A traditional Chinese medicine composition for treating chronic eczema and a preparation method thereof

Abstract

The application discloses a traditional Chinese medicine composition for treating chronic eczema and a preparation method thereof. The traditional Chinese medicine composition is prepared from the following raw materials in parts by weight: radix astragali 40-80, rhizoma et herba 10-50, raw ginger 5-40, radix glycyrrhizae 5-40, ephedra 5-40, ramulus cinnamomi 10-50, radix scrophulariae 10-40, radix sophorae 10-40, radix alpiniae oxyphyllae 10-50, rhizoma pinelliae 5-40, pericarpium citri reticulatae 5-40, rhizoma chuanxiong 5-40, radix ponicis cum cortex 10-40, fructus corni 5-40, radix gentianae 5-40, radix clematidis 10-40, radix rehmanniae 20-60, radix scrophulariae 10-50, radix paeoniae alba 10-50, cortex mali 5-40, radix et rhizoma 5-40, prepared scrophulariae 5-40, scolopendra 5-40 and rhabdophis 10-50. The traditional Chinese medicine composition can treat chronic eczema by oral administration, and has the advantages of remarkable effect and safety and reliability.

Description

TECHNICAL FIELD

[0001] The application relates to the technical field of traditional Chinese medicine, in particular to a traditional Chinese medicine composition for treating chronic eczema and a preparation method thereof. BACKGROUND

[0002] Eczema is a common skin disease, which can be divided into acute eczema, subacute eczema and chronic eczema according to the course of disease, and is prone to occur in the ear, lower leg, hand, scrotum and other parts, and is polymorphic and symmetrical, with itching and burning sensation. The causes are related to metabolic disorders, mental stress, excessive fatigue, cold stimulation, dry climate, hot and sweaty weather and the like.

[0003] Chronic eczema is often caused by repeated attacks of acute and subacute eczema and turns into chronic eczema; or it can be chronic eczema from the beginning. The performance is that the affected skin is thickened and infiltrated, brownish red or pigmented, rough and covered with scales, or scabbed due to scratching. The patient feels severe itching. It is commonly seen in the lower leg, hand, foot, elbow pit, popliteal fossa, vulva, anus and the like. The course of disease is indefinite, is prone to recurrence and is difficult to cure.

[0004] Glucocorticoids are the main drugs for treating chronic eczema. High skin thickening degree can select strong glucocorticoids, such as halometasone; moderate degree selects medium-strong glucocorticoids, such as elometasone; and weak glucocorticoids, such as udroles, are selected when the skin lesion is a little thickened. At present, the causes of eczema are complex, the disease is prone to recurrence after treatment and is difficult to cure, and the use of glucocorticoids for treatment has certain side effects.

[0005] From the perspective of traditional Chinese medicine mechanism, it is of great significance to develop a traditional Chinese medicine for treating chronic eczema, which is effective, safe and reliable. SUMMARY

[0006] The application provides a traditional Chinese medicine composition and traditional Chinese medicine preparation for treating chronic eczema, which can treat chronic eczema by oral administration, has remarkable effect and is safe and reliable.

[0007] To achieve the above object, the technical scheme of the application is as follows:

[0008] The traditional Chinese medicine composition for treating chronic eczema is prepared from the following raw materials in parts by weight:

[0009] Astragalus membranaceus 40-80g, Atractylodes lancea 10-50g, Zingiber officinale 5-40g, Glycyrrhiza uralensis 5-40g, Ephedra sinica 5-40g, Cinnamomum cassia 10-50g, Scutellaria baicalensis 10-40g, Sophora flavescens 10-40g, Dioscorea hypoglauca 10-50g, Pinellia ternata 5-40g, Citrus reticulata 5-40g, Ligusticum chuanxiong 5-40g, Typha orientalis 10-40g, Kochia scoparia 5-40g, Gentiana macrophylla 5-40g, Clematis chinensis 10-40g, Rehmannia glutinosa 20-60g, Scrophularia ningpoensis 10-50g, Paeonia lactiflora 10-50g, Paeonia suffruticosa 5-40g, Saposhnikovia divaricata 5-40g, Aconitum carmichaelii (processed) 5-40g, Eupolyphaga sinensis 5-40g, Buthus martensii 5-40g, Zaocys dhumnades 10-50g.

[0010] Preferably, it is prepared from the following raw materials in parts by weight:

[0011] Raw Astragalus 50-70g, Atractylodes lancea 20-40g, Fresh Ginger 10-30g, Licorice 10-30g, Ephedra 10-30g, Cinnamon Twig 20-40g, Scutellaria baicalensis 20-30g, Sophora flavescens 20-30g, Dioscorea hypoglauca 20-40g, Pinellia ternata 10-20g, Tangerine Peel 10-20g, Ligusticum chuanxiong 10-20g, Raw Typha pollen 20-30g, Kochia scoparia 10-30g, Gentiana macrophylla 10-30g, Clematis chinensis 20-30g, Rehmannia glutinosa 30-50g, Scrophularia ningpoensis 20-40g, White Peony Root 20-40g, Moutan Bark 10-20g, Saposhnikovia divaricata 10-20g, Prepared Aconitum carmichaelii 10-20g, Eupolyphaga sinensis 10-20g, Buthus martensii 10-20g, Zaocys dhumnades 20-40g.

[0012] The active ingredient in the traditional Chinese medicine composition for treating chronic eczema is prepared by water extraction or extraction with 40-80% volume percentage ethanol.

[0013] Preferably, the preparation method of its active ingredient includes the following steps:

[0014] Add water equal to 8-12 times the total weight of the herbs to all the herbs, decoct 1-3 times, 1-2 hours each time, combine the extracts, filter, and concentrate under reduced pressure into a thick paste to obtain the active ingredients.

[0015] Preferably, the preparation method of its active ingredient includes the following steps:

[0016] Take all the medicinal materials, mix them, and reflux extract them with 40-80% ethanol 2-3 times. Each time, the amount of ethanol used is 4-10 times the total amount of medicinal materials, and the extraction time is 1-3 hours. Combine the extracts, filter them, and concentrate the filtrate into a thick paste to obtain the active ingredients.

[0017] Preferably, the preparation method of the large honey pill includes the following steps:

[0018] All medicinal materials are dried at 60-80℃, and are crushed into fine powder with a mesh size of 80-120; honey is refined to obtain refined honey with a relative density of 1.28-1.32; the refined honey and the medicinal powder are mixed at a ratio of 1:1-2, and are left for 3-6 hours, and then are rolled into pills, each weighing 4-8g, to obtain the product.

[0019] The application also provides a traditional Chinese medicine preparation for treating chronic eczema, which uses the above-mentioned traditional Chinese medicine composition for treating chronic eczema and a pharmaceutically acceptable carrier.

[0020] The pharmaceutically acceptable carrier of the application includes but is not limited to the following components:

[0021] Diluents: zinc oxide, malachite, starch, powdered sugar, lactose, dextrin, microcrystalline cellulose, inorganic salts, sugar alcohols, etc.

[0022] Binders: gelatin, polyethylene glycol, cellulose derivatives, swine tallow, vaseline, silicone oil, lanolin, cellulose, gum, raw rubber, lead soap, lanolin, etc.

[0023] Organic solvents: boric acid, lead acetate, copper sulfate, zinc sulfate, aluminum acetate, rivanol, furacilin, neomycin, potassium permanganate, diethyl ether, ethanol, acetone, etc.

[0024] Disintegrants: starch, sodium carboxymethyl starch, cellulose derivatives, cross-linked polyvinyl pyrrolidone, etc.

[0025] Lubricants: magnesium stearate, micronized silica gel, talc, polyethylene glycol, triethanolamine, sodium lauryl sulfate, stearic acid, cetyl alcohol, polyethylene glycol, monoglyceride, span, tween, etc.

[0026] Emulsifiers: swine tallow, vaseline, silicone oil, lanolin, polyethylene glycol, cellulose, etc.

[0027] Co-solvents: water, ethanol, glycerol, propylene glycol, liquid paraffin, vegetable oil, dimethyl sulfoxide, azacosterone, etc.

[0028] Flavoring agents: sucrose, monosaccharides, fragrances, etc.

[0029] Preservatives: benzoic acid, sorbic acid, methyl ester, ethyl ester, propyl ester, etc.

[0030] The preparation methods of the various traditional Chinese medicine preparations are as follows:

[0031] 1. Powder:

[0032] The active ingredients of the traditional Chinese medicine composition for treating chronic eczema of the application are dried and crushed to obtain a powder;

[0033] 2. Tablets:

[0034] The active ingredients of the Chinese medicine composition for treating chronic eczema of the present application are dried, crushed, and tableted to obtain tablets.

[0035] 3. Capsules:

[0036] The active ingredients of the Chinese medicine composition for treating chronic eczema of the present application are dried, crushed, and then filled into hollow capsules or sealed into elastic soft capsules to obtain capsules; the materials for forming the hollow hard capsule shells or the elastic soft capsule shells are gelatin, glycerol, water and other medicinal materials.

[0037] 4. Granules:

[0038] The active ingredients of the Chinese medicine composition for treating chronic eczema of the present application are dried, crushed, and mixed with suitable excipients to granulate to obtain granules; the excipients include diluents, absorbents, wetting agents, binders, flavoring agents, effervescent excipients.

[0039] 5. Solutions or suspensions:

[0040] The active ingredients of the Chinese medicine composition for treating chronic eczema of the present application are dissolved in water, vegetable oil or other medicinal liquid solvents to obtain solutions or suspensions.

[0041] The present application is explained as follows:

[0042] The monarch drug: Astragalus and Atractylodes, invigorating the spleen and removing dampness; the ministerial drug: Wind-Preventing, Ginger, Ephedra, Scutellaria, Sophora, Dioscorea, Pinellia, Pericarpium Citri Reticulatae, Safflower, Kadsura, Gentiana, Rehmannia, Paeonia, clearing heat and removing dampness, resolving phlegm and blood stasis, dispelling wind and relieving itching; the assistant drug: Cinnamomum, Radix et Rhizoma Tripterygii, Eupolyphaga, Scorpio, Rhabdophis, assisting the monarch and minister to dredge the collaterals and relieve itching; the ministerial drug: Chuanxiong leading the drugs, and Licorice regulating the drugs.

[0043] [Function and indication] Invigorating the spleen and removing dampness, clearing heat and removing dampness, resolving phlegm and blood stasis, and dispelling wind and relieving itching. It is mainly used for treating chronic eczema and dermatitis.

[0044] The present application is summarized on the basis of a large number of clinical experimental researches of famous old Chinese medicine doctors, and is in line with the theories of traditional Chinese medicine and modern medicine, without toxic and side effects; the various Chinese medicines complement and cooperate with each other, invigorating the spleen and removing dampness, clearing heat and removing dampness, resolving phlegm and blood stasis, and dispelling wind and relieving itching, and have good effects on chronic eczema. DETAILED DESCRIPTION

[0045] The present application will be described in detail below through specific examples.

[0046] Example 1

[0047] The Chinese medicine composition for treating chronic eczema of the present embodiment is prepared from the following raw materials by weight:

[0048] Radix Astragali 40 kg, Rhizoma et Radix Notopterygii 10 kg, Rhizoma Zingiberis 5 kg, Radix Glycyrrhizae 5 kg, Herba Ephedrae 5 kg, Ramulus Cinnamomi 10 kg, Radix Scrophulariae 10 kg, Radix Sophorae 10 kg, Rhizoma Alpiniae Oxophyllae 10 kg, Rhizoma Pinelliae 5 kg, Pericarpium Citri Reticulatae 5 kg, Rhizoma Chuanxiong 5 kg, Radix et Rhizoma Polygoni Multiflori 10 kg, Radix et Rhizoma Bistortae 5 kg, Radix et Rhizoma Corydalis 10 kg, Radix Rehmanniae 20 kg, Radix Scrophulariae 10 kg, Radix Paeoniae Alba 10 kg, Radix et Rhizoma Stephaniae Tetrandrae 5 kg, Radix et Rhizoma Aconiti 5 kg, Scolopendra Subsp., Elaphe Moellendorffi 10-50 kg.

[0049] The preparation method of the large honeyed pills comprises the following steps:

[0050] All the medicinal materials are dried at 60°C and are ground into fine powder passing through an 80-mesh screen. Honey is refined to obtain refined honey with a relative density of 1.28. The refined honey and the medicinal powder are mixed in a proportion of 1:1, and are left to stand for 3 hours. Then, the mixture is rubbed into pill shapes, each weighing 4 g.

[0051] Example 2

[0052] The Chinese medicinal composition for treating chronic eczema of the present example is prepared from the following raw materials in the weight parts:

[0053] Radix Astragali 80 kg, Rhizoma et Radix Notopterygii 50 kg, Rhizoma Zingiberis 40 kg, Radix Glycyrrhizae 40 kg, Herba Ephedrae 40 kg, Ramulus Cinnamomi 50 kg, Radix Scrophulariae 40 kg, Radix Sophorae 40 kg, Rhizoma Alpiniae Oxophyllae 50 kg, Rhizoma Pinelliae 40 kg, Pericarpium Citri Reticulatae 40 kg, Rhizoma Chuanxiong 40 kg, Radix et Rhizoma Polygoni Multiflori 40 kg, Radix et Rhizoma Bistortae 40 kg, Radix et Rhizoma Corydalis 40 kg, Radix Rehmanniae 60 kg, Radix Scrophulariae 50 kg, Radix Paeoniae Alba 50 kg, Radix et Rhizoma Stephaniae Tetrandrae 40 kg, Radix et Rhizoma Aconiti 40 kg, Scolopendra Subsp., Elaphe Moellendorffi 50 kg.

[0054] The preparation method of the large honeyed pills comprises the following steps:

[0055] All the medicinal materials are dried at 80°C and are ground into fine powder passing through a 120-mesh screen. Honey is refined to obtain refined honey with a relative density of 1.32. The refined honey and the medicinal powder are mixed in a proportion of 1:2, and are left to stand for 6 hours. Then, the mixture is rubbed into pill shapes, each weighing 8 g.

[0056] Example 3

[0057] The Chinese medicinal composition for treating chronic eczema of the present example is prepared from the following raw materials in the weight parts:

[0058] Radix Astragali seu Hedysari 60 kg, Rhizoma et Radix Notopterygii 30 kg, Rhizoma Zingiberis Recens 20 kg, Radix Glycyrrhizae 20 kg, Herba Ephedrae 15 kg, Ramulus Cinnamomi 30 kg, Radix Scrophulariae 24 kg, Radix Sophorae 24 kg, Rhizoma Alpiniae Oxophyllae 30 kg, Rhizoma Pinelliae 15 kg, Pericarpium Citri Reticulatae 15 kg, Rhizoma Chuanxiong 15 kg, Radix et Rhizoma Polygoni Multiflori 24 kg, Fructus Kochiae 15 kg, Radix et Rhizoma Gentianae 15 kg, Radix et Rhizoma Stephaniae Tetrandrae 24 kg, Radix Rehmanniae 45 kg, Radix Scrophulariae 30 kg, Radix Paeoniae Alba 30 kg, Cortex Moutan 15 kg, Radix Saposhnikoviae 15 kg, Radix et Rhizoma Aconiti 10 kg, Scolithus 15 kg, Scorpio 10 kg, Amoeba 30 kg.

[0059] The preparation method of the large honeyed pill comprises the following steps:

[0060] All the medicinal materials are dried at 70℃, and are crushed into fine powder passing through a 100-mesh sieve. Honey is refined to obtain refined honey with a relative density of 1.30. The refined honey and the medicinal powder are mixed at a ratio of 1:1.3, and are left for 5 hours. Then, the mixture is rubbed into pill shape, and each pill weighs 6g.

[0061] Example 4

[0062] The Chinese medicinal composition for treating chronic eczema of the present example is prepared from the following raw materials by weight:

[0063] Radix Astragali seu Hedysari 50 kg, Rhizoma et Radix Notopterygii 20 kg, Rhizoma Zingiberis Recens 10 kg, Radix Glycyrrhizae 10 kg, Herba Ephedrae 10 kg, Ramulus Cinnamomi 20 kg, Radix Scrophulariae 20 kg, Radix Sophorae 20 kg, Rhizoma Alpiniae Oxophyllae 20 kg, Rhizoma Pinelliae 10 kg, Pericarpium Citri Reticulatae 10 kg, Rhizoma Chuanxiong 10 kg, Radix et Rhizoma Polygoni Multiflori 20 kg, Fructus Kochiae 10 kg, Radix et Rhizoma Gentianae 10 kg, Radix et Rhizoma Stephaniae Tetrandrae 20 kg, Radix Rehmanniae 30 kg, Radix Scrophulariae 20 kg, Radix Paeoniae Alba 20 kg, Cortex Moutan 10 kg, Radix Saposhnikoviae 10 kg, Radix et Rhizoma Aconiti 10 kg, Scolithus 10 kg, Scorpio 10 kg, Amoeba 20 kg.

[0064] The preparation method of the active ingredient comprises the following steps:

[0065] All the medicinal materials are added with water equivalent to 8 times the total weight of the medicinal materials, and are decocted for 2 times, each for 1 hour. The extraction liquid is combined, filtered, and concentrated into thick paste under reduced pressure to obtain the active ingredient.

[0066] The preparation method of the water pill comprises the following steps:

[0067] The active ingredient is dried at 75℃, and is crushed into fine powder passing through a 90-mesh sieve. Water is added to coat the pill, and 3mm small pills are prepared. The small pills are dried at 80℃ to obtain the water pill.

[0068] Example 5

[0069] The Chinese medicinal composition for treating chronic eczema of the present example is prepared from the following raw materials by weight:

[0070] 70kg of raw Astragalus membranaceus, 40kg of Atractylodes lancea, 30kg of raw ginger, 30kg of licorice, 30kg of Ephedra sinica, 40kg of cinnamon twig, 30kg of Scutellaria baicalensis, 30kg of Sophora flavescens, 40kg of Dioscorea hypoglauca, 20kg of Pinellia ternata, 20kg of Citrus reticulata peel, 20kg of Ligusticum chuanxiong, 30kg of raw Typha orientalis, 30kg of Kochia scoparia, 30kg of Gentiana macrophylla, 30kg of Clematis chinensis, 50kg of Rehmannia glutinosa, 40kg of Scrophularia ningpoensis, 40kg of Paeonia lactiflora, 20kg of Paeonia suffruticosa bark, 20kg of Saposhnikovia divaricata, 20kg of processed Aconitum carmichaelii, 20kg of Eupolyphaga sinensis, 20kg of Buthus martensii, and 40kg of Zaocys dhumnades.

[0071] The preparation method of its active ingredient includes the following steps:

[0072] Take all the medicinal materials, mix them, and extract them twice by reflux with 60% ethanol. Each time, the amount of ethanol used is 6 times the total amount of medicinal materials, and the extraction time is 2 hours. Combine the extracts, filter them, and concentrate the filtrate into a thick paste to obtain the active ingredients.

[0073] The traditional Chinese medicine composition of this embodiment is prepared into tablets by the following steps:

[0074] The active ingredient is dried, pulverized, mixed with an appropriate amount of starch and dextrin, passed through an 80-mesh sieve, and compressed into tablets to obtain tablets.

[0075] Example 6

[0076] The traditional Chinese medicine composition for treating chronic eczema in this embodiment is prepared from the following raw materials in parts by weight:

[0077] Raw Astragalus 55kg, Atractylodes lancea 25kg, fresh ginger 32kg, licorice 32kg, ephedra 25kg, cinnamon twig 25kg, Scutellaria baicalensis 28kg, Sophora flavescens 28kg, Dioscorea hypoglauca 36kg, Pinellia ternata 26kg, tangerine peel 26kg, Ligusticum chuanxiong 23kg, raw Typha pollen 24kg, Kochia scoparia 24kg, Gentiana macrophylla 28kg, Clematis chinensis 18kg, Rehmannia glutinosa 48kg, Scrophularia ningpoensis 36kg, white peony root 33kg, peony bark 25kg, Saposhnikovia divaricata 25kg, processed Aconitum carmichaelii 25kg, Eupolyphaga sinensis 30kg, scorpion 30kg, Zaocys dhumnades 33kg.

[0078] The preparation method of its active ingredient includes the following steps:

[0079] Add water equal to 12 times the total weight of the herbs to all the herbs, decoct once, one hour each time, combine the extracts, filter, and concentrate under reduced pressure into a thick paste to obtain the active ingredients.

[0080] The traditional Chinese medicine composition of this embodiment is prepared into capsules by the following method:

[0081] The active ingredients are dried, pulverized, passed through a 90-mesh sieve, and then filled into empty capsules to obtain capsules.

[0082] Example 7

[0083] The traditional Chinese medicine composition for treating chronic eczema of the present example is prepared from the following raw materials by weight:

[0084] Radix Astragali 63 kg, Rhizoma Atractylodis 32 kg, Rhizoma Zingiberis Recens 16 kg, Radix Glycyrrhizae 12 kg, Herba Ephedrae 12 kg, Ramulus Cinnamomi 27 kg, Radix Scrophulariae 28 kg, Radix Sophorae 22 kg, Rhizoma Alpiniae Oxophyllae 23 kg, Rhizoma Pinelliae 17 kg, Pericarpium Citri Reticulatae 13 kg, Rhizoma Chuanxiong 18 kg, Radix Pseudoginseng 21 kg, Fructus Kochiae 18 kg, Radix Gentianae 13 kg, Radix et Rhizoma Cynanchi 23 kg, Radix Rehmanniae 43 kg, Radix Scrophulariae 31 kg, Radix Paeoniae Alba 23 kg, Cortex Moutan 19 kg, Radix Saposhnikoviae 16 kg, Radix et Rhizoma Aconiti 17 kg, Tenodera arciferae 13 kg, Scorpio 15 kg, Amoeba 25 kg.

[0085] The preparation method of the active ingredient thereof includes the following steps:

[0086] All medicinal materials are added with water equivalent to 9 times the total weight of medicinal materials, decocted for 3 times, each time for 2 hours, the extraction liquid is combined, filtered, and concentrated into thick paste under reduced pressure to obtain the active ingredient.

[0087] The traditional Chinese medicine composition of the present example is made into granules, and the preparation method is as follows:

[0088] The active ingredient is mixed with an appropriate amount of starch and sugar powder to granulate and dry to obtain granules.

[0089] Experimental Example 1 Summary of Clinical Trials

[0090] I. Case selection: all cases come from patients treated in the clinic of the working studio of famous old Chinese medicine doctors in Sanya City Hospital of Traditional Chinese Medicine from October 2019 to March 2022. The selected cases are 120 cases, 60 cases in each of the treatment group and the control group. The age of the treatment group is between 18-62 years old, the average age is 44.98±9.05 years old, the course of disease is 16.22±12.46 months; the average age of the control group is 45.22±8.67 years old, the course of disease is 15.68±11.65 months. The basic conditions of the two groups have no significant difference (P>0.05) by statistical analysis.

[0091] II. Diagnostic criteria: refer to the "Standard for Diagnosis and Treatment of TCM Diseases" of the State Administration of Traditional Chinese Medicine: (1) limited to a certain part, clear boundary, obvious infiltration, rough surface, or lichenoid change. (2) Brown or brown color, often accompanied by papular rash, scab, scratch marks. (3) Tendency to wet change, often recurrent, sometimes severe, with paroxysmal itching.

[0092] III. Treatment group: use the large honeyed pills prepared in Example 3 for treatment, one pill at a time, 3 times a day.

[0093] Four, control group: choose hydrochloric acid cetirizine tablet (Suzhou East Russia pharmaceutical Co., Ltd. provides, 10 mg / tablet), 1 tablet at a time, 1 time per day, 4 weeks for a course, continuous course.

[0094] During the test, other Chinese and Western medicine for treating chronic eczema are prohibited. Patients are advised to avoid spicy diet, prohibit drinking, avoid scratching, sun exposure, prevent cold and overwork, over-tension, etc. during the treatment.

[0095] Five, efficacy criteria: according to the State Administration of Traditional Chinese Medicine "diagnostic criteria for TCM syndromes" is formulated. The lesion, skin itching is scored according to the no, mild, moderate, severe 4 level: no 0 points, mild 1 point, moderate 2 points, severe 3 points. The total score of the degree of symptoms such as erythema, papules, water scar, moss sample change, keratinization and desquamation and pruritus is recorded. Symptom score reduction index = (treatment before and after treatment) / treatment before and after treatment × 100%.

[0096] (1) recovery: skin lesions basically subsided, pruritus disappeared completely, symptom score reduction index ≥ 90%;

[0097] (2) significant effect: skin lesions improved significantly, pruritus was significantly reduced, symptom score reduction index 60%-89%;

[0098] (3) effective: skin lesions improved, pruritus was reduced, symptom score reduction index 20%-59%;

[0099] (4) no effect: skin lesions and pruritus improved not obviously, symptom score reduction index < 20%.

[0100] Six, the experimental conditions are shown in the following table:

[0101] Comparison of clinical efficacy

[0102]

[0103] By Mann-Whitney Test, Z =-3.180, p = 0.001 < 0.01, the difference between the treatment group and the control group was significant, and the clinical efficacy of the treatment group was significantly better than that of the control group.

[0104] This study was observed clinically, and the effect of eczema pill in treating chronic eczema was significant, and it was significantly better than that of hydrochloric acid cetirizine tablet.

[0105] Although the above has been described in detail by general description, specific embodiments and tests, some modifications or improvements can be made on the basis of the present application, which is obvious to those skilled in the art. Therefore, these modifications or improvements made on the basis of not deviating from the spirit of the present application, all belong to the scope of the present application.

Claims

1. A traditional Chinese medicine composition for treating chronic eczema, characterized in that, It is prepared from the following raw materials in parts by weight: Astragalus membranaceus 40-80g, Atractylodes lancea 10-50g, Zingiber officinale 5-40g, Glycyrrhiza uralensis 5-40g, Ephedra sinica 5-40g, Cinnamomum cassia 10-50g, Scutellaria baicalensis 10-40g, Sophora flavescens 10-40g, Dioscorea hypoglauca 10-50g, Pinellia ternata 5-40g, Citrus reticulata 5-40g, Ligusticum chuanxiong 5-40g, Typha orientalis 10-40g, Kochia scoparia 5-40g, Gentiana macrophylla 5-40g, Clematis chinensis 10-40g, Rehmannia glutinosa 20-60g, Scrophularia ningpoensis 10-50g, Paeonia lactiflora 10-50g, Paeonia suffruticosa 5-40g, Saposhnikovia divaricata 5-40g, Aconitum carmichaelii (processed) 5-40g, Eupolyphaga sinensis 5-40g, Buthus martensii 5-40g, Zaocys dhumnades 10-50g.

2. The traditional Chinese medicine composition for treating chronic eczema according to claim 1, characterized in that, It is prepared from the following raw materials in parts by weight: Raw Astragalus 50-70g, Atractylodes lancea 20-40g, Fresh Ginger 10-30g, Licorice 10-30g, Ephedra 10-30g, Cinnamon Twig 20-40g, Scutellaria baicalensis 20-30g, Sophora flavescens 20-30g, Dioscorea hypoglauca 20-40g, Pinellia ternata 10-20g, Tangerine Peel 10-20g, Ligusticum chuanxiong 10-20g, Raw Typha pollen 20-30g, Kochia scoparia 10-30g, Gentiana macrophylla 10-30g, Clematis chinensis 20-30g, Rehmannia glutinosa 30-50g, Scrophularia ningpoensis 20-40g, White Peony Root 20-40g, Moutan Bark 10-20g, Saposhnikovia divaricata 10-20g, Prepared Aconitum carmichaelii 10-20g, Eupolyphaga sinensis 10-20g, Buthus martensii 10-20g, Zaocys dhumnades 20-40g.

3. The traditional Chinese medicine composition for treating chronic eczema as described in claim 1 or 2, characterized in that, Its active ingredients are prepared by water extraction or extraction with 40-80% volume percentage of ethanol.

4. The traditional Chinese medicine composition for treating chronic eczema according to claim 3, characterized in that, The preparation method of its active ingredient includes the following steps: Add water equal to 8-12 times the total weight of the herbs to all the herbs, decoct 1-3 times, 1-2 hours each time, combine the extracts, filter, and concentrate under reduced pressure into a thick paste to obtain the active ingredients.

5. The traditional Chinese medicine composition for treating chronic eczema as described in claim 3, characterized in that, The preparation method of its active ingredient includes the following steps: Take all the medicinal materials, mix them, and reflux extract them with 40-80% ethanol 2-3 times. Each time, the amount of ethanol used is 4-10 times the total amount of medicinal materials, and the extraction time is 1-3 hours. Combine the extracts, filter them, and concentrate the filtrate into a thick paste to obtain the active ingredients.

6. The traditional Chinese medicine composition for treating chronic eczema according to claim 1, characterized in that, The preparation method of its large honey pills includes the following steps: Dry all medicinal materials at 60-80℃ and pulverize them into fine powder that passes through an 80-120 mesh sieve; refine honey to obtain refined honey with a relative density of 1.28-1.32; mix the refined honey with the medicinal powder in a ratio of 1:1-2, let it stand for 3-6 hours, and then roll it into pills, each weighing 4-8g.

7. A traditional Chinese medicine preparation for treating chronic eczema, comprising the traditional Chinese medicine composition for treating chronic eczema as described in any one of claims 1-5 and a pharmaceutically acceptable carrier.

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