Conjugated polymer-based activatable acoustically powered nanomaterials, methods of making and using the same

By synthesizing and modifying conjugated polymers to prepare activatable acoustic-dynamic nanomaterials, the problem of the lack of near-infrared II luminescent acoustic sensitizers in the existing technology has been solved, realizing efficient tumor treatment and drug delivery, and improving the specificity and safety of treatment.

CN117417534BActive Publication Date: 2026-08-25NANJING UNIV OF POSTS & TELECOMM
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Patent Information

Application Number
CN202311144192.9
Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
Filing Date
2023-09-06
Publication Date
2026-08-25
Estimated Expiration
2043-09-06

AI Technical Summary

Technical Problem

The lack of efficient, activatable near-infrared II luminescent sonosensitive agents in the current technology limits the penetration depth of optical diagnosis and treatment, and conventional sonosensitive agents produce side effects in normal tissues. The application of conjugated polymers in sonodynamic therapy has not been reported.

Method used

A conjugated polymer was synthesized using 2,6-di(trimethyltin)-4,4-di(2-ethylhexyl)-dithienenocyclopentadiene and 4,7-dibromo-5,6-dinitrobenzo[c][1,2,5]thiadiazole as monomers, and then modified with mesoporous silica to prepare an activatable sonodynamic nanomaterial for near-infrared fluorescence imaging and sonodynamic therapy.

Benefits of technology

It enables highly efficient sonodynamic therapy guided by near-infrared II fluorescence imaging, improving the specificity of tumor treatment, and achieves drug loading and delivery through mesoporous silica encapsulation, reducing damage to normal tissues.

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Abstract

The application belongs to the technical field of near-infrared luminescence and ultrasonic treatment materials, discloses a kind of activatable acoustic power nano materials based on conjugated polymer and its preparation method and application, comprising the following steps: 2,6-di (trimethyl tin) -4,4-di (2-ethylhexyl) -dithiophene and cyclopentadiene, 4,7-dibromo-5,6-dinitrobenzo [c] [1,2,5] thiazole, catalyst tetra (triphenylphosphine) palladium are added into reaction tube, toluene is added, and the reaction product is settled with methanol under nitrogen protection, to obtain conjugated polymer;Degradable mesoporous silica is used to wrap to realize the water-soluble of molecule, and the corresponding activatable acoustic treatment reagent is obtained.The material disclosed in the application can be used for activatable acoustic dynamics treatment guided by near-infrared two-zone imaging, which helps to improve the specificity of tumor treatment, and mesoporous silica wrapping can also be used for drug loading and transport.
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