Preparation method of a functionalized silica nanocontainer based on nanoemulsion and its application in adsorption and separation of blood lead

Water-in-oil nanoemulsions were prepared by the bubble burst method, and functionalized silica nanocontainers were prepared in one step using a silane coupling agent. This solved the problems of controllable continuous synthesis and morphology design of silica nanocontainer materials, and achieved the effect of efficient removal of lead ions in water and blood.

CN117285044BActive Publication Date: 2025-10-03JIANGSU UNIV
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Patent Information

Application Number
CN202311224275.9
Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
Filing Date
2023-09-21
Publication Date
2025-10-03
Estimated Expiration
2043-09-21

AI Technical Summary

Technical Problem

In the existing technology, the problems of controllable continuous synthesis and morphology design of silica nanocontainer materials have not been solved, which has limited their application in the clinical field of medicine, and it is difficult to unify the biosafety and efficiency of blood lead removal.

Method used

The bubble bursting method was used to prepare the oil-in-water nanoemulsion. The silane coupling agent dissolved in the oil phase was used to prepare the functionalized silica nanocontainer in one step by regulating the reaction parameters. The chelation effect of amino groups on lead ions was used to achieve adsorption and separation.

Benefits of technology

The continuous and controllable production of functionalized silica nanocontainers with high adsorption capacity and fast adsorption rate has been achieved, which is suitable for the efficient removal of lead ions in water and blood, simplifies the preparation process and avoids secondary modification.

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Abstract

The present invention belongs to the technical field of environmentally friendly and biomedical functional material preparation. It discloses a method for preparing a nanoemulsion-based functionalized silica nanocontainer and its application in the adsorption and separation of blood lead. The oil-in-water nanoemulsion is prepared by rupturing bubbles at the oil-water interface. Hexadecyl ammonium bromide is dissolved in the aqueous phase as a surfactant, and a functionalized silane coupling agent is dissolved in the oil phase for reaction. By adjusting the dosage ratio of the functionalized silane coupling agent and the reaction time, ten different hollow amino-functionalized silica materials can be obtained. This method not only solves the problems of multiple templates and complex preparation processes for single-pore hollow nanocontainers, but also addresses the issue of continuous production. The prepared functionalized single-pore hollow nanocontainer is used for adsorption of lead ions in water, reaching adsorption equilibrium within 100 minutes and achieving a maximum adsorption capacity of 167.7 mg / g. Its blood lead removal rate can reach 75%.
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