A kind of oral liquid extracted from honeysuckle family and preparation method thereof

Abstract

The invention discloses an oral liquid extracted from a plant of the Caprifoliaceae family, which is prepared from the following components: a honeysuckle extract and / or a honeysuckle vine extract, a flavoring agent, an antibacterial agent, and purified water. The invention uses water as an extraction solvent to extract the active ingredients in the medicinal materials of the Caprifoliaceae family, and combines Poria cocos, Astragalus, Saposhnikovia divaricata, and Radix Isatidis, and is supplemented with a flavoring agent to achieve a certain viscosity and a suitable taste, and retains as many high-concentration natural active ingredients in the plants of the Caprifoliaceae family as possible by means of distillation and decoction. The active ingredients in the oral liquid interact with each other and cooperate with each other, and have good heat-clearing, detoxifying, anti-inflammatory and analgesic effects.

Description

Technical Field

[0001] The present invention relates to the field of oral liquid extracted from Caprifoliaceae plants, and more specifically, to an oral liquid extracted from Caprifoliaceae plants and a preparation method thereof. Background Art

[0002] The dried buds or flowers of honeysuckle, a plant of the Caprifoliaceae family, are commonly known as honeysuckle. They are harvested before the flowers bloom in early summer and used as medicinal materials after being dried. Honeysuckle is a common Chinese medicinal material with multiple pharmacological effects such as clearing away heat and detoxification, antibacterial and anti-inflammatory. Honeysuckle contains a variety of effective ingredients, including rich organic acid components such as chlorogenic acid, caffeic acid, and ferulic acid. These organic acid components have multiple biological activities such as antibacterial and anti-inflammatory, antioxidant, and hypolipidemic. Among them, chlorogenic acid is one of the most important effective ingredients, which has a wide range of antibacterial and antiviral effects and can also enhance human immunity. Honeysuckle extract also contains a variety of flavonoids, such as luteolin and quercetin. These flavonoids have multiple biological activities such as antioxidant, anti-inflammatory, and anti-tumor, and have a good health care effect on human health. Among them, luteolin is a representative flavonoid compound with obvious anti-inflammatory and antioxidant effects, and can also improve microcirculation and lower blood pressure. In addition to organic acids and flavonoids, honeysuckle also contains volatile oils, polysaccharides, proteins, trace elements and other ingredients. These ingredients also have certain pharmacological effects, such as volatile oils have antibacterial and anti-inflammatory effects, antipyretic and analgesic effects, and polysaccharides have immunity enhancement and anti-tumor effects.

[0003] The dried stems and branches of honeysuckle, a plant of the Caprifoliaceae family, are commonly known as honeysuckle vines. They are harvested in autumn and winter and dried in the sun. They are sweet and cold in nature. Old branches taste slightly bitter, while young branches taste light. They are used in the lung, stomach, and heart meridians. Their effects are similar to those of honeysuckle. In addition to clearing away heat and detoxifying, they can also dispel rheumatism, promote blood circulation, and clear wind-heat in the meridians and relieve pain. They are harvested in autumn and winter every year, and impurities are removed. They are bundled or rolled into balls and dried in the sun. They can be made into honeysuckle vine wine, honeysuckle tea, honeysuckle vine herb tea, and isatis indigo leaf honeysuckle tea.

[0004] Honeysuckle and honeysuckle vine are usually prepared into liquid preparations or granules such as dew, syrup, oral liquid, and mixture on the market. In the preparation process of liquid preparations, only the distillate is generally collected, which is rich in volatile oil active ingredients and has the main function of clearing away heat and detoxifying; the preparation process of granules is mainly decoction extraction, concentration and drying granulation, mainly containing organic acids and flavonoids active ingredients, and the main function is antibacterial and anti-inflammatory; the above dosage forms cannot fully utilize the active ingredients of honeysuckle, reducing the clinical effects of honeysuckle and honeysuckle vine. Therefore, it is necessary to provide an oral liquid that retains as many high-concentration natural active ingredients in Caprifoliaceae plants as possible. Summary of the invention

[0005] In order to achieve these purposes and other advantages according to the present invention, a preferred embodiment of the present invention provides an oral liquid extracted from a plant of the family Caprifoliaceae, which is prepared from the following components:

[0006] Honeysuckle extract and / or honeysuckle vine extract, flavoring agent, antibacterial agent, purified water.

[0007] Honeysuckle is a heat-clearing and detoxifying medicine. It is the dried buds or newly opened flowers of the honeysuckle plant of the Caprifoliaceae family. Honeysuckle has the effects of clearing heat, detoxifying, and evacuating wind-heat.

[0008] According to a preferred embodiment of the present invention, it is prepared from the following components in parts by weight:

[0009] 20-30 parts of honeysuckle extract and / or 15-20 parts of honeysuckle vine extract, 0.5-1 part of flavoring agent, 0.01-0.5 part of antibacterial agent, and 20-30 parts of purified water.

[0010] Honeysuckle is a heat-clearing medicine, which is the dried stems and branches of the honeysuckle plant of the Caprifoliaceae family. The ones with red skin, tender texture and leaves are preferred. The main effects of honeysuckle are to clear away heat and detoxify, and to relieve wind and dredge the meridians.

[0011] According to a preferred embodiment of the present invention, it also includes 30-40 parts of a mixed solution, which is prepared by boiling Poria cocos, Astragalus membranaceus, Saposhnikovia divaricata, Isatis indigotica and pure water in a mass ratio of 1:1:1:1.5:40-50 for 30 minutes.

[0012] Poria cocos is a diuretic and dampness-inducing medicine, which is the dried sclerotium of the fungus Poria cocos of the Polyporaceae family. Poria cocos has the functions of diuretic and dampness-inducing, spleen-strengthening, and tranquilizing the mind.

[0013] Astragalus is a Qi-tonifying medicine, which is the dried root of the leguminous plant Astragalus mongolica or Astragalus membranaceus. Astragalus has the effects of tonifying Qi and raising Yang, consolidating the exterior and stopping sweating, promoting diuresis and reducing swelling, promoting body fluid and nourishing blood, relieving stagnation and relieving numbness, expelling toxins and draining pus, and healing sores and promoting tissue regeneration.

[0014] Saposhnikovia divaricata is a herbal medicine for dispelling wind and relieving exterior symptoms, and is the dried root of the Umbelliferae plant Saposhnikovia divaricata. It has the effects of dispelling wind and relieving exterior symptoms, relieving dampness and relieving pain, and stopping spasms.

[0015] The Chinese herbal medicine Isatis root is a heat-clearing medicine. It is the dried root of the cruciferous plant Isatis indigotica. It has the effects of clearing away heat and detoxifying, cooling blood and relieving sore throat.

[0016] According to a preferred embodiment of the present invention, the honeysuckle extract is prepared by the following steps: taking a certain amount of honeysuckle, performing a primary distillation, performing a secondary distillation on the distillate of the primary distillation, and then placing the distilled honeysuckle in water 5-10 times its weight and boiling for 1-2 hours, collecting the decoction, filtering and concentrating, and mixing the concentrate with the distillate obtained by the secondary distillation to obtain the honeysuckle extract;

[0017] The honeysuckle vine extract is prepared by the following steps: taking a certain amount of honeysuckle vine, performing a primary distillation, performing a secondary distillation on the distillate of the primary distillation, then placing the distilled honeysuckle vine in water with a weight of 5 to 10 times its weight and boiling it for 1 to 2 hours, collecting the decoction, filtering and concentrating it, and mixing the concentrated solution with the distillate obtained by the secondary distillation to obtain the honeysuckle vine extract.

[0018] According to a preferred embodiment of the present invention, the flavoring agent is any one of sorbitol, xylitol, sucralose, and aspartame, or a combination of two, three, or four thereof.

[0019] According to a preferred embodiment of the present invention, the antibacterial agent is one or more of methylparaben, ethylparaben, propylparaben, butylparaben, sodium benzoate, benzyl alcohol, and potassium sorbate.

[0020] According to a preferred embodiment of the present invention, the relative density of the oral liquid is 1.01-1.20, and the pH value of the oral liquid is 3.0-6.0.

[0021] According to a preferred embodiment of the present invention, the following steps are included:

[0022] Dissolve the above weight portions of flavor correctives and antibacterial agents with purified water, then add honeysuckle extract, honeysuckle vine extract and the mixed solution, stir evenly, adjust the pH value to 3-6 with a pH regulator, quantify, filter and sterilize to obtain a sterile liquid, and finally package to obtain the target oral solution.

[0023] The target oral liquid is a standard expression for a single-dose dosage for adults with a low medicinal material content. The packaging for multiple doses is called a mixture. The implementation scheme with a higher medicinal material content is called drops after its usage and dosage need to be adjusted according to the medicinal materials. That is, the above-mentioned dosage forms are all the contents of the present invention.

[0024] The present invention has at least the following beneficial effects:

[0025] The invention uses water as an extraction solvent to extract effective ingredients from the honeysuckle plant medicinal materials, and combines Poria cocos, Astragalus, Saposhnikovia divaricata, and Radix Isatidis, and is supplemented with flavor correctors to achieve a certain viscosity and a suitable taste. Through the two methods of distillation and decoction, the high-concentration natural active ingredients in the honeysuckle plant are retained as much as possible. The effective ingredients in the oral liquid interact with each other and cooperate with each other, and have good heat-clearing, detoxifying, anti-inflammatory and analgesic effects.

[0026] Other advantages, objectives and features of the present invention will be embodied in part through the following description, and in part will be understood by those skilled in the art through study and practice of the present invention. DETAILED DESCRIPTION

[0027] The present invention is further described in detail below in conjunction with embodiments so that those skilled in the art can implement the invention with reference to the description.

[0028] The following description is used to disclose the present invention so that those skilled in the art can implement the present invention. The preferred embodiments described below are only examples, and those skilled in the art can think of other obvious variations. The basic principles of the present invention defined in the following description can be applied to other embodiments, variations, improvements, equivalents, and other technical solutions that do not deviate from the spirit and scope of the present invention.

[0029] Example 1

[0030] The oral liquid extracted from honeysuckle plants is prepared from the following components in parts by weight:

[0031] 20 parts of honeysuckle extract, 15 parts of honeysuckle vine extract, 35 parts of mixed solution, 0.5 parts of flavoring agent, 0.01 parts of antibacterial agent, and 20 parts of purified water; wherein the antibacterial agent is methylparaben and the flavoring agent is sorbitol.

[0032] The mixed liquid is prepared by boiling Poria cocos, Astragalus membranaceus, Saposhnikovia divaricata, Isatis indigotica root and pure water in a mass ratio of 1:1:1:1.5:40-50 for 30 minutes.

[0033] The honeysuckle extract is prepared by the following steps: taking a certain amount of honeysuckle, performing a primary distillation, performing a secondary distillation on the distillate, then placing the distilled honeysuckle in water 5-10 times its weight and boiling for 1-2 hours, collecting the decoction, filtering and concentrating it, and mixing the concentrated solution with the distillate obtained by the secondary distillation to obtain the honeysuckle extract;

[0034] The honeysuckle vine extract is prepared by the following steps: taking a certain amount of honeysuckle vine, performing a primary distillation, performing a secondary distillation on the distillate of the primary distillation, then placing the distilled honeysuckle vine in water with a weight of 5 to 10 times its weight and boiling it for 1 to 2 hours, collecting the decoction, filtering and concentrating it, and mixing the concentrated solution with the distillate obtained by the secondary distillation to obtain the honeysuckle vine extract.

[0035] Dissolve the above weight portions of flavor correctives and antibacterial agents with purified water, then add honeysuckle extract, honeysuckle vine extract and the mixed solution, stir evenly, adjust the pH value to 3-6 with a pH regulator, quantify, filter and sterilize to obtain a sterile liquid, and finally package to obtain the target oral solution.

[0036] Example 2

[0037] The components and preparation method are consistent with those of Example 1, except that the weight parts of the raw material components are different, namely, 25 parts of honeysuckle extract, 18 parts of honeysuckle vine extract, 35 parts of mixed solution, 0.7 parts of flavoring agent, 0.1 parts of antibacterial agent, and 25 parts of purified water.

[0038] Example 3

[0039] The components and preparation method are consistent with those of Example 1, except that the weight parts of the raw material components are different, namely, 30 parts of honeysuckle extract, 20 parts of honeysuckle vine extract, 40 parts of mixed solution, 1 part of flavoring agent, 0.5 parts of antibacterial agent, and 30 parts of purified water.

[0040] Comparative Example 1

[0041] The components and preparation method are the same as those in Example 1, except that the comparative example 1 does not contain the honeysuckle vine extract and the mixed solution; the comparative example 2

[0042] The components and preparation method are the same as those in Example 1, except that the comparative example 2 does not contain the honeysuckle extract and the mixed solution; the comparative example 3

[0043] The components and preparation method are the same as those of Example 1, except that there is no mixed solution in Comparative Example 3;

[0044] Comparative Example 4

[0045] The components and preparation method are the same as those in Example 1, except that the mixed solution in Comparative Example 4 contains only Radix Isatidis;

[0046] Comparative Example 5

[0047] The components and preparation method are the same as those in Example 1, except that the mixed solution in Comparative Example 5 only contains Poria cocos and Radix Isatidis;

[0048] Comparative Example 6

[0049] The components and preparation method are consistent with those of Example 1, except that the mixed solution in Comparative Example 6 only contains Astragalus and Isatis;

[0050] Comparative Example 7

[0051] The components and preparation method are the same as those in Example 1, except that the mixed solution in Comparative Example 7 only contains Saposhnikovia divaricata and Radix Isatidis;

[0052] Comparative Example 8

[0053] The components and preparation method are the same as those in Example 1, except that the mixed solution in Comparative Example 8 only contains Poria cocos, Astragalus membranaceus, and Radix Isatidis;

[0054] Comparative Example 9

[0055] The components and preparation method are the same as those in Example 1, except that the mixed solution in Comparative Example 9 only contains Poria cocos, Saposhnikovia divaricata, and Radix Isatidis;

[0056] Comparative Example 10

[0057] The components and preparation method are consistent with those of Example 1, except that the mixed solution in Comparative Example 10 only contains Astragalus, Saposhnikovia and Isatis.

[0058] Test 1: Heat-clearing and detoxification test

[0059] New Zealand white rabbits with a basal body temperature of 38.5-39.2℃ were selected and the bacterial endotoxin physiological saline solution was taken.

[0060] The New Zealand white rabbits were injected intravenously with a dose of 1 mL / kg, and the temperature changes were observed. 140 New Zealand white rabbits whose body temperature rose by more than 0.5°C 1 hour after the injection were selected, half of which were male and half were female, and weighed 5-6 catties. They were divided into 14 groups (corresponding to the control group, Examples 1-3, and Comparative Examples 1-10, respectively), with 10 rabbits in each group. In 11 groups, the New Zealand white rabbits were gavaged with the oral liquids of Examples 1-3 and Comparative Examples 1-10, and the control group was gavaged with an equal amount of normal saline. After administration, the temperature changes were continuously observed and recorded every 0.5 hour for 5 hours.

[0061] Table 1 Comparison of heat-clearing and detoxifying effects in different experimental groups

[0062] Grouping Dose, mL / kg Body temperature difference 5 hours after administration, ℃ Control group 2 1.23±0.24 Example 1 2 0.22±0.22 Example 2 2 0.21±0.35 Example 3 2 0.21±0.34 Comparative Example 1 2 0.65±0.32 Comparative Example 2 2 0.63±0.24 Comparative Example 3 2 0.52±0.25 Comparative Example 4 2 0.45±0.17 Comparative Example 5 2 0.46±0.19 Comparative Example 6 2 0.48±0.24 Comparative Example 7 2 0.46±.031 Comparative Example 8 2 0.29±0.26 Comparative Example 9 2 0.44±0.24 Comparative Example 10 2 0.45±0.29

[0063] The result shows that the heat-clearing and detoxicating effect of the oral liquid of embodiment 1-3 is the best. Compared with the control group, comparative examples 1-10 all possess certain heat-clearing and detoxicating effect, and the body temperature of the rabbits decreases to varying degrees after administration for 5h. The heat-clearing and detoxicating effect of comparative example 3 is significantly better than that of comparative example 1 and comparative example 2, because comparative example 3 contains honeysuckle and honeysuckle vine at the same time, and both possess certain heat-clearing and detoxicating effect, and the two combine synergistic effect, so that the effect is further strengthened. The heat-clearing and detoxicating effect of comparative example 4-7 is better than that of comparative example 3, because comparative example 4-7 all contains the Radix Isatidis of heat-clearing and detoxicating, but the heat-clearing and detoxicating effect of comparative example 5-7 is not much different from that of comparative example 4, and it can be seen that adding Poria cocos, Radix Astragali, and Radix Saposhnikoviae alone on the basis of Radix Isatidis has little effect on improving the heat-clearing and detoxicating effect of oral liquid. The effect of comparative example 8 is significantly better than that of comparative example 5-7 and comparative example 9-10, which is due to the compatibility and mutual coordination between Radix Isatidis, Poria cocos, and Radix Astragali, which greatly improves the heat-clearing and detoxicating effect of oral liquid. The effect of Example 1-3 is much better than that of Comparative Example 8, which should be due to the synergistic effect between Radix Isatidis, Poria, Radix Astragali, Radix Saposhnikoviae and Flos Lonicerae and Caulis Honeysuckle in Examples 1-3. Flos Lonicerae and Caulis Honeysuckle and Radix Isatidis clear away heat, cool blood and detoxify, and the two medicines are used together as the main medicine, and Poria and Radix Astragali are the ministers, which help the main medicine to clear away heat and cool blood. The coordination between the main medicine and the minister medicine greatly improves the heat-clearing and detoxifying effect of the oral liquid.

[0064] Test 2: Swelling and Anti-Inflammation Test

[0065] 140 healthy mice, half male and half female, weighing 20±2 g, were selected and divided into 14 groups (corresponding to the control group, Examples 1-3, and Comparative Examples 1-10, respectively), with 10 mice in each group.

[0066] In both Examples 1-3 and Comparative Examples 1-10, 2 ml of the oral solution was gavaged into mice for 7 consecutive days; the control group was gavaged with an equal amount of normal saline for 7 consecutive days.

[0067] One hour after the last administration, 0.03 ml of 1% carrageenan solution was injected subcutaneously into the plantar of the left hind limb of the mouse. Four hours after the injection, the mouse was killed by cervical dislocation, and the left and right hind feet were cut off from the knee joint and weighed respectively, and the difference in weight between the two feet was taken as the degree of swelling.

[0068] Table 2 Comparison of foot swelling in mice in different experimental groups

[0069]

[0070]

[0071] The results show that the oral liquids of Examples 1-3 can significantly inhibit the swelling of the mouse foot, among which Example 1 has the best effect on inhibiting the swelling of the mouse foot, which is about 50% of the swelling of the control group. The effects of inhibiting the swelling of the mouse foot of Comparative Examples 4-7 are better than those of Comparative Example 3. This is because Comparative Examples 4-7 all contain Radix Isatidis for clearing away heat, detoxifying and anti-inflammatory, but the difference between the effects of inhibiting the swelling of the mouse foot of Comparative Examples 5-7 and Comparative Example 4 is not much. It can be seen that adding Poria cocos, Astragalus membranaceus, and Saposhnikovia divaricata alone on the basis of Radix Isatidis has little effect on improving the effect of inhibiting the swelling of the mouse foot of the oral liquid, but the effect of Comparative Example 8 is significantly better than that of Comparative Examples 5-7 and Comparative Examples 9-10, which is due to the compatibility and mutual coordination between Radix Isatidis, Poria cocos, and Astragalus membranaceus, which greatly improves the effect of clearing away heat and detoxifying of the oral liquid. The effect of Example 1-3 is much better than that of Comparative Example 8, which should be because Radix Isatidis, Poria cocos, Astragalus membranaceus, Saposhnikovia divaricata and Flos Lonicerae are used in combination, showing a strong synergistic effect of clearing heat, detoxifying and anti-inflammatory.

[0072] Test 3 Anti-inflammatory and analgesic test

[0073] 140 healthy mice, half male and half female, weighing 20±2 g, were selected and divided into 14 groups (corresponding to the control group, Examples 1-3, and Comparative Examples 1-10, respectively), with 10 mice in each group.

[0074] In both Examples 1-3 and Comparative Examples 1-10, 2 ml of the oral solution was gavaged into mice for 7 consecutive days; the control group was gavaged with an equal amount of normal saline for 7 consecutive days.

[0075] One hour after the last administration, each mouse was intraperitoneally injected with 0.6% acetic acid (0.2 ml / mouse), and the results were recorded for 20 minutes.

[0076] Table 3 Comparison of the number of writhing times of mice in different experimental groups

[0077]

[0078]

[0079] The results show that the oral liquids of Examples 1-3 can significantly inhibit the number of mouse body twists caused by acetic acid, indicating that Examples 1-3 have good anti-inflammatory and analgesic effects, and the anti-inflammatory and analgesic effects of Comparative Examples 4-7 are all better than those of Comparative Example 3. This is because Comparative Examples 4-7 all contain Radix Isatidis, which can clear away heat, detoxify and reduce inflammation, especially Comparative Example 7, which has a better effect. This is because in addition to Radix Isatidis, it also contains Radix Saposhnikoviae, which can dispel wind and relieve exterior symptoms, overcome dampness and relieve pain, and stop spasms. Compared with Comparative Example 7, the number of mouse body twists in Comparative Example 10 is greatly reduced, probably because Radix Isatidis, Radix Astragali, and Radix Saposhnikoviae can effectively relieve heat and reduce inflammation. The compatibility of the three main medicinal materials results in a synergistic effect on each other. It can also be seen that the number of body twists in mice in Comparative Example 10 is less than that in Comparative Example 9, indicating that the synergistic effect between Poria cocos, Saposhnikovia divaricata and Isatis root in Comparative Example 9 is not strong, or it may be that the synergistic effect between Poria cocos, Saposhnikovia divaricata, Isatis root, Honeysuckle and Lonicera japonica is not good. The number of body twists in mice in Examples 1-3 is much less than that in Comparative Example 10, which is due to the strong synergistic effect of anti-inflammatory and analgesic between Isatis root, Poria cocos, Astragalus membranaceus, Saposhnikovia divaricata and Honeysuckle and Lonicera japonica used in combination.

[0080] Although the embodiments of the present invention have been disclosed as above, they are not limited to the applications listed in the specification and the implementation modes. They can be fully applied to various fields suitable for the present invention. For those familiar with the art, additional modifications can be easily implemented. Therefore, without departing from the general concept defined by the claims and the scope of equivalents, the present invention is not limited to the specific details and the embodiments shown and described herein.

Claims

1. An oral liquid extracted from a plant of the family Caprifoliaceae, characterized in that: It is prepared from the following components in parts by weight: 20-30 parts of honeysuckle extract and / or 15-20 parts of honeysuckle vine extract, 0.5-1 part of flavoring agent, 0.01-0.5 part of antibacterial agent, 20-30 parts of purified water; It also includes 30-40 parts of a mixed solution, which is prepared by boiling Poria cocos, Astragalus membranaceus, Saposhnikovia divaricata, Isatis indigotica root and pure water in a mass ratio of 1:1:1:1.5:40-50 for 30 minutes.

2. The oral liquid extracted from the honeysuckle family according to claim 1, characterized in that: The honeysuckle extract is prepared by the following steps: taking honeysuckle and performing a primary distillation, performing a secondary distillation on the distillate, then placing the distilled honeysuckle in water with a weight of 5 to 10 times its weight and boiling it for 1 to 2 hours, collecting the decoction, filtering and concentrating it, and mixing the concentrate with the distillate obtained by the secondary distillation to obtain the honeysuckle extract; The honeysuckle vine extract is prepared by the following steps: taking honeysuckle vine and performing a primary distillation, performing a secondary distillation on the distillate of the primary distillation, and then placing the distilled honeysuckle vine in 5-10 times the weight of water and decocting it for 1-2 hours, collecting the decoction, filtering and concentrating it, and mixing the concentrate with the distillate obtained by the secondary distillation to obtain the honeysuckle vine extract.

3. The oral liquid extracted from the honeysuckle family according to claim 1, characterized in that: The flavoring agent is any one of sorbitol, xylitol, sucralose, and aspartame, or a combination of two, three, or four thereof.

4. The oral liquid extracted from the honeysuckle family according to claim 1, characterized in that: The antibacterial agent is a combination of one or more of methylparaben, ethylparaben, propylparaben, butylparaben, sodium benzoate, benzyl alcohol and potassium sorbate.

5. The oral liquid extracted from the honeysuckle family according to claim 1, characterized in that: The relative density of the oral liquid is 1.01-1.20, and the pH value of the oral liquid is 3.0-6.

0.

6. The method for preparing the oral liquid extracted from the honeysuckle family according to any one of claims 1 to 5, characterized in that: The following steps are involved: Dissolve the above weight portions of flavor correctives and antibacterial agents with purified water, then add honeysuckle extract, honeysuckle vine extract and the mixed solution, stir evenly, adjust the pH value to 3-6 with a pH adjuster, quantify, filter and sterilize to obtain a sterile liquid, and finally package to obtain the target oral solution.

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