一种可冻干保存的细胞膜仿生制剂的制备方法及其产品和应用
By combining lyophilization technology with lyophilization protectants, the problems of stability and membrane protein degradation in cell membrane biomimetic formulations during long-term storage have been solved, achieving long-term stable storage and good reconstitution performance of the formulations, while maintaining the targeting performance and drug release capacity of the cell membrane.
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Patents(China)
- Current Assignee / Owner
- ZHEJIANG UNIV
- Filing Date
- 2023-11-07
- Publication Date
- 2026-07-17
AI Technical Summary
Existing cell membrane biomimetic formulations suffer from stability issues during long-term storage, including formulation aggregation, fusion, and drug leakage, as well as rapid degradation of membrane protein function, failing to meet the needs of clinical treatment.
The freeze-drying technology combined with freeze-drying protectants is used to prepare freeze-dried formulations by introducing freeze-drying protectants, including sucrose, trehalose, lactose, mannitol, glucose, L-arginine, Tween 80, etc., into both the inner and outer sides of the cell membrane biomimetic formulation, and combining them with buffer solutions such as phosphate buffer, tris(hydroxymethyl)aminomethane, and glycine buffer solution.
This study achieves long-term stable storage of cell membrane biomimetic formulations, exhibits good reconstitution performance after lyophilization, retains cell membrane protein function, and possesses excellent disease targeting performance and drug release capability, thus solving the problem of long-term storage stability of cell membrane biomimetic formulations.
Smart Images
Figure CN117338731B_ABST