A skin barrier repair composition and its use in cosmetics

Abstract

The application discloses a kind of skin barrier repair compositions and its application in cosmetics.The present application is made into composition by compounding silanized glass acid ester and capparis zeylanica fruit complex liquid, can significantly promote ZO-1 and TGM-5 protein synthesis, to achieve the effect of effectively repairing skin barrier;Then the composition is prepared into skin care cosmetics as the main effective component, and it is verified by test to have good effect of improving dry skin, redness, barrier damage problem.

Description

Technical Field

[0001] This invention belongs to the field of cosmetic technology, specifically relating to a skin barrier repair composition and its application in cosmetics. Background Technology

[0002] Skin barrier repair plays a crucial role in maintaining skin health and normal function. A healthy skin barrier can resist the entry of harmful external irritants and also has moisturizing and anti-inflammatory effects. Damage to the skin barrier can cause problems such as dry skin, skin aging, and pigmentation. In severe cases, it can lead to skin problems such as atopic dermatitis, eczema, psoriasis, ichthyosis, and photodermatitis.

[0003] Tight junctions (TJs) are essential functional structures of the skin barrier, present in almost all epidermis, and are considered major controllers of the epidermal cell barrier system. Abnormalities in tight junctions lead to skin barrier damage. Various proteins, including occludin, claudin, the ZO protein family, and adhesion molecules, participate in the formation of tight junctions. Tight junction proteins interact to form TJ complexes, which connect cells to each other or to the extracellular matrix. ZO-1 protein directly binds to actin, forming a stable connection between the cytoskeleton and the TJ complex. The structural stability of tight junctions reflects the integrity of barrier function. Damage to ZO-1 protein leads to loosening of intercellular connections, cell dispersion or even detachment, increased barrier permeability, and escape of fluids, cells, or cytokines, causing damage to the body. Therefore, ZO-1, as a skeletal protein of tight junctions, plays a crucial role in maintaining the structural stability of the skin barrier, the integrity of the tight junction layer, and normal epidermal permeability.

[0004] Keratinocytes are the cells that make up most of the epidermis. Filament polymers cross-link with keratin filaments, providing strength and structure. Proteins in the keratinocyte membrane (FLG, IVL, LOR, KRT) cross-link in this layer via the calcium-demanding enzyme transglutaminase to form a keratinized capsule. This capsule determines the biomechanical properties of keratinocytes, providing them with robustness. Transglutaminase 5 (TGM-5) is a key differentiation protein for keratinocytes and an important component of the keratinized capsule. It maintains a healthy skin barrier by regulating proteins such as FLG, IVL, and LOR in the keratinized capsule. In normal epidermis, TGM-5 is mainly distributed in the granular layer and its expression is upregulated. It catalyzes the cross-linking of the aforementioned structural proteins, thereby inducing epidermal keratinization. When TGM-5 levels decrease, it affects the formation of the keratinized capsule and the differentiation of keratinocytes, preventing the formation of a complete skin barrier. Only when there is a precise balance between the normal gene expression of keratinized capsule proteins and TGM-5 can the epidermis form normally and produce keratin.

[0005] A healthy skin barrier is fundamental to many important physiological functions of the skin. Tight junctions and the keratinized capsule are crucial structures for maintaining a healthy skin barrier. Therefore, increasing ZO-1 and TGM-5 levels is significant for repairing a healthy skin barrier. Based on this, the applicant has developed a composition for repairing the skin barrier by increasing ZO-1 and TGM-5 levels. Summary of the Invention

[0006] To address the aforementioned problems, this invention provides a skin barrier repair composition and its application in cosmetics. The composition is prepared by compounding silanized hyaluronic acid ester and capernaum fruit extract, which significantly promotes the synthesis of ZO-1 and TGM-5 proteins. This composition is then used as the main active ingredient to prepare skincare cosmetics. Experimental results have verified its effectiveness in improving dry skin, redness, and damaged skin barrier, thus demonstrating promising application prospects in the cosmetics field.

[0007] To achieve the above-mentioned technical objectives, the present invention provides the following technical solution:

[0008] A first aspect of the present invention provides a skin barrier repair composition comprising the following components in parts by weight:

[0009] 0.01-0.1 parts of silanized hyaluronic acid ester (average molecular weight 700-800kDa) and 0.5-10.0 parts of citrus fruit compound solution.

[0010] Furthermore, the skin barrier repair composition comprises the following components in parts by weight:

[0011] 0.03-0.08 parts of silanized hyaluronic acid ester (average molecular weight 700-800kDa) and 1.0-8.0 parts of citrus fruit compound solution.

[0012] Preparation method: Dissolve the silanized hyaluronic acid ester and the compound solution of capernaum fruit in water (make up to 100 parts).

[0013] The silanized hyaluronic acid ester refers to a compound in which dimethylsilane monool or dimethylsilane diol is bonded to hyaluronic acid by an ester bond. It can be obtained by a publicly disclosed preparation method, such as reacting chlorosilane with hyaluronic acid suspended in an organic solution and then precipitating to obtain a solid substance (CN103450368A). It has good moisturizing, skin damage prevention and repair effects.

[0014] The preparation method of the prickly ash fruit compound liquid is as follows: prickly ash fruit powder is added to water and stirred and extracted 1-3 times at 60-90℃, and the filtrates are combined; then a complex enzyme composed of α-amylase, acidic protease and neutral protease is added for enzymatic hydrolysis to obtain a crude extract, which is filtered; then polyamide resin and activated carbon are added for adsorption, and glycerol is added and mixed evenly to obtain the prickly ash fruit compound liquid (3.5-4.0 times the mass of prickly ash fruit powder).

[0015] Preferably, the preparation method includes the following steps:

[0016] S1: Weigh the crushed and sieved (60-100 mesh) prickly pear fruit powder, add water and stir at 60-90℃ for 1.5-3.5h, filter to obtain filtrate, add water to the filter residue and stir at 60-90℃ for 1.5-3.25h, filter to obtain filtrate, and combine the two filtrates;

[0017] S2: Add 0.2-0.4% (relative to the weight of the capernaum fruit powder) of a complex enzyme consisting of α-amylase, acidic protease, and neutral protease to the filtrate, wherein the mass ratio of α-amylase, acidic protease, and neutral protease is 1:0.8-1.2:0.8-1.2. Stir and hydrolyze at 40-60℃ for 0.5-2 hours, then inactivate the enzyme to obtain a crude extract.

[0018] S3: Filter the crude extract, add polyamide resin and activated carbon to the filtrate (the mass of polyamide resin is 0.1-1% of the mass of capercia fruit powder, and the amount of activated carbon is 0.1-0.7% of the mass of capercia fruit powder), stir and adsorb at room temperature for 1-1.5 hours, filter, and obtain capercia fruit extract;

[0019] S4: Mix caper fruit extract with glycerin until homogeneous to obtain caper fruit compound solution.

[0020] Capparis spinosa L. is a perennial vine-like semi-shrub. Its main functions include dispelling wind and dampness, relieving pain, and reducing swelling. It is applied externally to treat rheumatoid arthritis and sores. Current research shows that capparis fruit extract contains various functional components such as flavonoids and alkaloids, which have anti-inflammatory, analgesic, and antioxidant effects. When used in cosmetics, it has a conditioning effect on the skin.

[0021] A second aspect of this invention provides the application of the above-described skin barrier repair composition in the preparation of cosmetics that repair the skin barrier and improve dry and red skin. Through experimental verification, this invention demonstrates that the above composition can improve dry and red skin by promoting the expression of ZO-1 and TGM-5, and can be used in cosmetics to repair the skin barrier and improve dry and red skin. The cosmetic can be a skincare product.

[0022] A third aspect of the present invention provides a cosmetic for repairing the skin barrier, said cosmetic comprising at least the above-described skin barrier repair composition.

[0023] The amount of the skin barrier repair composition added is 0.1-10%, preferably 1-8%, based on the total mass of the cosmetic product.

[0024] The cosmetics may also contain any other ingredients permitted in the cosmetics industry, including but not limited to emulsifiers, emollients, humectants, thickeners, and preservatives.

[0025] Furthermore, by rationally adding the above-mentioned raw material components, this invention can also be used to prepare different cosmetic formulations, such as essence water, essence lotion, essence cream, etc. In addition, based on the above-mentioned basic cosmetic categories, other cosmetic categories can be further derived and prepared, which obviously all fall within the protection scope of this application.

[0026] A fourth aspect of the present invention provides a method for preparing the above-described cosmetic, the method comprising the step of mixing the skin barrier repair composition with other raw material components. No specific limitations are specified herein.

[0027] The technical effects of this invention are as follows:

[0028] (1) The skin barrier repair composition obtained by the present invention can significantly promote the synthesis of ZO-1 and TGM-5 proteins, thereby achieving the effect of effectively repairing the skin barrier;

[0029] (2) The expression-promoting effect of silanized hyaluronic acid ester on ZO-1 and TGM-5 is relatively weak, especially on the expression of ZO-1. In this invention, silanized hyaluronic acid ester is combined with the compound liquid of citrus aurantium fruit (water heating extraction + enzymatic hydrolysis). This combination can more significantly promote the expression of ZO-1 and TGM-5 proteins, and expand the function and application of silanized hyaluronic acid ester in repairing the skin barrier.

[0030] (3) Through experimental verification, the prickly ash fruit compound liquid (water heating extraction + enzymatic hydrolysis) has better skin care effects than the prickly ash fruit compound liquid (65% ethanol ultrasonic extraction), thus making the product more effective and more cost-efficient;

[0031] (4) The preparation method of the skin barrier repair composition skin care cosmetic prepared by the present invention is simple and easy to implement, and saves costs. Through human efficacy test, it has good effects on improving dry skin and redness, and therefore has good practical application value. Attached Figure Description

[0032] Figure 1 : Changes in facial redness in subject 2 of Example 5 before and after sample use (D0, D14, and D28);

[0033] Figure 2 Changes in facial redness in subject number 13 of Example 5 before and after sample use (D0, D14, and D28). Detailed Implementation

[0034] The present invention will now be further illustrated with specific examples. These examples are for illustrative purposes only and do not limit the scope of the invention. Unless otherwise specified, experimental conditions not explicitly stated in the examples are generally performed under conventional conditions or as recommended by the reagent company. The reagents and consumables used in the following examples are commercially available unless otherwise specified. All technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this invention pertains.

[0035] It should be noted that the silanized hyaluronic acid ester in the embodiments of the present invention is obtained by reacting chlorosilane with hyaluronic acid suspended in an organic solution and then precipitating to obtain a solid complex (CN103450368A). The average molecular weight of the silanized hyaluronic acid ester is 700-800 kDa. In the comparative example, sodium hyaluronate (average molecular weight 700-800 kDa) was purchased from Shandong Baifu Furida Pharmaceutical Co., Ltd., trade name: sodium hyaluronate, INCI name: sodium hyaluronate.

[0036] The compound liquid of prickly ash fruit in the embodiments and comparative examples of the present invention (method 1) was obtained by the following method:

[0037] S1: Weigh the crushed and sieved (80 mesh) capernaum fruit powder and mix it with water at a material-to-liquid ratio of 1:5 (mass ratio). Stir and extract for 2 hours at 80℃ and 70 rpm. Filter to obtain filtrate. Add water to the filter residue at a material-to-liquid ratio of 1:4 (mass ratio). Stir and extract for 2 hours at 80℃ and 70 rpm. Filter to obtain filtrate. Combine the two filtrates.

[0038] S2: Add 0.3% (relative to the weight of the caperca macrantha fruit powder) of a complex enzyme consisting of α-amylase, acidic protease, and neutral protease to the filtrate. The mass ratio of the α-amylase (model 3000u / mL, product batch number MY20011001, from Ningxia Xiasheng Biotechnology), acidic protease (model 100,000u / g, product batch number 2191135, from Ningxia Xiasheng Biotechnology), and neutral protease (model 100,000u / g, product batch number F181070, from Ningxia Xiasheng Biotechnology) is 1:1:1. Stir at 45℃ for 1.5h for enzymatic hydrolysis, and then inactivate the enzyme at 90℃ for 10min to obtain the crude extract.

[0039] S3: Filter the crude extract through a 10μm polypropylene membrane to obtain a filtrate. Add polyamide resin and activated carbon to the filtrate. The mass of polyamide resin is 0.3% of the mass of the capernaum fruit powder, and the amount of activated carbon is 0.4% of the mass of the capernaum fruit powder. Stir and adsorb at room temperature for 1.5 hours, then filter through a 0.22μm polypropylene membrane to obtain a capernaum fruit extract. The mass of the capernaum fruit extract is 3 times that of the capernaum fruit powder.

[0040] S4: Mix caper fruit extract and glycerin at a volume ratio of 4:1 and stir until homogeneous to obtain caper fruit compound solution.

[0041] The compound liquid of prickly ash fruit in the embodiments and comparative examples of the present invention (method 2) was prepared by the following method:

[0042] S1: Sieve the prickly pear fruit powder (using an 80-mesh sieve), use 65% ethanol solution as the extraction solvent, with a material-to-liquid ratio of 1:20 (g / mL), and perform ultrasonic extraction at a power of 150W, a temperature of 35℃, and a processing time of 8min.

[0043] S2: The extract was subjected to vacuum distillation at 55°C and concentrated to 3 times the mass of the caperca sylvestris fruit powder. Glycerin was added, and the concentrate and glycerin were mixed and stirred evenly at a volume ratio of 4:1.

[0044] Examples 1-3 and Comparative Examples 1-8:

[0045] The specific plan is shown in Table 1 below, calculated by mass parts. The preparation method is as follows: mix all raw materials together according to the proportions described in Table 1 and dissolve them in purified water.

[0046] Table 1. List of components for specific embodiments and comparative examples.

[0047]

[0048] Example 5: Skin Barrier Repairing Essence Cream

[0049] The above composition is used to prepare an essence cream product containing the skin barrier repair composition, and the formula is shown in Table 2.

[0050] Table 2. Formula of the Essence Cream

[0051]

[0052] Preparation method of essence cream:

[0053] S1: Preparation of the aqueous phase: Add the raw materials from phase A separately, heat to 80-85℃ and stir to dissolve;

[0054] S2: Preparation of the oil phase: Add the raw materials from phase B separately and heat to 75-80℃ to melt;

[0055] S3: Combine phase A and phase B, turn on homogenizer (3000 rpm), homogenize for 12 minutes, and start cooling;

[0056] S4: When the temperature drops to 65-70℃, add phase C, stir to dissolve, and continue to cool down after dissolution is complete.

[0057] S5: When the temperature drops to 40-45℃, add phase D components, stir to dissolve and disperse evenly to obtain the essence cream product.

[0058] Experiment 1: Experiment to promote the expression of ZO-1 and TGM-5 proteins

[0059] Human keratinocytes (HaCat) were used as the model cell line in this study. Cells were seeded into 96-well plates and incubated overnight at 37°C in a 5% CO2 incubator. Each plate was divided into NC group, SLS group, and sample group. When the cell deposition rate in the 96-well plate reached 40%–60%, the drugs were administered to each group, with 3 replicates per group.

[0060] 1. Cell plate preparation: HaCat cells in the logarithmic growth phase were added to 96-well plates and cultured overnight at 37°C in a 5% CO2 incubator to allow the cells to adhere.

[0061] 2. SLS (Sodium Dodecyl Sulfate) Treatment: Samples were prepared using complete culture medium (Yuanpei Biotechnology) as shown in Table 3. Following Table 3, 100 μL of the test sample or complete culture medium was added to each well of a 96-well plate. Then, 100 μL of 60 μg / mL SLS solution (prepared with complete culture medium) was added to each well. For the NC group, only 200 μL of complete culture medium was added. The final concentration of the SLS group was 30 μg / mL SLS, and the final concentration of the sample group was 5 mg / mL test sample + 30 μg / mL SLS. The mixture was thoroughly mixed and incubated at 37℃ in a 5% CO2 incubator for 24 h. Each cell plate included an NC group, an SLS group, and a sample group, with at least three replicates per group.

[0062] 3. Immunofluorescence staining: Add 50 μL of TGM-5 and ZO-1 antibody solutions (Abcam; 1:200 dilution) to each well, incubate overnight at 4°C, then add 50 μL of fluorescent secondary antibody solution (Invitrigen; 1:1000 dilution), incubate at room temperature in the dark for 1 h, wash, add 100 μL of nuclear dye DAPI (Invitrigen; 1:1000 dilution) to each well, stain for 5 min, then add 100 μL of PBS, and photograph under a fluorescence microscope. Select 3 typical images from each group, analyze using ImageJ, and obtain RFU (relative fluorescence units).

[0063] Calculation formula: The rate of change of the sample group is calculated using RFU, with the SLS group set as 100%. The calculation formula is as follows:

[0064] Rate of change (%) = (RFU) 样品组 / RFU SLS组 -1)×100%

[0065] 4. Data Analysis: Quantitative data are expressed as mean ± standard deviation. A t-test was used to calculate significant differences, where *, **, and *** represent p < 0.05, p < 0.01, and p < 0.001, respectively.

[0066] Table 3 Test Plan

[0067]

[0068]

[0069] Table 4 Summary of ZO-1 Protein Content Detection Results

[0070] Sample Name RFU average SD P-value Upward adjustment rate (%, vs SLS group) NC Group 20.009 1.881 / / SLS Group 2.411 0.293 / / Example 1 3.889 0.257 0.0028** 61.3 Example 2 4.979 0.713 0.0045** 106.5 Example 3 5.841 0.771 0.0020** 142.3 Example 4 6.359 0.727 0.001** 163.7 Comparative Example 1 2.660 0.036 0.2178 10.3 Comparative Example 2 2.303 0.064 0.5666 -4.5 Comparative Example 3 3.851 0.274 0.0034** 59.7 Comparative Example 4 2.908 0.195 0.0708* 20.6 Comparative Example 5 3.271 0.418 0.0433* 35.7 Comparative Example 6 3.849 0.336 0.005** 59.6 Comparative Example 7 2.937 0.158 0.0521* 21.8

[0071] (Note: *, **, and *** represent p<0.05, p<0.01, and p<0.001, respectively.)

[0072] Table 4 shows that silanized hyaluronic acid ester alone (Comparative Example 1) had a very weak promoting effect on ZO-1 protein expression, while sodium hyaluronate alone (Comparative Example 2) had no promoting effect on ZO-1 protein expression. The capernaum fruit compound obtained by method 2 (Comparative Example 4) had a weak promoting effect on ZO-1 protein expression, which was not as strong as that obtained by method 1 (Comparative Example 3). The promoting effects on ZO-1 protein expression in Examples 1-4 were 61.3%, 106.5%, 142.3%, and 163.7%, respectively, indicating that the combination of silanized hyaluronic acid ester and capernaum fruit compound obtained by method 1 had a significant synergistic effect.

[0073] Table 5 Summary of TGM-5 Protein Content Detection Results

[0074] Sample Name RFU average SD P-value Upward adjustment rate (%, vs SLS group) NC Group 32.140 2.623 / / SLS Group 7.704 0.660 / / Example 1 13.769 1.581 0.0036** 78.7 Example 2 19.779 2.179 0.0008*** 156.7 Example 3 21.312 2.453 0.0008*** 176.6 Example 4 22.180 2.937 0.0011** 187.9 Comparative Example 1 9.811 0.185 0.006** 27.3 Comparative Example 2 8.300 0.716 0.3489 7.7 Comparative Example 3 11.456 0.074 0.0006*** 48.7 Comparative Example 4 9.270 0.031 0.0148* 20.3 Comparative Example 5 10.292 0.094 0.0025** 33.6 Comparative Example 6 11.122 1.176 0.0118* 44.4 Comparative Example 7 9.352 0.021 0.0124* 21.4

[0075] (Note: *, **, and *** represent p<0.05, p<0.01, and p<0.001, respectively.)

[0076] Table 5 shows that the expression-promoting effects of silanized hyaluronic acid ester and sodium hyaluronate alone (i.e., Comparative Example 1 and Comparative Example 2) on TGM-5 protein expression were weak, especially Comparative Example 2. The capernaum fruit complex obtained by method 2 (i.e., Comparative Example 4) showed a weaker expression-promoting effect on TGM-5 protein than that obtained by method 1 (i.e., Comparative Example 3). The expression-promoting effects of Examples 1-4 on TGM-5 protein were 78.7%, 156.7%, 176.6%, and 187.9%, respectively, indicating that the combination of silanized hyaluronic acid ester and the capernaum fruit complex obtained by method 1 has a significant synergistic effect.

[0077] Experimental Example 2: Evaluation of Moisturizing and Repairing Efficacy in Human Body

[0078] The skin barrier repair essence cream of Example 5 was tested on human skin for moisturizing and repairing effects. A total of 33 valid participants (5 males and 28 females) aged 20 to 40 years old were selected and excluded based on their willingness to participate.

[0079] Directions for use: After cleansing your face in the morning and evening, apply an appropriate amount of the essence cream from Example 5 evenly to your face and gently massage until absorbed. Use twice daily, once in the morning and once in the evening, for 28 consecutive days.

[0080] Testing time: before using the sample (D0), 14 days after using the sample (D14), and 28 days after using the sample (D28).

[0081] Test method:

[0082] 1. The VISIA-CR facial image analyzer is used for red zone image analysis to obtain the quantitative index red zone analysis a* value.

[0083] 2. The Corneometer is used to detect the relative moisture content of the skin surface.

[0084] 3. The Aqua Flux skin moisture loss tester is used to detect the transepidermal water loss (TWEL) value of the skin and assess the skin barrier function.

[0085] Experimental parameters:

[0086] 1. Skin moisture content: The higher the skin moisture content value, the higher the skin moisture content.

[0087] 2. Transepidermal water loss (TWEL) value: The lower the TWEL value, the better the skin barrier. The calculation formula is as follows:

[0088]

[0089] 3. Facial red area a* value: The higher the a* value in the red area analysis, the more severe the skin redness.

[0090] Statistical analysis was performed using SPSS Statistics 25 with a two-tailed test and a significance level of α = 0.05.

[0091] Based on the results of the normality test, the difference analysis method is selected for the measurement data: if the measurement values ​​are normally distributed, the t-test method is used for statistical analysis; if they are not normally distributed, the rank-sum test method is used for statistical analysis.

[0092] The test results are shown in Tables 6-8.

[0093] Table 6. Red Zone Analysis a* Descriptive Statistics (n=33)

[0094]

[0095] Statistical analysis results: "-": no statistically significant difference (P≥0.05); "*": statistically significant difference (0.01≤P<0.05); "**": statistically significant difference (0.001≤P<0.01); "***": statistically significant difference (P<0.001).

[0096] Table 7. Descriptive statistics of skin moisture content (n=33)

[0097]

[0098]

[0099] Statistical analysis results: "-": no statistically significant difference (P≥0.05); "*": statistically significant difference (0.01≤P<0.05); "**": statistically significant difference (0.001≤P<0.01); "***": statistically significant difference (P<0.001).

[0100] Table 8. Descriptive statistics of transcutaneous water loss (TEWL) values ​​(n=33)

[0101]

[0102] Statistical analysis results: "-": no statistically significant difference (P≥0.05); "*": statistically significant difference (0.01≤P<0.05); "**": statistically significant difference (0.001≤P<0.01); "***": statistically significant difference (P<0.001).

[0103] As shown in Tables 6-8, during the 4-week testing period, Example 5 significantly improved the facial red area (see the diagrams showing the changes in facial red area before and after sample use for subjects 2 and 13). Figure 1-2 As shown in the figure, the transepidermal water loss (TEWL) of the skin is significantly reduced, and the skin moisture content is significantly increased. Therefore, the essence cream containing this skin barrier repair composition has a good effect on improving facial hydration and repairing redness.

[0104] The above embodiments are only for illustrating the technical concept and features of the present invention, and are intended to enable those skilled in the art to understand the content of the present invention and implement it accordingly. They should not be construed as limiting the scope of protection of the present invention. All equivalent changes or modifications made in accordance with the spirit and essence of the present invention should be covered within the scope of protection of the present invention.

Claims

1. A composition for repairing the skin barrier, characterized in that, The product comprises the following components in parts by weight: 0.01-0.1 parts of silanized hyaluronic acid ester with an average molecular weight of 700-800 kDa, and 0.5-10.0 parts of capercia fruit compound liquid; The specific preparation method of the prickly ash fruit compound liquid is as follows: S1: Add water to caper fruit powder and stir to extract 1-3 times at 60-90℃, then combine the filtrates; S2: Add a complex enzyme consisting of α-amylase, acidic protease and neutral protease to the filtrate, wherein the mass ratio of α-amylase, acidic protease and neutral protease is 1:0.8-1.2:0.8-1.

2. Stir and hydrolyze at 40-60℃ for 0.5-2 hours, then inactivate the enzyme to obtain crude extract. S3: Filter the crude extract to obtain a filtrate, add polyamide resin and activated carbon to the filtrate, stir and adsorb at room temperature for 1-1.5 hours, filter, and obtain the extract of capercia fruit. S4: Mix caper fruit extract and glycerin at a volume ratio of 4:1 and stir until homogeneous to obtain caper fruit compound solution. The caper fruit compound solution is 3.5-4.0 times the mass of caper fruit powder.

2. The skin barrier repair composition as described in claim 1, characterized in that, The product comprises the following components in parts by weight: 0.03-0.08 parts of silanized hyaluronic acid ester with an average molecular weight of 700-800 kDa, and 1.0-8.0 parts of capercia fruit compound liquid.

3. The skin barrier repair composition as described in claim 1 or 2, characterized in that, Dissolve the silanized hyaluronic acid ester and caperca syrup in water to make up to 100 parts.

4. The use of the skin barrier repair composition according to any one of claims 1-3 in the preparation of cosmetics that repair the skin barrier and improve dry and red skin problems.

5. A cosmetic product for repairing the skin barrier, characterized in that, The cosmetic product comprises at least the skin barrier repair composition as described in claim 3.

6. A cosmetic product for repairing the skin barrier as described in claim 5, characterized in that, The amount of the skin barrier repair composition according to claim 3 added is 0.1-10% based on the total mass of the cosmetic product.

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