A specific protein analysis system
By combining a broadband light source, a polarization generator, and a wavelength selector, a specific protein analysis system was designed, which solved the problem that existing systems could not detect multiple proteins simultaneously, and achieved high-precision, low-cost detection of multiple proteins.
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Patents(China)
- Current Assignee / Owner
- SHENZHEN MINDRAY BIO MEDICAL ELECTRONICS CO LTD
- Filing Date
- 2022-06-02
- Publication Date
- 2026-04-21
AI Technical Summary
Existing specific protein detection systems lack the ability to detect multiple different specific proteins simultaneously, and conventional CRP tests have low sensitivity, making it difficult to meet clinical needs.
By employing a combination of a broadband light source, a polarization generator, and a wavelength selector, a specific protein analysis system is designed to achieve high-precision turbidimetric measurements of various specific proteins by selectively outputting polarized light of specific wavelengths.
It enables high-precision detection of a variety of specific proteins, simplifies the operation process, reduces costs, and improves detection sensitivity.
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Figure CN117214140B_ABST
Abstract
Description
Technical Field
[0001] This invention relates to the field of medical testing technology, and more particularly to a specific protein analysis system. Background Technology
[0002] Indicators such as white blood cell count, erythrocyte sedimentation rate, and acute-phase proteins can be used to observe signs and severity of inflammation in the human body. C-reactive protein (CRP) and serum amyloid-acid (SAA) are two representative acute-phase proteins. CRP concentrations in the blood increase rapidly after stimulation such as bacterial infection, inflammation, or surgery. SAA concentrations also increase rapidly after stimulation such as infection, trauma, or tumors. Therefore, they have important clinical significance.
[0003] Standard C-reactive protein (CRP) kits typically have a detection range of 3-200 mg / L, with a limit of detection (LOD) of 3-5 mg / L, and relatively low sensitivity. In pediatric interfering diseases, CRP levels in newborns are generally low, and routine testing often fails to detect minute changes. In cardiovascular disease diagnosis, CRP <1 mg / L indicates low risk, 1-3 mg / L indicates moderate risk, and >3 mg / L indicates high risk. Therefore, there is an urgent clinical need for CRP concentration detection methods with lower LODs and higher accuracy. In recent years, the concept of ultrasensitive CRP has emerged. Ultrasensitive kits, due to their high sensitivity and ability to detect even low CRP levels, greatly meet this pressing clinical need.
[0004] From the perspective of detection methods, coherent light has advantages such as high stability, high energy density, and narrow bandwidth. Therefore, whole blood CRP detection using coherent light offers advantages including high stability, high signal-to-noise ratio, and high sensitivity, making coherent light turbidimetric detection devices the mainstream detection method. However, most current detection systems for specific proteins are designed for single substrates, lacking measurement systems applicable to different specific proteins simultaneously. Summary of the Invention
[0005] In view of this, the present invention provides a specific protein analysis system that selectively outputs polarized light of a specific wavelength through the combination of a broadband light source, a polarization generator, and a wavelength selector. This system can achieve high-precision turbidimetric measurements while also enabling the detection of a variety of different specific proteins. Specifically, it includes the following scheme:
[0006] A specific protein analysis system includes a sample collection and dispensing module, a reagent supply module, a specific protein detection module, and a control module.
[0007] The sample collection and distribution module is used to pick up the sample to be tested and distribute the sample to the specific protein detection module;
[0008] The reagent supply module is used to supply reaction reagents to the specific protein detection module;
[0009] The specific protein detection module includes a light source assembly, a turbidimetric device, and a detection device.
[0010] The light source assembly includes a light source and a light processing module. The light source provides incident light. The light processing module is disposed in the optical path of the incident light, processes the incident light, and outputs detection light with a specific wavelength and concentrated energy, whose light vector vibrates along a predetermined direction. The light processing module includes a polarization generator, a beam shaping device, and a wavelength selector distributed along the optical path of the incident light. The polarization generator is configured to convert the incident light into polarized light. The wavelength selector is configured to select light of a specific wavelength from the incident light for output. The beam shaping device is configured to converge the incident light. The detection light illuminates the turbidimetric device.
[0011] The turbidimetric device is used to carry the test sample, and the detection light is transmitted and / or scattered after passing through the sample carried by the turbidimetric device;
[0012] The detection device is used to collect transmitted and / or scattered light signals and convert the light signals into electrical signals related to the light signal intensity for output.
[0013] The control module is used to process electrical signals from the detection device and output detection information for specific proteins.
[0014] Specifically, when the turbidimetric detection item is serum amyloid protein analysis, the wavelength selector outputs polarized light of a first specific wavelength, the control module processes the electrical signal from the detection device, and outputs the analysis result of serum amyloid protein.
[0015] When the turbidimetric detection item is C-reactive protein analysis, the wavelength selector outputs polarized light of a second specific wavelength, the control module processes the electrical signal from the detection device, and outputs the analysis result of C-reactive protein.
[0016] The beneficial effects of this invention are as follows: By combining a broadband light source, a polarization generator, and a wavelength selector, a specific protein analysis system that can selectively output polarized light of a specific wavelength is provided. While ensuring high-precision turbidimetric measurement, it can also meet the detection requirements of a variety of different specific proteins, effectively simplifying the operation process and reducing costs. Attached Figure Description
[0017] Figure 1 This is a schematic diagram of a specific protein detection module in one embodiment of the present invention;
[0018] Figure 2This is a schematic diagram of a beam shaping device in one embodiment of the present invention;
[0019] Figure 3 This is a schematic diagram of a specific protein detection module in another embodiment of the present invention. Detailed Implementation
[0020] The technical solutions of the embodiments of the present invention will be clearly and completely described below with reference to the accompanying drawings. Obviously, the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by those skilled in the art without creative effort are within the scope of protection of the present invention.
[0021] The serial numbers assigned to components in this document, such as "first" and "second," are merely used to distinguish the described objects and do not have any sequential or technical meaning. The terms "connection" and "linkage" used in this invention, unless otherwise specified, include both direct and indirect connections (linkages). In the description of this invention, it should be understood that the terms "upper," "lower," "front," "rear," "left," "right," "vertical," "horizontal," "top," "bottom," "inner," "outer," "clockwise," and "counterclockwise," etc., indicate the orientation or positional relationship based on the orientation or positional relationship shown in the accompanying drawings. They are used only for the convenience of describing the invention and for simplifying the description, and do not indicate or imply that the device or element referred to must have a specific orientation, or be constructed and operated in a specific orientation. Therefore, they should not be construed as limitations on the invention.
[0022] In this invention, unless otherwise explicitly specified and limited, "above" or "below" the second feature can mean that the first feature is in direct contact with the second feature, or that the first feature is in indirect contact with the second feature through an intermediate medium. Furthermore, "above," "over," and "on top" of the second feature can mean that the first feature is directly above or diagonally above the second feature, or simply that the first feature is at a higher horizontal level than the second feature. "Below," "below," and "under" the second feature can mean that the first feature is directly below or diagonally below the second feature, or simply that the first feature is at a lower horizontal level than the second feature.
[0023] This application provides a specific protein analysis system that, while ensuring high-precision turbidimetric measurement, can also detect a variety of different specific proteins, effectively simplifying the operation process and reducing costs. To facilitate understanding of this application, specific embodiments are described in further detail below with reference to the accompanying drawings.
[0024] The specific protein analysis system provided in this application includes a sample collection and dispensing module, a reagent supply module, a specific protein detection module, and a control module. The specific protein detection module includes a light source assembly, a turbidimetric device, and a detection device.
[0025] The sample collection and distribution module is used to collect samples to be tested and distribute them to at least the aforementioned specific protein detection modules. The sample may be a whole blood sample. In one embodiment, the sample collection and distribution module uses a sampling needle to aspirate the whole blood sample. The sample collection and distribution module includes a first sampling needle and a first displacement mechanism, wherein the first sampling needle is disposed on the first displacement mechanism. The first displacement mechanism is coupled to the aforementioned control module, and the control module is used to control the first displacement mechanism to drive the first sampling needle to move in the horizontal and / or vertical directions, so that the first sampling needle aspirates the whole blood sample to be tested and distributes the whole blood sample to be tested to the turbidimetric device of the specific protein detection module.
[0026] The reagent supply module supplies reaction reagents to the turbidimetric apparatus of the aforementioned specific protein detection module. In one implementation, the reagent supply module can be connected to a connection port on the turbidimetric apparatus via tubing, allowing the reaction reagents to be input into the turbidimetric apparatus through the connection port. In another implementation, the reaction reagents can be injected into the turbidimetric apparatus via a sampling needle; for example, a sampling needle structure can be used, meaning the reagent supply module can employ the same mechanism as the sample sampling and dispensing module. The reaction reagents and the sample mix in the turbidimetric apparatus to form the sample to be tested.
[0027] For the specific protein detection module, please refer to [link / reference]. Figure 1 The specific protein detection module 10 of the present invention shown includes a light source assembly 110, a turbidimetric device 120, and a detection device 130; wherein, the light source assembly 110 is used to emit a detection light source to the turbidimetric device 120. Specifically, the light source assembly 110 includes a light source 111 and a light processing module; wherein the light processing module includes a polarization light generator 112, a beam shaping device 113, and a wavelength selector 114; the light source 111 is used to provide broadband incident light, the polarization light generator 112 is used to convert the light emitted by the light source 111 into polarized light, the wavelength selector 114 is used to filter the incident light and selectively output light of a specific wavelength; the beam shaping device 113 is used to converge the incident light, which can converge the incident light into parallel light; the incident light provided by the light source 111, after being processed by the light processing module, can output detection light with a light vector vibrating in a predetermined direction, having a specific wavelength, and concentrated energy.
[0028] The turbidimetric device 120 includes a turbidimetric reaction cell. Polarized light of a specific wavelength emitted from the light source assembly 110 passes through a sample in the turbidimetric reaction cell and is transmitted and / or scattered after being acted upon by the sample in the turbidimetric reaction cell.
[0029] The detection device 130 collects the light signal transmitted and / or scattered by the turbidimetric device 120 and converts the light signal into an electrical signal output that is related to the intensity of the light signal.
[0030] The control module can be used to process the electrical signals output by the detection device 130 and to use existing or future algorithms to calculate the absorbance and / or scattering of the sample in the turbidimetric reaction cell to incident polarized light of a specific wavelength. Since specific proteins in the sample have absorption and / or scattering effects on polarized light of a specific wavelength corresponding to them, the absorption and / or scattering of specific wavelength polarized light will vary depending on the content of the specific protein. Therefore, the content of specific proteins in the sample in the turbidimetric reaction cell can be calculated based on the absorbance and / or scattering, thereby outputting the detection information of specific proteins.
[0031] The control module is coupled with the specific protein detection module, sample collection and distribution module, and reagent supply module. As the scheduling and control center of the entire specific protein analysis system, the control module configures specific protein detection modes for the specific protein detection module before sample detection, based on different sample types or user needs. During sample detection, it controls sample distribution and reagent supply. Specifically, the control module first acquires the specific protein detection mode of the whole blood sample to be tested; then, it controls the sample collection and distribution module to aspirate the whole blood sample and distribute it to the turbidimetric device 120 of the specific protein detection module. Additionally, it controls the reagent supply module to supply the turbidimetric device 120 containing the whole blood sample to the specific protein detection mode with the corresponding reagent. Furthermore, different protein detection modes require different wavelengths of light to irradiate the turbidimetric reaction cell; each type of protein detection mode has its corresponding specific wavelength of light. Therefore, the control module also controls the wavelength selector 114 of the specific protein detection module to selectively output specific wavelengths of light.
[0032] One example, see Figure 1The optical path setup is shown. The light source assembly 110 is arranged along the first optical path 140 in the order of light source 111, polarization generator 112, beam shaping device 113, and wavelength selector 114, with the centers of the light source 111, polarization generator 112, beam shaping device 113, and wavelength selector 114 located on the same straight line. After the light emitted by the light source 111 passes through the polarization generator 112, the light emitted by the light source 111 is converted into polarized light. The polarized light emitted from the polarization generator 112 reaches the beam shaping device 113, which converges the diverging polarized light, adjusting it into parallel polarized light along the direction of the first optical path 140. The parallel polarized light adjusted by the beam shaping device 113 further passes through the wavelength selector 114, which filters out light of non-target wavelengths and outputs parallel polarized light with a specific wavelength.
[0033] Understandably, light source 111 is a broadband light source, which can be selected from white light sources, LED light sources, halogen lamp light sources, etc. Light source 111 provides incident light for a specific protein analysis system, used to irradiate specific substances in the turbidimetric reaction cell and generate detection signals.
[0034] As is understandable, a polarized light generator includes a polarizer. The incident light from the light source is natural light, which is converted into linearly polarized light with a specific polarization direction after passing through the polarizer. The polarization direction of the polarizer can be horizontal, vertical, or at any angle to the horizontal plane. Linearly polarized light can effectively reduce light interference during the detection process and improve detection accuracy.
[0035] Understandably, the wavelength selector 114 is used to select a specific irradiation wavelength for different analytes in the sample. The wavelength selector 114 can select a specific wavelength via a rotating dial; it can be selected manually or automatically via parameter settings and a processor. The wavelength selector 114 can be a driven rotating color wheel with filters of different bandwidths; the filters can include, but are not limited to, the 630nm–635nm, 520nm–535nm, and 780nm–800nm bands. When a specific wavelength of light is required to pass through, a filter containing that wavelength can be adjusted into the optical path to allow that wavelength to pass through while light outside the filter's band is filtered out.
[0036] In this embodiment of the invention, a broadband light source is used to emit light without strictly limiting the wavelength range. A wavelength selector is then used to select a specific wavelength, enabling the detection instrument to be applicable to various protein detection modes. Furthermore, the broadband light emitted by the light source is converted into polarized light. The polarized light has a fixed direction of light vector vibration, making the specific protein detection module less susceptible to stray light interference and ensuring stable light propagation. A beam shaping device collects the divergent light, converging it to maintain high stability, high signal-to-noise ratio, and high sensitivity of the detection instrument as a whole.
[0037] Another embodiment, see Figure 2 A schematic diagram is shown. The beam shaping device 113 includes a shaping lens assembly 1131 and an output limiting aperture assembly 1132. The shaping lens assembly 1131 includes an incident light surface 1133 and an exit light surface 1134. The shaping lens assembly 1131 is used to adjust the incident light into parallel light, and the output limiting aperture assembly 1132 is used to limit the range of the beam illuminating the turbidimeter 120. It is understood that, in order to avoid the limiting aperture assembly 1132 causing secondary reflection of light and further interfering with the light source 111, thereby affecting the detection accuracy, the limiting aperture assembly 1132 should preferably be made of a light-absorbing material.
[0038] In another embodiment, the surfaces of the light-incident surface 1133 and / or the light-exit surface 1134 are coated with an anti-reflection coating (not shown). The anti-reflection coating (not shown) is used to reduce the reflectivity of the incident light from the light-incident surface, further reducing the potential impact of reflected light on the light source 111 and improving detection accuracy. Preferably, the anti-reflection coating (not shown) is disposed on the light-incident surface 1133, controlling the reflectivity at the light-incident surface 1133 to below 2.5‰, so that even if some reflected light still returns to the light source 111 through different paths, the interference caused by reflected light on the light source 111 can be reduced. It is understood that the anti-reflection coating (not shown) can also be disposed on the light-exit surface 1134 to reduce the reflectivity of the light-exit surface 1134 to the incident light. In this case, anti-reflection coatings (not shown) are disposed on both opposite sides of the outer surface of the shaping lens assembly 1131, further eliminating the influence of the shaping lens assembly 1131 on the light emitted by the light source 111. Understandably, the reflectivity of the antireflection coating (not shown) at the light-emitting surface 1134 is also controlled below 2.5‰.
[0039] For another embodiment, please refer to Figure 1 A schematic diagram. Figure 1The diagram shows another specific protein detection module 10 of the present invention, including a light source assembly 110, a turbidimetric reaction cell 120, and a detection device 130. The turbidimetric reaction cell 120 is disposed between the light source assembly 110 and the detection device 130. The light source assembly 110 emits incident light as a detection light source along a first optical path 140 toward the turbidimetric reaction cell 120. The incident light is received by the detection device 130 after passing through the turbidimetric reaction cell 120. By detecting the brightness and intensity of the received light and comparing it with the brightness and intensity of the light emitted by the light source assembly 110, the detection device 130 can calculate the absorbance and / or scattering of light by the sample in the turbidimetric reaction cell 120, and thus deduce the content of a specific protein in the sample, achieving the purpose of turbidimetric detection of the sample in the turbidimetric reaction cell 120.
[0040] In the specific protein analysis system of this invention, the turbidimetric reaction cell 120 also includes a light-incident surface, and the light-incident surface of the turbidimetric reaction cell 120 includes a first light-incident surface 1201 facing the light source assembly 110, and a second light-incident surface 1202 facing the first light-incident surface. The first light-incident surface 1201 is the surface of the outer wall of the turbidimetric reaction cell close to the light source assembly 110 along the first light path 140, and the second light-incident surface 1202 is the surface of the inner wall of the turbidimetric reaction cell away from the light source assembly 110 along the first light path 140. Light enters the interior of the turbidimetric reaction cell 120 from the first light-incident surface 1201 along the first light path 140, is absorbed and scattered by the sample in the turbidimetric reaction cell 120, and then incident on the second light-incident surface 1202, and finally exits from the turbidimetric reaction cell 120.
[0041] It is understandable that the turbidimetric reaction cell 120, as a testing container, will reflect light when it is projected onto its first light-incident surface 1201 along the first optical path 140. If the light reflected by the first light-incident surface 1201 is reflected back into the light source assembly 110, it may interfere with the light emitted by the light source assembly 110. Therefore, in the specific protein analysis system of this invention, the angle between the first light-incident surface 1201 and the first optical path 140 is also set accordingly to prevent the laser light reflected by the first light-incident surface 1201 from being reflected back into the light source assembly 110 along the first optical path 140.
[0042] Typically, the light source assembly 110 projects laser light into the turbidimetric reaction cell 120 with perpendicular incidence, meaning the first optical path 140 and the first incident surface 1201 are perpendicularly positioned. However, the perpendicular first incident surface 1201 and the first optical path 140 cause light reflected from the first incident surface 1201 to also be reflected back into the light source assembly 110 along the first optical path 140. Therefore, in the specific protein analysis system of this invention, the angle β between the first incident surface 1201 and the first optical path 140 needs to be set to a non-perpendicular angle to 1, in order to prevent light reflected from the first incident surface 1201 from being reflected back into the light source assembly 110 along the first optical path 140 and interfering with the light emitted by the light source assembly 110.
[0043] Typically, the angle β between the first light-incident surface 1201 and the first optical path 140 can be set to satisfy the condition: 75°≤β≤87°, preferably 83°. This can satisfy the situation where light reflected by the first light-incident surface 1201 is reflected back to the light source assembly 110 in most usage scenarios.
[0044] It should be noted that the non-perpendicular arrangement between the first light-incident surface 1201 and the first optical path 140 can be achieved by tilting the turbidimetric reaction cell 120, or by setting the first light-incident surface 1201 as an inclined side surface on the turbidimetric reaction cell 120. Since the function of the turbidimetric reaction cell 120 is to hold the sample and allow light to pass through, the specific shape of the turbidimetric reaction cell 120 is not strictly limited in the present invention. As long as the first light-incident surface 1201 of the turbidimetric reaction cell 120, when placed in a specific protein analysis system, forms an angle β with the first optical path 140, the situation where light reflected by the first light-incident surface 1201 is reflected back to the light source assembly 110 can be avoided, thereby improving the detection accuracy.
[0045] Regarding the tilt direction of the turbidimetric reaction cell 120 relative to the light source assembly, the specific protein colorimetric system of the present invention does not impose any particular limitation. That is, the turbidimetric reaction cell 120 can be tilted vertically relative to the light source assembly 110, or it can be tilted horizontally or in any direction relative to the light source assembly 110 to form an offset of the first light incident surface 1201 and / or the second light incident surface 1202 relative to the first optical path 140. This does not affect the implementation of the specific protein colorimetric system of the present invention and achieves the same beneficial effects.
[0046] It is understandable that the light source 111, polarization generator 112, beam shaping device 113, and wavelength selector 114 of the light source assembly 110 are arranged along the first optical path 140, but are not limited to this arrangement. Figure 1The arrangement order is shown. In one embodiment, the light source assembly can be arranged along the first optical path 140 in the order of light source 111, wavelength selector 114, polarization generator 112, and beam shaping device 113; in another embodiment, the light source assembly can be arranged along the first optical path 140 in the order of light source 111, polarization generator 112, wavelength selector 114, and beam shaping device 113; as long as the incident beam from light source 111 is polarized by polarization generator 112, wavelength selected by wavelength selector 114, and shaped by beam shaping device 113, a detection light with a specific wavelength and concentrated energy, parallel to the first optical path 140, with the light vector vibrating in a predetermined direction, is obtained, and then output to the turbidimetric reaction cell 120.
[0047] For another embodiment, please refer to Figure 1 The schematic diagram shows that the detection device includes a scattered light detection device 130. The scattered light detection device 130 is disposed in the optical path of the scattered light and is used to receive and detect the scattered light signal. The scattered light detection device 130 can also transmit the detected scattered light signal to a processor for calculation to obtain the turbidity of the analyte corresponding to the scattered light signal. Alternatively, the scattered light detection device 130 itself has a processor; after detecting the scattered light signal, its built-in processor calculates the turbidity of the analyte corresponding to the scattered light signal.
[0048] For another embodiment, please refer to Figure 3 The schematic diagram shows that the detection device includes a transmitted light detection device 150. The transmitted light detection device 150 is disposed in the optical path of the transmitted light and is used to receive and detect the transmitted light signal. The transmitted light detection device 150 can also transmit the detected transmitted light signal to a processor for calculation to obtain the turbidity of the analyte corresponding to the transmitted light signal. Alternatively, the transmitted light detection device 150 itself has a processor; after detecting the transmitted light signal, its built-in processor calculates the turbidity of the analyte corresponding to the transmitted light signal.
[0049] In another embodiment, the turbidimetric reaction chamber 120 can be a serum amyloid turbidimetric reaction chamber, and the corresponding turbidimetric measurement item of the specific protein detection module 10 is serum amyloid analysis (SAA). In another embodiment, the turbidimetric reaction chamber 120 can be a C-reactive protein turbidimetric reaction chamber, and the corresponding turbidimetric measurement item of the specific protein detection module 10 is C-reactive protein analysis (CRP). It is understood that the specific protein detection module 10 of the present invention does not limit the specific detection items of the turbidimetric reaction chamber 120. Based on the needs of different samples, the operator can set the wavelength selector 114 to arbitrarily match the samples contained in the turbidimetric reaction chamber 120, thereby realizing the detection of different samples on the same system. In some application scenarios, different clinical data can be obtained by analyzing samples collected from the same subject based on different detection items.
[0050] The embodiments described above do not constitute a limitation on the scope of protection of this technical solution. Any modifications, equivalent substitutions, and improvements made within the spirit and principles of the above embodiments should be included within the scope of protection of this technical solution.
Claims
1. A specific protein analysis system characterized by comprising: The sample collection and distribution module, the reagent supply module, the specific protein detection module and the control module, The sample collection and distribution module is used for sucking and distributing the sample to be detected to the specific protein detection module; The reagent supply module is used for supplying the specific protein detection module with reaction reagents; The specific protein detection module comprises a light source assembly, a turbidimetry device and a detection device, The light source assembly comprises a light source and a light processing module, the light source is used for providing incident light with a wide spectrum; the light processing module is arranged on the light path of the incident light, processes the incident light, and outputs detection light with a specific wavelength, energy concentration and vibration of light vectors along a predetermined direction; the light processing module comprises a polarized light generator, a beam shaping device and a wavelength selector which are distributed along the light path of the incident light; the polarized light generator is configured to convert the incident light into linearly polarized light with a certain polarization direction, so as to effectively reduce light interference in the detection process; The wavelength selector is configured to select light with a specific wavelength corresponding to the specific protein from the incident light according to the type of the specific protein to be detected, and the beam shaping device is configured to converge the incident light into parallel light; the detection light is parallel light and irradiates the turbidimetry device; The turbidimetry device is used for carrying the test sample, and the detection light is transmitted and / or scattered after acting on the test sample carried by the turbidimetry device; The detection device is used for collecting the transmitted and / or scattered light signal and converting the light signal into an electrical signal output related to the intensity of the light signal; The control module is used for processing the electrical signal from the detection device and outputting the detection information of the specific protein.
2. The specific protein analysis system according to claim 1, characterized by The light processing module comprises a polarized light generator, a beam shaping device and a wavelength selector which are distributed along the propagation direction of the incident light.
3. The specific protein analysis system according to claim 1, characterized by The control module is further used for controlling the wavelength selector to selectively output polarized light with a specific wavelength.
4. The specific protein analysis system according to claim 1, wherein The angle between the outer wall surface of the turbidimetry device facing the light source assembly and the detection light is not equal to 90 degrees.
5. The specific protein analysis system according to claim 4, wherein The angle between the outer wall surface of the turbidimetry device facing the light source assembly and the detection light is greater than or equal to 75 degrees and less than or equal to 87 degrees.
6. The specific protein analysis system according to claim 1, wherein The wavelength selector comprises a rotating color wheel, the rotating color wheel comprises a plurality of filter plates of different wave bands, and the rotating color wheel is configured to adjust the filter plate corresponding to the specific protein to the light path of the incident light according to the type of the specific protein to be detected, so as to output light with a specific wavelength.
7. The specific protein analysis system according to claim 1, wherein The light source is a white light source.
8. The specific protein analysis system according to claim 1, wherein The polarized light generator comprises a polarizer with a predetermined polarization direction.
9. The specific protein analysis system according to claim 1, wherein The beam shaping device further comprises a shaping lens assembly and an output limiting diaphragm assembly, the shaping lens assembly has an incident surface close to the light source and an exit surface opposite to the incident surface; the output limiting diaphragm assembly is arranged on the exit surface side of the shaping lens assembly along the light path.
10. The specific protein analysis system according to claim 9, wherein The surface of the shaping lens assembly is further attached with an anti-reflection film.
11. The specific protein analysis system according to claim 1, characterized by: The turbidimetry device comprises a turbidimetry reaction pool, the turbidimetry reaction pool is located between the light source assembly and the detection device, and the detection device comprises a scattered light detection device and / or a transmitted light detection device; The scattering light detection device is used for collecting and detecting the scattering light passing through the turbidimetry reaction cell, and the transmission light detection device is used for collecting and detecting the transmission light passing through the turbidimetry reaction cell.
12. The specific protein analysis system according to any one of claims 1 to 11, wherein When the turbidimetry detection item is serum amyloid analysis, the wavelength selector outputs polarized light of a first specific wavelength, the control module processes the electrical signal from the detection device, and outputs the analysis result of serum amyloid.
13. The specific protein analysis system according to any one of claims 1 to 11, wherein When the turbidimetry detection item is C-reactive protein analysis, the wavelength selector outputs polarized light of a second specific wavelength, the control module processes the electrical signal from the detection device, and outputs the analysis result of C-reactive protein.
Citation Information
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Automatic analysis apparatus and automatic analysis method
CN101339198A