An insecticidal composition containing pyrethroid compounds and its use

Abstract

The present application belongs to the technical field of pesticides, and relates to a kind of pyrethroid-containing insecticidal composition and application.The insecticidal composition includes active ingredient A and active ingredient B, the active ingredient A is a compound of formula (I), and the active ingredient B is a pyrethroid compound.The composition of the present application has a synergistic effect on the control effect of agricultural and forestry pests within a certain ratio range, has good speed effect on the target, is safe to crops, and can effectively reduce the amount of pesticide.

Description

TECHNICAL FIELD

[0001] The present application belongs to the technical field of pesticides, and particularly relates to a pyrethroid-containing insecticidal composition and application thereof. BACKGROUND

[0002] Pyrethroids are a class of highly efficient and broad-spectrum insecticides, which are widely used in agricultural pest control and public health. Pyrethroids are a class of insecticides with strong neurotoxicity, which mainly act on voltage-gated ion channels and can regulate the opening or closing of sodium ion channels, causing synaptic discharge, depolarization and damage to the nervous system, especially strong toxicity to the peripheral nervous system and central nervous system.

[0003] Pyrethroid pesticides gradually replace organochlorine and other highly toxic and long-residual insecticides due to their high efficiency, wide range of action, strong stability and relatively low toxicity, and are widely used in agricultural, forestry and residential pest control. Pyrethroid insecticides grow fastest among the four major categories of insecticides. While pyrethroids are widely used, they also have problems such as easy resistance, high fish toxicity and low systemicity. Currently, many pests and mites such as cotton bollworm, diamondback moth, whitefly and two-spotted spider mite have developed moderate or higher resistance to pyrethroid insecticides.

[0004] Therefore, there is a continuous demand for more efficient, lower-cost and more environmentally safe insecticidal compositions. SUMMARY

[0005] The present application aims to provide a pyrethroid-containing insecticidal composition, and the insecticidal activity of the insecticidal composition of the present application is significantly higher than the sum of the insecticidal activity of each active ingredient. There is an unpredictable and true synergistic effect, rather than just an additive effect.

[0006] To achieve the above-mentioned purpose, the technical solution adopted by the present application is as follows: a pyrethroid-containing insecticidal composition, comprising active ingredient A and active ingredient B, wherein the active ingredient A is a compound of formula (I) The active ingredient B is a pyrethroid compound.

[0007] Furthermore, the pyrethroid compounds include acrinathrin, allethrin (d-cis-trans, d-trans), beta-cyfluthrin, bifenthrin, bioallethrin, bioallethrin S-cyclopentylisomer, bioethanomethrin, and biopermethrin. (biopermethrin), bioresmethrin, chlovaporthrin, cis-cypermethrin, cis-resmethrin, cis-permethrin, clocythrin, cycloprothrin, cyfluthrin, (RS) cyhalothrin, theta-cypermethrin methrin, cyphenothrin, deltamethrin, empenthrin (1-R isomer), esfenvalerate, etofenprox, fenfluthrin, fenpropathrin, fenpyrithrin, fenvalerate, flubrocythrinate, flufenacet Flucythrinate, flufenprox, flumethrin, fluvalinate, fubfenprox, gamma-cyhalothrin, imiprothrin, kadethrin, lambda-cyhalothrin, metofluthrin, permethrin (cis-, trans-permethrin)trans-), phenothrin (1R trans isomer) , prallethrin, profluthrin, protrifenbute, pyresmethrin, resmethrin, silafluofen, tau-fluvalinate, tefluthrin, terallethrin, tetramethrin (1R isomer) , tralomethrin, transfluthrin, pyrethrins;

[0008] Furthermore, the pyrethroid compounds include flufenacetate, lambda-cyhalothrin, bifenthrin, lambda-cyhalothrin, lambda-cyhalothrin, deltamethrin, cypermethrin, deltamethrin, fenvalerate, cypermethrin, lambda-cyhalothrin, deltamethrin, lambda-cyhalothrin, pyrethroid, pyrethroid, tetrabromopyrethrin, tetrafluoroethylene, and pyrethroid.

[0009] Typically, the insecticidal compositions of the present invention contain compound (I) and active ingredient B in preferred, particularly preferred and especially preferred mixing ratios as listed in the table below.

[0010] B component Preferred mixing ratios Particularly preferred mixtures Very particularly preferred mixing ratios Flumethrin 1:100～100:1 1:40～30:1 1:40～25:1 Lambda-cyhalothrin 1:40～60:1 1:25～60:1 1:12～15:1 Bifenthrin 1:30～80:1 1:30～45:1 1:14～45:1 Cyfluthrin 1:50～50:1 1:30～25:1 1:10～20:1 Transfluthrin 1:45～45:1 1:35～35:1 1:15～15:1 Fenpropathrin 1:50～50:1 1:40～20:1 1:30～18:1 Deltamethrin 1:50～24:1 1:30～24:1 1:18～12:1 Fenpropathrin 1:50～50:1 1:25～25:1 1:15～25:1 Flumethrin 1:50～40:1 1:25～35:1 1:10～20:1 Fluvalinate 1:50～50:1 1:30～25:1 1:20～20:1 Flucythrinate 1:100～100:1 1:40～30:1 1:20～15:1 Acrinathrin 1:100～100:1 1:40～35:1 1:10～20:1 Flumethrin 1:50～30:1 1:25～25:1 1:25～25:1 Acrinathrin 1:50～50:1 1:25～30:1 1:15～15:1 Kappa-cypermethrin 1:50～50:1 1:25～25:1 1:15～20:1 Fenpropathrin 1:100～100:1 1:55～50:1 1:15～20:1 Chlorpyrifos-methyl 1:55～50:1 1:25～25:1 1:15～20:1 Tetramethrin 1:100～100:1 1:45～35:1 1:20～25:1 Tetramethrin Pyrethrin 1:50～45:1 1:45～25:1 1:25～20:1

[0011] Furthermore, the pyrethroid compounds include lambda-cyhalothrin, bifenthrin, trans-cypermethrin, deltamethrin, and lambda-cyhalothrin.

[0012] Furthermore, the mass ratio between active ingredient A and active ingredient B is 1:50 to 80:1;

[0013] Furthermore, the mass ratio between active ingredient A and active ingredient B is 1:35 to 60:1;

[0014] Furthermore, the mass ratio of the compound of formula (I) to the high-efficiency cypermethrin is 1:40 to 60:1.

[0015] Furthermore, the mass ratio of the compound of formula (I) to the high-efficiency cypermethrin is 1:25 to 60:1, such as 1:25, 1:12, 1:2, 5:1, 15:1, 40:1, 60:1 or any value between the above values;

[0016] Further, the mass ratio of the compound of formula (I) to the bifenthrin is 1:30-80:1,

[0017] Still further, the mass ratio of the compound of formula (I) to the bifenthrin is 1:30-45:1, such as 1:30, 1:14, 1:6, 10:1, 20:1, 45:1 or any value between the above values;

[0018] Further, the mass ratio of the compound of formula (I) to the lambda-cyhalothrin is 1:35-35:1, such as 1:35, 1:28, 1:24, 1:15, 1:12, 1:6, 1:3, 2:5, 3:1, 5:1, 8:1, 15:1, 17:1, 25:1, 5:1 or any value between the above values;

[0019] Further, the mass ratio of the compound of formula (I) to the lambda-cyhalothrin is 1:25-60:1, 1:25, 1:15, 1:5, 1:1, 4:1, 15:1, 30:1, 60:1 or any value between the above values;

[0020] Further, the mass ratio of the compound of formula (I) to the lambda-cyhalothrin is 1:35-35:1, such as 1:35, 1:28, 1:24, 1:15, 1:12, 1:6, 1:3, 2:5, 3:1, 5:1, 8:1, 15:1, 17:1, 25:1, 5:1 or any value between the above values;

[0021] Still further, the mass ratio of the compound of formula (I) to the lambda-cyhalothrin is 1:30-24:1, such as 1:30, 1:18, 1:9, 1:3, 12:1, 24:1 or any value between the above values;

[0022] Further, the sum of the content of the active ingredient A and the active ingredient B in the insecticidal composition is 0.5%-90% based on the total mass of the insecticidal composition being 100wt%;

[0023] Further, the sum of the content of the active ingredient A and the active ingredient B in the insecticidal composition is 5%-70% based on the total mass of the insecticidal composition being 100wt%;

[0024] Further, the sum of the content of the active ingredient A and the active ingredient B in the insecticidal composition is 10%-60% based on the total mass of the insecticidal composition being 100wt%;

[0025] Further, the sum of the content of the active ingredient A and the active ingredient B in the insecticidal composition is 5%, 8%, 10%, 14%, 20%, 30%;

[0026] Further, the insecticidal composition further comprises an auxiliary agent, and the auxiliary agent comprises a carrier and an adjuvant;

[0027] Further, the carrier is one or more of water, solvent or filler;

[0028] Further, the carrier is deionized water;

[0029] Further, the solvent is selected from a mixture of one or more of N, N-dimethylformamide, cyclohexanone, toluene, xylene, dimethyl sulfoxide, methanol, ethanol, trimethylcyclohexanone, N-octyl pyrrolidone, ethanolamine, triethanolamine, isopropylamine, N-methyl pyrrolidone, propanol, butanol, ethylene glycol, diethylene glycol, ethylene glycol methyl ether, butyl ether, ethanolamine, isopropylamine, ethyl acetate or acetonitrile;

[0030] Further, the filler is selected from a mixture of one or more of kaolin, diatomite, bentonite, attapulgite, white carbon black, starch or light calcium carbonate;

[0031] The adjuvant at least includes one surfactant, and according to different use occasions and requirements, other functional adjuvants such as antifreeze, thickening agent, stabilizer, disintegrant, defoaming agent, sustained-release agent, binder and the like can also be added;

[0032] The surfactant is selected from one or more of emulsifier, dispersant, wetting agent, dispersion medium or penetrant;

[0033] The surfactant is a single agent or a compounded preparation of common non-ionic surfactant or anionic surfactant; and the other functional adjuvant is selected from one or more of antifreeze, thickening agent, stabilizer, disintegrant or defoaming agent;

[0034] Further, the emulsifier is selected from a mixture of one or more of agricultural emulsifier 500# (calcium alkyl benzene sulfonate), OP series phosphate ester (surfactant phosphate ester), 600# phosphate ester (phenyl phenol polyoxyethylene ether phosphate ester), styrene polyoxyethylene ether wetting agent salt, alkyl biphenyl ether disulfate magnesium salt, triethanolamine salt, agricultural emulsifier 400# (benzyl dimethyl phenol polyoxyethyl ether), agricultural emulsifier 700# (alkyl phenol formaldehyde resin polyoxyethyl ether), ning emulsion 36# (benzyl phenol formaldehyde resin polyoxyethyl ether), agricultural emulsifier 1600# (benzyl phenol polyoxyethyl polypropylene ether), ethylene oxide-propylene oxide block copolymer, OP series (surfactant), BY series (castor oil polyoxyethylene ether), agricultural emulsifier 33# (alkyl aryl polyoxyethylene polyoxypropylene ether), Span series (sorbitan monostearate), Tween series (sorbitan fatty acid ester polyoxyethylene ether) or AEO series (fatty alcohol polyoxyethylene ether);

[0035] Further, the dispersing agent is selected from a mixture of one or more of polycarboxylate, lignin sulfonate, alkylphenol polyoxyethylene formaldehyde condensate sulfate, calcium alkylbenzenesulfonate, naphthalene sulfonate formaldehyde condensate sodium salt, alkylphenol polyoxyethylene, fatty amine polyoxyethylene, fatty acid polyoxyethylene, or glycerol fatty acid ester polyoxyethylene;

[0036] Further, the wetting agent is selected from a mixture of one or more of sodium dodecyl sulfate, sodium dodecyl benzene sulfonate, Laikan Powder BX, wetting penetrant F, soap powder, silkworm excrement, or soapberry powder;

[0037] Further, the penetrating agent is selected from a mixture of one or more of penetrating agent JFC (fatty alcohol polyoxyethylene ether), penetrating agent T (diisooctyl sulfonate), azone, or organosilicon;

[0038] Further, the dispersing medium is one or more of soybean oil, rapeseed oil, wheat oil, methyl oleate, diesel oil, machine oil, mineral oil, etc.

[0039] Further, the antifreezing agent is selected from a mixture of one or more of ethylene glycol, propylene glycol, glycerol, or urea;

[0040] Further, the thickening agent is selected from a mixture of one or more of xanthan gum, disintegrating agent, bentonite, carboxymethyl cellulose, or magnesium aluminum silicate;

[0041] Further, the stabilizing agent is selected from a mixture of one or more of epoxidized soybean oil, epichlorohydrin, BHT, ethyl acetate, triphenyl phosphate;

[0042] Further, the disintegrating agent is selected from a mixture of one or more of bentonite, urea, aluminum chloride, low-substituted hydroxypropyl cellulose, lactose, citric acid, succinic acid, or sodium bicarbonate;

[0043] Further, the antifoaming agent is selected from a mixture of one or more of silicone oil, silicone compound, C 10 ~C 20 saturated fatty acid compound, or C8~C 10 fatty alcohol compound.

[0044] Further, the pesticidal composition can be formulated into a formulation dosage form acceptable in the pesticide industry, including solid formulations, liquid formulations, seed treatment agents, or other formulations;

[0045] Further, the formulation dosage form is emulsifiable concentrate, suspension concentrate, water dispersible granule, water emulsion, microemulsion, granule, microcapsule suspension concentrate, ultra-low volume liquid, wettable powder, or dispersible oil suspension concentrate;

[0046] Use of a pyrethroid-containing insecticidal composition for controlling agricultural, forestry, horticultural or sanitary pests;

[0047] Further, the agricultural, forestry, horticultural or sanitary pests are pests of the order Hemiptera, Thysanoptera, Lepidoptera, Diptera;

[0048] Further, the Hemiptera pests are Acrosternum hilare, Blissus leucopterus, Cyrtopeltis notatus, Dysdercus cingulatus, Dysdercus intermedius, Eurygaster integriceps, Euschistus impictiventris, Leptoglossus phyllopus, Lygus lineolaris, Lygus pratensis, Nezara viridula, Piesma quadrata, Solubea insularis, Thyanta perditor, Acyrthosiphon onobrychis, Adelges laricis, Aphidula nasturtii, Aphis fabae, Aphis forbesi, Aphis pomi, Aphis gossypii, Aphis grossulariae, Aphis schneideri, Aphis spiraecola, Aphis sambuci, Acyrthosiphon pisum, Aulacorthum solani, Bemisia argentifoliil, Brachycaudus cardui, Brachycaudus helichrysi, Brachycaudus persicae, Brachycaudus prunicola, Brevicoryne brassicae, Capitophorus horni, Cerosipha gossypii, Chaetosiphon fragaefolii, Cryptomyzus ribis, Dreyfusia nordmannianae, Dreyfusia piceae, Dysaphis banksiae, Dysaphis radicola, Dysaphis plantaginea, Dysaphis pyri, Empoasca fabae, Hyalopterus pruni, Macrosiphum aubum, Macrosiphum euphorbiae, Megoura viciae, Melanaphis pyrarius, Myzus persicae, Myzus cerasii, Myzus varians, Myzus ascalonicus, Nasonovia ribis, Nilaparvata lugens, Pemphigus bursarius, Perkinsiella saccharicida, Phorodon humuli, Psylla piri, Psylla rosae, Rhopalosiphum maidis, Rhopalosiphum padi, Sogatella furcifera, Schizaphis graminum, Sitobion avenae, Trialeurodes vaporariorum, Toxoptera citricola, and Viteus vitif.Dysaphis radicola, Dysaulacorthum pseudosolani, Dysaphis plantaginea, Dysaphis pyri, Empoasca fabae, Hyalopterus pruni, Hyperomyzus lactucae, Macrosiphum avenae, Macrosiphum euphorbiae, Macrosiphon rosae, Megoura viciae, Melanaphis pyrarius, Metopolophium dirhodum, Myzodes persicae, Myzus ascalonicus, Myzus cerasi, Myzus varians, Nasonovia ribis-nigri, Nilaparvata lugens, Pemphigus bursarius, Perkinsiella saccharicida, Phorodon humuli, Psylla mali, Psylla pyri, Rhopalomyzus ascalonicus, Rhopalosiphum maidis, Rhopalosiphum padi, Rhopalosiphum insertum, Sappaphis mala, Sappaphis mali, Schizaphis graminum, Schizoneura lanuginosa, Sitobion avenae, Trialeurodes vaporariorum, Toxoptera aurantii and, Viteus vitifolii, Cimex lectularius, Cimex hemipterus, Reduvius senilis, Triatoma spp. and Arilus critatus;

[0049] Further, the Thysanoptera pest is Dichromothrips corbetti, Dichromothrips spp., Frankliniella fusca, Frankliniella occidentalis, Frankliniella tritici, Scirtothrips citri, Thrips oryzae, Thrips palmi, and Thrips tabaci;

[0050] Further, the Lepidopteran pest is Agrotis ypsilon, Agrotis segetum, Alabama argillacea, Anticarsia gemmatalis, Argyresthia conjugella, Autographa gamma, Bupalus piniarius, Cacoecia murinana, Capua reticulana, Cheimatobia brumata, Choristoneura fumiferana, Choristoneura occidentalis, Cirphis unipuncta, Cydia pomonella, Dendrolimus pini, Diaphania nitidalis, Diatraea grandiosella, Earias insulana, Elasmopalpus lignosellus, Eupoecilia ambiguella, Evetria bouliana, Feltia subterranea, Galleria mellonella, Grapholitha funebrana, Grapholitha molesta, Heliothis armigera, Heliothis virescens, Heliothis zea, Hellula undalis, Hibernia defoliaria, Hyphantria cunea, Hyponomeuta malinellus, Keiferia lycopersicella, Lambdina fiscellaria, Laphygma exigua, Leucoptera coffeella, Leucoptera scitella, Lithocolletis blancardella, Lobesia botrana, Loxostege sticticalis, Lymantria dispar, Lyonetia prunifoliella, Lyonetia clerkella, Melanchra persicariae, Mamestra brassicae, Orgyia pseudotsugata, Oria melanopa, Ostrinia nubilalis, Panolis flammea, Pectinophora gossypiella, PeridromaAgrotis segetum, Alabama argillacea, Amorbus c-nigrum, Anticarsia gemmatalis, Autographa gamma, Biston betularia, Cacoecia murinana, Capua reticulana, Cheima- tobia brumata, Chilo indicus, Choristoneura fumiferana, Cirphis unipuncta, Cydalima perspectalis, Dendrolimus pini, Earias insulana, Earias vitella, Euxoa auxiliaris, Euxoa messoria, Feltia jacarba, Heliothis virescens, Heliothis subncta, Hibernia deflorata, Hyphantria cunea, Keiferia lycopersicella, Lambdina fiscellaria, Leucoptera coffeella, Lithocolletis gossypii, Loxostege sticticalis, Lymantria dispar, Lymantria monacha, Lyonetia clerkella, Malacosoma neustria, Mamestra brassicae, Orgyia pseudotsugata, Ostrinia nubilalis, Panolis flammea, Pectinophora gossypiella, Peridroma saucia, Phalera bucephala, Phthorimaea operculella, Phyllocnistis citrella, Pieris brassicae, Plathypena scabra, Plutella xylostella, Pseudoplusia includens, Rhyacionia frustrana, Scrobipalpula absoluta, Sitotroga cerealella, Sparganothis pilleriana, Spodoptera frugiperda, Spodoptera littoralis, Spodoptera litura, Thaumatopoea pityocampa, Tortrix viridana, Trichoplusia ni and Zeiraphera canadensis;

[0051] Further, the Diptera is Aedes aegypti, Aedes albopictus, Aedes vexans, Anastrepha ludens, Anopheles maculipennis, Anopheles crucians, Anopheles albimanus, Anopheles gambiae, Anopheles freeborni, Anopheles leucosphyrus, Anopheles miimus, Bradysia odoriphaga Yang et Zhang, Anopheles quadrimaculatus, Calliphora vicina, Ceratitis capitata, Chrysomya bezziana, Chrysomya hominivorax, Chrysomya macellaria, Chrysops discalis, Chrysops silacea, Chrysops atlanticus, Cochliomyia hominivorax, Contarinia sorghicola, Cordylobia anthropophaga, Culicoides furens, Culex pipiens, Culex nigripalpus, Culex quinquefasciatus, Culex tarsalis, Culiseta inornata, Culiseta melanura, Dacus cucurbitae, Dacus oleae, Dasineura brassicae, Delia antique, Delia coarctata, Delia platura, Delia radicum, Dermatobia hominis, Fannia canicularis, Geomyza Tripunctata, Gasterophilus intestinalis, Gasterophilus haemorrhoidalis, Gasterophilus nasalis, Glossina morsitans, Haematobia irritans, Hippelates spp., Hyppobosca equina, Liriomyza brassicae, Liriomyza trifolii, Lucilia caprina, Lucilia cuprina, Lucilia exigua, Lucilia grisegrista, Lucilia megcarpa, Lucilia porphyrina, Lucilia richardii, Musca autumnalis, Musca domestica, Musca vetustissima, Oestrus ovis, Opomyza florum, Pegomyxex varyngarae, Phorbia antiqua, Phorbia brassicae, Phorbia coarctata, Phorbia plumosella, Phorbia regina, Phorbia santipauana, Phorbia spinifasciata, Phorbia survejana, Phorbia terrae, Phorbia variegata, Phlebotomus argentipes, Psorophora columbiae, Psorophora discolor, Rhagoletis cerasi, Rhagoletis cingulata, Rhagoletis pomonella, Rhodnius prolixus, Sarcophaga haemorrhoidalis, Sarcophaga peregrina, Stomoxys calcitrans, Tabanus atratus, Tabanus lineola, Tabanus quinquevittatus, Tipula oleracea, and / or Tipula irrmula.Haematobia irritans, Haplodiplosis equestris, Hippelates spp., Hylemyia platura, Hypoderma lineata, Leptoconops torrens, Liriomyza sativae, Liriomyza trifolii, Lucilia caprina, Lucilia cuprina, Lucilia sericata, Lycoria pectoralis, Mansonia titillanus, Mayetiola destructor, Musca autumnalis, Musca domestica, Muscina stabulans, Oestrus ovis, Opomyza florum, Oscinella frit, Pegomya hysocyami, Phorbia antiqua, Phorbia brassicae, Phorbia coarctata, Phlebotomus argentipes, Psorophora columbiae, Psila rosae, Psorophora discolor, Prosimulium mixtum, Rhagoletis cerasi, Rhagoletis pomonella, Sarcophaga haemorrhoidalis, Sarcophaga spp., Simulium vittatum, Stomoxys calcitrans, Tabanus bovinus, Tabanus atratus, Tabanus lineola, Tabanus similis, Tipula oleracea, and Tipula paludosa;

[0052] Further, the insecticidal composition is applied to the pests or the medium where the pests grow in an effective amount.

[0053] The insecticidal composition of the present application has the following advantages:

[0054] The insecticidal composition of the present application shows synergistic effect within a certain ratio range, is highly effective to the pests in agriculture and forestry, obviously reduces the amount of pesticide used, lowers the cost of pesticide use, and reduces the influence on the environment; the two active ingredients have different action mechanisms, and can delay the generation of pest resistance. DETAILED DESCRIPTION

[0055] The present application is further illustrated by the following examples, in which the percentages are all by weight, but the present application is not limited thereto.

[0056] The composition of the present application can be provided in the form of a preparation. The emulsifiable concentrate, suspension concentrate and the like can be prepared as needed. The content of the active ingredient in the composition of the present application depends on the application amount when used alone, and also depends on the mixing ratio and the degree of synergistic effect. The optimal range of the content of the active ingredient is different according to the type of the composition of the preparation.

[0057] Preparation example of the preparation:

[0058] Example 1: 8% compound of formula (I)· lambda-cyhalothrin emulsifiable concentrate (3:5)

[0059] Formulation composition: 3% compound of formula (I), 5% lambda-cyhalothrin, 8% isomeric alcohol polyoxyethylene ether, 1% sodium lignosulfonate, 10% fatty alcohol polyoxyethylene ether, 4% soybean oil, 18% cyclohexanone, and the balance of methyl oleate;

[0060] Preparation method: the active ingredients are first added to the solvent to completely dissolve, then the emulsifiers and the like are added, stirred uniformly, and a uniform transparent oily liquid is obtained, which is filled into a container to prepare the emulsifiable concentrate of the composition of the present application.

[0061] Example 2: 10% compound of formula (I)· bifenthrin emulsifiable concentrate (9:1)

[0062] Formulation composition: 9% compound of formula (I), 1% bifenthrin, 10% DMF, 10% dimethyl sulfoxide, 20% decanamide, 2% calcium dodecylbenzenesulfonate, 14% fatty alcohol polyoxyethylene ether, 4% soybean oil, 10% cyclohexanone, and the balance of methyl oleate;

[0063] Preparation method: the same as example 1.

[0064] Example 3: 14% compound of formula (I)· high-efficiency trans-chlorpyrifos emulsifiable concentrate (2:12)

[0065] Formula: 2% of the compound of formula (I), 12% of high-efficiency trans-chlorpyrifos, 8.5% of propylene carbonate, 15% of fatty alcohol polyoxyethylene ether, 5% of soybean oil, 2% of calcium dodecylbenzenesulfonate, 20% of cyclohexanone, and the rest of trimethylbenzene;

[0066] Preparation method: same as Example 1.

[0067] Example 4: 10% of the compound of formula (I)·bromocyclen emulsifiable concentrate (2:8)

[0068] Formula: 2% of the compound of formula (I), 8% of bromocyclen, 8% of DMF, 2% of propylene carbonate, 12% of triphenyl ethenyl phenol polyoxyethylene ether, 5% of soybean oil, 15% of cyclohexanone, 1% of calcium dodecylbenzenesulfonate, and the rest of methyl oleate;

[0069] Preparation method: same as Example 1.

[0070] Example 5: 5% of the compound of formula (I)·high-efficiency lambda-cyhalothrin emulsifiable concentrate (2.5:2.5)

[0071] Formula: 2.5% of the compound of formula (I), 2.5% of high-efficiency lambda-cyhalothrin, 6% of isomeric alcohol polyoxyethylene ether, 1% of calcium dodecylbenzenesulfonate, 10% of fatty alcohol polyoxyethylene ether, 5% of peanut oil, 12% of cyclohexanone, 15% of DMF, and the rest of methyl oleate;

[0072] Preparation method: same as Example 1.

[0073] Example 6: 30% of the compound of formula (I)·high-efficiency lambda-cyhalothrin suspension concentrate (10:20)

[0074] Formula: 10% of the compound of formula (I), 20% of high-efficiency lambda-cyhalothrin, 1% of fatty alcohol polyoxyethylene ether, 3% of benzyl phenol polyether phosphate ester salt, 1% of polycarboxylic acid sodium salt, 2.5% of alkyl aryl polyoxyethylene polyoxypropylene ether, 1% of magnesium aluminum silicate, 0.2% of xanthan gum, 0.1% of methyl isothiazolinone, 5% of glycerol, 0.4% of silicone antifoaming agent, and the rest of deionized water;

[0075] Preparation method: according to the formula proportion, the effective components, surfactants and other functional additives are sequentially placed in a reaction kettle, mixed uniformly with water, subjected to high-speed shearing, wet sand milling, and finally filtered to obtain the suspension concentrate product.

[0076] Example 7: 20% of the compound of formula (I)·high-efficiency trans-chlorpyrifos suspension concentrate (5:15)

[0077] Formula: 5% of the compound of formula (I), 15% of high-efficiency trans-chlorpyrifos, 2% of EO-PO block copolymer, 3% of phenylethyl phenol polyether phosphate salt, 1% of sodium polycarboxylate, 3% of castor oil polyoxyethylene ether, 1% of magnesium aluminum silicate, 0.2% of xanthan gum, 0.1% of methylisothiazolinone, 5% of ethylene glycol, 0.4% of silicone antifoaming agent, and deionized water to make up the balance.

[0078] Preparation method: same as example 6.

[0079] The following biological test examples are used to illustrate the present application. However, the present application is not limited to these examples, and the required agents and solvents for the tests are provided by the Group Research and Development Center.

[0080] Indoor biological activity determination

[0081] Determination of joint toxicity of different proportions on aphids

[0082] Test target: cotton aphid (Aphis gossypii Glover)

[0083] Select wingless adult insects that are reared indoors and have consistent physiological states. The temperature is (25±1)℃, the relative humidity is 65%±5%, and the light cycle is 16 / 8h (L / D);

[0084] Select robust cucumber seedlings with roots (4-leaf-one-heart stage), carefully wash and dry the roots, and insert the plant roots into a beaker containing the drug solution, provide light and normal conditions to ensure normal growth of the plant roots.

[0085] Agent preparation: prepare single-agent stock solutions respectively, and design the proportions according to the mixing purposes and the activities of the agents. Each single agent and each group of mixed agents is configured in 5 series of mass concentrations according to the method of equal proportion, and the amount of drug solution for each mass concentration is not less than 50mL.

[0086] Agent treatment: take the plants treated for 24h out of the drug solution, pick the second leaves on the upper part that are uniform in size, and place them in a culture dish for moisturizing; place the culture dish on the bottom tray of the Potter spray tower for spraying, the amount of sprayed liquid is 1ml, and the culture dish is taken out after the drug solution is settled for 1min and is transferred to the culture dish containing the leaves for feeding.

[0087] Each treatment is repeated 4 times, and 15 insects are tested in each repeat. A treatment without agents is set as a blank control.

[0088] Data statistics and analysis:

[0089] Check the death of the test insects 48h after the treatment, and record the total number of insects and the number of dead insects respectively. According to the investigation data, calculate the corrected mortality rate of each treatment. The calculation is according to the following formula:

[0090]

[0091] Wherein:

[0092] P - mortality, in percentage (%);

[0093] K - represents the number of dead insects, in head;

[0094] N - represents the total number of insects, in head.

[0095]

[0096] Wherein:

[0097] P1 - corrected mortality, in percentage (%);

[0098] P t - treatment mortality, in percentage (%);

[0099] P0 - blank control mortality, in percentage (%).

[0100] If the control mortality is < 5%, no correction is needed; if the control mortality is between 5% and 20%, the correction should be made according to the formula; if the control mortality is > 20%, the test should be redone.

[0101] The data are processed by the method of odds value analysis. The DPS statistical analysis system can be used to analyze, to obtain the LC 50 value of the toxicity regression line and its 95% confidence limit, b value and correlation coefficient r, to evaluate the activity of the test agent on the biological test material.

[0102] The co-toxicity coefficient (CTC value) of the mixture is calculated according to the following formula:

[0103]

[0104] Wherein:

[0105] ATI - measured toxicity index of the mixture;

[0106] S - LC 50 of the standard insecticide, in milligrams per liter (mg / L);

[0107] M - LC 50 of the mixture, in milligrams per liter (mg / L).

[0108] TTI = TI A *P A + TI B *P B

[0109] Wherein:

[0110] TTI - theoretical toxicity index of the mixture;

[0111] TI A Toxicity index of A agent;

[0112] P A Percentage of A agent in the mixture, in percentage (%);

[0113] TI B Toxicity index of B agent;

[0114] P B Percentage of B agent in the mixture, in percentage (%).

[0115]

[0116] In the formula:

[0117] CTC - Co-toxicity coefficient;

[0118] ATI - Actual toxicity index of the mixture;

[0119] TTI - Theoretical toxicity index of the mixture.

[0120] The co-toxicity coefficient of the compound mixture: CTC≥120 shows synergistic effect; CTC≤80 shows antagonistic effect; 80<CTC<120 shows additive effect.

[0121] The results show that the LC 50 of the compound of formula (I) against aphids is 79.204 mg·L -1 , the LC 50 of lambda-cyhalothrin against aphids is 0.928 mg·L -1 , the LC 50 of bifenthrin against aphids is 0.713 mg·L -1 , the LC 50 of high-efficiency trans-chlorpyrifos against aphids is 5.433 mg·L -1 , the LC 50 of high-efficiency cyhalothrin against aphids is 1.376 mg·L -1 .

[0122] The results in Table 1 show that the compound of formula (I) and high-efficiency lambda-cyhalothrin mixed in the range of 1:40-60:1 show additive or synergistic effect in controlling aphids; among them, the compound of formula (I) and high-efficiency lambda-cyhalothrin mixed in the range of 1:25-60:1 show synergistic effect in controlling aphids, and in the range of 1:12-15:1, the co-toxicity coefficient is greater than 200, showing obvious synergistic effect.

[0123] Table 1 Toxicity determination results of different ratios of the compound of formula (I) and high-efficiency lambda-cyhalothrin against aphids

[0124]

[0125] The results in Table 2 show that the combination of the compound of formula (I) and bifenthrin in the range of 1:30-80:1 for controlling aphids shows additive or synergistic effect. The combination of the compound of formula (I) and bifenthrin in the range of 1:30-45:1 for controlling aphids shows synergistic effect, and the combination in the range of 1:14-45:1 shows obvious synergistic effect.

[0126] Table 2 Toxicity test results of different ratios of the compound of formula (I) and bifenthrin for aphids

[0127]

[0128] The results in Table 3 show that the combination of the compound of formula (I) and high-efficiency trans-chlorpyrifos in the range of 1:28-35:1 for controlling aphids shows synergistic effect, and the combination in the range of 1:15-8:1 shows obvious synergistic effect.

[0129] Table 3 Toxicity test results of different ratios of the compound of formula (I) and high-efficiency trans-chlorpyrifos for aphids

[0130]

[0131]

[0132] The results in Table 4 show that the combination of the compound of formula (I) and high-efficiency lambda-cyhalothrin in the range of 1:25-30:1 for controlling cotton bollworms shows synergistic effect. The combination of the compound of formula (I) and high-efficiency lambda-cyhalothrin in the range of 1:15-15:1 for controlling cotton bollworms shows obvious synergistic effect with the co-toxicity coefficient greater than 180.

[0133] Table 4 Toxicity test results of different ratios of the compound of formula (I) and high-efficiency lambda-cyhalothrin for aphids

[0134]

[0135] Toxicity test of different ratios for cotton bollworms

[0136] Test target: cotton bollworm, the cotton bollworm larvae were collected from cotton fields in Tai'an, Shandong, and were artificially bred in a rearing room for more than 3 generations. Healthy, uniform 3rd instar larvae were taken for the test.

[0137] Test reference: Guidelines on Laboratory Bioassay of Pesticides, Part 6: Test for Insecticidal Activity, Immersion Method, NY / T 1154.6-2006;

[0138] Formulation of pesticides: Single agent mother liquor was prepared respectively, and the ratio was designed according to the purpose of mixing, the activity of the pesticide. Each single agent and each group of mixed agent was configured with 5 series of mass concentration according to the method of equal ratio.

[0139] Pesticide treatment: The test insects were gently picked up with tweezers and immersed in pesticide solution for 5s, then taken out and placed on absorbent paper to crawl freely. After slight drying, they were moved into culture dishes with artificial feed and bred at a temperature of 29±1℃, with a light cycle of 14 / 10h(L / D).

[0140] Each treatment was repeated 4 times, and 15 test insects were used for each repetition. A treatment without pesticide was set as a blank control.

[0141] Data statistics and analysis:

[0142] The mortality of test insects was checked 48h after treatment, and the total number of insects and the number of dead insects were recorded respectively. According to the investigation data, the corrected mortality of each treatment was calculated. The calculation formula was as follows:

[0143]

[0144] In the formula:

[0145] P——mortality, unit: percentage(%);

[0146] K——represents the number of dead insects, unit: head;

[0147] N——represents the total number of insects, unit: head.

[0148]

[0149] In the formula:

[0150] P1——corrected mortality, unit: percentage(%);

[0151] P t ——treatment mortality, unit: percentage(%);

[0152] P0——blank control mortality, unit: percentage(%).

[0153] If the control mortality is <5%, no correction is needed; if the control mortality is between 5% and 20%, correction should be made according to the formula; if the control mortality is >20%, the test needs to be redone.

[0154] The data was processed by the method of probability value analysis. DPS statistical analysis system can be used to analyze and obtain the LC 50 value of toxicity regression line, its 95% confidence limit, b value and correlation coefficient r, to evaluate the activity of the test pesticide on biological test materials.

[0155] The co-toxicity coefficient (CTC value) of the mixture is calculated according to the following formula:

[0156]

[0157] In the formula:

[0158] ATI - the measured toxicity index of the mixture;

[0159] S - LC of the standard insecticide 50 , in milligrams per liter (mg / L);

[0160] M - LC of the mixture 50 , in milligrams per liter (mg / L).

[0161] TTI = TI A * P A + TI B * P B

[0162] In the formula:

[0163] TTI - the theoretical toxicity index of the mixture;

[0164] TI A - the toxicity index of the A agent;

[0165] P A - the percentage content of the A agent in the mixture, in percentage (%);

[0166] TI B - the toxicity index of the B agent;

[0167] P B - the percentage content of the B agent in the mixture, in percentage (%).

[0168]

[0169] In the formula:

[0170] CTC - the co-toxicity coefficient;

[0171] ATI - the measured toxicity index of the mixture;

[0172] TTI - the theoretical toxicity index of the mixture.

[0173] The co-toxicity coefficient of the compound mixture: CTC≥120 shows synergistic effect; CTC≤80 shows antagonistic effect; 80

[0174] The results show that the LC 50 of the compound of formula (I) against cotton bollworm is 0.855 mg·L -1The results in Table 5 show that the compound of formula (I) and high-efficiency trans-chlorpyrifos mixed in the range of 1:35-25:1 have a synergistic effect in controlling cotton bollworm; among them, the compound of formula (I) and high-efficiency trans-chlorpyrifos mixed in the range of 1:24-15:1 have a synergistic effect in controlling cotton bollworm with a co-toxicity coefficient greater than 160.

[0175] Table 5 Toxicity determination results of the compound of formula (I) and high-efficiency trans-chlorpyrifos in different proportions on cotton bollworm

[0176]

[0177] The results in Table 6 show that the compound of formula (I) and dimethoate mixed in the range of 1:50-24:1 have an additive or synergistic effect in controlling cotton bollworm; among them, the compound of formula (I) and dimethoate mixed in the range of 1:30-24:1 have a synergistic effect in controlling cotton bollworm; in the range of 1:18-12:1, the co-toxicity coefficient is greater than 140; and the synergistic effect is obvious.

[0178] Table 6 Toxicity determination results of the compound of formula (I) and dimethoate in different proportions on cotton bollworm

[0179]

[0180] Field efficacy examples

[0181] Efficacy test of different pesticides in controlling cucumber aphids

[0182] Test time and place: June 2023, vegetable planting base of Haide College in Laizhang City, Shandong Province;

[0183] Test crop: cucumber, variety: Jinyou No. 5; control object: cucumber aphid;

[0184] Test field: the management level of the test field is general, the soil fertility is consistent, and the previous crop is potato; no other insecticides are used during the test period.

[0185] Plot setting: the area of each treatment plot is 30 m 2 , and 4 repetitions are set. The cultivation conditions of all test plots are uniform.

[0186] Test method: spray treatment at the initial stage of cucumber aphid occurrence, uniform spray application by using a backpack sprayer, uniform and consistent spray is required, and the capacity is about 450 L / hm 2 .

[0187] Investigation: investigate the initial population before application, investigate once at 3d and 7d after application, a total of 3 times, sample 5 points in each plot, and investigate at least the number of live aphids on 10 labeled plants.

[0188] Application treatment:

[0189] Table 7. Agent treatment and dosage

[0190]

[0191]

[0192] Method for calculating efficacy:

[0193]

[0194] Test results:

[0195] Field efficacy tests showed that the mixtures of the compound of formula (I) and lambda-cyhalothrin, bifenthrin, trans-chlorpyrifos and cyhalothrin had good control effects on aphids of cucumber as shown in Tables 8 and 9. Table 8 shows that the control effects of the mixtures of the test agents reached more than 87% after 2 days of application, showing good quick-acting properties, and the control effects from high to low were 14% compound of formula (I)·trans-chlorpyrifos emulsion (2:12), 5% compound of formula (I)·cyhalothrin emulsion (2.5:2.5), 8% compound of formula (I)·lambda-cyhalothrin emulsion (3:5), and 10% compound of formula (I)·bifenthrin emulsion (9:1).

[0196] Table 8. Field control effect test of each treatment on aphids

[0197]

[0198] Note: The above data are average values of 4 repetitions, and the numerical values are retained to two decimal places.

[0199] Table 9 shows that the control effects of the mixtures of the test agents continued to increase after 7 days of application, showing good persistence, and the control effects from high to low were 8% compound of formula (I)·lambda-cyhalothrin emulsion (3:5), 10% compound of formula (I)·bifenthrin emulsion (9:1), 5% compound of formula (I)·cyhalothrin emulsion (2.5:2.5), and 14% compound of formula (I)·trans-chlorpyrifos emulsion (2:12).

[0200] Table 9. Field control effect test of each treatment on aphids

[0201]

[0202] Note: The above data are average values of 4 repetitions, and the numerical values are retained to two decimal places.

[0203] Efficacy test of different agents on control of cotton bollworm

[0204] Test time and place: August 2022 in Jining Jinxiang County cotton planting base;

[0205] Test crop: cotton (Cree cotton No. 3); control object: cotton bollworm;

[0206] Test field: planting density 667m 2 / 1500 plants; plot setting: the area of each treatment plot is 20m 2 , 4 times of repetition, and the cultivation conditions of all test plots are uniform;

[0207] Test method: ground spray method;

[0208] Investigation: investigate the insect population before application, investigate the number of live insects 3d and 7d after application, take the middle 2 rows of each plot to investigate the number of cotton bollworms and hang a card for marking.

[0209] Application treatment:

[0210] Table 10 Formulation and dosage of pesticides

[0211]

[0212]

[0213] Pharmacodynamic calculation method:

[0214]

[0215] Test results:

[0216] The field efficacy test shows that, as shown in Table 11, the compound of formula (I) and high-efficiency trans-chlorpyrifos, deltamethrin mixed preparation have good control effect on cotton bollworm.

[0217] Table 11 Field control effect test of each treatment on cotton bollworm

[0218]

[0219] Note: the above data are the average values of 4 times of repetition, the numerical value is retained to two decimal places, and the letters represent the difference significance (0.05 / DMRT method).

[0220] The insecticidal composition or its preparation obtained by compounding has significant control effect, is better than single agent in delaying the generation of drug resistance and prolonging the drug resistance, and no drug damage to crops is found in the test, which shows that in the case of synergistic effect of the obtained insecticidal composition or preparation, the production cost and use cost can be reduced, and the crops are safe.

[0221] Although the present application has been described in detail with particular references to illustrative embodiments thereof, it should be understood that modifications and / or improvements can be made to the present application which do not depart from the spirit and scope of the present application, and such modifications and / or improvements are intended to be included within the scope of the present application.

Claims

1. A pyrethroid-containing insecticidal composition, characterized by: comprising active ingredient A and active ingredient B, The active ingredient A is a compound of formula (I) The active ingredient B is a pyrethroid compound, which includes lambda-cyhalothrin, bifenthrin, transfluthrin, deltamethrin and cyhalothrin; the mass ratio of the compound of formula (I) to lambda-cyhalothrin is 1:25-60:1, the mass ratio of the compound of formula (I) to bifenthrin is 1:30-45:1, the mass ratio of the compound of formula (I) to transfluthrin is 1:35-35:1, the mass ratio of the compound of formula (I) to cyhalothrin is 1:25-30:1, and the mass ratio of the compound of formula (I) to deltamethrin is 1:30-24:

1.

2. The insecticidal composition according to claim 1, characterized in that: The mass ratio of the compound of formula (I) to lambda-cyhalothrin is 1:25, 1:12, 1:2, 5:1, 15:1, 40:1, 60:1, the mass ratio of the compound of formula (I) to bifenthrin is 1:30, 1:14, 1:6, 10:1, 20:1, 45:1, the mass ratio of the compound of formula (I) to trans-chlorpyrifos is 1:35, 1:28, 1:24, 1:15, 1:12, 1:6, 1:3, 2:5, 3:1, 5:1, 8:1, 15:1, 17:1, 25:1, 35:1, the mass ratio of the compound of formula (I) to lambda-cyhalothrin is 1:25, 1:15, 1:5, 1:1, 4:1, 15:1, 30:1, and the mass ratio of the compound of formula (I) to deltamethrin is 1:30, 1:18, 1:9, 1:3, 12:1, 24:

1.

3. The insecticidal composition according to claim 1, wherein: The content of the active ingredient A and the active ingredient B in the insecticidal composition is 0.5% to 90% based on the total mass of the insecticidal composition.

4. The insecticidal composition according to claim 1, wherein: The insecticidal composition further comprises an auxiliary agent, and the auxiliary agent comprises a carrier and an adjuvant.

5. The insecticidal composition according to claim 1, wherein: The insecticidal composition can be formulated into a pesticide-acceptable preparation form, including a solid preparation and a liquid preparation.

6. The insecticidal composition according to claim 5, wherein: The preparation form is emulsifiable concentrate, suspension concentrate, water dispersible granule, water emulsion, microemulsion, granule, microcapsule suspension concentrate, ultra-low volume liquid, wettable powder or dispersible oil suspension concentrate.

7. Use of the insecticidal composition according to any one of claims 1 to 6 for controlling agricultural, forestry, horticultural or sanitary pests, characterized in that: The pests are aphids and cotton bollworms.

8. Use according to claim 7, characterized in that: The insecticidal composition is applied to pests in need of control or media where pests grow in an effective dose.

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