A pre-flushing method, device and storage medium of a blood purification device

Abstract

This invention provides a pre-flushing method, equipment, and storage medium for a blood purification device. The pre-flushing method includes: closing the connection between the hemoperfusion unit and the dialyzer, opening the connection between the hemoperfusion unit and the waste liquid tank, and inputting pre-flushing fluid into the hemoperfusion unit for pre-flushing; determining a first pre-flushing flow rate of the pre-flushing fluid; if the first pre-flushing flow rate is higher than a first threshold, activating a vacuum pump to extract gas from the waste liquid tank until the pre-flushing of the hemoperfusion unit is confirmed to be complete; opening the connection between the hemoperfusion unit and the dialyzer, closing the connection between the hemoperfusion unit and the waste liquid tank, and inputting pre-flushing fluid into the hemoperfusion unit to pre-flushing the dialyzer until the pre-flushing of the dialyzer is confirmed to be complete. This invention solves the problems of poor pre-flushing effect and low efficiency in existing blood purification devices.

Description

Technical Field

[0001] This invention relates to the field of blood purification technology, and more specifically, to a pre-priming method, equipment, and storage medium for a blood purification device. Background Technology

[0002] A combined artificial kidney is a blood purification device that combines hemodialysis (HD) with hemoperfusion (HP). It utilizes two different blood purification methods with complementary advantages to comprehensively remove metabolic products, toxins, and pathogenic factors from end-stage renal disease, regulate the water and electrolyte balance in the blood, prevent and treat long-term dialysis complications, and improve the patient's quality of life.

[0003] Before blood purification, the blood purification tubing, specifically the combined artificial kidney tubing, needs to be pre-flushed to ensure the safety of the blood purification process. Pre-flushing of the combined artificial kidney tubing involves infusing a pre-flushing solution, such as normal saline, into the tubing. As the pre-flushing solution fills and flows within the tubing, it washes away impurities and removes air. Pre-flushing is an essential step in the blood purification process; if the tubing is not sufficiently pre-flushed, residual gas or impurities can remain, affecting the safety of the patient's blood purification.

[0004] The combined artificial kidney includes two types of blood purification devices: a dialyzer and a hemoperfusion device. These two devices have different internal structures and complex connecting tubing. To prevent particles and air from entering the human blood, medical staff need to spend a lot of time manually priming and venting before blood purification. This is not only difficult and inefficient, but also results in poor priming, which is not conducive to the widespread application of the combined artificial kidney. Summary of the Invention

[0005] The present invention aims to solve the problems of poor pre-flushing effect and low efficiency of existing blood purification devices.

[0006] To address the aforementioned problems, the first aspect of this invention provides a pre-flushing method for a blood purification device, the blood purification device comprising a hemoperfusion device, a first output end of the hemoperfusion device being connected to the input end of a waste liquid tank, a second output end being connected to the input end of a dialyzer, and the output end of the waste liquid tank being connected to a vacuum pump.

[0007] The pre-flushing method includes the following steps:

[0008] Close the connection between the hemoperfusion device and the dialyzer, open the connection between the hemoperfusion device and the waste liquid tank, and input pre-flushing fluid into the hemoperfusion device for pre-flushing;

[0009] Determine the first pre-flush flow rate of the pre-flush liquid. If the first pre-flush flow rate is higher than the first threshold, start the air pump to extract the gas in the waste liquid tank until the blood perfusion device is determined to be pre-flushed.

[0010] Connect the hemoperfusion device and the dialyzer, disconnect the hemoperfusion device and the waste liquid tank, and input pre-flushing fluid into the hemoperfusion device to pre-flushing the dialyzer until the dialyzer is confirmed to be pre-flushing complete.

[0011] A second aspect of the present invention provides a blood purification device, the blood purification device including a hemoperfusion device, a first output end of the hemoperfusion device being connected to the input end of a waste liquid tank, a second output end being connected to the input end of a dialyzer, and the output end of the waste liquid tank being connected to a vacuum pump.

[0012] The blood purification device further includes a pre-flushing component, which comprises:

[0013] The first pre-flushing module is used to close the connection between the hemoperfusion device and the dialyzer, open the connection between the hemoperfusion device and the waste liquid tank, and input pre-flushing fluid into the hemoperfusion device for pre-flushing.

[0014] The air extraction module is used to determine the first pre-flushing flow rate of the pre-flushing liquid. If the first pre-flushing flow rate is higher than the first threshold, the air extraction pump is started to extract the gas in the waste liquid tank until it is determined that the blood perfusion device has been pre-flushed.

[0015] The second pre-flushing module opens the connection between the hemoperfusion device and the dialyzer, closes the connection between the hemoperfusion device and the waste liquid tank, and inputs pre-flushing fluid into the hemoperfusion device to pre-flushing the dialyzer until it is determined that the dialyzer has been pre-flushed.

[0016] A third aspect of the present invention provides an electronic device, including a memory, a processor, and a computer program stored in the memory, characterized in that the processor executes the computer program to implement the steps of the method according to any one of the first aspects.

[0017] A fourth aspect of the present invention provides a computer-readable storage medium having a computer program stored thereon, characterized in that, when the computer program is executed by a processor, it implements the steps of the method described in any one of the first aspects.

[0018] The blood purification device, its pre-flushing method, equipment, and storage medium described in this invention pre-flushing the hemoperfusion device, determining a first pre-flushing flow rate of the pre-flushing fluid during this process, and determining whether to activate the air pump by comparing the first pre-flushing flow rate with a first threshold value. This optimizes the venting process of the hemoperfusion device and related tubing, ensuring that no gas subsequently enters the dialyzer and related tubing, thereby guaranteeing the overall venting effect of the blood purification device. After pre-flushing the hemoperfusion device, the dialyzer is then pre-flushed. This invention removes residual impurities and gases from the dialyzer and related tubing, ensuring the dialyzer's pre-flushing effect. By pre-flushing the hemoperfusion device first and then the dialyzer, the pre-flushing operation is simplified, ensuring both the effectiveness of the blood purification device's pre-flushing and improving pre-flushing efficiency. Furthermore, this invention enables automated control, reducing the workload of medical staff and minimizing the risk of infection for patients. Blood purification equipment pre-flushed using this invention exhibits higher safety, facilitating the promotion and application of combined artificial kidneys in clinical treatment. Attached Figure Description

[0019] Figure 1 This is a schematic diagram of the structure of an embodiment of the blood purification device provided in this invention;

[0020] Figure 2 This is a schematic diagram of another embodiment of the blood purification device provided in this invention;

[0021] Figure 3 A flowchart of the pre-flushing method for the blood purification device provided in an embodiment of the present invention;

[0022] Figure 4 This is a flowchart of pre-flushing a blood perfusion device provided in an embodiment of the present invention;

[0023] Figure 5 This is a flowchart of pre-flushing a hemodialysis machine provided in an embodiment of the present invention;

[0024] Figure 6 This is a schematic diagram of another embodiment of the blood purification device provided in this invention;

[0025] Figure 7 This is a schematic diagram of the structure of the electronic device provided in this embodiment. Detailed Implementation

[0026] The technical solution of this application and how the technical solution of this application solves the above-mentioned technical problems are described in detail below with specific embodiments. These specific embodiments can be combined with each other, and the same or similar concepts or processes may not be described again in some embodiments. The embodiments of this application will now be described with reference to the accompanying drawings.

[0027] It should be noted that examples of embodiments of this application are shown in the accompanying drawings, wherein the same or similar reference numerals denote the same or similar elements or elements having the same or similar functions throughout. The embodiments described below with reference to the accompanying drawings are exemplary and are only used to explain this application, and should not be construed as limiting this application.

[0028] Those skilled in the art will understand that, unless explicitly stated otherwise, the singular forms “a,” “an,” and “the” used herein may also include the plural forms. It should be further understood that the term “comprising” as used in the specification of this application means the presence of features, integers, steps, operations, elements, and / or components, but does not exclude the presence or addition of one or more other features, integers, steps, operations, elements, components, and / or groups thereof. It should be understood that when we say an element is “connected” or “coupled” to another element, it can be directly connected or coupled to the other element, or there may be intermediate elements. Furthermore, “connected” or “coupled” as used herein can include wireless connections or wireless coupling. The term “and / or” as used herein includes all or any units and all combinations of one or more associated listed items.

[0029] See Figure 1 , Figure 1 This is a schematic diagram of one embodiment of the blood purification device in this application. (In conjunction with...) Figure 1 As shown, the blood purification device includes a hemoperfusion device 1, a dialyzer 2, a waste liquid tank 3, a vacuum pump 4, a blood pump 5, a first clamp 6, a second clamp 7, a third clamp 8, a fourth clamp 9, a first tubing 10, a second tubing 11, a third tubing 12, a fourth tubing 13, and a fifth tubing 14. During pre-flushing, the input end of the third tubing 12 is connected to the pre-flushing fluid bag, and the output end of the third tubing 12 is connected to the hemoperfusion device 1. The first output end of the hemoperfusion device 1 is connected to the input end of the waste liquid tank 3 through the first tubing 10. The input end of the waste liquid tank 3 is connected to the vacuum pump 4 through the second tubing 11. The second output end of the hemoperfusion device 1 is connected to the input end of the dialyzer 2 through the fourth tubing 13. The output end of the dialyzer 2 is connected to the waste liquid bag through the fifth tubing 14. In this way, a connector can be set on the fourth pipeline 13, and the output end of the blood perfusion device 1 can be connected to the first pipeline 10 and the fourth pipeline 13 respectively through the connector T1, so that the blood perfusion device 1 has a first output end and a second output end.

[0030] A blood pump 5 is installed on the third pipeline 12 to provide driving force, enabling the pre-flushing fluid to be transmitted at a specific flow rate to ensure that the pre-flushing fluid in each pipeline is in a normal flow state. A first clamp 6 is installed on the fourth pipeline 13, and is located between the connector and the dialyzer 2. It is used to control the connection between the hemoperfusion device 1 and the dialyzer 2. When the first clamp 6 is closed, the connection between the hemoperfusion device 1 and the dialyzer 2 is closed; when the first clamp 6 is open, the hemoperfusion device 1 and the dialyzer 2 are connected. A second clamp 7 is installed on the first pipeline 10, and is located between the connector and the waste fluid tank 3. It is used to control the connection between the hemoperfusion device 1 and the waste fluid tank 3. When the second clamp 7 is closed, the connection between the hemoperfusion device 1 and the waste fluid tank 3 is closed; when the second clamp 7 is open, the hemoperfusion device 1 and the waste fluid tank 3 are connected. The third clamp 8 is installed on the fifth pipeline 14 and is located between the dialyzer 2 and the waste bag. It controls the connection between the dialyzer 2 and the waste bag. When the third clamp 8 is closed, the connection between the dialyzer 2 and the waste bag is closed; when the third clamp 8 is open, the dialyzer 2 and the waste bag are connected. The fourth clamp 9 is installed on the second pipeline 11 and is located between the waste tank 3 and the vacuum pump 4. It controls the connection between the waste tank 3 and the vacuum pump 4. When the fourth clamp 9 is closed, the connection between the waste tank 3 and the vacuum pump 4 is closed; when the fourth clamp 9 is open, the waste tank 3 and the vacuum pump 4 are connected.

[0031] The blood purification device in this embodiment can be a combined artificial kidney. Both the hemoperfusion device 1 and the dialyzer 2 are conventional hemoperfusion and dialyzers, and their structures are not modified in this embodiment. The hemoperfusion device 1 contains a hemoperfusion adsorbent. Blood is introduced into the hemoperfusion device 1, where the adsorbent removes endogenous or exogenous toxins or pathogens from the patient's blood. The dialyzer 2 contains a hollow fiber membrane. Blood is introduced into the dialyzer 2, with the blood and dialysate on opposite sides of the membrane. Utilizing the principle of a semi-permeable membrane, various harmful and excess metabolic wastes and excess electrolytes are removed from the body to correct the water, electrolyte, and acid-base balance in the blood.

[0032] This blood purification device includes a hemoperfusion unit 1 and a dialyzer 2, as well as various connecting tubing. In practical applications, the volume of the hemoperfusion unit 1 and dialyzer 2 is generally much larger than the volume of the connecting tubing, and the internal structure of the hemoperfusion unit 1 and dialyzer 2 is quite complex. Therefore, thorough and efficient flushing of the hemoperfusion unit 1 and dialyzer 2 is a challenge in the pre-flushing of the combined artificial kidney. In existing technologies, before blood purification, medical staff need to spend a lot of time performing manual pre-flushing and air purging operations, which is not only difficult and inefficient but also yields poor pre-flushing results.

[0033] To improve the efficiency of pre-rinsing and ensure the pre-rinsing effect, the first aspect of this embodiment provides a pre-rinsing method for a blood purification device. Figure 3 A flowchart illustrating the pre-priming method for the blood purification device provided in this application embodiment. See also... Figure 3 The pre-charging method of the blood purification device in this embodiment includes:

[0034] S310. Close the connection between hemoperfusion device 1 and dialyzer 2, open the connection between hemoperfusion device 1 and waste liquid tank 3, and input pre-flushing fluid into hemoperfusion device 1 for pre-flushing.

[0035] Specifically, the connection between the hemoperfusion device 1 and the dialyzer 2 can be closed by shutting down the first clamp 6, and the connection between the hemoperfusion device 1 and the waste liquid tank 3 can be opened by opening the second clamp 7. Pre-flushing fluid is introduced into the third line 12, and the blood pump 5 is started. Driven by the blood pump 5, the pre-flushing fluid flows sequentially through the third line 12, the hemoperfusion device 1, the fourth line 13, and the first line 10, until it reaches the waste liquid tank 3. This allows the gas and impurities in each line and the hemoperfusion device 1 to be carried into the waste liquid tank 3, thus achieving pre-flushing of the hemoperfusion device 1.

[0036] S320. Determine the first pre-flush flow rate of the pre-flush liquid. If the first pre-flush flow rate is higher than the first threshold, start the air pump 4 to extract the gas in the waste liquid tank 3 until the blood perfusion device 1 is determined to be pre-flushed.

[0037] In this process, during the pre-flushing of the hemoperfusion device 1, the first pre-flushing flow rate Q1 of the pre-flushing fluid is determined in real time. As an optional implementation, the first pre-flushing flow rate Q1 can be calculated by monitoring the average rotational speed v1 of the blood pump 5 and based on the operating time t1 of the blood pump 5 using the following formula: Q1 = v1 × t1. Alternatively, a flow meter can be installed on the third pipeline 12 to determine the first pre-flushing flow rate Q1 of the pre-flushing fluid in real time.

[0038] Combination Figure 4As shown, if the first pre-flushing flow rate Q1 is higher than the first threshold Q3, the fourth clamp 9 is opened, and the vacuum pump 4 is started to extract the gas in the waste liquid tank 3, creating a negative pressure in the waste liquid tank 3 and causing the gas in the waste liquid tank 3 to escape. Thus, since the blood purification equipment is a closed environment, when the hemoperfusion device 1 is pre-flushed, the gas and impurities in each pipeline and inside the hemoperfusion device 1 are carried into the waste liquid tank 3. When the vacuum pump 4 extracts the gas in the waste liquid tank 3, it can create a negative pressure in the waste liquid tank 3, causing the gas in the waste liquid tank 3 to escape, ensuring that there is no gas in each pipeline and inside the hemoperfusion device 1. Furthermore, the third pipeline 12, the hemoperfusion device 1, and the fourth pipeline 13 are all located at the front end of the dialyzer 2. After the gas in the third pipeline 12, the hemoperfusion device 1, and the fourth pipeline 13 is discharged, it can be ensured that no gas enters the dialyzer 2 and the fifth pipeline 14 afterward, thereby ensuring that there is no excess gas inside the blood purification equipment.

[0039] Wherein, the first threshold Q3 is the flow rate of the pre-flushing liquid when half the volume of the third pipeline 12, the blood perfusion device 1, the fourth pipeline 13, the first pipeline 10, and the waste liquid tank 3 is filled with pre-flushing liquid. In this embodiment, the specific value of the first threshold Q3 is not further limited, and those skilled in the art can determine it according to the actual situation.

[0040] As an optional implementation, step S320 further includes: controlling the hemoperfusion device 1 to reciprocate and oscillate, so as to expel the gas and impurities hidden inside the hemoperfusion device 1. Specifically, the blood purification device further includes a first clamp for clamping the hemoperfusion device 1. The first clamp can control the hemoperfusion device 1 to reciprocate and oscillate, so that the hemoperfusion device 1 shakes, expelling the air bubbles and impurities hidden inside the hemoperfusion device 1, and accelerating the rinsing of the hemoperfusion device 1 with pre-rinsing fluid. Figure 4 As shown, if the first pre-flow rate Q1 is higher than the third threshold Q4, the first clamp controls the blood perfusion device 1 to swing back and forth, wherein the third threshold Q4 is less than the first threshold Q3.

[0041] Wherein, the third threshold Q4 is the flow rate of the pre-flushing fluid when both the third pipeline 12 and the blood perfusion device 1 are filled with pre-flushing fluid. In this embodiment, the specific value of the third threshold Q4 is not further limited, and those skilled in the art can determine it according to the actual situation.

[0042] In this embodiment, the first clamp can control the hemoperfusion device 1 to tilt 60° to the right and then swing back and forth in the 60° direction, or the first clamp can control the hemoperfusion device 1 to tilt 60° to the left and then swing back and forth in the 60° direction. Therefore, by controlling the hemoperfusion device 1 to tilt 60° and swing back and forth by the first clamp, it is beneficial to improve the effect of venting hidden gas and impurities inside the hemoperfusion device 1, thereby improving the pre-flushing effect of the hemoperfusion device 1.

[0043] In this embodiment, the specific structure of the first clamp is not further limited. Those skilled in the art can make the settings according to the actual situation. For example, those skilled in the art can choose the rocking clamp in patent document CN204428500U as the first clamp in this embodiment.

[0044] As an optional implementation, step S320 involves starting the air pump to extract gas from the waste liquid tank until the blood perfusion device is pre-filled, including: determining the content of the first bubble S1 remaining in the blood perfusion device 1; if the content of the first bubble is less than the second threshold S2, then determining that the blood perfusion device is pre-filled.

[0045] Specifically, the blood purification device also includes a first bubble detector (not shown in the figure). The first bubble detector is connected to the first output end of the hemoperfusion device 1. The first bubble detector is used to detect the residual bubble content in the hemoperfusion device 1. The first bubble detector can be installed on the fourth pipeline 13 and is located between the hemoperfusion device 1 and the connector. The first bubble detector can detect the residual first bubble content S1 in the hemoperfusion device 1 in real time. When the first bubble content S1 is less than the second threshold S2, it indicates that the pre-flushing of the hemoperfusion device 1 and related pipelines has been completed. At this time, the pre-flushing of the hemoperfusion device 1 can be stopped, allowing the hemoperfusion device 1 to reset and stop swinging.

[0046] In this embodiment, the smaller the second threshold S2, the better. The smaller the second threshold S2, the less bubble content there is. Those skilled in the art can set it according to the bubble diameter range that medical personnel can tolerate. For example, the second threshold S2 is 0.15ml.

[0047] Combination Figure 4 As shown, in this embodiment, after determining the first pre-flush flow rate Q1, the magnitudes of the first pre-flush flow rate Q1 and the third threshold Q4 are first determined. If the first pre-flush flow rate Q1 is higher than the third threshold Q4, the first clamp controls the blood perfusion device 1 to swing back and forth to facilitate the discharge of hidden gas and impurities inside the blood perfusion device 1 and accelerate the rinsing of the blood perfusion device 1 with pre-flush fluid. While the first clamp controls the blood perfusion device 1 to swing back and forth, the magnitudes of the first pre-flush flow rate Q1 and the first threshold Q3 are determined again. If the first pre-flush flow rate Q1 is higher than the first threshold Q3, the air pump 4 is started to extract the gas in the waste liquid tank 3. At the same time, the first bubble detector detects the content of the first bubble S1 remaining in the blood perfusion device 1 in real time. When the content of the first bubble S1 is less than the second threshold S2, the pre-flushing of the blood perfusion device 1 is stopped, and the blood perfusion device 1 is reset and stops swinging.

[0048] For example, the hemoperfusion device is an HA130 perfusion device. When pre-flushing the hemoperfusion device, the first clamp 6 is closed first, and the pre-flushing liquid flows sequentially through the third pipe 12, the hemoperfusion device 1 (i.e., the HA130 perfusion device), the fourth pipe 13, and the first pipe 10 until it reaches the waste liquid tank 3. When the first pre-flushing flow rate Q1 reaches 160ml (i.e., the third threshold Q4), the first clamp controls the hemoperfusion device 1 to reciprocate, causing the gas and impurities hidden inside the perfusion device to be discharged with the pre-flushing liquid. When the first pre-flushing flow rate Q1 reaches 1000ml (i.e., the first threshold Q3), the air pump 4 is started to extract the gas in the waste liquid tank 3. At the same time, the residual bubble content S1 in the hemoperfusion device 1 is detected. When S1 is less than 0.15mL, the pre-flushing of the perfusion device is stopped, the perfusion device is reset and the reciprocating swing stops.

[0049] In this embodiment, the first pre-flushing flow rate Q1 is determined in real time, and the magnitude of the first pre-flushing flow rate Q1 and the first threshold Q3 are compared. The pre-flushing process is optimized by controlling the reciprocating oscillation of the hemoperfusion device 1 to promote the discharge of hidden gas and impurities inside the hemoperfusion device 1. At the same time, since the adsorbent inside the hemoperfusion device 1 is spherical or granular, filter structures are designed at both ends of the hemoperfusion device 1 to prevent the adsorbent from being flushed out. However, air bubbles inside the hemoperfusion device 1 tend to stick to the filter screen and are difficult to discharge, increasing the difficulty of venting the hemoperfusion device 1. In this embodiment, the vacuum pump 4 is activated by judging the magnitude of the first pre-flushing flow rate Q1 and the third threshold Q4 to increase negative pressure venting, thereby improving the venting effect of the hemoperfusion device 1. The content of the first air bubble S1 remaining in the hemoperfusion device 1 is detected in real time by the first air bubble detector to judge the venting effect, thus optimizing the venting process. In this embodiment, the pre-flushing process and the venting process are combined, and the above-mentioned pre-flushing method is used to ensure the pre-flushing effect of the hemoperfusion device 1 and improve the efficiency and reliability of pre-flushing.

[0050] S330. Open the connection between the hemoperfusion device 1 and the dialyzer 2, close the connection between the hemoperfusion device 1 and the waste liquid tank 3, and input pre-flushing fluid into the hemoperfusion device 3 to pre-flushing the dialyzer 2 until it is confirmed that the dialyzer 2 has been pre-flushed.

[0051] Specifically, after the hemoperfusion device 1 is pre-flushed, the connection between the hemoperfusion device 1 and the dialyzer 2 can be opened by opening the first clamp 6, the connection between the hemoperfusion device 1 and the waste liquid tank 3 can be closed by closing the second clamp 7, and the connection between the dialyzer 2 and the waste liquid bag can be opened by opening the third clamp 8. Pre-flushing fluid is introduced into the third line 12, and the blood pump 5 is started. Driven by the blood pump 5, the pre-flushing fluid flows sequentially through the third line 12, the hemoperfusion device 1, the fourth line 13, the dialyzer 2, and the fifth line 14, until it reaches the waste liquid bag, thereby carrying the gas and impurities in each line and the dialyzer 2 into the waste liquid bag, thus achieving the pre-flushing of the dialyzer 2.

[0052] In this embodiment, during the pre-flushing of dialyzer 2, the second pre-flushing flow rate Q2 of the pre-flushing fluid is determined in real time. As an optional implementation, the running time of blood pump 5 can be reset to zero. When the first clamp 6 and the third clamp 8 are opened, the running time and average speed of blood pump 5 are re-monitored. Based on the average speed v2 of blood pump 5 and the running time t2 of blood pump 5, the second pre-flushing flow rate Q2 is calculated using the following formula: Q2 = v2 × t2. Alternatively, a flow meter can be installed on the third pipeline 12. Before determining the second pre-flushing flow rate Q2, the flow meter is reset to zero. When measuring the second pre-flushing flow rate Q2, the flow meter is used to determine the second pre-flushing flow rate Q2 in real time.

[0053] As an optional implementation, step S330 further includes: controlling the dialyzer 2 to reciprocate, thereby facilitating the discharge of gases and impurities hidden inside the dialyzer 2. Specifically, the blood purification device further includes a second clamp for holding the dialyzer 2. The second clamp can control the dialyzer 2 to reciprocate, causing the dialyzer 2 to shake, thereby discharging air bubbles and impurities hidden inside the dialyzer 2, and accelerating the flushing of the hemodialysis machine 2 with pre-rinsing solution. Figure 5 As shown, if the second pre-flushing flow rate Q2 is higher than the fifth threshold Q5, the second clamp controls the dialyzer 2 to swing back and forth.

[0054] Wherein, the fifth threshold Q5 is the flow rate of the pre-flushing fluid when both the fourth pipeline 13 and the dialyzer 2 are filled with pre-flushing fluid. In this embodiment, the specific value of the fifth threshold Q5 is not further limited, and those skilled in the art can determine it according to the actual situation.

[0055] In this embodiment, the second clamp can control the dialyzer 2 to tilt 60° to the right and then oscillate back and forth in the 60° direction, or the second clamp can control the dialyzer 2 to tilt 60° to the left and then oscillate back and forth in the 60° direction. Therefore, controlling the dialyzer 2 to tilt 60° and oscillate back and forth by the second clamp helps to improve the removal of gases and impurities hidden inside the dialyzer 2, thereby improving the pre-flushing effect of the dialyzer 2.

[0056] In this embodiment, the specific structure of the second clamp is not further limited, and the second clamp can adopt the same structure as the first clamp.

[0057] As an optional implementation, step S330 involves inputting pre-flushing fluid into the hemoperfusion device 1 to pre-flushing the dialyzer 2 until it is determined that the dialyzer 2 has been pre-flushed, including: determining the content of the second bubble remaining in the dialyzer 2 S3; if the content of the second bubble is less than the fourth threshold S4, then it is determined that the dialyzer 2 has been pre-flushed.

[0058] Specifically, the blood purification device also includes a second bubble detector (not shown in the figure). The second bubble detector is connected to the output end of dialyzer 2 and is used to detect the bubble content of the residual pre-flushing fluid in dialyzer 2. The second bubble detector can be installed on the fifth pipeline 14 and is located between dialyzer 2 and the waste bag. The second bubble detector can detect the residual second bubble content S3 in dialyzer 2 in real time. When the second bubble content S3 is less than the fourth threshold S4, it indicates that the pre-flushing of dialyzer 2 and related pipelines has been completed. At this time, the pre-flushing of dialyzer 2 can be stopped, allowing dialyzer 2 to reset and stop oscillating.

[0059] In this embodiment, the smaller the fourth threshold S4, the better. The smaller the fourth threshold S4, the less bubble content there is. Those skilled in the art can set it according to the bubble diameter range that medical personnel can tolerate. For example, the fourth threshold S4 is 0.15ml.

[0060] Combination Figure 5 As shown, in this embodiment, after determining the second pre-flushing flow rate Q2, the magnitudes of the second pre-flushing flow rate Q2 and the fifth threshold Q5 are first determined. If the second pre-flushing flow rate Q2 is higher than the fifth threshold Q5, the second clamp controls the dialyzer 2 to swing back and forth to facilitate the discharge of hidden gas and impurities inside the dialyzer 2 and accelerate the flushing of the dialyzer 2 with pre-flushing liquid. At the same time, the second bubble detector detects the content of the second bubble S3 remaining in the dialyzer 2 in real time. When the content of the second bubble S3 is less than the fourth threshold S4, the pre-flushing of the dialyzer 2 is stopped, the dialyzer 2 is reset and the swinging stops.

[0061] In this embodiment, the second pre-flushing flow rate Q2 is determined in real time, and the magnitude of the second pre-flushing flow rate Q2 and the fifth threshold Q5 are compared. The dialyzer 2 is controlled to oscillate back and forth to promote the discharge of hidden gas and impurities inside the dialyzer 2, thus optimizing the pre-flushing process. At the same time, the content of the second bubble S3 remaining in the dialyzer 2 is detected in real time by the second bubble detector to judge the venting effect, thus optimizing the venting process. In this embodiment, the pre-flushing process and the venting process are combined, and the above-mentioned pre-flushing method is used to ensure the pre-flushing effect of the dialyzer 2 and improve the efficiency and reliability of pre-flushing. In addition, the interior of the dialyzer 2 is made of hollow fiber without a filter structure, making venting easy and eliminating the need for an additional negative pressure device, which helps to reduce the footprint of the blood purification device.

[0062] In this embodiment, the blood purification device includes a first branch pipe 10a and a second branch pipe 10b. The input end of the first branch pipe 10a is connected to the first output end of the hemoperfusion device 1, i.e., the input end of the first branch pipe 10a is connected to the fourth pipeline 13 via a connector. The output end of the first branch pipe 10a is detachably connected to the input end of the second branch pipe 10b, and the output end of the second branch pipe 10b is connected to the input end of the waste liquid tank 3. Based on the above embodiment, the pre-flushing method further includes: after determining in step S330 that the dialyzer 2 has been pre-flushed, disassembling the first branch pipe 10a and the second branch pipe 10b, and sealing the output end of the first branch pipe 10a.

[0063] As an optional implementation, the first branch pipe 10a and the second branch pipe 10b can be connected by a Luer connector assembly to achieve a detachable connection between the first branch pipe 10a and the second branch pipe 10b, and to prevent gas and impurities from penetrating into the interior of the fourth pipe 13 through the first branch pipe 10a, thus affecting the pre-flushing effect. As an optional implementation, in this embodiment, a Luer connector cap can be used to seal the output end of the first branch pipe 10a to ensure a good sealing effect and prevent the infiltration of gas and impurities.

[0064] Figure 2 This is a schematic diagram of another embodiment of the blood purification device described in this application. Figure 2 This is a schematic diagram showing the structure of the blood purification device after the waste liquid tank 3, the air pump 4, and related pipelines have been removed. In this embodiment, after pre-flushing, the waste liquid tank 3, the air pump 4, and related pipelines are removed, allowing the blood purification device to be directly installed on the blood purification equipment without adversely affecting it. This also avoids medical staff having to repeatedly disassemble and reassemble the hemoperfusion device 1 and the dialyzer 2, which not only facilitates operation for medical staff but also reduces the risk of infection for patients, thus improving the safety of blood purification.

[0065] The pre-flushing method for the blood purification device provided in this embodiment pre-flushing the hemoperfusion device. During the pre-flushing process, a first pre-flushing flow rate of the pre-flushing fluid is determined. By comparing the first pre-flushing flow rate Q1 with a first threshold, it is determined whether to activate the air pump to optimize the venting process of the hemoperfusion device and related pipelines, ensuring that no gas subsequently enters the dialyzer and related pipelines, thereby guaranteeing the overall venting effect of the blood purification device. After the hemoperfusion device is pre-flushed, the dialyzer is pre-flushed to remove residual impurities and gas from the dialyzer and related pipelines, ensuring the pre-flushing effect of the dialyzer. This embodiment simplifies the pre-flushing operation by pre-flushing the hemoperfusion device first and then the dialyzer, which not only ensures the pre-flushing effect of the blood purification device but also improves the pre-flushing efficiency. Furthermore, this method can achieve automated control, reducing the workload of medical staff and the risk of infection for patients. The blood purification device pre-flushed by the pre-flushing method of this embodiment has higher safety, which is conducive to promoting and applying the combined artificial kidney in clinical treatment.

[0066] Figure 6 This is a schematic diagram of another embodiment of the blood purification device provided in this application. (In conjunction with...) Figure 5 As shown, the second aspect of this embodiment provides a blood purification device, including: a hemoperfusion device 1, the first output end of the hemoperfusion device 1 being connected to the input end of a waste liquid tank 3, the second output end being connected to the input end of a dialyzer 2, and the output end of the waste liquid tank 3 being connected to a vacuum pump 4.

[0067] The blood purification device also includes a pre-flushing assembly, which includes:

[0068] The first pre-flushing module 61 is used to close the connection between the hemoperfusion device 1 and the dialyzer 2, open the connection between the hemoperfusion device 1 and the waste liquid tank 3, and input pre-flushing fluid into the hemoperfusion device 1 for pre-flushing.

[0069] The air extraction module 62 is used to determine the first pre-flushing flow rate of the pre-flushing liquid. If the first pre-flushing flow rate is higher than the first threshold, the air extraction pump 4 is started to extract the gas in the waste liquid tank 3 until the blood perfusion device 1 is determined to be pre-flushing complete.

[0070] The second pre-flushing module 63 opens the connection between the hemoperfusion device 1 and the dialyzer 3, closes the connection between the hemoperfusion device 1 and the waste liquid tank 3, and inputs pre-flushing fluid into the hemoperfusion device 1 to pre-flushing the dialyzer 2 until it is determined that the dialyzer 2 has been pre-flushed.

[0071] The blood purification device provided in this application specifically executes the process described in the above method embodiments. For details, please refer to the content of the above pre-flushing method embodiments, which will not be repeated here. Since the blood purification device in this application executes at least one of the above methods, it includes all the beneficial effects of at least one of the above methods, which will not be repeated here.

[0072] A third aspect of this embodiment provides an electronic device comprising: a memory and a processor; at least one program stored in the memory, which, when executed by the processor, enables the processor to perform the corresponding content in the foregoing method embodiments. Compared with the prior art, this electronic device can perform at least one of the above methods, and therefore the electronic device includes all the beneficial effects of at least one of the above methods, which will not be elaborated here.

[0073] In one alternative embodiment, an electronic device is provided, such as Figure 7 As shown, Figure 7 The illustrated electronic device 70 includes a processor 71 and a memory 73. The processor 71 and the memory 73 are connected, for example, via a bus 72. Optionally, the electronic device 70 may also include a transceiver 74. It should be noted that in practical applications, the transceiver 74 is not limited to one type, and the structure of this electronic device 70 does not constitute a limitation on the embodiments of this application.

[0074] Processor 71 may be a CPU (Central Processing Unit), a general-purpose processor, a DSP (Digital Signal Processor), an ASIC (Application Specific Integrated Circuit), an FPGA (Field Programmable Gate Array), or other programmable logic devices, transistor logic devices, hardware components, or any combination thereof. It can implement or execute the various exemplary logic blocks, modules, and circuits described in conjunction with the disclosure of this application. Processor 71 may also be a combination that implements computational functions, exemplary including one or more microprocessor combinations, combinations of DSPs and microprocessors, etc.

[0075] Bus 72 may include a pathway for transmitting information between the aforementioned components. Bus 72 may be a PCI (Peripheral Component Interconnect) bus or an EISA (Extended Industry Standard Architecture) bus, etc. Bus 72 can be divided into address bus, data bus, control bus, etc. For ease of representation, Figure 7 The bus is represented by a single thick line, but this does not mean that there is only one bus or one type of bus.

[0076] The memory 73 may be a ROM (Read Only Memory) or other type of static storage device capable of storing static information and instructions, RAM (Random Access Memory) or other type of dynamic storage device capable of storing information and instructions, or an EEPROM (Electrically Erasable Programmable Read Only Memory), CD-ROM (Compact Disc Read Only Memory) or other optical disc storage, optical disc storage (including compressed optical discs, laser discs, optical discs, digital universal optical discs, Blu-ray discs, etc.), magnetic disk storage media or other magnetic storage devices, or any other medium capable of carrying or storing desired program code in the form of instructions or data structures and accessible by a computer, but not limited thereto.

[0077] The memory 73 is used to store application code that executes the solution of this application, and its execution is controlled by the processor 71. The processor 71 is used to execute the application code stored in the memory 73 to implement the content shown in the foregoing method embodiments.

[0078] A fourth aspect of this application provides a computer-readable storage medium storing a computer program that, when run on a computer, enables the computer to execute the corresponding content in the foregoing method embodiments. Compared with the prior art, this computer-readable storage medium executes at least one of the above methods, and therefore includes all the beneficial effects of at least one of the above methods, which will not be elaborated further here.

[0079] It should be understood that although the steps in the flowcharts of the accompanying figures are shown sequentially as indicated by the arrows, these steps are not necessarily executed in the order indicated by the arrows. Unless explicitly stated herein, there is no strict order restriction on the execution of these steps, and they can be executed in other orders. Moreover, at least some steps in the flowcharts of the accompanying figures may include multiple sub-steps or multiple stages. These sub-steps or stages are not necessarily completed at the same time, but can be executed at different times, and their execution order is not necessarily sequential, but can be performed alternately or in turn with other steps or at least some of the sub-steps or stages of other steps.

[0080] While the disclosure is as stated above, its scope of protection is not limited thereto. Those skilled in the art can make various changes and modifications without departing from the spirit and scope of this disclosure, and all such changes and modifications will fall within the protection scope of this invention.

Claims

1. A pre-priming method for a blood purification device, characterized in that, The blood purification device includes a hemoperfusion device and a third pipeline. The input end of the third pipeline is connected to the pre-flushing bag, and the output end of the third pipeline is connected to the hemoperfusion device. The first output end of the hemoperfusion device is connected to the input end of the waste liquid tank, and the second output end is connected to the input end of the dialyzer. The output end of the waste liquid tank is connected to the vacuum pump. The pre-flushing method includes the following steps: Close the connection between the hemoperfusion device and the dialyzer, open the connection between the hemoperfusion device and the waste liquid tank, and input pre-flushing fluid into the hemoperfusion device for pre-flushing; Determine the first pre-flush flow rate of the pre-flush liquid. If the first pre-flush flow rate is higher than the first threshold, start the air pump to extract the gas in the waste liquid tank and create a negative pressure in the waste liquid tank to cause the gas in the waste liquid tank to escape until the blood perfusion device is determined to be pre-flushed. Open the connection between the hemoperfusion device and the dialyzer, close the connection between the hemoperfusion device and the waste liquid tank, and input pre-flushing fluid into the hemoperfusion device to pre-flushing the dialyzer until it is determined that the dialyzer has been pre-flushed. The blood purification device further includes a first clamp, which is used to clamp the blood perfusion device and can control the blood perfusion device to swing back and forth. The pre-flushing method further includes: if the first pre-flushing flow rate is higher than the third threshold, the first clamp controls the blood perfusion device to swing back and forth, wherein the third threshold is less than the first threshold; the third threshold is the flow rate value of the pre-flushing liquid when both the third pipeline and the blood perfusion device are filled with pre-flushing liquid.

2. The pre-priming method for the blood purification device according to claim 1, characterized in that, The process of activating the vacuum pump to extract gas from the waste liquid tank until the blood perfusion device is pre-primed includes: Determine the content of the first air bubble remaining in the blood perfusion device; If the content of the first bubble is less than the second threshold, then the blood perfusion device is determined to be pre-flushed.

3. The pre-priming method for the blood purification device according to claim 1, characterized in that, The step of introducing pre-flushing fluid into the hemoperfusion device to pre-flushing the dialyzer until it is determined that the dialyzer has been pre-flushed is complete includes: Determine the content of the second gas bubbles remaining in the dialyzer; If the content of the second bubble is less than the fourth threshold, then the dialyzer is determined to have completed pre-flushing.

4. The pre-priming method for the blood purification device according to claim 1, characterized in that, The blood purification device further includes a second clamp for holding the dialyzer, and the second clamp can control the dialyzer to swing back and forth. After opening the connection between the hemoperfusion device and the dialyzer, closing the connection between the hemoperfusion device and the waste tank, and inputting pre-flushing fluid into the hemoperfusion device to pre-flushing the dialyzer, before determining that the dialyzer pre-flushing is complete, the procedure further includes: The second pre-flush flow rate of the pre-flush fluid is determined. If the second pre-flush flow rate is higher than the fifth threshold, the second clamp controls the dialyzer to reciprocate.

5. The pre-priming method for the blood purification device according to claim 1, characterized in that, The blood purification device further includes a first pipeline, which includes a first branch pipe and a second branch pipe. The input end of the first branch pipe is connected to the first output end of the blood perfusion device, the output end of the first branch pipe is detachably connected to the input end of the second branch pipe, and the output end of the second branch pipe is connected to the input end of the waste liquid tank. The pre-flushing method further includes: After confirming that the dialyzer has been pre-flushed, the first branch tube and the second branch tube are disassembled, and the output end of the first branch tube is sealed.

6. The pre-priming method for the blood purification device according to claim 4, characterized in that, The blood purification device also includes a blood pump, which is connected to the input end of the blood perfusion device; Determining the first pre-flush flow rate of the pre-flush fluid includes: determining the first pre-flush flow rate of the pre-flush fluid based on the first average rotational speed and the first running time of the blood pump; And / or, determining the second pre-flush flow rate of the pre-flush fluid includes: determining the second pre-flush flow rate of the pre-flush fluid based on the second average rotational speed and the second operating time of the blood pump.

7. A blood purification device, characterized in that, The blood purification device includes a hemoperfusion device and a third pipeline. The input end of the third pipeline is connected to the pre-flushing bag, and the output end of the third pipeline is connected to the hemoperfusion device. The first output end of the hemoperfusion device is connected to the input end of the waste liquid tank, and the second output end is connected to the input end of the dialyzer. The output end of the waste liquid tank is connected to the vacuum pump. The blood purification device further includes a pre-flushing component, which comprises: The first pre-flushing module is used to close the connection between the hemoperfusion device and the dialyzer, open the connection between the hemoperfusion device and the waste liquid tank, and input pre-flushing fluid into the hemoperfusion device for pre-flushing. The air extraction module is used to determine the first pre-flushing flow rate of the pre-flushing liquid. If the first pre-flushing flow rate is higher than the first threshold, the air extraction pump is started to extract the gas in the waste liquid tank until it is determined that the blood perfusion device has been pre-flushed. The second pre-flushing module opens the connection between the hemoperfusion device and the dialyzer, closes the connection between the hemoperfusion device and the waste liquid tank, and inputs pre-flushing fluid into the hemoperfusion device to pre-flushing the dialyzer until it is determined that the dialyzer has been pre-flushed. The blood purification device further includes a first clamp for holding the blood perfusion device. The first clamp can control the blood perfusion device to swing back and forth. If the first pre-flushing flow rate is higher than a third threshold, the first clamp controls the blood perfusion device to swing back and forth. The third threshold is less than the first threshold. The third threshold is the flow rate of the pre-flushing fluid when both the third pipeline and the blood perfusion device are filled with pre-flushing fluid.

8. An electronic device comprising a memory, a processor, and a computer program stored in the memory, characterized in that, The processor executes the computer program to implement the steps of the method according to any one of claims 1-6.

9. A computer-readable storage medium having a computer program stored thereon, characterized in that, When the computer program is executed by a processor, it implements the steps of the method according to any one of claims 1-6.

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