, and in particular to an outdoor emergency device. Background Technology

[0003] Drugs or biological tissues require specific storage environments to maintain their efficacy or preserve active substances. For example, bioactive biomaterials, based on their high biocompatibility and growth-promoting properties, enable tissue repair, replacement, and regeneration in biological organisms, as well as the formation of a connection between tissues and materials, making them widely used in the biomedical field. However, bioactive biomaterials typically require cryogenic or light-protected storage, and the specific temperature range for cryogenic storage must be strictly controlled; otherwise, drug inactivation or even toxicity to tissues may occur. Therefore, for drugs with different physicochemical properties, their storage conditions, such as the construction of cryogenic environments and specific temperatures, should be tailored to the drug components and drug activity.

[0004] Especially in special circumstances such as energy shortages or outdoor emergency rescue scenarios, carrying the aforementioned medications for treatment places high demands on storage devices. Specifically, storage devices need to meet the differentiated cryogenic preservation requirements of medications with different physicochemical properties while facilitating easy access. However, most existing emergency storage devices achieve cryogenic preservation using electric cooling equipment powered by mobile power sources, which has limited energy storage. Storage devices that directly achieve cryogenic preservation through a cold source rarely involve multi-layered or multi-space enclosure structures for both medication and cold source storage, or differentiated cryogenic preservation based on such enclosure structures. This makes it impossible to set the cryogenic preservation temperature specifically according to the properties of the medication, and impossible to maintain the cryogenic preservation temperature continuously under scenarios involving multiple intervals of medication retrieval. Existing drug storage devices only specify medications containing biological dressings and cytokines, but different medications may have different physicochemical properties, thus requiring different storage conditions. Therefore, how to store medications with different physicochemical properties in various ways, how to strictly control the internal temperature according to the specific cryogenic preservation temperature range required by bioactive materials, and how to adapt to extreme situations such as outdoor rescues with energy shortages are urgent problems that existing technologies need to solve.

[0005] Chinese patent CN105857933B discloses a drug storage device, comprising: a shell with a first chamber; an insulated container disposed in the first chamber; and a second chamber surrounding the insulated container, the second chamber containing a sealed refrigerant used to lower the temperature inside the insulated container. The drug storage device applying this patent's technical solution, by setting a first chamber in the shell, a heat-insulating container in the first chamber, and a second chamber surrounding the heat-insulating container with a sealed refrigerant, can lower the temperature inside the heat-insulating container, keeping the drug placed in the heat-insulating container in a consistently low-temperature environment. This solves the technical problem in the prior art of carrying and storing drugs containing biological dressings and cytokines during emergency treatment, while also being small in size and easy to carry, well-suited for emergency treatment. However, the patent's drawback is that the specified drugs for storage only include those containing biological dressings and cytokines; different drugs may have different physicochemical properties, thus requiring different storage conditions. When outdoor emergency rescue requires a variety of active materials with different physicochemical properties, this device cannot properly store all of them, making it difficult to transport them to the rescue location. Its uniform internal temperature environment cannot meet the storage requirements of different active materials, easily leading to loss of their medicinal properties. Therefore, this device cannot meet the high efficiency and high storage capacity requirements of outdoor emergency rescue.

[0006] Furthermore, on the one hand, there are differences in understanding among those skilled in the art; on the other hand, the applicant studied a large number of documents and patents when making this invention, but due to space limitations, not all details and contents were listed in detail. However, this does not mean that the present invention does not possess the features of these prior art. On the contrary, the present invention already possesses all the features of the prior art, and the applicant reserves the right to add relevant prior art to the background art. Summary of the Invention

[0007] To address the shortcomings of existing technologies, this invention provides a medical storage and transportation device, comprising: a plurality of storage units for storing active materials requiring low-temperature storage, and a plurality of refrigeration units that maintain the temperature of the storage units in a one-to-one correspondence. Preferably, the device further comprises: a first refrigerant storage module for storing a first refrigerant at a temperature T1, and a second refrigerant storage module for storing a second refrigerant at a temperature T2. The first and second refrigerant storage modules are respectively connected to the plurality of refrigeration units in a controlled manner. Preferably, the storage and transportation device controls the temperature of the refrigeration units by adjusting the phase composition and ratio of the first and second refrigerants in the refrigeration units, thereby controlling the temperature of the storage units corresponding to the refrigeration units. The device of this application is equipped with several storage units. Compared with the portable storage boxes based on refrigerant storage in the prior art, several storage units can be used to store active materials with different low-temperature storage requirements, rather than maintaining them in a temperature range or range close to the liquid temperature of the refrigerant based on liquid refrigerant. The storage units are equipped with independent low-temperature maintenance mechanisms, which can adjust and maintain the low-temperature storage temperature based on independent low-temperature storage structures, significantly improving the adaptability and specificity of the device for low-temperature storage of different types of active materials.

[0008] According to a preferred embodiment, the device further includes an intelligent module, which is based on a preset temperature control of the storage unit and the phase composition and ratio of the first and second refrigerants in the corresponding refrigeration unit of the storage unit. By combining different ratios of the first and second refrigerants, the temperature control range of several storage units is expanded, avoiding the problem of temperature difficulty in control due to the use of the same refrigerant. This invention, through the control of the amounts of the first and second refrigerants, and based on adjustments to different heat capacities and ratios, forms refrigerant combinations with different temperatures, broadening the applicability of the refrigerants and enabling the active materials in several storage units to be placed within suitable temperature ranges.

[0009] According to a preferred embodiment, the first refrigerant and the second refrigerant are in different phases. Preferably, the first refrigerant and / or the second refrigerant undergo a phase change during the refrigeration process, and the latent heat during the phase change is used to adjust the temperature of the refrigeration unit. The difference in phase and heat capacity between the two refrigerants allows for more flexible adjustment of the refrigeration unit temperature within an appropriate range. It enables the selection of an appropriate refrigerant combination based on the required temperature range and temperature control accuracy. To a certain extent, it expands the applicable temperature range. This invention utilizes the latent heat during the phase change of the first and / or second refrigerants to adjust the temperature of the refrigeration unit and, combined with the ratio of the first and second refrigerants, expands the temperature range of the refrigeration unit. The phase and ratio of the first and / or second refrigerants are selected according to the required temperature threshold range.

[0010] According to a preferred embodiment, during the cooling stage, the intelligent module calculates the phase and ratio of the first and second refrigerants to be added to the corresponding refrigeration unit based on the temperature required to be maintained for at least one active material and the dosage carried, so that the storage unit can reach the preset temperature. Preferably, during the holding stage, the monitoring unit of the device monitors the actual temperature change in the storage unit, and the intelligent module adjusts the phase and ratio of the first and / or second refrigerants in the refrigeration unit based on the monitored actual temperature change, so that the actual temperature in the storage unit is maintained at the preset temperature. This invention, by dividing the low-temperature preservation stage of the active material, can monitor the temperature within the storage unit in real time, maintaining it within the temperature range required by the active material, thereby ensuring that active materials with different physicochemical properties can be preserved within the most suitable temperature range. The setting of the first and second refrigerants in this invention eliminates the need for electric refrigeration equipment, reduces energy consumption, and can be used in extreme scenarios such as outdoor emergency rescue. The method of achieving low-temperature preservation directly based on a cold source is low-cost, and this method allows for the targeted setting of the first and second refrigerants and the continuous maintenance of the low-temperature preservation temperature in scenarios such as multiple intervals of active material use.

[0011] According to a preferred embodiment, when the storage unit is configured with a material cavity for containing active materials, and the refrigeration unit is configured with a cold source cavity for containing the first refrigerant and / or the second refrigerant, the intelligent module calculates a second duty cycle of the first refrigerant and / or the second refrigerant in the cold source cavity based on a first duty cycle of the active material in the material cavity. This allows the active material in the material cavity to lower its temperature and maintain it at a corresponding preset temperature through heat exchange with the first refrigerant and / or the second refrigerant in the cold source cavity. The intelligent unit replenishes refrigerant to the cold source cavity based on temperature deviations to eliminate the corresponding temperature deviations, enabling the active material to be maintained in a low-temperature preservation state for a long time. This also provides good applicability in scenarios where the active material is used intermittently.

[0012] According to a preferred embodiment, a plurality of cold source cavities are arranged to surround or partially surround a plurality of material cavities. Preferably, the intelligent module adjusts the temperature range for different types of active materials by controlling the surrounding parameters of the cold source cavities and the corresponding material cavities. Preferably, the surrounding parameters include at least a first surrounding parameter determined by the spatial structure of the material cavities and the cold source cavities, and a second surrounding parameter determined by the loading ratio of the material cavities and the cold source cavities.

[0013] According to a preferred embodiment, the plurality of storage units correspond to the plurality of refrigeration units, and the material cavity and the corresponding cold source cavity have different first enclosure parameters. Preferably, the first enclosure parameter refers to the ratio of the spatial enclosure degree and / or radial dimension between the storage unit and the corresponding refrigeration unit. This application allows the first enclosure parameter of the storage unit to be determined during the loading and manufacturing design process, or the first enclosure parameter can be set to be adjustable, and the first enclosure parameter and the second enclosure parameter can be controlled by the intelligent module of the device, enabling intelligent low-temperature storage of different types of drugs by the storage unit.

[0014] According to a preferred embodiment, when the first enclosure parameter is determined, the intelligent module controls the actual temperature of the storage unit to remain within a corresponding temperature range by adjusting the second enclosure parameter of the plurality of refrigeration units. The intelligent module can also adjust the specific refrigeration temperature or maintain a stable high refrigeration temperature by adjusting the second enclosure parameter. This is particularly important during the gradual use of a drug, where the reduction in drug loading requires a synchronous change in the cold source loading to ensure the refrigeration temperature remains stable within a suitable temperature range or at a suitable temperature, thereby ensuring the stability and applicability of the drug's low-temperature storage temperature.

[0015] According to a preferred embodiment, when the cold source cavity and the material cavity are co-centered, the second enclosure parameter refers at least to: the ratio of the loading amount of the first refrigerant and / or the second refrigerant in the cold source cavity to the loading amount of the active material in the material cavity and / or the ratio of the loading height of the first refrigerant and / or the second refrigerant in the cold source cavity to the loading height of the active material in the material cavity. The storage unit of the device of the present invention adjusts the temperature or temperature range for different types of drugs by controlling the enclosure parameter of the cold source cavity to the corresponding material cavity in the storage unit. The enclosure parameter includes at least a first enclosure parameter and a second enclosure parameter. The first enclosure parameter is determined by the spatial structure of the material cavity and the cold source cavity. The second enclosure parameter is determined by the loading ratio of the material cavity and the cold source cavity, allowing the storage unit of the device to pre-set the applicable temperature range based on the first enclosure parameter, making the storage unit suitable for storing drugs with a low-temperature storage temperature within the corresponding temperature range.

[0016] According to a preferred embodiment, the refrigeration unit further includes a cold source configuration module, which changes the ratio of the loading amount of the first refrigerant and / or the second refrigerant to the loading amount of the active material, and changes the ratio of the first refrigerant to the second refrigerant, in a manner that controls the input and output of the first refrigerant and / or the second refrigerant. Attached Figure Description

[0017] Figure 1 This is a simplified structural diagram of a medical storage and transportation device according to a preferred embodiment of the present invention;

[0018] Figure 2 This is a simplified schematic diagram of the module connection relationship of an intelligent module according to a preferred embodiment of the present invention.

[0019] List of reference numerals

[0020] 100: Cabinet; 101: Insulation layer; 200: Storage unit; 201: Material cavity; 300: Refrigeration unit; 301: First refrigerant; 302: Second refrigerant; 303: Cold source cavity; 400: Intelligent module; 401: Monitoring unit; 402: Cold source configuration module. Detailed Implementation

[0021] The following is a detailed explanation with reference to the accompanying drawings.

[0022] Example 1

[0023] Drugs or biological tissues require specific storage environments to maintain their efficacy or preserve active substances. For example, bioactive materials, based on their high biocompatibility and growth-promoting properties, enable tissue repair, replacement, and regeneration in biological organisms, as well as the formation of connections between tissues and materials. This has led to their widespread application in the biomedical field. However, bioactive materials often require low-temperature or light-protected storage, and the specific temperature range for low-temperature storage must be strictly controlled; otherwise, drug inactivation or even toxicity to tissues may occur. Therefore, for drugs with different physicochemical properties, storage conditions, such as the construction of low-temperature environments and specific temperatures, should be tailored to the drug components and drug activity. For example, insulin is a biological product that is easily degraded by heat. Unopened insulin should be refrigerated at 2°C–8°C to avoid activity loss, with a shelf life of 2 years. Opened insulin should be stored at room temperature (not exceeding 30°C), as its activity will gradually decrease, with a shelf life of 4 weeks. Vitamin C is an easily oxidized substance and should be stored in a tightly sealed container in a dry place. The optimal storage temperature for Vitamin C is 15℃~25℃. Aspirin is a hygroscopic drug and should be stored in a tightly closed container in a dry place. Aspirin will hydrolyze into salicylic acid and acetic acid in high temperature and humid environments, losing its efficacy and producing an acetic acid odor. The optimal storage temperature for aspirin is 15℃~30℃. For example, antibodies may require different storage temperatures due to variations in their forms. Especially for conjugated antibodies, the different conjugates and cryoprotectants necessitate specific storage conditions. Fluorescent dye-conjugated antibodies, enzyme-conjugated antibodies, and biotin-conjugated antibodies need to be aliquoted to avoid repeated freeze-thaw cycles. If the conjugated antibody contains a cryoprotectant and its long-term stability at -20℃ has been verified, it should be stored at -20℃; otherwise, it should be stored below 4℃ and above 0℃. Furthermore, some drugs have different stabilizations in different solutions. Penicillin G potassium has poor stability in aqueous solutions and is more prone to decomposition in alkaline solutions, requiring storage in acidic solutions. Solvents or hydrates can undergo desolvation or dehydration under different temperatures or relative humidity, leading to crystal transformation or reduced activity. Therefore, they need to be stored under suitable temperature and humidity conditions.

[0024] Especially in special circumstances such as energy shortages or outdoor emergency rescue scenarios, carrying the aforementioned medications for treatment places high demands on storage devices. Specifically, they need storage devices that can meet the differentiated cryogenic preservation requirements of medications with different physicochemical properties and facilitate easy access. However, most existing emergency storage devices rely on electric cooling equipment powered by mobile power sources for cryogenic preservation, which has limited energy storage. Storage devices that directly achieve cryogenic preservation based on a cold source rarely involve multi-layered or multi-space enclosure structures for both medication storage and cold source storage, nor can they achieve differentiated cryogenic preservation based on these enclosure structures. This makes it impossible to specifically set the cryogenic preservation temperature according to the properties of the medication and maintain that temperature continuously under scenarios involving multiple intervals of medication retrieval. Existing drug storage devices only specify drugs that may contain biological dressings and cytokines, but different physicochemical properties require different storage conditions. Therefore, the present invention provides a storage and transportation device for storing a variety of drugs by configuring multiple storage units 200. By adding temperature sensors, the amount of refrigerant stored in different cold source cavities between the inner and outer storage units 200 can be adjusted, thereby regulating the internal temperature of each storage unit 200 to adapt to specific drugs that require different storage conditions.

[0025] This invention provides a medical storage and transportation device, such as... Figure 1As shown, the device includes: a plurality of storage units 200 for storing active materials requiring low-temperature storage; and a plurality of refrigeration units 300 that maintain the temperature of the storage units 200 in a one-to-one correspondence. Preferably, the medical storage and transportation device further includes: a first refrigerant storage module for storing a first refrigerant 301 at a temperature of T1; and a second refrigerant storage module for storing a second refrigerant 302 at a temperature of T2. Preferably, T1 is not equal to T2. Preferably, the first and second refrigerant storage modules are respectively connected in a controlled manner to each of the refrigeration units 300. Preferably, the storage and transportation device controls the temperature of each refrigeration unit 300 by adjusting the amounts of the first refrigerant 301 and the second refrigerant 302 in each refrigeration unit 300, thereby controlling the temperature T0 of each storage unit 200 corresponding to the refrigeration unit 300. Preferably, the medical storage and transportation device further includes a housing 100 for arranging the insulation layer 101 and forming an internal cavity for accommodating a plurality of storage units 200 based on the insulation layer 101, and an intelligent module 400 for regulating the internal temperature of the plurality of storage units 200. Preferably, when the storage unit 200 is configured with a material cavity 201 for accommodating active materials and the refrigeration unit 300 is configured with a cold source cavity 303 for accommodating a first refrigerant 301 and / or a second refrigerant 302, the intelligent module 400 calculates the second duty cycle of the first refrigerant 301 and / or the second refrigerant 302 in the cold source cavity 303 based on the first duty cycle of the active material in the material cavity 201, so that the temperature of the active material in the material cavity 201 is reduced and maintained at a corresponding preset temperature by heat exchange with the first refrigerant 301 and / or the second refrigerant 302 in the cold source cavity 303. The aforementioned housing 100 refers to the external shell structure of the device, and the insulation layer 101 for heat preservation and protection of the internal structure is arranged inside the shell. The insulation layer 101 is used to prevent heat transfer and is composed of insulation material. It should be noted that... Figure 1 The storage units 200 and cooling units 300 shown are not in a positional relationship, but are an adjustment to reflect a one-to-one correspondence in planar representation. In this invention, the storage units 200 can be located on a certain plane within the housing 100, while the cooling units 300 are located on another plane within the housing 100 that is parallel to that plane.

[0026] The device of this application is equipped with several storage units 200. Compared with the portable storage boxes based on refrigerant preservation in the prior art, the several storage units 200 can be used to store active materials with different low temperature preservation requirements, rather than maintaining them in a temperature range or range close to the liquid temperature of the refrigerant based on liquid refrigerant. The storage unit 200 is equipped with an independent low temperature maintenance mechanism, which can adjust and maintain the low temperature preservation temperature based on the independent low temperature preservation structure, significantly improving the adaptability and specificity of the device for low temperature preservation of different types of active materials.

[0027] According to a preferred embodiment, the intelligent module 400 is configured to control the amounts of a first refrigerant 301 and a second refrigerant 302 in the corresponding refrigeration unit 300 of each storage unit 200 based on a preset temperature (Tpreset) of each storage unit 200. The first refrigerant 301 and the second refrigerant 302 refer to cryogenic substances used to maintain a low-temperature environment, such as liquid nitrogen or dry ice. Preferably, the intelligent module 400 controls the temperature of several storage units 200 by controlling at least the ratio of the first refrigerant 301 to the second refrigerant 302. By combining different ratios of the first refrigerant 301 and the second refrigerant 302, the temperature control range of several storage units 200 is expanded, avoiding the problem of temperature difficulty caused by using the same refrigerant. That is, the disadvantage of using the same refrigerant is that temperature control depends on heat conduction, and the controllable temperature is maintained within the temperature range of that refrigerant. This method relies on the use and removal of the refrigerant to achieve temperature control. When the temperature required by the stored active material is lower than the refrigerant temperature, the temperature inside the storage unit 200 cannot reach the required standard. When the temperature required for storing the active material is much higher than the refrigerant temperature, and the ambient temperature is also much higher than the temperature required for the stored active material, it is necessary to repeatedly add and remove refrigerant to maintain the temperature within the storage unit 200 within the storage temperature range of the active material. This makes the adjustment method overly complicated. Especially in situations where energy is scarce and active materials need to be carried out for outdoor rescue, this complicated operation may lead to a significant increase in the energy consumption of the medical storage and transportation device, making it impossible to maintain the cooling effect for a long time. To address this, the present invention, through the control of the amount of the first refrigerant 301 and the second refrigerant 302, and based on the adjustment of different heat capacities and ratios, forms refrigerant combinations with different temperatures, broadening the applicable range of refrigerants, so that the active materials in several storage units 200 can be placed within suitable temperature ranges.

[0028] It should be noted that this invention describes the use of a first refrigerant 301 and a second refrigerant 302 in a specific ratio, but this does not mean that a third and / or fourth refrigerant, or even more refrigerants, cannot be used to participate in the temperature control of the storage unit 200. Preferably, when the first refrigerant 301 is pentafluoroethane, the second refrigerant 302 can be one of trifluoroethane, difluoromethane, or 1,1,1,2-tetrafluoroethane, preferably trifluoroethane. Preferably, when the first refrigerant 301 is pentafluoroethane and the second refrigerant 302 is trifluoroethane, the mixture of the first refrigerant 301 and the second refrigerant 302 forms an azeotropic refrigerant mixture. That is, it has a uniform boiling point, and this boiling point is lower than the boiling points of the first refrigerant 301 and the second refrigerant 302. Preferably, the first refrigerant 301 can also be a non-azeotropic refrigerant mixture composed of pentafluoroethane, trifluoroethane, and 1,1,1,2-tetrafluoroethane, and the second refrigerant 302 is preferably trifluoromethane. Different cooling effects are achieved by varying the ratio of the first refrigerant 301 and the second refrigerant 302. For example, when the mass fraction of the non-azeotropic mixture of pentafluoroethane, trifluoroethane, and 1,1,1,2-tetrafluoroethane with trifluoromethane is 0.8 / 0.2, the evaporation temperature is -80°C. When the mass fraction of the non-azeotropic mixture of pentafluoroethane, trifluoroethane, and 1,1,1,2-tetrafluoroethane with trifluoromethane is 0.6 / 0.4, the evaporation temperature is -100°C. Preferably, the first refrigerant 301 can also be propane, and the second refrigerant 302 is preferably isobutane. When the mass fraction of propane and isobutane is 0.7 / 0.3, the evaporation temperature is -10°C; when the mass fraction of propane and isobutane is 0.5 / 0.5, the evaporation temperature is -20°C. Preferably, the first refrigerant 301 can also be ammonia, and the second refrigerant 302 is preferably carbon dioxide. When the mass fractions of ammonia and carbon dioxide are 0.9 / 0.1, the evaporation temperature is -40℃. When the mass fractions of ammonia and carbon dioxide are 0.8 / 0.2, the evaporation temperature is -50℃.

[0029] The first refrigerant 301, the second refrigerant 302, and / or the remaining refrigerants, formulated in the aforementioned proportions, achieve better freezing temperatures and specific volumes in both the gaseous and liquid states, thereby creating an environment that meets the refrigeration range and conditions required by the storage unit 200. Different proportions of the first refrigerant 301, the second refrigerant 302, and / or the remaining refrigerants cause changes in the thermodynamic properties, heat transfer performance, and chemical stability of the mixed refrigerant, thus affecting the efficiency of the refrigeration cycle. In this invention, the proportions of the first refrigerant 301, the second refrigerant 302, and / or the remaining refrigerants are adjusted by the intelligent module 400 according to the needs of the storage unit 200 and the slip coefficients (i.e., slip phenomenon, where the gas and liquid phases are not identical) of different refrigerants, thereby achieving optimal refrigeration performance. The change in proportion alters the evaporation pressure, latent heat of vaporization, critical temperature, condensation pressure, freezing temperature, specific volumes in both the gaseous and liquid states of the mixed refrigerant, ensuring its chemical and thermal stability while preventing decomposition, deterioration, and corrosion during the refrigeration process. In addition, the first refrigerant 301, the second refrigerant 302 and / or other refrigerants can also be refrigerants with low GWP (global warming potential) and ODP (ozone depletion potential) to reduce the negative impacts on the atmosphere and climate change.

[0030] According to a preferred embodiment, the first refrigerant 301 and the second refrigerant 302 are different substances, and they are separated within the refrigeration unit 300. Preferably, the first refrigerant 301 and the second refrigerant 302 are different substances with different temperatures, and their heat capacities also differ, allowing for more flexible adjustment of the temperature of the refrigeration unit 300 within an appropriate range. This enables the selection of an appropriate refrigerant combination based on the required temperature range and temperature control accuracy, thus expanding the applicable temperature range to a certain extent. Preferably, the first refrigerant 301 and the second refrigerant 302 are separated to avoid the impact of their combined heat effect on temperature regulation. This also facilitates the recovery of both the first and second refrigerants 301 and 302.

[0031] According to a preferred embodiment, the first refrigerant 301 and the second refrigerant 302 are in different phases. Preferably, the first refrigerant 301 and / or the second refrigerant 302 undergo a phase change during the refrigeration process, and the latent heat during the phase change is used to adjust the temperature of the refrigeration unit 300. Preferably, the different phases of the first refrigerant 301 and the second refrigerant 302 increase the range of refrigerant selection, allowing the selection of the phases of the first refrigerant 301 and the second refrigerant 302 according to the desired temperature. Preferably, for the convenience of material transport, when the first refrigerant 301 or the second refrigerant 302 is in a solid state, a particulate or microparticle-state refrigerant is used.

[0032] According to a preferred embodiment, the intelligent module 400 is configured to further adjust the amount of the first refrigerant 301 and / or the second refrigerant 302 in the refrigeration unit 300 based on the actual temperature (Tactual) of each storage unit 200. Preferably, the intelligent module 400 adjusts the phase composition and ratio of the first refrigerant 301 and / or the second refrigerant 302 in the refrigeration unit 300 based on the actual temperature within the storage unit 200, so that the actual temperature of the storage unit 200 is maintained within a threshold range. This invention utilizes the latent heat during the phase change process of the first refrigerant 301 and / or the second refrigerant 302 to adjust the temperature of the refrigeration unit 300 and, combined with the ratio of the first refrigerant 301 and the second refrigerant 302, expands the temperature range of the refrigeration unit 300, selecting the phase composition and ratio of the first refrigerant 301 and / or the second refrigerant 302 according to the required temperature threshold range.

[0033] According to a preferred embodiment, the first refrigerant storage module is configured to recover the first refrigerant 301 from the refrigeration unit 300. Preferably, the second refrigerant storage module is configured to recover the second refrigerant 302 from the refrigeration unit 300. This invention, based on direct cooling from a cold source, eliminates the need to integrate electric refrigeration equipment into the storage and transportation device, reducing reliance on batteries and electric refrigeration equipment. This facilitates integrated miniaturization and ensures the portability, applicability, and functional stability of the device during mobile transportation and emergency rescue operations.

[0034] According to a preferred embodiment, each storage unit 200 has good thermal conductivity with its corresponding cooling unit 300, and the storage units 200, the cooling units 300, and non-corresponding storage units 200 and cooling units 300 are thermally isolated from each other.

[0035] To achieve accurate and automated cryogenic preservation, the medical storage and transportation device of the present invention divides the cryogenic preservation of active materials into a cooling stage and a holding stage. In the cooling stage, for the active material placed in the storage unit 200, based on the required temperature and quantity, the amount of the first refrigerant 301 and the second refrigerant 302 to be added to the corresponding refrigeration unit 300 is calculated, ensuring that the refrigeration unit 300 reaches the preset temperature range. In the holding stage, the actual temperature change in the storage unit 200 is detected, and the amount of the first refrigerant 301 and / or the second refrigerant 302 in the refrigeration unit 300 is further adjusted according to the detected actual temperature change, ensuring that the temperature in the storage unit 200 is maintained at the preset temperature. Preferably, in the cooling stage, the intelligent module 400 calculates the phase composition and ratio of the first refrigerant 301 and the second refrigerant 302 to be added to the corresponding refrigeration unit 300 based on the required temperature and dosage of at least one active material, ensuring that the storage unit 200 reaches the preset temperature. Preferably, during the holding phase, the monitoring unit 401 monitors the actual temperature change in the storage unit 200, and the intelligent module 400 further adjusts the phase and ratio of the first refrigerant 301 and / or the second refrigerant 302 in the refrigeration unit 300 based on the monitored actual temperature change, so that the actual temperature in the storage unit 200 is maintained at the preset temperature. Figure 2 The communication connection between the intelligent module 400 and the monitoring unit 401 is shown. The monitoring unit 401 may include a temperature sensor to monitor the actual temperature of the storage unit 200 and the temperature changes within the refrigeration unit 300. By dividing the active material into cryogenic preservation stages, this invention can monitor the temperature within the storage unit 200 in real time, maintaining it within the temperature range required by the active material, thus ensuring that active materials with different physicochemical properties can be preserved within the most suitable temperature range. The design of the first refrigerant 301 and the second refrigerant 302 eliminates the need for electrically powered refrigeration equipment, reducing energy consumption and enabling its use in extreme scenarios such as outdoor emergency rescue. The method of achieving cryogenic preservation directly based on a cold source is low-cost, and this method allows for the targeted setting of the first refrigerant 301 and the second refrigerant 302, and the continuous maintenance of the cryogenic preservation temperature in scenarios such as multiple intervals of active material use.

[0036] According to a preferred embodiment, the heat exchange between the active material and the refrigerant in the storage unit 200 is implemented such that the temperature of the material cavity 201 decreases to a corresponding preset temperature and the first refrigerant 301 and / or the second refrigerant 302 absorbs and rises to a thermally conductive temperature. Preferably, the first duty cycle in the material cavity 201 refers to the ratio of the amount of active material loaded to the capacity of the material cavity 201. Preferably, the second duty cycle of the first refrigerant 301 and / or the second refrigerant 302 in the cold source cavity 303 refers to the ratio of the amount of the first refrigerant 301 and / or the second refrigerant 302 loaded to the capacity of the cold source cavity 303. Preferably, the intelligent module 400 calculates the second duty cycle of the first refrigerant 301 and / or the second refrigerant 302 in the cold source cavity 303 based on the first duty cycle of the active material in the material cavity 201 in an manner that the heat dissipated by the drug dropping to the preset temperature in the first duty cycle is equal to or corresponds to the heat absorbed by the cold source in the second duty cycle. When the structure of several storage units 200 of the device is fixed, the loading amount of active material and refrigerant can be determined by a first duty cycle and a second duty cycle. The first duty cycle and the second duty cycle can be obtained from the capacity and liquid level height, which are easy to measure automatically. Given the type of active material, the type of refrigerant, and the corresponding initial state, the heat dissipation of the active material from the initial state to the target state in the first duty cycle corresponds to or is equal to the heat absorption of the refrigerant from the initial state to the target state in the second duty cycle. This allows the intelligent module to set the optimal low-temperature storage temperature and the preset temperature based on the physicochemical properties of the active material, and long-term low-temperature maintenance is achieved by the refrigerant at its thermal conductivity temperature.

[0037] According to a preferred embodiment, the storage unit 200 is configured such that its cold source cavity 303 surrounds or partially surrounds the corresponding material cavity 201. When the heat exchange between the first refrigerant 301 and / or the second refrigerant 302 in the cold source cavity 303 and the active material in the material cavity 201 is balanced, the preset temperature of the active material is set such that there is a thermal conductivity temperature difference between it and the thermal conductivity temperature of the refrigerant. When the user needs to access the material cavity 201 of the storage unit 200 multiple times at intervals, different active materials are selected for low-temperature storage in a manner where the magnitude of their preset low-temperature storage temperature is negatively correlated with the thermal conductivity temperature difference of the storage unit 200. Several storage units 200 are configured differently based on their different thermal conductivity temperature differences and can be used to store different drugs. Specifically, the greater the thermal conductivity temperature difference, the greater the difference between the preset temperature of the active material and the thermal conductivity temperature of the first refrigerant 301 and / or the second refrigerant 302 under the target state of heat exchange equilibrium. When the preset temperature changes due to long-term storage or multiple intermittent uses, the deviation between the temperature of the active material and the temperature of the first refrigerant 301 and / or the second refrigerant 302 further widens, enabling the first refrigerant 301 and / or the second refrigerant 302 to absorb the increased heat in the active material at a faster rate. In other words, this storage unit 200, with its greater "low-temperature retention inertia," is suitable for storing active materials with lower low-temperature storage requirements and can improve the low-temperature stability of the active material temperature and the rate at which it recovers to the low-temperature storage temperature.

[0038] Example 2

[0039] This embodiment is a further improvement on embodiment 1, and repeated content will not be described again.

[0040] According to a preferred embodiment, for the active material placed in the material cavity 201 with a first duty cycle, the intelligent module 400 configures a refrigerant with a second duty cycle based on the state of the active material and the corresponding target state. This allows the temperature of the active material in the material cavity 201 to decrease and be maintained at a corresponding preset temperature through heat exchange with the refrigerant in the cold source cavity 303. The refrigerant in the cold source cavity 303 absorbs the increased temperature and maintains it at a state slightly below the preset temperature, thereby effectively controlling the temperature of the active material to drop to the preset temperature of the target state. The refrigerant in the cold source cavity 303 then maintains the low temperature. During the maintenance phase, the intelligent unit detects the state of the active material in the material cavity 201. When the state of the active material deviates from the target state, i.e., when the temperature of the active material is higher than the preset temperature, the intelligent unit replenishes the refrigerant in the cold source cavity 303 based on the temperature deviation to eliminate the corresponding temperature deviation. This allows the active material to be maintained in the target state of low-temperature preservation for a long period of time, and also has good applicability in scenarios such as multiple intervals of active material retrieval.

[0041] According to a preferred embodiment, the storage unit 200 is configured with a plurality of material cavities 201 for storing different types of drugs, and the refrigeration unit 300 is configured with a plurality of cold source cavities 303 in a manner that surrounds or partially surrounds the plurality of material cavities 201, such that the device adjusts the temperature or temperature range for different types of drugs by controlling the surrounding parameters of the corresponding material cavities 201 in the storage unit 200 through the cold source cavities 303 of the refrigeration unit 300. Preferably, the surrounding parameters include at least a first surrounding parameter determined by the spatial structure of the material cavities 201 and the cold source cavities 303 and a second surrounding parameter determined by the loading ratio of the material cavities 201 and the cold source cavities 303.

[0042] According to a preferred embodiment, when the second enclosure parameter is determined, the intelligent module 400 controls the temperature of different types of active materials within several preset temperature ranges according to the first enclosure parameters of the several storage units 200. Preferably, the several preset temperature ranges can be set in a manner that at least partially overlaps and / or at least partially alternates. Preferably, when the first enclosure parameter is determined, the intelligent module 400 adjusts the second enclosure parameter of the several storage units 200 to control the cooling temperature within the corresponding temperature range.

[0043] According to a preferred embodiment, when the cold source cavity 303 and the material cavity 201 are co-centered, the first enclosure parameter of the storage unit 200 is differentiated by at least the following: different spatial enclosure degree of the cold source cavity 303 over the material cavity 201 and / or different ratios of the radial dimensions of the cold source cavity 303 to the radial dimensions of the material cavity 201. Preferably, the spatial enclosure degree refers to the ratio of the solid angle range covered by the cold source cavity 303 relative to the center to the solid angle range covered by the material cavity 201 relative to the center. Preferably, the medical storage and transportation device is further configured with a structural configuration unit for adjusting the first enclosure parameter, so that the first enclosure parameter of the cold source cavity 303 and the material cavity 201 of the storage unit 200 is adjusted based on changes in their relative spatial positions. Preferably, the intelligent module 400 changes the relative spatial position between the material cavity 201 and the cold source cavity 303 through mechanical transmission. Preferably, the first enclosure parameter can also be a fixed value. That is, in the medical storage and transportation device, several storage units 200 respectively correspond to several refrigeration units 300. Each storage unit 200 has a corresponding cooling unit 300 with different first enclosure parameters, allowing different active materials to be selectively placed into different storage units 200. The different first enclosure parameters between the cooling units 300 and each storage unit 200 refer to different ratios of spatial enclosure degree and / or radial dimension. These first enclosure parameters between the different storage units 200 and their corresponding cooling units 300 can be arranged in a gradient, ensuring that different active materials can be placed into storage units 200 suitable for their storage. For example, if the active material is a liquid, the spatial enclosure degree above its storage unit 200 can be reduced; that is, the storage unit 200 suitable for this active material does not require a large first enclosure parameter, and only needs to cover the bottom of the material cavity 201 to achieve temperature control of the material cavity 201. As another example, if the active material is a relatively smooth solid and the storage quantity is small, the first enclosure parameter required for its storage unit 200 is smaller. That is, the active material only needs the cold source cavity 303 to cover the four walls of its material cavity 201 or the opposite direction of the medical storage and transportation device's forward movement to achieve the same cooling effect. For example, if the optimal storage temperature of the active material is slightly below room temperature, it is not necessary to completely enclose the material cavity 201; simply selecting a material cavity 201 with a lower first enclosure parameter is sufficient to meet the active material's temperature requirements. The appropriate material cavity 201 selected above can match the physicochemical properties of the active material, avoiding waste of the first refrigerant 301 and / or the second refrigerant 302, and controlling the temperature inside the material cavity 201 within the optimal range with less energy consumption.This application can determine the first enclosure parameter of the storage unit 200 during the loading and manufacturing design process, or the first enclosure parameter can be set to be adjustable, and the first enclosure parameter and the second enclosure parameter can be controlled by the intelligent module 400 of the device, so as to realize the intelligent low temperature storage of different types of drugs by the storage unit 200.

[0044] According to a preferred embodiment, when the cold source cavity 303 and the material cavity 201 of the storage unit 200 are co-centered, adjusting the second enclosure parameter of the refrigeration unit 300 includes at least: changing the ratio of the cold source loading amount in the cold source cavity 303 to the active material loading amount in the material cavity 201 and / or changing the ratio of the cold source loading height in the cold source cavity 303 to the active material loading height in the material cavity 201. Preferably, the refrigeration unit 300 is equipped with a cold source configuration module 402 for controlling the input and / or output of the first refrigerant 301 and / or the second refrigerant 302 to the cold source cavity 303. Preferably, the cold source configuration module 402 of the refrigeration unit 300 can change the second enclosure parameter by controlling the input and output of the first refrigerant 301 and / or the second refrigerant 302. That is, the cold source configuration module 402 of the refrigeration unit 300 can change the ratio of the first refrigerant 301 and / or the second refrigerant 302 to the loading amount of the active material by controlling the input and output of the first refrigerant 301 and / or the second refrigerant 302, and also change the ratio of the first refrigerant 301 to the second refrigerant 302. The storage unit 200 of the device of the present invention adjusts the temperature or temperature range for different types of drugs by controlling the enclosure parameters of the cold source cavity 303 around the corresponding material cavity 201 in the storage unit 200. The enclosure parameters include at least a first enclosure parameter and a second enclosure parameter. The first enclosure parameter is determined by the spatial structure of the material cavity 201 and the cold source cavity 303. The second enclosure parameter is determined by the loading ratio of the material cavity 201 and the cold source cavity 303, so that the storage unit 200 can be pre-set to the applicable temperature range based on the first enclosure parameter, making the storage unit 200 suitable for storing drugs whose low-temperature storage temperature is located in the corresponding temperature range. The intelligent module 400 can also adjust the specific cooling temperature or maintain a stable high cooling temperature based on the adjustment of the second enclosure parameter. Especially during the gradual use of drugs, the reduction of drug loading requires the synchronous change of cold source loading to ensure that the cooling temperature is stable within a suitable temperature range or temperature, thereby ensuring the stability and applicability of the drug's low-temperature storage temperature.

[0045] According to a preferred embodiment, the intelligent module 400 is data-connected to the cold source configuration module 402, enabling the intelligent module 400 to control the refrigeration temperature of the storage unit 200 to remain stable within a set temperature range or at a set temperature via the cold source configuration module 402. Preferably, the set temperature range and the set temperature are within the temperature range of the storage unit 200. The device of this application can be configured with several storage units 200 for cryogenic preservation of different types of drugs. Each storage unit 200 is equipped with an independent cryogenic maintenance structure, which allows for the adjustment and maintenance of the refrigeration temperature, significantly improving the adaptability and specificity of the device for cryogenic preservation of different types of drugs.

[0046] Throughout the text, the features indicated by “preferred” are only optional and should not be construed as mandatory. Therefore, the applicant reserves the right to abandon or delete the relevant preferred features at any time.

[0047] It should be noted that the specific embodiments described above are exemplary. Those skilled in the art can devise various solutions inspired by the disclosure of this invention, and these solutions all fall within the scope of this invention and its protection. Those skilled in the art should understand that this specification and its accompanying drawings are illustrative and not intended to limit the scope of the claims. The scope of protection of this invention is defined by the claims and their equivalents. This specification contains multiple inventive concepts; terms such as "preferredly," "according to a preferred embodiment," or "optionally" indicate that the corresponding paragraph discloses an independent concept. The applicant reserves the right to file divisional applications based on each inventive concept.

Claims

1. An outdoor emergency device, characterized in that, It includes an intelligent module (400) that monitors actual temperature changes and a cold source configuration module (402) that controls the input and / or output of at least two refrigerants. The intelligent module (400) is configured as follows: Based on the monitored actual temperature changes, the phase composition and ratio of the refrigerant containing the first refrigerant (301) and the second refrigerant (302) in the cold source configuration module (402) are adjusted so that the actual temperature is maintained at the preset temperature. The first refrigerant (301) and the second refrigerant (302) are different substances in different phases to increase the range of refrigerant selection; Furthermore, the first refrigerant (301) and the second refrigerant (302) are separated in the refrigeration unit (300) to avoid the impact of the heat effect of their mixing on temperature regulation; According to the required temperature range and temperature control accuracy, select an appropriate combination of refrigerants, and expand the temperature control range of several storage units (200) by combining the first refrigerant (301) and the second refrigerant (302) in different proportions; Several cold source cavities (303) are arranged to surround or partially surround several material cavities (201); the intelligent module (400) adjusts the temperature range for different types of active materials by controlling the surrounding parameters of the cold source cavities (303) and the corresponding material cavities (201); the surrounding parameters include at least a first surrounding parameter determined by the spatial structure of the material cavities (201) and the cold source cavities (303) and a second surrounding parameter determined by the loading ratio of the material cavities (201) and the cold source cavities (303); The first enclosure parameter refers to the spatial enclosure degree between the storage unit (200) and the corresponding refrigeration unit (300), or the ratio of the radial dimension of the cold source cavity (303) to the radial dimension of the material cavity (201); the spatial enclosure degree refers to the ratio of the solid angle range covered by the cold source cavity (303) relative to the center to the solid angle range covered by the material cavity (201) relative to the center. When the cold source cavity (303) and the material cavity (201) are arranged in the same center, the second enclosure parameter refers to at least the ratio of the loading amount of the first refrigerant (301) and / or the second refrigerant (302) in the cold source cavity (303) to the loading amount of the active material in the material cavity (201), or the ratio of the loading height of the first refrigerant (301) and / or the second refrigerant (302) in the cold source cavity (303) to the loading height of the active material in the material cavity (201).

2. The outdoor emergency device according to claim 1, characterized in that, The cold source configuration module (402) adjusts the ratio of the loading amount of the first refrigerant (301) and / or the second refrigerant (302) to the loading amount of the active material, or The ratio of the loading height of the first refrigerant (301) and / or the second refrigerant (302) to the loading height of the active material is used to adjust the temperature or temperature range for different types of active materials.

3. The outdoor emergency device according to claim 2, characterized in that, The intelligent module (400) includes a temperature sensor that monitors the actual temperature of the space storing the active material and the temperature changes of the cold source configuration module (402).

4. The outdoor emergency device according to claim 2, characterized in that, The first refrigerant (301), the second refrigerant (302) and / or the remaining refrigerants are different substances, and the first refrigerant (301), the second refrigerant (302) and / or the remaining refrigerants are separate in the cold source configuration module (402).

5. The outdoor emergency device according to claim 2, characterized in that, The first refrigerant (301), the second refrigerant (302) and / or the remaining refrigerants differ in at least one aspect of heat capacity and proportion to form a refrigerant combination with different temperatures.

6. The outdoor emergency device according to claim 5, characterized in that, The intelligent module (400) is configured as follows: Based on the reduction of drug loading, the phase and ratio of the refrigerant in the cold source configuration module (402) are adjusted so that the refrigeration temperature is stabilized within the set temperature range or at the set temperature.

7. The outdoor emergency device according to claim 6, characterized in that, When the first refrigerant (301) is pentafluoroethane, the second refrigerant (302) can be one of trifluoroethane, difluoromethane or 1,1,1,2-tetrafluoroethane.

8. A box for storing active substances, characterized in that, The enclosure (100) includes an insulation layer (101), a plurality of storage units (200) formed by the insulation layer (101) and disposed in the internal cavity of the enclosure (100), and a refrigeration unit (300) corresponding to each of the storage units (200), wherein the insulation layer (101) is arranged inside the enclosure (100); The refrigeration unit (300) is configured with a cold source cavity (303) for containing a first refrigerant (301) and / or a second refrigerant (302). The first refrigerant (301) and the second refrigerant (302) are different substances in different phases to increase the range of refrigerant selection; Furthermore, the first refrigerant (301) and the second refrigerant (302) are separated in the refrigeration unit (300) to avoid the impact of the heat effect of their mixing on temperature regulation; According to the required temperature range and temperature control accuracy, select an appropriate combination of refrigerants, and expand the temperature control range of several storage units (200) by combining the first refrigerant (301) and the second refrigerant (302) in different proportions; Several cold source cavities (303) are arranged to surround or partially surround several material cavities (201); the intelligent module (400) adjusts the temperature range for different types of active materials by controlling the surrounding parameters of the cold source cavities (303) and the corresponding material cavities (201); the surrounding parameters include at least a first surrounding parameter determined by the spatial structure of the material cavities (201) and the cold source cavities (303) and a second surrounding parameter determined by the loading ratio of the material cavities (201) and the cold source cavities (303); The first enclosure parameter refers to the spatial enclosure degree between the storage unit (200) and the corresponding refrigeration unit (300), or the ratio of the radial dimension of the cold source cavity (303) to the radial dimension of the material cavity (201); the spatial enclosure degree refers to the ratio of the solid angle range covered by the cold source cavity (303) relative to the center to the solid angle range covered by the material cavity (201) relative to the center. When the cold source cavity (303) and the material cavity (201) are arranged in the same center, the second enclosure parameter refers to at least the ratio of the loading amount of the first refrigerant (301) and / or the second refrigerant (302) in the cold source cavity (303) to the loading amount of the active material in the material cavity (201), or the ratio of the loading height of the first refrigerant (301) and / or the second refrigerant (302) in the cold source cavity (303) to the loading height of the active material in the material cavity (201).

9. The box for preserving active substances according to claim 8, characterized in that, A plurality of the storage units (200) can be located on one plane within the housing (100), while a plurality of the refrigeration units (300) are located on another plane within the housing (100) parallel to the plane.

10. The container for preserving active substances according to claim 8, characterized in that, The storage unit (200) and the corresponding refrigeration unit (300) change their relative spatial positions through mechanical transmission.

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