A stirring device for the preparation of tinidazole suppositories

Abstract

The present invention relates to the technical field of drug stirring, and discloses a stirring device for the preparation of tinidazole suppositories, which includes a stirring cylinder, a feed pipe and a discharge pipe arranged on the side wall of the stirring cylinder, and a control console arranged on the outer wall of the stirring cylinder. It also includes a stirring unit arranged in the stirring cylinder, and the stirring unit includes a degassing component and a stirring component arranged in the stirring cylinder; the degassing component includes a limiting groove opened on the inner wall of the stirring cylinder, a plurality of connecting rods arranged at the lower end of the limiting plate, and an extrusion disk arranged at the lower ends of the plurality of connecting rods. In this application, by setting an extrusion disk and a gas permeable membrane, the gas is extruded from between the drug molecules by compression, and at the same time flows out of the stirring cylinder through the gas permeable membrane, so as to reduce the bubbles generated during the stirring process. At the same time, by continuously sliding the stirring sliding frame in the vertical direction during the stirring process, the stirring blind area during the stirring process is reduced, and the stirring efficiency and uniform mixing degree of the drug in the stirring cylinder are improved.

Description

Technical Field

[0001] The present invention relates to the technical field of drug stirring, and particularly relates to a stirring device for the preparation of tinidazole suppositories. Background Art

[0002] Tinidazole suppository is an antibacterial drug that has bactericidal effects on many protozoa and bacteria and can be used to treat various infections. It is usually used to treat vaginal infections. The production process of tinidazole suppository generally includes drug preparation, stirring and mixing, molding, curing, and packaging, etc. Among them, mixing and stirring is to mix tinidazole and suppository matrix to ensure that the drug is evenly distributed in the suppository matrix. In this process flow, to ensure the uniformity and stability of the drug and suppository matrix, it is necessary to strictly control the stirring time and speed, the strength during the stirring process, temperature control, and the feeding order. By reasonably controlling the above matters, the product quality and stability during the mixing and stirring process can be ensured, thereby ensuring the product quality and stability during the mixing process.

[0003] In the prior art, the staff can strictly control the stirring time and speed, stirring strength, and temperature control during the stirring process of tinidazole suppository through the control system. However, there are still the following problems. During the stirring and mixing process, due to the solubility of tinidazole and suppository matrix in gas, when the temperature changes during the stirring process, the gas solubility of tinidazole and suppository matrix decreases, and the gas will be released from the liquid to form bubbles. If the bubbles are not processed in time, the formed drug will show uneven distribution. At the same time, the appearance of bubbles may cause unevenness or bubble-like defects on the surface of the drug, affecting the appearance quality of the drug. At the same time, in the existing stirring device, due to the different shapes of the designed stirring rollers, during the stirring process, some drugs may be in the action blind area of the stirring rollers, resulting in insufficient stirring of some drugs, affecting the uniformity of the drug and reducing the quality and stability of the drug. Summary of the Invention

[0004] In view of the problems in the prior art that when producing tinidazole suppository, due to the certain solubility of the drug in gas, bubbles will appear during the stirring and mixing process. If the bubbles are not processed, the drug production quality will be reduced. At the same time, there may be a stirring blind area in the existing stirring device, resulting in insufficient stirring of some drugs, a stirring device for the preparation of tinidazole suppositories is proposed.

[0005] The present application provides a stirring device for the preparation of tinidazole suppositories, and its purpose is: by setting an extrusion disc and a gas permeable membrane, the gas is extruded from between the drug molecules in a compressed manner, and at the same time flows out of the stirring cylinder through the gas permeable membrane, so as to reduce the bubbles generated during the stirring process, improve the production quality of the drug, and at the same time, by continuously sliding the stirring sliding frame in the vertical direction and the vertical rod one and the vertical rod two in the horizontal direction during the stirring process, the stirring blind area during the stirring process is reduced, and the stirring efficiency and uniform mixing degree of the drug in the stirring cylinder are improved.

[0006] The technical solution of the present invention is: a stirring device for the preparation of tinidazole suppositories, including a stirring cylinder, a feed pipe and a discharge pipe arranged on the side wall of the stirring cylinder, a control console arranged on the outer wall of the stirring cylinder, and further including a stirring unit arranged in the stirring cylinder, and the stirring unit includes a degassing component and a stirring component arranged in the stirring cylinder;

[0007] The degassing component includes a limiting groove opened on the inner wall of the stirring cylinder, a limiting block slidably arranged in the limiting groove, a limiting plate arranged between the two limiting blocks, a plurality of connecting rods arranged at the lower end of the limiting plate, an extrusion disc arranged at the lower end of the plurality of connecting rods, a plurality of mounting rods arranged on the outer wall of the upper end of the stirring cylinder, a control motor arranged on the plurality of mounting rods, a threaded rod arranged on the driving end of the control motor, a mounting groove opened on the limiting plate, a nut arranged in the mounting groove, a ventilation ring arranged on the extrusion disc, a plurality of ventilation holes opened on the ventilation ring, and a gas permeable membrane arranged at the lower end of the extrusion disc;

[0008] Both the feed pipe and the discharge pipe are fixedly communicated with the inside of the stirring cylinder, and the communicating pipe orifices are both located below the extrusion disc. The height of the discharge pipe is lower than that of the feed pipe. The gas permeable membrane has the same size and shape as the end face of the ventilation ring, and the gas permeable membrane is located directly below the ventilation ring. A plurality of flow grooves for gas flow are opened at the lower end of the extrusion disc, and one end of each flow groove is located directly below the gas permeable membrane.

[0009] Furthermore, the stirring component includes a driving motor fixedly installed at the upper end of the extrusion disc, a driving shaft hermetically and slidably penetrating through the center of the extrusion disc, a stirring square rod one arranged at the lower end of the driving shaft, a stirring square rod two slidably arranged inside the stirring square rod one. A plurality of telescopic components are jointly installed between the stirring square rod one and the stirring square rod two. The stirring square rod one and the stirring square rod two have the same shape, and the end face shapes of both are set as hexagons. The radius of the stirring square rod two is smaller than the radius of the stirring square rod one.

[0010] Further, the telescopic assembly includes a cross bar disposed on the first stirring square rod and the second stirring square rod, a first vertical rod slidably disposed on the upper cross bar, and a second vertical rod slidably disposed within the first vertical rod. The second vertical rod has the same shape as the first vertical rod, the radius of the second vertical rod is smaller than that of the first vertical rod, the lower end of the second vertical rod is slidably mounted on the corresponding lower cross bar, and a sliding element is commonly provided on a plurality of corresponding first vertical rods.

[0011] Further, a convex rod is provided on each cross bar. Reciprocating arc-shaped chutes are formed at the lower end near the outer ring of the extrusion disc and on the inner wall of the lower end of the stirring cylinder. Each convex rod is located within the corresponding reciprocating arc-shaped chute.

[0012] Further, the sliding element includes a sliding frame plate provided on each first vertical rod, a plurality of sliding blocks provided on a plurality of sliding frame plates, a sliding stirring frame provided on a plurality of corresponding sliding blocks, a plurality of suspension ropes provided at the lower end of the sliding stirring frame, a suspension rod provided between a plurality of corresponding suspension ropes, the lowermost suspension rod is fixedly connected to the corresponding cross bar, and a trigger fitting is installed between each sliding stirring frame and the corresponding first vertical rod.

[0013] Further, the trigger fitting includes a seat plate provided on the first vertical rod, a short plate provided on the sliding stirring frame, a spring rod provided between the seat plate and the short plate, a resisting rod provided at the middle of the upper end of the short plate, a resisting block provided on the upper cross bar, and an inclined groove formed in the resisting block. The lower part of the resisting rod and the resisting block are in close contact and pressing against each other.

[0014] Further, both the control motor and the driving motor are electrically connected to the console.

[0015] Further, a pressure sensor is provided below the extrusion disc, and the pressure sensor is signal-connected to the console.

[0016] Advantages of the present invention:

[0017] 1. By providing the extrusion disc and the flow grooves formed on the extrusion disc, before the stirring cylinder stirs the drug mixture, the extrusion disc is used to compress the drug mixture, the gas dissolved in the drug mixture is pressed out, and flows out through the ventilation holes on the ventilation ring, effectively reducing the generation of a large number of bubbles caused by stirring, and improving the quality and appearance of the produced drugs.

[0018] 2. Through the extrusion of the extrusion disc, the drug mixture is compressed below the extrusion disc. By applying pressure, it can promote more intensive contact and mixing between the materials, improve the mixing efficiency. Compression stirring can effectively promote the mutual diffusion and transfer between the components, thereby obtaining a more uniform mixture. At the same time, it can reduce the mixing time and improve the production efficiency.

[0019] 3. By setting the reciprocating arc-shaped groove, when the first stirring square rod and the second stirring square rod rotate for stirring, the first vertical rod and the second vertical rod will be driven to continuously reciprocate and slide in the horizontal direction, driving the stirring sliding frame to reciprocate and slide in the vertical direction, so as to reduce the stirring blind area during the stirring process and improve the stirring efficiency of the drug mixture. BRIEF DESCRIPTION OF THE DRAWINGS

[0020] Figure 1 is a first perspective three-dimensional structural schematic diagram of the present invention;

[0021] Figure 2 of the present invention Figure 1 internal structural schematic diagram;

[0022] Figure 3 is a second perspective three-dimensional structural schematic diagram of the present invention;

[0023] Figure 4 is a structural schematic diagram of the degassing component of the present invention;

[0024] Figure 5 is a structural schematic diagram of the extrusion disc of the present invention;

[0025] Figure 6 of the present invention Figure 5 partial cross-sectional three-dimensional view;

[0026] Figure 7 is a structural schematic diagram of the stirring component of the present invention;

[0027] Figure 8 of the present invention Figure 7 enlarged structural schematic diagram at A in;

[0028] Figure 9 of the present invention Figure 8 partial structural schematic diagram in;

[0029] Figure 10 is an installation schematic diagram of the sliding frame plate of the present invention.

[0030] In the figure:

[0031] 1. Stirring cylinder; 2. Feed pipe; 3. Discharge pipe; 4. Console; 5. Limit groove; 6. Limit block; 7. Limit plate; 8. Connecting rod; 9. Extrusion disc; 10. Mounting rod; 11. Control motor; 12. Threaded rod; 13. Nut; 14. Ventilation ring; 15. Gas permeable membrane; 16. Flow groove; 17. Driving motor; 18. First stirring square rod; 19. Second stirring square rod; 20. Cross bar; 21. First vertical rod; 22. Second vertical rod; 23. Convex rod; 24. Reciprocating arc chute; 25. Sliding frame plate; 26. Sliding block; 27. Sliding stirring frame; 28. Suspension rope; 29. Suspension rod; 30. Seat plate; 31. Short board; 32. Spring rod; 33. Pressing rod; 34. Pressing block; 35. Inclined plane groove; 36. Ventilation hole. Detailed implementation manners

[0032] In order to make the above objects, features and advantages of the present invention more obvious and understandable, the following detailed description of the specific implementation manners of the present invention will be given in conjunction with the accompanying drawings of the specification.

[0033] Embodiment 1

[0034] Referring to Figures 1 - 6 , for the first embodiment of the present invention, a stirring device for the preparation of tinidazole suppositories is provided, including a stirring cylinder 1, a feed pipe 2 and a discharge pipe 3 fixedly connected to the side wall of the stirring cylinder 1, and a console 4 fixedly installed on the outer wall of the stirring cylinder 1. It also includes a stirring unit installed in the stirring cylinder 1, and the stirring unit includes a degassing component and a stirring component installed in the stirring cylinder 1; the degassing component includes a limit groove 5 opened on the inner wall of the stirring cylinder 1, a limit block 6 slidably installed in the limit groove 5, a limit plate 7 fixedly installed between the two limit blocks 6, a plurality of connecting rods 8 fixedly installed at the lower end of the limit plate 7, an extrusion disc 9 fixedly installed at the lower ends of the plurality of connecting rods 8, a plurality of mounting rods 10 fixedly installed on the outer wall of the upper end of the stirring cylinder 1, a control motor 11 fixedly installed on the plurality of mounting rods 10, a threaded rod 12 fixedly installed on the driving end of the control motor 11, a mounting groove opened on the limit plate 7, a nut 13 fixedly installed in the mounting groove, a ventilation ring 14 fixedly installed on the extrusion disc 9, a plurality of ventilation holes 36 opened on the ventilation ring 14, and a gas permeable membrane 15 fixedly installed at the lower end of the extrusion disc 9; both the feed pipe 2 and the discharge pipe 3 are fixedly connected to the inside of the stirring cylinder 1, and the connecting pipe openings are both located below the extrusion disc 9. The height of the discharge pipe 3 is lower than that of the feed pipe 2. The gas permeable membrane 15 has the same size and shape as the end face of the ventilation ring 14, and the gas permeable membrane 15 is directly below the ventilation ring 14. A plurality of flow grooves 16 for gas flow are opened at the lower end of the extrusion disc 9, and one end of each flow groove 16 is directly below the gas permeable membrane 15. The shape and size of the extrusion disc 9 are the same as the inner wall end face of the stirring cylinder 1. A pressure sensor is provided below the extrusion disc 9, and the pressure sensor (not shown in the figure) is signal-connected to the console 4.

[0035] Specifically, the function of the degassing component is as follows: the drug mixture is extruded by the extrusion disc 9, so that the gas in the drug mixture is pressed out, preventing a large number of bubbles from appearing in the drug mixture during the stirring process due to the presence of more gas inside, which affects the drug stirring efficiency and reduces the production quality of the drug.

[0036] The limiting block 6 limits the limiting plate 7, so that while the limiting plate 7 slides vertically in the limiting groove 5, it prevents the limiting plate 7 from rotating. Since the limiting plate 7 is limited and cannot rotate, when the control motor 11 drives the threaded rod 12 to rotate through the driving end, the threaded rod 12 cooperates with the nut 13 to drive the limiting plate 7 to move downward, and then drives the extrusion disc 9 at the lower end to move downward through the connecting rod 8. Since the drug mixture is located below the extrusion disc 9, when the extrusion disc 9 moves downward, because the size and shape of the extrusion disc 9 are equal to the inner wall of the stirring cylinder 1, the lower part of the extrusion disc 9 is in a relatively sealed state. The extrusion disc 9 extrudes the drug mixture located below. After the drug mixture is extruded, the gas inside it is pressed out of the drug mixture and flows into the gas permeable membrane 15 through the flow groove 16 (the gas permeable membrane 15 is a special film with the characteristic of selectively allowing gas to pass through while preventing liquid from passing through. This is the prior art and will not be elaborated here). The gas permeable membrane 15 only allows gas to flow through and will not allow the drug mixture to flow through. Therefore, the pressed-out gas flows out through the gas permeable membrane 15, and the flowing-out gas flows out through the ventilation holes 36 on the ventilation ring 14, preventing a large number of bubbles from appearing when the drug mixture is stirred.

[0037] The function of the pressure sensor is to detect the pressure between the extrusion disc 9 and the drug mixture in real time. When the pressure reaches a certain value, the pressure sensor transmits a signal to the control console 4, and the control console 4 stops the control motor 11 from running, thereby stopping the extrusion disc 9 from descending, preventing the pressure of the drug mixture from being too large and affecting the subsequent stirring. At the same time, by applying pressure to the drug mixture, it can promote more intensive contact and mixing between the materials, improve the mixing efficiency, and the compression stirring can effectively promote the mutual diffusion and transfer between the components, so as to obtain a more uniform mixture. At the same time, it can reduce the mixing time and improve the production efficiency.

[0038] During use, the staff feeds the drug raw materials into the mixing drum 1 through the feed pipe 2 in sequence. Subsequently, the feed pipe 2 is closed, and the control motor 11 is started through the console 4, so that the control motor 11 drives the driving end to rotate slowly. When the control motor 11 rotates, it will drive the threaded rod 12 to rotate synchronously. Since the limiting plate 7 and the nut 13 are limited by the limiting block 6, the limiting plate 7 moves vertically downward along the direction of the threaded rod 12. Then, the connecting rod 8 drives the extrusion disc 9 at the lower end to move synchronously. When the extrusion disc 9 moves downward, it will extrude the drug mixture below. After the drug mixture is extruded, the gas inside it flows through the flow groove 16 to the gas permeable membrane 15 and flows out through the ventilation holes 36 on the ventilation ring 14 of the gas permeable membrane 15, completing the discharge of the gas in the drug mixture to reduce the bubbles generated during stirring. When the pressure sensor detects that the pressure reaches the set threshold, the pressure sensor transmits a signal to the console 4, and the console 4 closes the control motor 11 to cancel the downward movement of the extrusion disc 9.

[0039] Embodiment 2

[0040] Referring to Figure 7 , which is the second embodiment of the present invention. The difference between this embodiment and the first embodiment is that the stirring component includes a driving motor 17 fixedly installed at the upper end of the extrusion disc 9, a driving shaft sealed and slidably installed through the center of the extrusion disc 9, a stirring square rod one 18 fixedly installed at the lower end of the driving shaft, a stirring square rod two 19 slidably installed inside the stirring square rod one 18. A plurality of telescopic components are jointly installed between the stirring square rod one 18 and the stirring square rod two 19. The stirring square rod one 18 and the stirring square rod two 19 have the same shape, and the end face shapes of both are set to hexagons. The radius of the stirring square rod two 19 is smaller than the radius of the stirring square rod one 18. The telescopic component includes a cross bar 20 provided on the stirring square rod one 18 and the stirring square rod two 19, a vertical rod one 21 slidably installed on the upper cross bar 20, a vertical rod two 22 slidably installed inside the vertical rod one 21. The vertical rod two 22 and the vertical rod one 21 have the same shape, and the radius of the vertical rod two 22 is smaller than the radius of the vertical rod one 21. The lower end of the vertical rod two 22 is slidably installed on the corresponding lower cross bar 20. The control motor 11 and the driving motor 17 are both electrically connected to the console 4.

[0041] Specifically, the staff can control the driving motor 17 and the opening and closing of the control motor 11 through the console 4 to ensure the normal operation of the mixing drum 1. After the extrusion disc 9 extrudes the drug mixture, the driving motor 17 is started. The driving motor 17 drives the first stirring square rod 18 and the second stirring square rod 19 to rotate through the driving end. When the first stirring square rod 18 and the second stirring square rod 19 rotate, they drive the corresponding first vertical rod 21 and the second vertical rod 22 to rotate synchronously. Since the second stirring square rod 19 is slidably installed inside the first stirring square rod 18 and the second vertical rod 22 is slidably installed inside the first vertical rod 21, when the extrusion disc 9 moves downward to extrude the drug mixture, the stirring component will not affect the normal descent of the extrusion disc 9. At the same time, when the driving end of the driving motor 17 rotates, the second vertical rod 22 and the first vertical rod 21 rotate to stir the drug mixture in a compressed state. By applying pressure, it can promote the more intensive contact and mixing between the materials, improve the mixing efficiency. Compression stirring can effectively promote the mutual diffusion and transfer between the components, so as to obtain a more uniform mixture. At the same time, it can reduce the mixing time and improve the production efficiency.

[0042] During the use process, when the extrusion disc 9 no longer moves downward, the console 4 starts the driving motor 17. The driving motor 17 drives the first stirring square rod 18 and the second stirring square rod 19 to rotate synchronously through the driving end. At the same time, when the first stirring square rod 18 and the second stirring square rod 19 rotate, they drive the corresponding first vertical rod 21 and the second vertical rod 22 to rotate, and stir the drug mixture in a compressed state.

[0043] The rest of the structure is the same as that of Embodiment 1.

[0044] Embodiment 3

[0045] Refer to Figures 8 - 10, which is the third embodiment of the present invention. The difference between this embodiment and the second embodiment is that: a convex rod 23 is provided on each cross bar 20, a reciprocating arc-shaped chute 24 is provided at the lower end of the extrusion disc 9 near the outer ring and on the inner wall of the lower end of the stirring cylinder 1, and each convex rod 23 is located in the corresponding reciprocating arc-shaped chute 24. The sliding element includes a sliding frame plate 25 fixedly installed on each first vertical rod 21, a plurality of sliding blocks 26 slidably installed on a plurality of sliding frame plates 25, a sliding stirring frame 27 fixedly installed on the corresponding plurality of sliding blocks 26, a plurality of suspension ropes 28 fixedly installed at the lower end of the sliding stirring frame 27, a suspension rod 29 fixedly installed between the corresponding plurality of suspension ropes 28, the lowermost suspension rod 29 is fixedly connected to the corresponding cross bar 20, and a trigger fitting is installed between each sliding stirring frame 27 and the corresponding first vertical rod 21. The trigger fitting includes a seat plate 30 fixedly installed on the first vertical rod 21, a short plate 31 fixedly installed on the sliding stirring frame 27, a spring rod 32 fixedly installed between the seat plate 30 and the short plate 31, a resisting rod 33 fixedly installed in the middle of the upper end of the short plate 31, a resisting block 34 fixedly installed on the upper cross bar 20, an inclined surface groove 35 opened on the resisting block 34, the resisting rod 33 and the lower part of the resisting block 34 are tightly pressed against each other, and the initial state of the spring rod 32 is a telescopic state.

[0046] Specifically, when the first stirring square rod 18 and the second stirring square rod 19 rotate and stir, the convex rod 23 and the reciprocating arc-shaped chute 24 cooperate with each other, so that when the convex rod 23 slides in the reciprocating arc-shaped chute 24, the convex rod 23 will drive the corresponding first vertical rod 21 and the second vertical rod 22 to slide along the horizontal direction relative to the cross bar 20. At the same time, the first vertical rod 21 drives the corresponding first vertical rod 21 to slide synchronously through the sliding frame plate 25, so that when the plurality of first vertical rods 21 and the second vertical rods 22 rotate and stir, they can slide reciprocally in the vertical direction, and thus can stir the drug mixture in more spaces, so as to reduce the stirring blind area during the stirring process, and make the drug mixture in each space be fully stirred as much as possible, and improve the stirring efficiency of the device. At the same time, when the first vertical rod 21 slides in the horizontal direction, it will drive the sliding frame plate 25 to slide synchronously, and the sliding of the sliding frame plate 25 drives the short plate 31 to slide synchronously. Since the initial state of the spring rod 32 is a stretched state, the spring rod 32 generates an upward pulling force on the short plate 31, so that when the resisting rod 33 on the short plate 31 slides into the inclined surface groove 35, the short plate 31 will drive the sliding frame plate 25 to move upward, and then drive the sliding stirring frame 27 to move reciprocally in the horizontal direction and also move reciprocally in the vertical direction, thereby further reducing the stirring blind area during stirring, so that the drug mixture in more spaces is fully stirred, and improving the stirring efficiency and quality of the device.

[0047] During use, when the first stirring square rod 18 and the second stirring square rod 19 rotate for stirring, they will drive the first vertical rod 21 and the second vertical rod 22 to rotate synchronously through the cross bar 20. When the two rotate, the convex rods 23 on them slide in the reciprocating arc-shaped chute 24. When the convex rod 23 moves to the reciprocating arc-shaped chute 24 at the arc, the convex rod 23 will drive the first vertical rod 21 and the second vertical rod 22 to slide horizontally with reference to the cross bar 20, thereby reducing the stirring blind area during the stirring of the device. At the same time, when the first vertical rod 21 and the second vertical rod 22 slide horizontally, they will drive the sliding frame plate 25 at their upper ends to slide synchronously. When the sliding frame plate 25 slides, it drives the short plate 31 and the abutting rod 33 to slide synchronously. When the abutting rod 33 slides to the inclined plane groove 35, it will move upward under the pulling force of the spring rod 32, thereby driving the sliding stirring frame 27 on the sliding block 26 to slide vertically, so that the sliding stirring frame 27 slides reciprocally in the vertical direction while reciprocating in the horizontal direction, enabling the drug mixture in each space in the stirring cylinder 1 to be fully stirred. After the stirring is completed, the drug flows out through the discharge pipe 3 and enters the next process.

[0048] The remaining structures are the same as those in Embodiment 2.

[0049] Combining Embodiments 1-3, the working principle of the present invention is as follows: The staff feeds the drug raw materials into the stirring cylinder 1 sequentially through the feed pipe 2, and then closes the feed pipe 2. The control motor 11 is started through the console 4, so that the control motor 11 drives the driving end to rotate slowly. When the control motor 11 rotates, it will drive the threaded rod 12 to rotate synchronously. Since the limiting plate 7 and the nut 13 are limited by the limiting block 6, the limiting plate 7 moves vertically downward along the direction of the threaded rod 12, and then drives the lower extrusion disc 9 to move synchronously through the connecting rod 8. When the extrusion disc 9 moves downward, it will extrude the drug mixture below. After the drug mixture is extruded, the gas inside it flows through the flow groove 16 to the gas permeable membrane 15 and flows out through the ventilation holes 36 on the ventilation ring 14 of the gas permeable membrane 15, completing the discharge of the gas in the drug mixture to reduce the bubbles generated during stirring. When the pressure sensor detects that the pressure reaches the set threshold, the pressure sensor transmits a signal to the console 4, and the console 4 closes the control motor 11 to cancel the downward movement of the extrusion disc 9.

[0050] When the extrusion disc 9 stops moving downward, the control console 4 activates the drive motor 17. The drive motor 17 drives the first stirring square rod 18 and the second stirring square rod 19 to rotate synchronously through the drive end. At the same time, when the first stirring square rod 18 and the second stirring square rod 19 rotate, they drive the corresponding first vertical rod 21 and the second vertical rod 22 to rotate, stirring the drug mixture in the compressed state. When the first stirring square rod 18 and the second stirring square rod 19 rotate and stir, they will drive the first vertical rod 21 and the second vertical rod 22 to rotate synchronously through the cross bar 20. When the two rotate, the convex rods 23 on them slide in the reciprocating arc-shaped chute 24. When the convex rods 23 move to the reciprocating arc-shaped chute 24 at the arc, the convex rods 23 will drive the first vertical rod 21 and the second vertical rod 22 to slide horizontally with reference to the cross bar 20, thereby reducing the stirring blind area during the stirring of the device. At the same time, when the first vertical rod 21 and the second vertical rod 22 slide horizontally, they will drive the sliding frame plate 25 at their upper ends to slide synchronously. When the sliding frame plate 25 slides, it drives the short plate 31 and the abutting rod 33 to slide synchronously. When the abutting rod 33 slides to the inclined plane groove 35, it will move upward under the pulling force of the spring rod 32, thereby driving the sliding stirring frame 27 on the sliding block 26 to slide vertically, so that the sliding stirring frame 27 slides reciprocally in the vertical direction while reciprocating in the horizontal direction, enabling the drug mixture in each space in the stirring cylinder 1 to be fully stirred. After the stirring is completed, the drug flows out through the discharge pipe 3 and enters the next process.

[0051] It should be noted that the above embodiments are only used to illustrate the technical solutions of the present invention and not to limit them. Although the present invention has been described in detail with reference to the preferred embodiments, those of ordinary skill in the art should understand that the technical solutions of the present invention can be modified or equivalently replaced without departing from the spirit and scope of the technical solutions of the present invention, and they should all be covered by the scope of the claims of the present invention.

Claims

1. A stirring device for the preparation of tinidazole suppositories, comprising a stirring cylinder, a feed pipe and a discharge pipe arranged on the side wall of the stirring cylinder, and a control console arranged on the outer wall of the stirring cylinder, characterized in that: It further includes a stirring unit disposed inside the mixing drum, and the stirring unit includes a degassing component and a stirring component disposed inside the mixing drum; The degassing component includes a limiting groove opened on the inner wall of the mixing drum, a limiting block slidably disposed in the limiting groove, a limiting plate disposed between the two limiting blocks, a plurality of connecting rods disposed at the lower end of the limiting plate, an extrusion disc disposed at the lower ends of the plurality of connecting rods, a plurality of mounting rods disposed on the outer wall at the upper end of the mixing drum, a control motor disposed on the plurality of mounting rods, a threaded rod disposed at the driving end of the control motor, a mounting groove opened on the limiting plate, a nut disposed in the mounting groove, a ventilation ring disposed on the extrusion disc, a plurality of ventilation holes opened on the ventilation ring, and a gas permeable membrane disposed at the lower end of the extrusion disc; Both the feed pipe and the discharge pipe are fixedly communicated with the inside of the mixing drum, and the communicating pipe orifices are both located below the extrusion disc. The height of the discharge pipe is lower than that of the feed pipe. The gas permeable membrane has the same size and shape as the end face of the ventilation ring, and the gas permeable membrane is located directly below the ventilation ring. A plurality of flow grooves for gas flow are opened at the lower end of the extrusion disc, and one end of each flow groove is located directly below the gas permeable membrane. The shape and size of the extrusion disc are the same as the end face of the inner wall of the mixing drum; The stirring component includes a driving motor fixedly installed at the upper end of the extrusion disc, a driving shaft hermetically and slidably penetrating through the center of the extrusion disc, a stirring square rod one disposed at the lower end of the driving shaft, and a stirring square rod two slidably disposed inside the stirring square rod one. A plurality of telescopic components are jointly installed between the stirring square rod one and the stirring square rod two. The stirring square rod one and the stirring square rod two have the same shape, and the end face shapes of both are set to be hexagonal. The radius of the stirring square rod two is smaller than that of the stirring square rod one; The telescopic component includes cross bars disposed on the stirring square rod one and the stirring square rod two, a vertical rod one slidably disposed on the upper cross bar, a vertical rod two slidably disposed inside the vertical rod one. The vertical rod two has the same shape as the vertical rod one. The radius of the vertical rod two is smaller than that of the vertical rod one. The lower end of the vertical rod two is slidably installed on the corresponding lower cross bar. A sliding element is jointly provided on a plurality of corresponding vertical rod ones; A convex rod is provided on each cross bar. Reciprocating arc-shaped chutes are opened at the lower end near the outer circle of the extrusion disc and on the inner wall at the lower end of the mixing drum. Each convex rod is located in the corresponding reciprocating arc-shaped chute; The sliding element includes a sliding frame plate provided on each vertical rod one, a plurality of sliding blocks slidably disposed on the plurality of sliding frame plates, a sliding stirring frame provided on the corresponding plurality of sliding blocks, a plurality of suspension ropes provided at the lower end of the sliding stirring frame, a suspension rod provided between the corresponding plurality of suspension ropes. The lowermost suspension rod is fixedly connected to the corresponding cross bar. A triggering fitting is installed between each sliding stirring frame and the corresponding vertical rod one; The triggering accessory includes a seat plate arranged on the first vertical rod, a short plate arranged on the sliding stirring frame, a spring rod arranged between the seat plate and the short plate, a pressing rod arranged in the middle of the upper end of the short plate, a pressing block arranged on the upper cross bar, and an inclined groove formed on the pressing block. The lower parts of the pressing rod and the pressing block are tightly pressed against each other, and the initial state of the spring rod is a telescopic state.

2. The stirring device for the preparation of tinidazole suppositories according to claim 1, wherein: Both the control motor and the driving motor are electrically connected to the console.

3. The stirring device for the preparation of tinidazole suppositories according to claim 2, characterized in that: A pressure sensor is arranged below the extrusion disc, and the pressure sensor is signal-connected to the console.

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