Preparation method and application of indole diterpene compound

By extracting, isolating, and purifying indole diterpenoids from plant endophytic fungus F4a, the challenges of fall armyworm resistance and type 2 diabetes treatment have been solved, enabling the preparation of natural insecticides and hypoglycemic drugs with significant antifeedant, insecticidal, and PTP1B inhibitory effects.

CN118745447BActive Publication Date: 2025-12-09SHENYANG INST OF APPL ECOLOGY CHINESE ACAD OF SCI
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Patent Information

Application Number
CN202410949705.1
Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
Filing Date
2024-07-16
Publication Date
2025-12-09
Estimated Expiration
2044-07-16

AI Technical Summary

Technical Problem

In the current technology, the fall armyworm has developed resistance to chemical pesticides and there is a lack of effective insecticides from natural sources. The activity of type 2 diabetes-associated protein tyrosine phosphatase 1B (PTP1B) is difficult to inhibit, making prevention and treatment difficult.

Method used

Indole diterpenoids were extracted, isolated, and purified from plant endophytic fungus F4a using specific fermentation conditions and processes, and were used to prepare compounds with antifeedant, insecticidal, and hypoglycemic activities.

Benefits of technology

The prepared indole diterpenoid compounds exhibit significant antifeedant and insecticidal dual activity against fall armyworm larvae, and also show strong inhibitory activity against PTP1B, providing a safe and sustainable control method and a potential hypoglycemic agent.

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Abstract

The present application relates to the technical field of microbial medicine, and particularly to a preparation method and application of indole diterpenoid compounds. Specifically, the extract of plant endophytic fungus F4a after solid fermentation culture is separated and purified to obtain indole diterpenoid compounds; the plant endophytic fungus F4a is a strain with the preservation number CCTCC NO: M 2012531. The indole diterpenoid compounds provided by the present application have significant antifeedant, insecticidal and hypotensive activities, and they can be used as ideal candidate compounds of antifeedants, insecticides or hypoglycemic drugs. The compounds can be produced through fungal fermentation, and the preparation method is simple, efficient and high in product purity. The present application has good application prospect.
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